Artificial intelligence-enabled discovery of a RIPK3 inhibitor with neuroprotective effects in an acute glaucoma mouse model by Xing Tu, Zixing Zou, Jiahui Li, Simiao Zeng, Zhengchao Luo, Gen Li, Yuanxu Gao, Kang Zhang, Jing Ni

“…Subsequently, these target candidates were validated using molecular simulations (molecular docking, absorption, distribution, metabolism, excretion, and toxicity [ADMET] prediction, and molecular dynamics simulations) and biological experiments (Western blotting and fluorescence staining) in vitro and in vivo. …”
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Assessing the efficacy of iso-mukaadial acetate and betulinic acid against selected Plasmodium falciparum glycolytic pathway proteins: in silico and in vitro studies by Lindiwe Khumbuzile Zuma, Ofentse Jacob Pooe, Nonduduzo Hlengiwe Mabaso, John Alake, Vincent A. Obakachi, Sinethemba Yakobi, Nothando Gasa, Rajshekhar Karpoormath, Mthokozisi Simelane

“…Molecular docking and molecular dynamics simulation studies were used to measure and confirm the interactive strength of complexes. …”
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Protein kinases MpkA and SepH transduce crosstalk between CWI and SIN pathways to activate protective hyphal septation under echinocandin cell wall stress by Alexander G. Doan, Jessica E. Schafer, Casey M. Douglas, Matthew S. Quintanilla, Meredith E. Morse, Harley Edwards, Walker D. Huso, Kelsey J. Gray, JungHun Lee, Joshua K. Dayie, Steven D. Harris, Mark R. Marten

“…In this work, we show that echinocandin resistance hinges on this dynamic response, rather than on innate septation alone. …”
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Pre-pandemic cross-reactive antibody and cellular responses against SARS-CoV-2 among female sex workers in Dakar, Senegal by Bobby Brooke Herrera, Bobby Brooke Herrera, Bobby Brooke Herrera, Bobby Brooke Herrera, Beth Chaplin, Souleymane MBoup, Adam Abdullahi, Adam Abdullahi, Michelle He, Sydney M. Fisher, Sulaimon Akanmu, Charlotte A. Chang, Donald J. Hamel, Ravindra K. Gupta, Ravindra K. Gupta, Phyllis J. Kanki

“…Our study provides unique data on the dynamics of hCoV and SARS-CoV-2 immunity in Senegal and underscores the importance of understanding the role of pre-existing immunity in shaping COVID-19 outcomes globally.…”
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Both light and soil moisture affect the rhizosphere microecology in two oak species by Jinshuo Lian, Keke Cai, Aijing Yin, Yuan Yuan, Xinna Zhang, Chengyang Xu

“…These experiments aimed to offer scientific theoretical support for the dynamic changes in rhizosphere soil enzyme activities and microbial community compositions of these two oak species under varying light and moisture conditions, and subsequently assist in the future breeding and cultivation efforts. …”
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The regulatory role of cystatin C in autophagy and neurodegeneration by T. A. Korolenko, A. B. Shintyapina, A. B. Pupyshev, A. A. Akopyan, G. S. Russkikh, M. A. Dikovskaya, V. A. Vavilin, E. L Zavjalov, M. A. Tikhonova, T. G. Amstislavskaya

“…Autophagy is a dynamic cellular process involved in the turnover of proteins, protein complexes, and organelles through lysosomal degradation. …”
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Clinical validation of an individualized auto-adaptative serious game for combined cognitive and upper limb motor robotic rehabilitation after stroke by Ioannis Doumas, Thierry Lejeune, Martin Edwards, Gaëtan Stoquart, Yves Vandermeeren, Bruno Dehez, Stephanie Dehem

“…Objective The aim of this study is to clinically validate the dynamic difficulty adjustment (DDA) mechanism of ROBiGAME, a robot serious game designed for simultaneous rehabilitation of motor impairments and hemispatial neglect. …”
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Early assessment of IL8 and PD1+ Treg predicts response and guides treatment monitoring in cemiplimab-treated cutaneous squamous cell carcinoma by Teresa Troiani, Fabiana Napolitano, Luigi Formisano, Roberto Bianco, Daniela Russo, Daniela Esposito, Giuseppe Ercolano, Angela Ianaro, Alberto Servetto, Daniela Claudia Maresca, Marcella Scala, Annarita Amato, Stefania Belli, Claudia Maria Ascione, Angela Vallefuoco, Giovanna Attanasio, Fabio Somma, Silvia Varricchio, Massimo Mascolo, Claudia Costa, Alessia Villani, Massimiliano Scalvenzi, Gianfranco Orlandino

“…However, reliable biomarkers for patient selection are still lacking.Experimental design In this translational study, clinical annotations, tissue and liquid biopsies were acquired to investigate the association between sustained objective responses and transcriptional profiles, immune cell dynamics in tumor tissue and peripheral blood samples, as well as circulating cytokine levels.Results First, we investigated the baseline characteristics of the immune landscape of cSCC biopsies. …”
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The change rule of smoke dispersion and temperature evolution in fires within lithium iron phosphate energy storage prefabricated cabin by ZHANG Yin, QIN Chaoqun, TIAN Shuangshuang, GE Zhichao, DONG Jun, ZHANG Xiaoxing

“…The simulation results demonstrate that smoke displays distinct dynamic behaviors depending on the thermal runaway positions within the energy storage prefabricated cabin. …”
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The presence of iteroparous salmonid spawning grounds affects the stable isotope signatures of food web components in Swedish boreal streams by Rahmat Naddafi, Magnus Enbom, Carin Magnhagen, Nazila Hajizadeh Koupayh, Daniel Holmqvist, Hans Lundqvist

“…Marine-derived nutrients (MDN) translocated by anadromous fish can strongly be linked to the dynamics and structure of resident freshwater communities. …”
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Impact of Wetting-Drying Cycles on Soil Intra-Aggregate Pore Architecture Under Different Management Systems by Luiz F. Pires, Jocenei A. T. de Oliveira, José V. Gaspareto, Adolfo N. D. Posadas, André L. F. Lourenço

“…In many soil processes, including solute and gas dynamics, the architecture of intra-aggregate pores is a crucial component. …”
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The Evaluation of Tau Deposition with [18F]PI-2620 by Using a Semiquantitative Method in Cognitively Normal Subjects and Patients with Mild Cognitive Impairment and Alzheimer’s Dis... by Attapon Jantarato, Sira Vachatimanont, Natphimol Boonkawin, Sukanya Yaset, Anchisa Kunawudhi, Chetsadaporn Promteangtrong, Jintana Assanasen, Nithi Mahanonda, Chanisa Chotipanich

“…Twenty-six cognitively normal (CN) subjects, 7 patients with AD, and 36 patients with MCI were enrolled. A dynamic positron emission tomography (PET) scan was performed 30–75 min postinjection. …”
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Population genetic analysis of clinical Mycobacterium abscessus complex strains in China by Xiangchen Li, Xiangchen Li, Yelei Zhu, Yewei Lu, Kunyang Wu, Yang Che, Xiaomeng Wang, Weixin Wang, Junli Gao, Junshun Gao, Zhengwei Liu, Zhengwei Liu, Zhuxian Zhou

“…An acquired erm(46) gene, likely obtained via phage-mediated horizontal gene transfer, was detected in one MabA strain.ConclusionThis study provides key genetic insights into the dynamics of MABC in China. The widespread distribution of DCCs, high genomic clustering rates, open pan-genome, and distinct resistance patterns between MabA and MabM, along with MGEs, highlight the need for targeted surveillance and tailored therapies to address emerging challenges in MABC infections.…”
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Real-Time Neuropsychological Testing for Hydrocephalus: Ultra-Fast Neuropsychological Testing During Infusion and Tap Test in Patients with Idiopathic Normal-Pressure Hydrocephalus by Ilaria Guarracino, Sara Fabbro, Daniele Piccolo, Serena D’Agostini, Miran Skrap, Enrico Belgrado, Marco Vindigni, Francesco Tuniz, Barbara Tomasino

“…Based on cerebrospinal fluid dynamics, 63.15% of the patients presented a resistance to outflow > 12 mmHg/mL/min, while 88% had a positive tap test response. …”
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Dataset of microscale atmospheric flow and pollutant concentration large-eddy simulations for varying mesoscale meteorological forcing in an idealized urban environmentZenodo by Eliott Lumet, Thomas Jaravel, Mélanie C. Rochoux

“…Computational Fluid Dynamics (CFD) has emerged as a powerful tool to address this challenge by providing obstacle-resolved flow and dispersion predictions. …”
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Stock price prediction with attentive temporal convolution-based generative adversarial network by Ying Liu, Xiaohua Huang, Liwei Xiong, Ruyu Chang, Wenjing Wang, Long Chen

“…Traditional prediction models such as ARIMA and classic linear regression models are often inadequate for capturing the complex dynamics of stock prices. The advent of deep learning has led to substantial improvements in prediction accuracy, with various recurrent neural networks widely employed for representation learning from stock sequences. …”
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Characterization and Selection of WiFi Channel State Information Features for Human Activity Detection in a Smart Public Transportation System by Roya Alizadeh, Yvon Savaria, Chahe Nerguizian

“…Since the environment of a transportation system changes dynamically and non-deterministically, we propose analyzing these changes with a heuristic algorithm that leverages a decision tree to automate a decision-making solution for feature selection. …”
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Patellofemoral Joint Loading During Bodyweight One-Legged and Two-Legged BOSU and Floor Squats by Rafael Escamilla, Naiquan Zheng, Toran D. MacLeod, Rodney Imamura, Kevin E Wilk, Shangcheng Wang, Robert Asuncion, Irwin S. Thompson, Arnel L. Aguinaldo, Glenn S Fleisig

“…Kinematic and ground-reaction force data were used to calculate resultant knee force and torque using inverse-dynamics, with electromyographic data employed in a knee muscle model to predict resultant knee force and torque at every 10° between 10°-100° knee-angles during the squat-descent and squat-ascent. …”
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Optical-electrical-acoustic wave multiparameter response characteristics of typical rocks in coal-bearing strata throughout the loading process by Pingsong ZHANG, Chang LIU

“…Objective The deformations and rupture of rocks under loading will cause potential changes in parameters. Dynamic parameter capture assists in characterizing the generation, propagation, and closure processes of fractures, serving as a significant method for assessing rock quality. …”
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Sensitive windows for within- and trans-generational plasticity of anti-predator defences by Tariel-Adam, Juliette, Luquet, Émilien, Plénet, Sandrine

“…Determining these sensitive windows is essential to understand the temporal dynamic of environmental cue detection, phenotype induction and selection. …”
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