Interleukin 6 Function in the Skin and Isolated Keratinocytes Is Modulated by Hyperglycemia by Eric G. Lee, Lerin R. Luckett-Chastain, Kaitlin N. Calhoun, Benjamin Frempah, Anja Bastian, Randle M. Gallucci

“…Annual health care cost of diabetes exceeds $254 billion and is associated with a distinct set of diabetic complications that include delayed wound healing and diabetic ulcers. …”
Get full text

Alleviating symptoms of paediatric acute rhinosinusitis and acute otitis media with otorrhea using nasal-spraying Bacillus probiotics: a randomized controlled trial by Thanh Huu Khieu, Dung Phuong Le, Binh Thanh Nguyen, Binh Thanh Ngo, Hong Thi Chu, Duc Minh Truong, Hung Minh Nguyen, Anh Hoa Nguyen, Tung Dinh Pham, Anh Thi Van Nguyen

“…This study evaluated the efficacy of the nasal-spraying probiotics (LiveSpo Navax containing 5 billion Bacillus subtilis and B. clausii spores/5 mL) as a supportive treatment for dual ARS and AOM with otorrhea in a randomized, single-blind, controlled clinical trial. …”
Get full text

The Global Burden of Migraine: A 30-Year Trend Review and Future Projections by Age, Sex, Country, and Region by Lingkang Dong, Wenqi Dong, Yuchen Jin, Yumeng Jiang, Zhuangzhuang Li, Dongzhen Yu

“…Results From 1990 to 2021, the global burden of migraine significantly increased: prevalence increased by 58.15%, from 732.56 million to 1.16 billion cases, and incidence increased by 42.06%. …”
Get full text

Assessing water demand and supply in the Upper Indus Basin using integrated hydrological modeling under varied socioeconomic scenarios by Sareer Ahmad, Muhammad Waseem, Hira Wahab, Abdul Qadeer Khan, Zulqarnain Jehan, Izhar Ahmad, Megersa Kebede Leta

“…The baseline scenario indicates a significant rise in water demand from 35.74 billion cubic meters (BCMs) in 2020 to 60.28 BCM by 2035, driven by population growth and increased domestic water consumption. …”
Get full text

Understanding Citizens’ Response to Social Activities on Twitter in US Metropolises During the COVID-19 Recovery Phase Using a Fine-Tuned Large Language Model: Application of AI by Ryuichi Saito, Sho Tsugawa

“…As of March 2024, >676 million cases, 6 million deaths, and 13 billion vaccine doses have been reported. It is crucial to evaluate sociopsychological impacts as well as public health indicators such as these to understand the effects of the COVID-19 pandemic. …”
Get full text

Dynamics of ecosystem service values in the Tarim River Basin by Mengxin Sun, Mengxin Sun, Xin Shen, Xin Shen, Hailiang Xu, Hailiang Xu, Ai Shajiang·Aili, Ai Shajiang·Aili

“…Glaciers have reduced in area, though their meltwater contributed to the increase in water bodies and wetlands. (2) ESV increased by 99.34 billion, with grasslands and water bodies contributing 60% and 10%, respectively. …”
Get full text

Pulmonary and systemic immune alterations in rats exposed to airborne lunar dust by Brian E. Crucian, Heather Quiriarte, Chiu-wing Lam, Mayra Nelman, Audrie A. Colorado, Douglass M. Diak, John T. James

“…BackgroundDue to cosmic radiation bombardment and over 4 billion meteorite and micrometeoroid impacts on the airless Moon, the lunar surface is covered by a layer of fine, reactive dust. …”
Get full text

Determinants of Anemia among Pregnant Women at Public Hospitals in West Shewa, Central Ethiopia: A Case-Control Study by Berhanu Senbeta Deriba, Elias Teferi Bala, Gizachew Abdissa Bulto, Tinsae Abeya Geleta, Agumas Fentahun Ayalew, Addis Adera Gebru, Habtamu Oljira Desta, Mengistu Benayew Shiferaew, Lidya Zerihun Sahile

“…Anemia is highly dominant among pregnant women due to the need for iron for women themselves and their fetuses. Nearly half a billion globally and around one-third in Ethiopia of pregnant women were affected by anemia which has both health and economic impact. …”
Get full text

Efficacy and safety of intermittent fasting for type 2 diabetes mellitus: A systematic review and meta-analysis of randomized trials by Joshua Chadwick, Lavanya Ayyasamy, Madhanraj Kalyanasundaram, Ganeshkumar Parasuraman, Bhavani Shankara Bagepally, Jeyashree Kathiresan, Lokesh Shanmugam

“…Background & objectives: Type 2 diabetes mellitus (T2DM) is a pressing public health concern, contributing to 11 % of annual deaths and incurring direct expenses of $760 billion. Studies show intermittent fasting (IF) can effectively lower glycated haemoglobin (HbA1c) levels and reduce weight and levels in individuals with type 2 diabetes. …”
Get full text

Ultrahigh-Performance Radio Frequency System-on-Chip Implementation of a Kalman Filter-Based High-Precision Time and Frequency Synchronization for Networked Integrated Sensing and... by Roghayeh Ghasemi, Patrick Fenske, Tobias Koegel, Markus Hehn, Ingrid Ullmann, Martin Vossiek

“…Due to the deterministic processing time inherent in the FPGA, the proposed synchronization method achieves exceptional precision, with clock offset deviations in the nanosecond range and clock rate deviations limited to only a few parts per billion, even across considerable distances between the network nodes.…”
Get full text

Dataset on electricity usage measurement for lower-to-middle-income primary and secondary schools in Western Cape, South AfricaMendeley Data by Jason Avron Samuels, Terhemba Michael-Ahile, M. J. (Thinus) Booysen

“…With over 24,000 public primary and secondary schools using an estimated 3.5 TWh annually, the collective utility expense amounts to ZAR 5.0 billion (approximately US$ 330 million). Given this substantial financial burden, a comprehensive dataset to support the sustainability and financial viability of these schools is essential, ensuring that more resources can be directed toward their core educational missions. …”
Get full text

Association between Helicobacter pylori Infection and Occurrence of Anemia among Pregnant Women Attending Antenatal Care in Kulito Health Center, Halaba Zone, South Ethiopia, 2018 by Bahredin Abdella, Mohammed Ibrahim, Iyasu Tadesse, Kalkidan Hassen, Mekonnin Tesfa

“…Globally, it affects 1.62 billion people. In developing countries, anemia is a major cause of maternal and child morbidity and mortality. …”
Get full text

Non-pharmacological interventions for primary hypertension: a systematic review and network meta-analysis protocol by Tao Xu, Fan-rong Liang, Qifu Li, Taipin Guo, Ziwen Chen, Yun-Jie Shu, Xueli Zhou

“…Introduction Primary hypertension (PH) affects over one billion individuals globally, yet less than 30% achieve controlled blood pressure (BP) with medication. …”
Get full text

Magnitude of urban malaria and its associated risk factors in Damboya town, Kambata zone, Central Ethiopia by Biruk Mulachew, Temesgen Bezuayehu, Solomon Asnake

“…Malaria is thought to directly cost Africa $12 billion annually and reduce GDP growth by 3 %. In addition, it is thought to cause cognitive disorders and school absences, which are barriers to the development of human capital (Monroe et al., 2022). 95 % confidence interval (CI) and p-value of <0.05. …”
Get full text

The Impact of Targeted Therapies on Red Blood Cell Aggregation in Patients with Chronic Lymphocytic Leukemia Evaluated Using Software Image Flow Analysis by Anika Alexandrova-Watanabe, Emilia Abadjieva, Lidia Gartcheva, Ariana Langari, Miroslava Ivanova, Margarita Guenova, Tihomir Tiankov, Velichka Strijkova, Sashka Krumova, Svetla Todinova

“…Despite advances in therapies targeting Bruton’s tyrosine kinase and anti-apoptotic protein BCL-2, little is known about their effect on red blood cell (RBC) aggregation in blood flow. …”
Get full text

SGCL-LncLoc: An Interpretable Deep Learning Model for Improving lncRNA Subcellular Localization Prediction with Supervised Graph Contrastive Learning by Min Li, Baoying Zhao, Yiming Li, Pingjian Ding, Rui Yin, Shichao Kan, Min Zeng

“…SGCL-LncLoc transforms lncRNA sequences into de Bruijn graphs and uses the Word2Vec technique to learn the node representation of the graph. …”
Get full text

Aberrant heterochromatin silences immune response genes in chronic lymphocytic leukemia by Olivia M. Depies, Qianqian Guo, Yuan Gao, Sutapa Sinha, Zhenqing Ye, Weiguo Han, Kari G. Rabe, Mingma S. Hoel, Heather C. Darby, Chuanhe Yu, Esteban Braggio, Sameer A. Parikh, Susan L. Slager, Neil E. Kay, Zhiquan Wang

“…Finally, when treated with the Bruton tyrosine kinase inhibitor ibrutinib, these silenced enhancers are relatively stable during therapy compared with the CLL-gained enhancers. …”
Get full text

Immune responses of cattle vaccinated by various routes with Mycobacterium bovis Bacillus Calmette-Guérin (BCG) by Mitchell V. Palmer, Soyoun Hwang, Carly Kanipe, Ellie J. Putz, Luis Guilherme Virgilio Fernandes, Anna Didkowska, Paola M. Boggiatto

“…Abstract Background Mycobacterium bovis BCG is the human tuberculosis vaccine and is the oldest vaccine still in use today with over 4 billion people vaccinated since 1921. The BCG vaccine has also been investigated experimentally in cattle and wildlife by various routes including oral and parenteral. …”
Get full text

Quantification of Volatile Acetone Oligomers Using Ion-Mobility Spectrometry by Tobias Hüppe, Dominik Lorenz, Felix Maurer, Tobias Fink, Ramona Klumpp, Sascha Kreuer

“…The calibration reference was pure acetone vaporized by a gas generator at concentrations from 5 to 45 ppbv (parts per billion by volume). Results. Acetone concentrations in ambient laboratory air were only slightly greater (5.6 ppbv; 95% CI 5.1–6.2) than in ambient air in an intensive care unit (5.1 ppbv; 95% CI 4.4–5.5; p<0.001). …”
Get full text

Engineering of l-threonine and l-proline biosensors by directed evolution of transcriptional regulator SerR and application for high-throughput screening by Wei Pu, Jinhui Feng, Jiuzhou Chen, Jiao Liu, Xuan Guo, Lixian Wang, Xiaojia Zhao, Ningyun Cai, Wenjuan Zhou, Yu Wang, Ping Zheng, Jibin Sun

“…Abstract Amino acids are important bio-based products with a multi-billion-dollar market. The development of efficient high-throughput screening technologies utilizing biosensors is essential for the rapid identification of high-performance amino acid producers. …”
Get full text