Distinguishing Low Expression Levels of Human Epidermal Growth Factor Receptor 2 in Breast Cancer: Insights from Qualitative and Quantitative Magnetic Resonance Imaging Analysis by Yiyuan Shen, Xu Zhang, Jinlong Zheng, Simin Wang, Jie Ding, Shiyun Sun, Qianming Bai, Caixia Fu, Junlong Wang, Jing Gong, Chao You, Yajia Gu

“…Background: The discovery of novel antibody–drug conjugates for low-expression human epidermal growth factor receptor 2 (HER2-low) breast cancer highlights the inadequacy of the conventional binary classification of HER2 status as either negative or positive. …”
Get full text

Size and Shape of Jupiter Trojan (2207) Antenor from Stellar Occultations by F. S. Ferreira, J. I. B. Camargo, B. E. Morgado, V. F. Peixoto, J. Desmars, F. Braga-Ribas, A. R. Gomes-Júnior, B. Sicardy, J. L. Ortiz, R. Vieira-Martins, C. L. Pereira, L. Liberato, M. Assafin, Y. Kilic, R. C. Boufleur, F. L. Rommel, G. Benedetti-Rossi, M. V. Banda-Huarca, F. Marchis, P. Tanga, B. Blanc, E. Bondoux, A. Burnett, S. Calavia-Belloc, O. Canales-Moreno, N. Carlson, M. Conjat, T. George, R. Gonçalves, R. Iglesias-Marzoa, G. Krannich, D. Lafuente-Aznar, P. D. Maley, J. Marco, C. Schnabel, D. Shand, K. Wagner

“…For the best-fitted ellipse in the sky-plane, we determined that Antenor has a 2D apparent equatorial radius of 54.30  ±  0.99 km at the moment of the occultations, with an apparent oblateness of 0.144  ±  0.051. We highlight the positive detection from 2021 June 12, which shows an intriguing feature that can be interpreted as a very large topographical feature (of about 11 km) of the body or that can provide further evidence that this object is, in fact, a close or contact binary. …”
Get full text

Impacts of pre-pregnancy exposure to per- and polyfluoroalkyl substances on menstrual characteristics among women undergoing assisted reproductive technology by Huyi TAO, Yujie CAO, Yitao PAN, Jiuru ZHAO, Zhiwei LIU, Yu GAO, Ying TIAN

“…The single PFAS exposure analysis revealed a positive correlation between PFAS and irregular menstrual cycles. …”
Get full text

Investigation of methicillin, beta lactam, carbapenem, and multidrug resistant bacteria from blood cultures of septicemia suspected patients in Northwest Ethiopia by Abebe Birhanu, Getachew Gebre, Eden Getaneh, Hana Yohannes, Netsanet Baye, Gizeaddis Belay Mersha, Mitkie Tigabie, Mulat Dagnew, Getachew Ferede, Teshiwal Deress, Wondwossen Abebe

“…Aimed to characterize pathogens isolated from positive blood cultures, including bacterial profiles and antibiotic susceptibility patterns, and to identify predictors of blood culture positivity in septicemia-suspected patients at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia. …”
Get full text

Evaluating perineural invasion severity in head and neck cutaneous squamous cell carcinomas to refine prognostic accuracy: A retrospective case-control study by Filippo Nozzoli, Silvia Mancini, Andrea Ambrosini-Spaltro, Emilia Crisanti, Luca Riccioni, Giovanni De Luca, Annarita Lombardi, Fabio Falcini, Rosa Vattiato, Federica Zamagni, Lorenzo Borgognoni, Serena Sestini, Vincenzo De Giorgi, Laura Doni, Ismaela Vascotto, Angelo Cassisa, Chiara Anichini, Romina Nassini, Pierangelo Geppetti, Emanuele Crocetti, Ignazio Stanganelli, Daniela Massi

“…An additional 20 patients treated with immunotherapy and 25 external PNI-positive cases were included for validation. Prognostic correlations were then analyzed by Cox proportional hazards regression model. …”
Get full text

Associations of obesity and novel lipid indicators in the risk of type 2 diabetes mellitus in Chinese elderly hypertensive patients by Xihui Jin, Xihui Jin, Yushuang Wei, Yushuang Wei, YeMei Mo, Qiuling Zhang, Mingjie Xu, Mingjie Xu, Xiaoyou Mai, Xiaoyou Mai, Boteng Yan, Boteng Yan, Wenchao Xie, Shengzhu Huang, Mingli Li, Zengnan Mo, Zengnan Mo

“…In the cross-sectional study, binary logistic regression, restricted cubic splines (RCS), and receiver operating characteristic (ROC) were used to analyze the relationships between WC, BMI, LAP, CVAI, and TyG with and T2DM in hypertensive patients. …”
Get full text

FpRS-Additive Cyclic Codes are Asymptotically Good by Bhanu Pratap Yadav

“…For example, a family of binary linear codes with parameters <inline-formula> <tex-math notation="LaTeX">$[n, k, d] = [{2^{r}-1, 2^{r}-1-r, 3}]$ </tex-math></inline-formula> is known as the Hamming codes, where <inline-formula> <tex-math notation="LaTeX">$r \geq 2$ </tex-math></inline-formula>. …”
Get full text

The association of exposure to multiple metals with the risk of idiopathic oligoasthenoteratozoospermia: The mediating role of sperm chromatin by Tao Yin, Sen Liang, XinYu Zhou, Xueting Lai, Xun Su, Jiajing Tao, Shiwei Ren, Danyang Li, Yunxia Cao, Dongmei Ji, Chunmei Liang

“…Results: Using sperm DFI and sperm HDS as binary variables, multivariate logistic regression models showed that the second and third tertiles of Cr levels in seminal plasma were positively associated with high sperm DFI risk, with reference to the first tertile. …”
Get full text

Association between maternal antibiotic exposure and emotional and behavioural problems in children at four years of age: A biomonitoring-based prospective study by Wanhong Xiong, Baolin Wang, Feifei Han, Juan Tong, Hui Gao, Peng Ding, Kaiyong Liu, Xiaoyan Wu, Kun Huang, Menglong Geng, Fangbiao Tao

“…Second-trimester trimethoprime concentrations and third-trimester ciprofloxacin concentrations were positively associated with hyperactivity-inattention. …”
Get full text

Ultra-fast [18F]florbetapir PET imaging using the uMI Panorama PET/CT system by Xueqian Yang, Meiqi Wu, Menglin Liang, Haiqiong Zhang, Bo Li, Chenhui Mao, Liling Dong, Yuan Wang, Haiqun Xing, Chao Ren, Zhenghai Huang, Qingxiang Wen, Qi Ge, Zhengqing Yu, Feng Feng, Jing Gao, Li Huo

“…Methods Thirty-eight participants (29 Aβ positive and 9 Aβ negative) from a prospective dementia cohort at Peking Union Medical University Hospital underwent routine [18F]florbetapir PET scans using the uMI Panorama PET/CT scanner and a T1-weighted brain MRI scan. …”
Get full text

Modular and efficient assembly of CRISPR vectors and construction of an apple gene editing efficiency evaluation system by HOU Feifan, HUANG Chuanmi, HAO Pengbo, CONG Liu, BAI Tuanhui, SHI Jiangli, WANG Miaomiao, LIU Yu, ZHAO Yujie, WAN Ran, SHEN Yawen, ZHANG Hengtao, ZHANG Kunxi, ZHENG Xianbo, JIAO Jian

“…[Methods] The conventional vectors pUC19 (DNA cloning plasmid) and pHK2 (Dicotyledonous gene editing plasmid based on pCAMBIA1300 modification) were firstly modified by inserting a pair of type Ⅱ S restriction enzyme sites (such as Esp3 Ⅰ or Bsa Ⅰ etc.) into selected positions, to construct the intermediate vector pUC19-Esp3 Ⅰ-Bb and the plant expression vector backbone pHK2-Bsa Ⅰ-Bb. …”
Get full text

Determination of Phenolic Compounds from Lignin Decomposition Products in Marine Sediments by Ultra-High Performance Liquid Chromatography-High Resolution Mass Spectrometry by Jianbo YANG, Junhui CHEN, Xiuping HE, Jiuming WANG, Ming XIN, Xia SUN, Baodong WANG

“…Hence, ESI-TOF/MS in positive mode was selected to determine phenolic compounds of lignin decomposition products in marine sediment. …”
Get full text

Increasing uptake of self-management education programmes for type 2 diabetes in primary care: the Embedding research programme including an RCT by Melanie J Davies, Shona Agarwal, Danielle H Bodicoat, Alan Brennan, Simon Dixon, Helen Eborall, Agnieszka Glab, Laura J Gray, Michelle Hadjiconstantinou, Lisa Huddlestone, Nicky Hudson, Anju Keetharuth, Kamlesh Khunti, Caroline Kristunas, Graham Martin, Alison Northern, Mike Patterson, Daniel Pollard, Rebecca Pritchard, Sally Schreder, Jane Speight, Bernie Stribling, Jackie Sturt, Jess Turner, Christina Weis

“…Feedback on virtual programmes was highly positive, particularly for the financial and logistical benefits. …”
Get full text

Human immunodeficiency virus prevention and testing strategies among men who have sex with men in the UK: the PANTHEON research programme including the SELPHI RCT by Janey Sewell, T Charles Witzel, David Dunn, Fiona Lampe, Fiona Burns, Peter Weatherburn, Sheena McCormack, Leanne McCabe, Alec Miners, Valentina Cambiano, Roger Pebody, Roy Trevelion, Nadia Hanum, Andrew Phillips, Alison Rodger

“…Approximately 25% of all HIV-positive MSM were unaware of their infection and disproportionately contributed to onward transmission (between 60% and 80% of transmissions) and late presentations, with greatly increased risk of death. …”
Get full text

Evaluation of parenting interventions for those with additional health and social care needs during pregnancy: THRIVE a multi-arm RCT with embedded economic and process components by Marion Henderson, Anja Wittkowski, Katie Buston, Karen Crawford, Alice MacLachlan, Alex McConnachie, Emma McIntosh, Claudia-Martina Messow, Catherine Nixon, Rosaleen O’Brien, Shona Shinwell, Daniel Wight, Yiqiao Xin, Rachel Calam, Ruth Dundas, James Law, Helen Minnis, Lucy Thompson, Philip Wilson

“…Binary as ETPB versus MB (on subgroup receiving any active intervention). …”
Get full text

Re-use of Building Products in the Netherlands by Loriane Icibaci

“…To perceive the continuity of the strategy of reuse, this research positions the object of study from an evolutionary perspective where relations condition the action of reuse. …”
Get full text

Decolonization Projects by Cornelius Ewuoso

“…Second, exclusion and inclusion are also not binary. Individuals may experience exclusion, even while included (the phenomenon called internal exclusion). …”
Get full text

Digital augmentation of aftercare for patients with anorexia nervosa: the TRIANGLE RCT and economic evaluation by Janet Treasure, Katie Rowlands, Valentina Cardi, Suman Ambwani, David McDaid, Jodie Lord, Danielle Clark Bryan, Pamela Macdonald, Eva Bonin, Ulrike Schmidt, Jon Arcelus, Amy Harrison, Sabine Landau

“…Participants were generally positive about the written and recovery tip videos. …”
Get full text

A Phase-resolved View of Millihertz Quasiperiodic Oscillations in the Ultraluminous X-Ray Source M51 ULX-7: Evidence for a Magnetically Truncated Disk and Geometrical Beaming by Qing-Cang Shui, Shu Zhang, Hua Feng, Yu-Peng Chen, Shuang-Nan Zhang, Jing-Qiang Peng

“…X-ray quasiperiodic oscillations (QPOs) are commonly observed in Galactic X-ray binaries and extragalactic ultraluminous X-ray sources (ULXs). …”
Get full text

TRANSGENDER IDENTITY AND DIALECTICS OF REAL AND UNREAL by Surinder KAUR

“…Basing the analysis on Judith Butler’s theory of gender performativity, I posit that Mock urges us to see beyond heterosexual binaries and allow for a space for transgender people to be themselves. …”
Get full text