Original drugs approved by the Food and Drug Administration (Center for Drug Evaluation and Research) in 2024 by D. V. Kurkin, N. A. Osadchenko, A. R. Makarova, D. A. Galkina, D. A. Bakulin, O. V. Shatalova, A. V. Strygin, V. I. Petrov, O. V. Marincheva, Yu. V. Gorbunova, Yu. A. Kolosov, A. V. Zaborovsky, D. V. Yunina, K. N. Koryanova, E. I. Morkovin, M. A. Dzhavakhyan, V. I. Zvereva, R. V. Drai, I. E. Makarenko, A. S. Shuvaeva

“…Most of the original drug market is still made up of small molecules, among which there are medicines — ligands of new targets and oligonucleotide sequences.…”
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The Orthopedic Strategy for Patients with Larsen Syndrome by Ali Al Kaissi, Alexander Gubin, Sergey Ryabykh, Vasileios Dougales, Hamza Al Kaissi, Susanne Gerit Kircher, Franz Grill

“…<b>Background:</b> Facial features are the first basic sign of medical knowledge of children and adults with congenital malformations. …”
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Music intervention mitigates LPS-induced gut barrier disruption and immune stress in broilers via TLR4/NF-κB regulation by Shengzi Jin, Haowen Wang, Haiyue Gong, Lu Guo, Haoran Zhang, Jiaqi Zhang, Qingqing Chang, Jianhong Li, Runxiang Zhang, Jun Bao

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Effect of home-based pulmonary rehabilitation on ventilation dynamics and small airway dysfunction in people with post-tuberculosis lung disease by Iasmim Maria Pereira Pinto Fonseca, Samantha Gomes de Alegria, Jéssica Gabriela Messias Oliveira, Thaís Souza Rodrigues, Carolina Alves Osório da Silva Chagas, Alícia Sales Carneiro, Walter Costa, Ana Paula Santos, Thiago Thomaz Mafort, Agnaldo José Lopes

“…Background: As the world moves toward eliminating tuberculosis (TB), there is a large population of TB survivors who still face a significant burden of TB complications. …”
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Exploitation of enhanced prime editing for blocking aberrant angiogenesis by Xionggao Huang, Wenyi Wu, Hui Qi, Xiaohe Yan, Lijun Dong, Yanhui Yang, Qing Zhang, Gaoen Ma, Guoming Zhang, Hetian Lei

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Women’s health and maternal care services: seizing missed opportunities to prevent and manage preterm birth by Bo Jacobsson, Jennifer Harris Requejo, Teesta Dey, Tina Lavin, Margaret Titty Mannah, Ramkumar Menon, Catalina Valencia, Gaurav Sharma, Andrew Shennan, Elham Shakibazadeh, Pisake Lumbiganon, Sarah Bar-Zeev, Sue Steen, Angela Nguku, Hiromi Obara, Lisa Noguchi, Pius Okong, Sanjukta Amrita Singh, Jane Sandall, Anna Gruending, Zahida Qureshi, Joshua P. Vogel

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Lower respiratory tract microbiome dysbiosis impairs clinical responses to immune checkpoint blockade in advanced non‐small‐cell lung cancer by Yong Zhang, Xiang‐Xiang Chen, Ruo Chen, Ling Li, Qing Ju, Dan Qiu, Yuan Wang, Peng‐Yu Jing, Ning Chang, Min Wang, Jian Zhang, Zhi‐Nan Chen, Ke Wang

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Effects of Preoperative HbA1c Levels on the Postoperative Outcomes of Coronary Artery Disease Surgical Treatment in Patients with Diabetes Mellitus and Nondiabetic Patients: A Syst... by Jinjing Wang, Xufei Luo, Xinye Jin, Meng Lv, Xueqiong Li, Jingtao Dou, Jing Zeng, Ping An, Yaolong Chen, Kang Chen, Yiming Mu

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Determinants of Banten Young People's Intention to Pay Waqf Through Digital Platforms by Mohamad Ainun Najib, Yayat Sujatna

“…The potential for cash waqf in Banten reaches IDR 55 billion per month or IDR 667.2 billion per year, but the realization is still far from expectations. One of the factors is related to the low literacy of the community, especially generation Y and Z about waqf. …”
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The impact of routines on emotional and behavioural difficulties in children and on parental anxiety during COVID-19 by Vera Lees, Rosie Hay, Helen Bould, Helen Bould, Helen Bould, Alex S. F. Kwong, Daniel Major-Smith, Daniel Major-Smith, Daphne Kounali, Rebecca M. Pearson, Rebecca M. Pearson

“…Routine was taken as keeping to the same basic activities such as mealtimes and bedtimes. …”
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Specific Morphology of Coronary Artery Aneurysms in Mainly White Patients With Kawasaki Disease: Initial Data From the Cardiac Catheterization in Kawasaki Disease Registry by Julia Weisser, Leonie Arnold, Wolfgang Wällisch, Daniel Quandt, Bernd Opgen‐Rhein, Frank‐Thomas Riede, Florentine Gräfe, Jörg Michel, Raoul Arnold, Heike Schneider, Daniel Tanase, Ulrike Herberg, Christoph Happel, Mali Tietje, Gleb Tarusinov, Jochen Grohmann, Johanna Hummel, André Rudolph, Nikolaus Haas, André Jakob

“…Although respective evidence‐based recommendations are missing, cardiac catheterization is still considered the gold standard for diagnosing detailed coronary pathology. …”
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MP-LLAVRec: an agricultural product recommendation algorithm based on LLAVA and user modal preference by Peishan Li, Peishan Li, Peishan Li, Lutao Gao, Lutao Gao, Lutao Gao, Lilian Zhang, Lilian Zhang, Lilian Zhang, Lin Peng, Lin Peng, Lin Peng, Chunhui Bai, Chunhui Bai, Chunhui Bai, Linnan Yang, Linnan Yang, Linnan Yang

“…However, the following three problems still exist in the traditional agricultural product recommendation domain: (1) the problem of missing modalities made it difficult for consumers to intuitively and comprehensively understood the product information; (2) most of them relied on shallow information about the basic attributes of agricultural products and ignored the deeper associations among the products; (3) they ignored the deeper connections among individual users and the intrinsic associations between the user embedding and the localized user representation in different modalities, which affected the accuracy of user modeling and hindered the final recommendation effect.MethodsTo address these problems, this paper innovatively proposed an agricultural product recommendation algorithm based on LLAVA and user behavioral characteristics, MP-LLaVRec(Modal Preference - Large Language and Vision Recommendation). …”
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Economic burden of breast cancer in Chinese women: analysis o from 2016 to 2018 using national health insurance data by Yu Qi, Yaqun Fu, Yumeng Lv, Ye Zhang, Xia Wei, Li Sun, Bin Cui, Ranjit Manchanda, Rosa Legood, Li Yang

“…Approximately 72.54% of patients were covered by Urban Employee Basic Medical Insurance (EBMI). In this study, 73.56% of breast cancer patients utilized inpatient services, although, this study found the proportion of patients seeking medical treatment in lower-level hospitals increased over time, over 82.07% of the study population still seek care at tertiary hospitals in China. …”
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Plasminogen deficiency reduces disease severity and immune responses in enterovirus A71-infected mice by Zheng-Xun Li, Ya-Fang Wang, Li-Ting Chiang, Li-Jin Hsu, Shih-Min Wang, Jen-Ren Wang, Hua-Lin Wu, Shun-Hua Chen, Chuan-Fa Chang

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Gender- and Age-Specific Differences in the Association of Hyperuricemia and Hypertension: A Cross-Sectional Study by Xiaoyun Lin, Xiqian Wang, Xin Li, Lili Song, Zhaowei Meng, Qing Yang, Wenjuan Zhang, Yuxia Gao, Zhenwen Yang, Heng Cai, Bo Bian, Yongle Li, Xuefang Yu, Xin Du, Shaopeng Xu, Jing Nie, Ming Liu, Jinhong Sun, Qing Zhang, Ying Gao, Kun Song, Xing Wang, Li Zhao, Yaguang Fan

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Progranulin deficiency associates with postmenopausal osteoporosis via increasing ubiquitination of estrogen receptor α by Guangfei Li, Aifei Wang, Wei Tang, Wenyu Fu, Qingyun Tian, Jinlong Jian, Michal Lata, Aubryanna Hettinghouse, Yuanjing Ding, Jianlu Wei, Xiangli Zhao, Mingyong Wang, Qirong Dong, Chuanju Liu, Youjia Xu

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Persistent opioid use among patients who underwent intermediate-to-major elective surgery at a Swiss cantonal hospital: a prospective cohort study by Flavia Breitenmoser, Aaron Rixecker, Rahel Naef, Pascal Probst, Nils Horn, Markus K. Müller, Alexander Dullenkopf, JoEllen Welter

“…Only those patients who were still taking opioids at the 6-week interview were contacted 12 weeks after surgery. …”
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Spatiotemporal Characterization of Human Early Intervertebral Disc Formation at Single‐Cell Resolution by Taifeng Zhou, Yu Chen, Zhiheng Liao, Long Zhang, Deying Su, Zhuling Li, Xiaoming Yang, Xiaona Ke, Hengyu Liu, Yuyu Chen, Ricong Weng, Huimin Shen, Caixia Xu, Yong Wan, Ren Xu, Peiqiang Su

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Biofilm Inhibition: The Role of Fixed Oil from <i>Caryocar coriaceum</i> in Fighting Resistant Bacterial Communities by José Weverton Almeida-Bezerra, José Thyálisson da Costa Silva, Saulo Almeida Menezes, Gabriel Gonçalves Alencar, Daiany Alves Ribeiro, Bárbara Fernandes Melo, João Pereira da Silva-Junior, Francisca de Fátima Silva de Sousa, Severino Denicio Gonçalves de Sousa, Marcos Aurélio Figueirêdo dos Santos, Dieferson Leandro de Souza, Luiz Neldecílio Alves Vitor, Ademar Maia Filho, Murilo Felipe Felício, Jacqueline Cosmo Andrade-Pinheiro, Viviane Bezerra da Silva, José Jailson Lima Bezerra, Maria Flaviana Bezerra Morais-Braga, Henrique Douglas Melo Coutinho

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PENGARUH PENAMBAHAN TRIPOLYFOSFAT PADA KITOSAN BEADS UNTUK ADSORPSI METHYL ORANGE by ADR Madjid, M Nitsae, Atikah Atikah, A Sabarudin

“…Mekanisme adsorpsi lebih bersifat fisik karena spektra FTIR kitosan <em>beads</em> setelah adsorpsi tidak jauh berbeda dengan kitosan <em>beads</em> sebelum adsorpsi yang ditandai oleh serapan pada 2362 cm^-1 yang menunjukkan terdapatnya <em>methyl orange</em> di dalam kitosan <em>beads</em>.</p><p class="BasicParagraph"><em>Chitosan modifications </em><em>performed</em><em> in order to increase the adsorption capacity of chitosan. …”
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