Advancing the therapeutic effectiveness of paclitaxel in chronic lymphocytic leukemia through the simultaneous inhibition of NOTCH1 and SF3B1 by Shiva Abolhasani, Armin Mahmoud salehi Khesht, Atefeh Khodakarami, Ali Masjedi, Bentolhoda Rashidi, Sepideh Izadi, Fatemeh Karimian Noukabadi, Vahid Karpisheh, Khatereh Torabi Poudeh, Pooya Jalali, Zahra Salehi, Rafieh Bagherifar, Seyyed Sina Hejazian, AliAkbar Movassaghpour, Abbas Ali Hosseinpour Feizi, Farhad Jadidi

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Experiment on physical and mechanical properties of tomato seedling pot for automatic vegetable transplanter by Liang Xifeng, Cai Yangyang, Wang Yongwei

“…The transplanters can meet the basic seedling transplanting requirements, but still stays in the semi-mechanization level. …”
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Production of low-oxygen titanium powder by thermochemical and electrochemical processes: Current state and perspectives by Liguo Zhu, Lingxin Kong, Bin Yang, Baoqiang Xu

“…This review summarizes the basic principles, characteristics, oxygen concentrations, limitations of these new methods. …”
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RPA-CRISPR/Cas12a detection based on HCMV-UL123 gene: A way with higher detection rate than clinical detection methods by Tianyang Liu, Yao Wang, Zihao Liao, Xiaowen Li, Shanshan Tang, Zhongming Zhang, Ming Chu, Lanlan Wei

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Heterosynaptic Regulation of α2A-Adrenoceptors on Glutamate/GABA Release in the Prefrontal Cortex of Rats by Yaru Wei, Yuhan Jiao, Xiaoting He, Xiaodong Tao, Baoming Li, Xuehan Zhang

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Hypertension specific patient-reported outcome measure. Part II: validation survey and item selection process by M. V. Ionov, N. E. Zvartau, E. A. Dubinina, N. N. Khromov-Borisov, A. O. Konradi

“…Improvement of the health-related quality of life (HRQoL) is one of the basic principles of value-based medicine. HRQoL could be assessed by the patient-reported outcome measures (PROMs) also in case of arterial hypertension (HTN). …”
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Distribution Characteristics and Temporal Variation of Climate Comfortableness in the Yellow River Basin under the Background of Climate Change by Tian JIN, Caihong CHEN, Jinkui WU

“…Climate comfortableness is the key factor that has impact in many fields， such as residents’ life quality， tourism development， and urban planning layout.The Universal Thermal Climate Index （UTCI is currently the most important and effective way to evaluate climate comfortableness at the international level.In-depth research on the climate comfortableness of the Yellow River Basin can not only fill the gap in the study of climate comfortableness in the Yellow River Basin area but also supplement a comprehensive understanding.Based on the results of climate zoning， the Yellow River Basin is divided into six sub-regions Using the reanalyzing data of ERA 5， the spatial distribution and temporal change of climate comfortableness in the Yellow River Basin from 1979 to 2022 were analyzed and discussed with the adoption of UTCI.The results show as follows： （1） From an overall perspective， the annual average UTCI value of the Yellow River Basin is 2.8 ℃， with a comfortable grade of coolness.The UTCI value is mostly in the cold zone and comfortable zone.The distribution of hot zone is relatively less.There is a large difference in UTCI distribution among the internal regions.Region I has a relatively longer duration of low temperature， and the area， with mild cold stress （coolness） and stronger cold stress （uncomfortable coldness）， is larger.Region II is mostly in the cold zone.Region III and Region IV are relatively close， and are dominated by “comfortableness” and “coolness”.The UTCI values in region V and region VI are at a higher level， but most areas are still in the comfortable zone.（2） In terms of the seasons， the four regions of III， IV， V， and VI have relatively extensive comfortable zones in spring and autumn， the overall comfortable area will be expanded in summer across the entire Yellow River basin， and the cold and uncomfortable zone will become dominant in winter， while the overall comfortable zone will be shrinked across the entire Yellow River basin.（3） The average UTCI in China as a whole has shown an overall upward trend from 1979 to 2022， with a change rate of 0.4 ℃·（10a）-1.The range of change in sub-regions is 0.14~0.85 ℃·（10a）-1.The annual UTCI change in the Yellow River basic shows a significant feature of west-high-east-low and north-high-south-low in the spatial distribution.（4） The level of climate comfortableness， taken as a whole， is mainly in the comfortable and slightly uncomfortable categories.The number of days in each of the six comfortable levels is as follows： 24 days （cold discomfort）， 126 days （slightly cold， discomfort）， 59 days （cool）， 131 days （comfort）， 19 days （slightly hot discomfort）， and 6 days （hot discomfort）.Region I and Region II have not been affected by the discomfort caused by heat.However， regions in the Yellow River basin， and regions of III， IV， V， and VI， are affected by slightly hot discomfort and the average duration in the slightly hot discomfort zone throughout the year is 19 days， 23 days， 24 days， 46 days， and 60 days respectively.…”
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Intervention and regulation effect of Haematococcus pluvialis extract on blood glucose and lipid of diabetic mice by Huang Heru, Wang Shanshan, Ni Xiaofeng, Chen Riping, Zhang Jiali, Chen Yixiang, Shen Shengrong

“…The blood glucose increased in 120 min; however, the level in the high dose group of H. pluvialis extract was still much lower than that of model group (P<0.01). …”
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Huanglian Jiedu Decoction improves the"central-peripheral"inflammatory microenvironment and enhances the cognitive function of APP/PS1 mice by inhibiting the activation of NLRP3 in... by Yani Zhang, Jiahua Wang, Xuetao Li, Ruibo Guo, Liyan Wang, Yang Liu, Yang Yu, Liang Kong

“…Abstract Background Huanglian Jiedu Decoction (HLJDD) is a representative formula for clearing heat and removing toxins, and some basic studies indicated that it can improve the learning cognitive ability of Alzheimer’s disease (AD) mice, but the underlying molecular mechanism of its improvement in AD mice is still unclear, therefore, this paper delves into the mechanism of HLJDD to improve AD. …”
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The role of acupuncture and moxibustion in the treatment, prevention, and rehabilitation of patients with COVID-19: A scoping review by Mengjuan Ren, Yunlan Liu, Xiaojia Ni, Zhuoran Kuang, Xufei Luo, Yikai Zhang, Huishan Li, Yaolong Chen

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Immunosenescence-related T cell phenotypes, structural brain imaging, and cognitive impairment in patients with schizophrenia: a moderated mediation analysis by Na Li, Yanli Li, Ting Yu, Wenjin Chen, Mengzhuang Gou, Wenkai Zheng, Zhaofan Liu, Xiaoying Wang, Jiao Fang, Jinghui Tong, Song Chen, Baopeng Tian, Chiang-Shan R. Li, Li Tian, Yunlong Tan

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Effect of exogenous antibiotics on soil microbial community structure in tea garden by Xu Chenguang, Zhang Qichun, Hou Changping

“…Soils were spiked with a range of tetracycline or penicillin concentrations. The basic physicochemical properties of the tested soil were measured by routine analysis methods. …”
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Systematic collection, annotation, and pattern analysis of viral vaccines in the VIOLIN vaccine knowledgebase by Anthony Huffman, Mehul Gautam, Arya Gandhi, Priscilla Du, Lauren Austin, Kallan Roan, Jie Zheng, Yongqun He, Yongqun He

“…The annotated information included basic vaccine names, pathogens and diseases, vaccine components, vaccine formulations, and their induced host responses. …”
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Surgical treatment of abdominal aortic aneurysm in combination with obliterating atherosclerosis of the lower extremities by O. V. Gubka, V. A. Gubka

“…Choice of the surgical method was determined by the data of aneurysm’s state in the dynamics received by instrumental methods, the presence of comorbidities, patient’s age, the state of vital functions and the risk of bleeding and restore of the lower limbs circulation. The basic way of surgical interventions for abdominal aortic aneurysm in combination with obliterating atherosclerosis of the lower extremities was a resection of the aneurysm with opening of the aneurysmal bag and prosthetics of the aorta. …”
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Scutellaria barbata D.Don and Hedyotis diffusa Willd herb pair combined with cisplatin synergistically inhibits ovarian cancer progression through modulating oxidative stress via N... by Xue Sui, Bingqing Gao, Liu Zhang, Yanmin Wang, Junnan Ma, Xingchen Wu, Chenyu Zhou, Min Liu, Lin Zhang

“…Traditional Chinese medicines (TCMs) often presented in the form of formula, in which the herb pair was the basic unit. Scutellaria barbata D.Don and Hedyotis diffusa Willd (SB-HD) are famous TCMs herb pair that have been shown to help treat multiple types of cancers. …”
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Justice-centered best practices for accessibility to public buildings in a tier II city: Insights from a Delphi expert consensus [version 1; peer review: 2 approved] by Sidhiprada Mohapatra, Rashmi Sheelvant, Ullas U Nayak, Vennila J, G Arun Maiya, Rama Devi Nandineni, Joanne Watson

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Agricultural legacy shapes plant diversity patterns in mountain grasslands of Maramureș and Bukovina: A cross‐border perspective (Ukraine, Romania) by Monika Janišová, Martin Magnes, Igor Bojko, Liubov M. Borsukevych, Vasyl V. Budzhak, Illya Chorney, Anamaria Iuga, Cosmin Marius Ivașcu, Roman Kish, Anna Kuzemko, Salza Palpurina, Katarína Skokanová, Pavel Širka, Alla Tokaryuk, Polina Dayneko

“…Although the timing of spring and autumn grazing in hay meadows still adhered to tradition, mowing schedules shifted earlier, especially for the first cut of two‐cut hay meadows. …”
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Frontiers and hotspot evolution in research on Alzheimer’s disease and hypertension: a bibliometric analysis from 2004 to 2023 by Wenying Liu, Wenying Liu, Yaya Zhao, Yaya Zhao, Yutong Rao, Yutong Rao, Zijing Wu, Zijing Wu, Yun Peng, Yun Peng, Lianggeng Gong, Lianggeng Gong

“…Researchers have carried out a series of studies ranging from basic research to clinical research on AHDs for the treatment of AD. …”
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Clinical manifestations, therapy and outcome of pandemic influenza a (H1N1) 2009 in hospitalized patients by Mikić Dragan, Nožić Darko, Kojić Miroslav, Popović Svetlana, Hristović Dejan, Rajić-Dimitrijević Radmila, Ćurčić Petar, Milanović Milomir, Glavatović Rade, Begović-Kuprešanin Vesna, Veljović Milić, Đorđević Dragan, Kuljić-Kapulica Nada, Čekanac Radovan, Stefanović Dara

“…In all the patients we registered the basic demographic data, risk factors for severe disease, symptoms and signs of influenza, laboratory tests and chest radiography. …”
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Preface by Editor-in-Chief by Ingrida Baranauskienė

“…But life does not stand still, so we look forward to your new research works. …”
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