Practice affairs committee by Dan Sadowski

“…The principle mandate of the committee is to address all issues relevant to the practice of gastroenterology, such as participation in the development of clinical practice guidelines and education programs, and the facilitation of clinical research. A major activity in 2003 was participation in the drafting of several new clinical practice guidelines: Infliximab and the management of Crohn's disease;Screening for colorectal cancer; andManagement of gastroesophageal reflux disease.…”
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Cyanoacrylate Associated Foreign Body Granulomatous Gastritis: A Report of Three Cases by Gunes Guner, Olcay Kurtulan, Taylan Kav, Cenk Sokmensuer, Gokhan Gedikoglu, Aytekin Akyol

“…Granulomas are rarely seen in gastric biopsies mostly as an involvement of granulomatous diseases like sarcoidosis, Crohn’s disease, infections, neoplasms, and vasculitis. …”
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Diagnostic Potential of Systemic Eosinophil-Associated Cytokines and Growth Factors in IBD by Katarzyna Neubauer, Malgorzata Matusiewicz, Iwona Bednarz-Misa, Sabina Gorska, Andrzej Gamian, Malgorzata Krzystek-Korpacka

“…We assessed the concentrations of eosinophil-associated cytokines and growth factors in the group of 277 individuals (101 patients with Crohn’s disease (CD), 77 with ulcerative colitis (UC), 16 with irritable bowel syndrome (IBS), and 83 healthy controls) and referred to IBD activity and the levels of hsCRP. …”
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Secukinumab in the treatment of psoriatic arthritis: efficacy and safety results through 3 years from the year 1 extension of the randomised phase III FUTURE 1 trial by Philip J Mease, Arthur Kavanaugh, Andreas Reimold, Hasan Tahir, Jürgen Rech, Stephen Hall, Piet Geusens, Pascale Pellet, Evie Maria Delicha, Shephard Mpofu, Luminita Pricop

“…Exposure-adjusted incidence rates for selected adverse events per 100 patient-years (secukinumab 150/75 mg) were serious infections (1.7/1.6), Candida infections (1.4/0.7), Crohn’s disease (0/0.3), ulcerative colitis (0/0.3) and major adverse cardiac events (0.3/0.8).Conclusion Subcutaneous secukinumab provided sustained improvements in the signs and symptoms, quality of life and physical function of patients with active PsA with low rate of radiographic disease progression through 3 years. …”
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Interplay of Transcriptomic Regulation, Microbiota, and Signaling Pathways in Lung and Gut Inflammation-Induced Tumorigenesis by Beatriz Andrea Otálora-Otálora, César Payán-Gómez, Juan Javier López-Rivera, Natalia Belén Pedroza-Aconcha, Sally Lorena Arboleda-Mojica, Claudia Aristizábal-Guzmán, Mario Arturo Isaza-Ruget, Carlos Arturo Álvarez-Moreno

“…ZNF91 and TP53TG1 in Crohn’s disease are related to the regulation of PPAR, MAPK, and metabolic signaling pathways. …”
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IBD 2009: Emerging Research Frontiers on the Path to a Cure by A Hillary Steinhart, G Tolomiczenko

“…Following the scientific presentations, discussions endorsed current activities of the CCFC and supported the creation of a new pediatric inflammatory bowel disease initiative.…”
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In silico data mining of large-scale databases for the virtual screening of human interleukin-2 inhibitors by Halim Sobia Ahsan, Zaheer-Ul-Haq, Khan Ajmal, Al-Rawahi Ahmed, Al-Harrasi Ahmed

“…Interleukin-2 (IL-2) is involved in the activation and differentiation of T-helper cells. Uncontrolled activated T cells play a key role in the pathophysiology by stimulating inflammation and autoimmune diseases like arthritis, psoriasis and Crohn’s disease. …”
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Gut Mesenchymal Stromal Cells in Immunity by Valeria Messina, Carla Buccione, Giulia Marotta, Giovanna Ziccheddu, Michele Signore, Gianfranco Mattia, Rossella Puglisi, Benedetto Sacchetti, Livia Biancone, Mauro Valtieri

“…The reversal of myofibroblasts/MSCs from an immune-modulator to an activator phenotype in Crohn’s disease results in the formation of a fibrotic tube subverting the intestinal structure. …”
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Rapamycin Alleviates 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Colitis through Autophagy Induction and NF-κB Pathway Inhibition in Mice by Zhen Ni, Hao Li, Dong Mu, Juanni Hou, Xiaoyan Liu, Shanhong Tang, Shumei Zheng

“…Recent genetic studies indicated that variants of autophagy genes were associated with the predisposition of Crohn’s disease (CD). The autophagy deficiency may affect the innate and adaptive immunity, which is related to persistent and excessive inflammation of the bowel. …”
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Interleukin-23 and Th17 Cells in the Control of Gut Inflammation by Ivan Monteleone, Francesco Pallone, Giovanni Monteleone

“…Crohn's Disease and Ulcerative Colitis, the major forms of inflammatory bowel diseases (IBDs) in humans, have been traditionally associated with exaggerated and poorly controlled T helper (Th) type 1 or Th2 cell response, respectively. …”
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Lipopolysaccharide and silica-stimulated mononuclear cell prostaglandin production in ulcerative colitis by Neville A. Punchard, John Cason, Jonathan Mullins, Chaman Chander, Richard P. H. Thompson

“…That PBMNC PGE2 production is not increased in UC, as it is in Crohn’s disease, suggests that there are differences in PBMNC behaviour between these two diseases.…”
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The Chemical Composition of Endotoxin Isolated from Intestinal Strain of Desulfovibrio desulfuricans by Jolanta Lodowska, Daniel Wolny, Marzena Jaworska-Kik, Sławomir Kurkiewicz, Zofia Dzierżewicz, Ludmiła Węglarz

“…There are suggestions that they take part in the pathogenesis of periodontitis and some gastrointestinal inflammatory disorders, such as ulcerative colitis or Crohn’s disease. Endotoxin is one of Gram-negative bacteria cellular components that influence these microorganisms pathogenicity. …”
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High Levels of Proinflammatory Cytokines, but Not Markers of Tissue Injury, in Unaffected Intestinal Areas from Patients with IBD by Alberto J. León, Emma Gómez, Jose A. Garrote, David Bernardo, Asterio Barrera, Jose L. Marcos, Luis Fernández-Salazar, Benito Velayos, Alfredo Blanco-Quirós, Eduardo Arranz

“…Biopsy specimens from patients with ulcerative colitis (UC) and Crohn's disease (CD), from both affected and unaffected areas, and also from a group of colonic biopsies from healthy controls, were included in our study. …”
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