Long-Term Clinical Behavior of Jejunoileal Involvement in Crohn’s Disease by Hugh J Freeman

“…Diffuse and extensive jejunoileal Crohn's disease is an uncommon entity. In 39 patients, including 21 males and 18 females, followed for a mean duration of over 16 years between 1979 and 2004, the extent of disease was defined and disease behaviour characterized. …”
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Computed tomography enterography-based radiomics nomograms to predict inflammatory activity for ileocolonic Crohn’s disease: a preliminary single-center retrospective study by Yuping Ma, Luanxin Zhu, Bota Cui, Faming Zhang, Haige Li, Jianguo Zhu

Subjects: “…Crohn’s disease…”
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A phase 1b clinical trial to determine the safety, tolerability and immunogenicity of simian adenovirus and poxvirus vectored vaccines against Mycobacterium avium complex subspecies in patients with active Crohn’s diseaseResearch in context by Jeremy Sanderson, Jeremy Aboagye, Rebecca Makinson, Katerina Rapi, Samuel Provstgaard-Morys, Lisa Stockdale, Alison Lawrie, Isabelle Lanigan, Nishat Halim, Abdel Douiri, Emily Greenlay, Rayka Malek, Emma Gray, Lindsey West, Fatima El Oulidi, Paul Ian Cross, Michael Stallibrass, Sarah C. Gilbert, Adrian V.S. Hill, Katie J. Ewer

“…Secondary objectives of immunogenicity were assessed by ELISpot (enzyme-linked immunosorbent spot) and clinical response by Crohn’s Disease Activity Index (CDAI) and Simple Endoscopic Score for Crohn’s Disease (SES-CD). …”
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Response to Infliximab in Crohn’s Disease: Genetic Analysis Supporting Expression Profile by Luz María Medrano, Carlos Taxonera, Cristina González-Artacho, Virginia Pascual, María Gómez-García, Manuel Barreiro-de Acosta, José L. Pérez-Calle, Fernando Bermejo, Antonio López-Sanromán, Dolores Martín Arranz, Javier P. Gisbert, Juan Luis Mendoza, Javier Martín, Concepción Núñez, Elena Urcelay

“…Substantial proportion of Crohn’s disease (CD) patients shows no response or a limited response to treatment with infliximab (IFX) and to identify biomarkers of response would be of great clinical and economic benefit. …”
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Difficulties the Conservative Treatment of Crohn’s Disease Complicated by Autoimmune Hemophilia A by E. L. Belyaeva, O. I. Filippova, A. V. Koloskov, A. A. Naydenov, F. D. Albegova

“…To present a clinical case describing the management of a patient with Crohn’s disease complicated by recurrent intestinal bleeding and autoimmune hemophilia A.General provisions: A 21-year-old patient was admitted to St. …”
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A Pilot Study Examining the Relationship among Crohn Disease Activity, Glucagon-Like Peptide-2 Signalling and Intestinal Function in Pediatric Patients by David L Sigalet, Dragan Kravarusic, Decker Butzner, Bolette Hartmann, Jens J Holst, Jon Meddings

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Thrombotic Complications in Inflammatory Bowel Disease by A. V. Borota, A. A. Borota, E. V. Onishchenko

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Leukocytapheresis in patients with inflammatory bowel diseases by Małgorzata Woźniak, Ilona Kurnatowska, Ewa Małecka-Panas, Renata Talar-Wojnarowska

“…However, there is inadequate evidence to draw any conclusions about the efficacy of leukocytapheresis in patients with Crohn’s disease, and it should only be used in accordance with special arrangements for consent. …”
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AhR Activation Transcriptionally Induces Anti-Microbial Peptide Alpha-Defensin 1 Leading to Reversal of Gut Microbiota Dysbiosis and Colitis by Manikandan Palrasu, Khadija Kakar, Amarnath Marudamuthu, Hamida Hamida, Shruthi Thada, Yin Zhong, Shanieka Staley, Philip Brandon Busbee, Jie Li, Monica Garcia-Buitrago, Mitzi Nagarkatti, Prakash Nagarkatti

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Utility of Computed Tomographic Enteroclysis/Enterography for the Assessment of Mucosal Healing in Crohn's Disease by Shinichi Hashimoto, Kensaku Shimizu, Hiroaki Shibata, Satoko Kanayama, Ryo Tanabe, Hideko Onoda, Naohumi Matsunaga, Isao Sakaida

“…When determining therapeutic strategy, it is important to diagnose small intestinal lesions in Crohn's disease (CD) precisely and to evaluate mucosal healing as well as clinical remission in CD. …”
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Infliximab Combined with Enteral Nutrition for Managing Crohn’s Disease Complicated with Intestinal Fistulas by Xiao-Li Wu, Ren-Pin Chen, Li-Ping Tao, Jian-Sheng Wu, Xiang-Rong Chen, Wei-Chang Chen

“…We evaluated the laboratory indexes, Crohn’s disease activity index (CDAI), Crohn’s disease simplified endoscopic score (SES-CD), and healing of fistula in the two groups before treatment, at 14 weeks, and at 30 weeks, respectively. …”
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Exclusive Enteral Nutrition versus Infliximab in Inducing Therapy of Pediatric Crohn’s Disease by Youyou Luo, Jindan Yu, Jingan Lou, Youhong Fang, Jie Chen

“…To compare the effectiveness of exclusive enteral nutrition (EEN) and infliximab (IFX) therapy in pediatric Crohn’s disease (CD). Methods. In a prospective study of children initiating EEN or infliximab therapy for CD, we compared clinical outcomes using the pediatric Crohn’s disease activity index (PCDAI), growth improvement, endoscopic mucosal healing, and adverse effects. …”
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Leucine-rich alpha-2 glycoprotein in combination with C-reactive protein for predicting endoscopic activity in Crohn’s disease: a single-centre, cross-sectional study by Yoshiaki Takada, Hiroki Kiyohara, Yohei Mikami, Masataka Taguri, Ryoya Sakakibara, Yasuhiro Aoki, Kosaku Nanki, Takaaki Kawaguchi, Yusuke Yoshimatsu, Shinya Sugimoto, Tomohisa Sujino, Kaoru Takabayashi, Naoki Hosoe, Haruhiko Ogata, Motohiko Kato, Yasushi Iwao, Nobuhiro Nakamoto, Takanori Kanai

“…In patients undergoing ileocolonoscopy or balloon-assisted enteroscopy within 60 days before or after LRG measurement, endoscopic activity was evaluated with the simple endoscopic score for Crohn’s disease (SES-CD). …”
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Oral exclusive enteral nutrition for induction of clinical remission, mucosal healing, and improvement of nutritional status and growth velocity in children with active Crohn’s disease – a prospective multicentre trial by Małgorzata Matuszczyk, Monika Meglicka, Piotr Landowski, Elżbieta Czkwianianc, Beata Sordyl, Edyta Szymańska, Jarosław Kierkuś

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Activity trypsin-like proteinases and intestinal mucosa collagen degradation at gastro-intestinal diseases by О. E. Akbasheva, V. A. Burkovskaya, A. E. Dehand, E. I. Beloborodova, L. A. Akimova, E. L. Naumova, E. A. Kvach

“…At ulcerative colitis and Crohn’s disease in mucosa of intestine activation of trypsin-, elastase- and collagenase-like proteinases on a background of decrease of activity of a1-PI and a2-MG that results in degradation of connective tissue proteins is observed. …”
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Early Endoscopic Outcomes After Risankizumab Are Associated With Fewer Hospitalizations and Surgeries in Crohn’s Disease by Brian G. Feagan, Jean-Frederic Colombel, Remo Panaccione, Stefan Schreiber, Marc Ferrante, Koji Kamikozuru, Christopher Ma, Wan-Ju Lee, Jenny Griffith, Namita Joshi, Kristina Kligys, Jasmina Kalabic, Si Xuan, Marla Dubinsky

“…Background and Aims: We evaluated the association between endoscopic outcomes following risankizumab induction and subsequent rates of hospitalization and surgery through 52 weeks of risankizumab (both doses) maintenance therapy in patients with Crohn’s disease (CD). Methods: Patients with moderately to severely active CD and clinical response to 12-week risankizumab induction were rerandomized to continued therapy or drug withdrawal in the phase 3 FORTIFY maintenance trial. …”
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Ileal Adenocarcinoma with Liver Metastasis in Patient with Crohn’s Disease: A 9-Year Survival by Jiten P. Kothadia, Deepa H. Nagaraju, Seymour Katz, Howard Bruckner, Steven H. Itzkowitz, Myron Schwartz

“…Small bowel adenocarcinoma is a rare but well-known complication of Crohn’s disease. The diagnosis of small bowel adenocarcinoma remains difficult since its presentation is highly variable and mimics active or obstructive Crohn’s disease. …”
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Bile Acids and the Microbiome: Making Sense of This Dynamic Relationship in Their Role and Management in Crohn’s Disease by Aditi Kumar, Hafid O. Al-Hassi, Helen Steed, Oliver Phipps, Matthew J. Brookes

“…Bile acid sequestrants have been shown to have anti-inflammatory, cytoprotective, and anti-apoptotic properties with the potential to alter the intestinal microbial composition, suggesting a possible role in inducing and maintaining Crohn’s disease. Conclusions. Active Crohn’s disease has been correlated with changes in bacterial concentrations, which may be associated with changes in bile acid modification. …”
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Adalimumab for endoscopic and histopathological mucosal healing in paediatric patients with moderate to severe Crohn’s disease by Edyta Szymanska, Maciej Dadalski, Wieslawa Grajkowska, Sylwia Szymanska, Maciej Pronicki, Jaroslaw Kierkus

“…Colonoscopy and gastroscopy with sample collection were performed in all patients before and after induction treatment with ADA. Clinical activity of the disease was assessed using the Paediatric Crohn’s Disease Activity Index (PCDAI), and the endoscopic activity was scored using the Simple Endoscopic Score (SES-CD). …”
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Application of Spectral Computed Tomography Single-energy Technique to Small Bowel Crohn’s Disease by Pengfei WU, Chuanbing WANG

“…Differences in imaging features of Crohn’s disease activity were determined using the paired \begin{document}$\chi^2 $\end{document} test. …”
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