Genetic determinants of COVID-19 severity and mortality: ACE1 Alu 287 bp polymorphism and ACE1, ACE2, TMPRSS2 expression in hospitalized patients by João Locke Ferreira de Araújo, Átila Duque Rossi, Jessica Maciel de Almeida, Hugo José Alves, Isabela de Carvalho Leitão, Renata Eliane de Ávila, Anna Carla Pinto Castiñeiras, Jéssica da Silva Oliveira, Rafael Mello Galliez, Marlon Daniel Lima Tonini, Débora Souza Faffe, Shana Priscila Coutinho Barroso Barroso, Gustavo Gomes Resende, Cássia Cristina Alves Gonçalves, Terezinha Marta Pereira Pinto Castiñeiras, Amilcar Tanuri, Mauro Martins Teixeira, Renato Santana Aguiar, Cynthia Chester Cardoso, Renan Pedra de Souza

“…Evidence indicates that ACE1 may influence ACE2 expression. This study aims to determine whether ACE1, ACE2, and TMPRSS2 mRNA expression levels, along with the ACE1 Alu 287 bp polymorphism (rs4646994), contribute to the severity and mortality of COVID-19. …”
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Evaluation of Biologics ACE2/Ang(1–7) Encapsulated in Plant Cells for FDA Approval: Safety and Toxicology Studies by Henry Daniell, Geetanjali Wakade, Smruti K. Nair, Rahul Singh, Steven A. Emanuel, Barry Brock, Kenneth B. Margulies

“…Angiotensin Converting Enzyme 2 (ACE2) gum is the first engineered human blood protein expressed in plant cells approved by the FDA without the need for purification and is a cold-chain and noninvasive drug delivery. …”
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Regulatory T cell-like response to SARS-CoV-2 in Jamaican fruit bats (Artibeus jamaicensis) transduced with human ACE2. by Bradly Burke, Savannah M Rocha, Shijun Zhan, Miles Eckley, Clara Reasoner, Amin Addetia, Juliette Lewis, Anna Fagre, Phillida A Charley, Juergen A Richt, Susan R Weiss, Ronald B Tjalkens, David Veesler, Tawfik Aboellail, Tony Schountz

“…Bats were then intranasally inoculated with a replication-defective adenovirus encoding human ACE2 and 5 days later challenged with SARS-CoV-2. …”
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Human ACE2 transgenic pigs are susceptible to SARS-CoV-2 and develop COVID-19-like disease by Long Fung Chau, Simon Lillico, Tanja Opriessnig, Rosemary Blake, Luc Tardy, Chen-Hsuin Lee, Scott Maxwell, Claire Warren, Elizabeth Thornton, Catherine L. Mclaughlin, Gerry McLachlan, Christine Tait-Burkard, Sarah Fletcher, Stephen Anderson, Sharon Brown, Louise Gibbard, Thomas Tzelos, Dawn MacMillan-Christensen, J. Kenneth Baillie, David A. Dorward, David J. Griffiths, Finn Grey

“…This study establishes human ACE2 transgenic pigs as a large animal model that accurately reflects many aspects of COVID-19 disease.…”
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Compressive Strength Prediction of Alkali-Activated Slag Concretes by Using Artificial Neural Network (ANN) and Alternating Conditional Expectation (ACE) by Xiaoyu Qin, Qianmin Ma, Rongxin Guo, Zhigang Song, Zhiwei Lin, Haoxue Zhou

“…Compressive strength of alkali-activated slag (AAS) concrete is influenced by multi-factors in a nonlinear way. Both artificial neural network (ANN) and alternating conditional expectation (ACE) models of 3-day (3 d) and 28-day (28 d) compressive strength of AAS were established in this study by using the data reported in related literature, where alkali concentration of activator (Na2O%), modulus of activator (Ms), water/binder ratio (W/B), surface area of slag (SA), and basicity index of slag (Kb) were taken as input parameters. …”
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Liraglutide Enhances the Activity of the ACE-2/Ang(1–7)/Mas Receptor Pathway in Lungs of Male Pups from Food-Restricted Mothers and Prevents the Reduction of SP-A by J. Fandiño, A. A. Vaz, L. Toba, M. Romaní-Pérez, L. González-Matías, F. Mallo, Y. Diz-Chaves

“…Liraglutide restored surfactant protein A (SP-A) mRNA expression in pup lungs from food-restricted mothers. …”
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Unravelling the Digestibility and Structure–Function Relationship of Lentil Protein Through Germination and Molecular Weight Fractionation by Armin Mirzapour-Kouhdasht, Samaneh Shaghaghian, Marjan Majdinasab, Jen-Yi Huang, Marco Garcia-Vaquero

“…This study explores for the first time the impact of a 6-day germination process on the structure (FTIR), antioxidant activity, nutritional/safety attributes (ACE-I inhibitory activity, digestibility, and cytotoxicity), and functional properties of fractions of variable molecular weight (W > 5 kDa; 3 kDa < MW < 5 kDa; and MW < 3 kDa) isolated from proteins extracted from lentils. …”
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Black Chokeberry (<i>Aronia melanocarpa</i>) Juice Supplementation Affects Age-Related Myocardial Remodeling in Rats by Elena Daskalova, Mina Pencheva, Slavi Delchev, Lyudmila Vladimirova-Kitova, Spas Kitov, Stoyan Markov, David Baruh, Petko Denev

“…Methods: Healthy male Wistar rats (n = 24) were divided into three groups: (1) young controls (CY)—age 2 months; (2) old controls (CO)—age 27 months; (3) AMJ group—27-month-old animals, supplemented with <i>Aronia melanocarpa</i> juice (AMJ) at a dose of 10 mL∙kg⁻¹ for 105 days. After this period, the hearts of the animals were fixed, embedded in paraffin, and immunohistochemical and morphometric analyses were performed. …”
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TĂNG CƯỜNG SỰ THAM GIA CỦA PHỤ NỮ TRONG LĨNH VỰC CHÍNH TRỊ - GIẢI PHÁP THÚC ĐẨY BÌNH ĐẲNG GIỚI by Kim Anh Duong

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Utilization of Project Kind-Er (Engagement in Reading) to Strengthen the Foundation of Learning in Kindergarten by Ma. Benilda Ricaplanca, Mart Albert De Guzman, Christian Bautista

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Alchornea cordifolia leaf-extract ameliorates bisphenol A-induced obesity in male Wistar rats by Abdulhakeem Rotimi Agboola, Ako Hogan Itam, Chinedum Martins Ekeleme, Eyuwa Ignatius Agwupuye, Zuwairatu Oyiza Ahmed, Godswill Peter Igiakong, Gideon Bassey Agbor, Asmau Niwoye Abubakar, Zainab Adamu, Esien David-Oku, Item Justin Atangwho

“…Methods Thirty (30) young male Wistar rats (80–100 g) divided into five groups of six rats each, were administered BPA (50 mg/kg), once a day, p.o. for four weeks in order to induce obesity. …”
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Experimental Evidence of Rapidly Decaying Environmental DNA Highlights Infection Risk from Two Major Amphibian Pathogens by Joseph D. Trafford, Trenton W. J. Garner, David J. Murrell, Julia J. Day

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Sex-specific effects of prenatal bisphenol A exposure on transcriptome-interactome profiles of autism candidate genes in neural stem cells from offspring hippocampus by Kasidit Kasitipradit, Surangrat Thongkorn, Songphon Kanlayaprasit, Thanit Saeliw, Pattanachat Lertpeerapan, Pawinee Panjabud, Depicha Jindatip, Valerie W. Hu, Takako Kikkawa, Noriko Osumi, Tewarit Sarachana

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A REALITY OF MAN by Edmundas Krakauskas

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Acute cerebral edema: a lethal neurological complication in a patient with COVID-19 infection. Case report and literature review by M. Puodžiūnaitė, R. Sadeckaitė, A. Čikotienė

“…A few days later, he developed worsening respiratory function with an acute seizure episode. …”
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A Rare Cause of Secondary Amyloidosis: Common Variable Immunodeficiency Disease by Ali Kemal Kadiroğlu, Yaşar Yıldırım, Zülfükar Yılmaz, Hasan Kayabaşı, Yahya Avcı, M. Serdar Yıldırım, M. Emin Yılmaz

“…She had proteinuria at a rate of 3.5 gr/day, and her serum albumin was 1.5 gr/dl. …”
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The Use of a Novel Quantitative Marker of Echogenicity of Pleural Fluid in Parapneumonic Pleural Effusions by Charalampos Varsamas, Alexandros Kalkanis, Konstantinos I. Gourgoulianis, Foteini Malli

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A Low-Protein Diet Enhances Angiotensin II Production in the Lung of Pregnant Rats but Not Nonpregnant Rats by Haijun Gao, Daren Tubianosa Tanchico, Uma Yallampalli, Chandrasekhar Yallampalli

“…Nonpregnant rats were fed a normal (CT) or LP diet for 8, 12, or 17 days and timed pregnant rats fed for 17 days from Day 3 of pregnancy. …”
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Dual repair of traumatic flank hernia using laparoscopic and open approaches: a case report by Yoonjung Heo, Dong Hun Kim

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Determining whether ethnic minorities with severe obesity face a disproportionate risk of serious disease and death from COVID-19: outcomes from a Southern California-based retrosp... by Qiaowu Li, Hemesh Mahesh Patel, Shefali Khandwala, Poonam Somani, Stephanie Tovar, Alejandra Montano

“…We aim to determine if ethnic minorities with severe obesity—defined as a body mass index (BMI) above 40 kg/m²—experience higher rates of hospitalisation, invasive ventilation and death.Design and setting Retrospective cohort study from 1 March 2020 to 28 February 2021 within an integrated healthcare organisation in Southern California.Participants We identified 373 831 patients by COVID-19 diagnosis code or positive laboratory test.Methods Multivariable Poisson regression with robust error variance estimated adjusted risks of hospitalisation, invasive ventilator use and death within 30 days. …”
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