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    The Role of Thickening Agent Proportions in Optimizing Nanoemulsion Gel for Dermatophytosis Treatment by Zhang X, Wu CC, Jiang H, Zhao JF, Pan ZJ, Zheng Y

    Published 2025-01-01
    “…A series of α-pinene NGs (αNG1, αNG2, αNG3) containing 0.5%, 0.75% and 1% (w/w) Carbomer 940 were developed and evaluated for stability, rheological properties, and skin irritation; assessed for ex vivo skin permeation, deposition, and fluorescent imaging of drug distribution within skin layers; and tested in vivo for efficacy against Trichophyton rubrum infection in guinea pigs, with PAS (Periodic Acid–Schiff) staining confirming fungal clearance.Results: The steady-state skin flux rates of α-pinene over 24 hours were αNG1 (46.93± 2.52 μg/cm²/h) > αNG2 (26.01± 2.65 μg/cm²/h) > αNG3 (11.36± 1.69 μg/cm²/h). …”
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