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  1. 9081
  2. 9082
  3. 9083
  4. 9084

    TP53 germline testing and hereditary cancer: how somatic events and clinical criteria affect variant detection rate by Paula Rofes, Carmen Castillo-Manzano, Mireia Menéndez, Álex Teulé, Sílvia Iglesias, Elisabet Munté, Mireia Ramos-Muntada, Carolina Gómez, Eva Tornero, Esther Darder, Eva Montes, Laura Valle, Gabriel Capellá, Marta Pineda, Joan Brunet, Lidia Feliubadaló, Jesús del Valle, Conxi Lázaro

    Published 2025-01-01
    “…Methods TP53 was analyzed in 6161 suspected hereditary cancer non-related patients categorized into three subgroups: (1) 495 patients fulfilling any LFS/Chompret clinical criteria; (2) 2481 patients diagnosed with early-onset breast/colorectal cancer; (3) 3185 patients without clinical criteria suggestive of hTP53rc. …”
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  5. 9085
  6. 9086

    3D bioprinting lobule-like hepatorganoids with induced vascularization for orthotopic implantation by Jianing Yan, Zhichao Ye, Yiwei Lu, Yuyang Yuan, Xiaofeng Wang, Tingting Yan, Jun Yin, Yifan Wang

    Published 2025-04-01
    “…In this research, we developed a 3D bioprinting method using gelatin methacryloyl (GelMA) hydrogel to fabricate lobule-like hepatorganoids, which faithfully mimic the structure of hepatic lobules with lower level of hypoxia (lobule vs 60°, 90°, control; 0.4880 vs 1.009, 0.6778, 0.8704; p < 0.01), high secretion of albumin (lobule vs 60°, 90°, control; 13.47 vs 12.39, 12.65, 10.08 mg/L; p < 0.01) and urea (lobule vs 60°, 90°, control; 5.304 vs 5.233, 4.781, 4.358 mg/L; p < 0.01) in vitro; and promotion of angiogenesis and maintenance of activity following orthotopic implantation. …”
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  7. 9087
  8. 9088

    AICpred: Machine Learning-Based Prediction of Potential Anti-Inflammatory Compounds Targeting TLR4-MyD88 Binding Mechanism by Lucindah N. Fry-Nartey, Cyril Akafia, Ursula S. Nkonu, Spencer B. Baiden, Ignatus Nunana Dorvi, Kwasi Agyenkwa-Mawuli, Odame Agyapong, Claude Fiifi Hayford, Michael D. Wilson, Whelton A. Miller, Samuel K. Kwofie

    Published 2025-01-01
    “…The AdaBoost and decision tree models also excelled with accuracies ranging from 0.981 to 0.992, balanced accuracies between 0.921 and 0.944, and recall scores between 0.845 and 0.891 on both training and test datasets. …”
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  9. 9089

    控制性卵巢刺激对多囊卵巢综合征患者和正常排卵妇女卵源性因子表达的差异

    Published 2013-01-01
    “…在PCOS患者的卵母细胞中,GDF9和BMP15 mRNA的表达水平在未刺激组分别为23.83 (2.29-65.72)和0.09 (0.05-29.32),在卵巢刺激组分别为44.81 (5.93-489.19)和0.10 (0.05-11.44),两种因子的表达在未刺激组和卵巢刺激组均没有差异(P > 0.05)。…”
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  10. 9090
  11. 9091

    Two-field mydriatic fundus photography to assess the prevalence of macular disorder in diabetes by T.A. Avanesova, Zh.G. Oganezova, V.V. Anisimova, A.B. Baeva, D.H. Miaev

    Published 2024-09-01
    “…</p> <p> <b>Results: </b>diabetic maculopathy (DM) was found in 47 (12.81%) patients. DM was associated with diabetic retinopathy (DR) in 18 (4.90%) patients. …”
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  12. 9092

    Decreased vitamin D increase the risk for subclinical hypothyroidism in individuals with T2DM: a cross-sectional study by Yaling Fang, Yaling Fang, Xin Wen, Hui You, Yueye Huang, Shen Qu, Xingchun Wang, Le Bu

    Published 2025-01-01
    “…After adjusting for height, BMI, HGB, TCH, TG, FFA, and LDL, FT3 and FT4 remained significantly positively associated with VD (r = 0.227, p &lt; 0.001; r = 0.089, p = 0.030), while TT4 and TSH continued to show significant negative associations (r = 0.091, p = 0.033; r = −0.081, p = 0.049). Linear regression analysis revealed a significant positive association between VD and FT3 (β = 4.144, p &lt; 0.001) and negative associations with TT4 (β = −0.167, p &lt; 0.001) and TSH (β = −0.412, p = 0.020). …”
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  13. 9093

    Carriage of Extended-Spectrum-β-Lactamase- and AmpC-β-Lactamase-Producing Enterobacteriaceae (ESBL-PE) in Healthy Community and Outpatient Department (OPD) Patients in Nepal by Dipendra Kumar Mandal, Shiv Kumar Sah, Shyam Kumar Mishra, Sangita Sharma, Hari Prasad Kattel, Sanjeet Pandit, Pranav Kumar Yadav, Ujjwal Laghu, Rajani Lama, Niranjan Prasad Sah, Jeevan Bahadur Sherchand, Keshav Parajuli, Anup Bastola, Sher Bahadur Pun, Basista Prasad Rijal, Bharat Mani Pokharel

    Published 2020-01-01
    “…The prevalence of ESBL, AmpC-β-lactamases, and coproducer (ESBL + AmpC-β-lactamase) producing Enterobacteriaceae in OPD participants were 30.92%, 18.4%, and 13.81%, respectively, while 25%, 6.4%, and 1.8% in healthy population. …”
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  14. 9094
  15. 9095

    Effects of Intrathecal Bupivacaine with Adjuvants Midazolam versus Magnesium Sulphate in Tibia Fibula Surgeries: A Randomised Clinical Study by Tejash H Sharma, Jagrati Jain, Aanal Sha, Dushyant Chavda, Dinesh K Chauhan

    Published 2025-01-01
    “…Results: The mean Standard Deviation (SD) age in group BM was 37.63±11.50 years and in group BMS was 40.81±11.93 years. The onset and duration of sensory and motor blockade were better in group BM than in group BMS (p-value <0.05). …”
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  16. 9096
  17. 9097
  18. 9098

    Pharmacogenetic and pharmacokinetic factors for dexmedetomidine-associated hemodynamic instability in pediatric patients by Yanping Guan, Bilian Li, Yiyu Zhang, Hao Luo, Xueding Wang, Xue Bai, Zhuoling Zheng, Yaying Huang, Wei Wei, Min Huang, Xingrong Song, Guoping Zhong

    Published 2025-01-01
    “…The areas under the curve for the training and test cohorts were 0.881 and 0.762, respectively. The calibration curve indicated excellent agreement.ConclusionThe predictive nomogram, which incorporates genetic variants (UGT2B10, CYP2A6, ADRA2B, CACNA2D2, NR1I2, and CACNB2) along with clinical factors such as weight, DEX clearance, and propofol use, may help prevent DEX-associated hemodynamic instability. …”
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  19. 9099
  20. 9100