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  1. 8401
  2. 8402

    Changes over a decade in psychotropic prescribing for people with intellectual disabilities: prospective cohort study by Paula McSkimming, Angela Henderson, Sally-Ann Cooper, Deborah Kinnear, Colin McCowan, Linda Allan, Alasdair McIntosh

    Published 2020-09-01
    “…Longitudinal cohort study with detailed health assessments at T1 and record linkage to T2 prescribing data.Setting General community.Participants 1190 adults with intellectual disabilities in T1 compared with 3906 adults with intellectual disabilities in T2. 545/1190 adults with intellectual disabilities in T1 were alive and their records linked to T2 prescribing data.Main outcome measures Encashed regular and as-required psychotropic prescriptions.Results 50.7% (603/1190) of adults in T1 and 48.2% (1881/3906) in T2 were prescribed at least one psychotropic; antipsychotics: 24.5% (292/1190) in T1 and 16.7% (653/3906) in T2; antidepressants: 11.2% (133/1190) in T1 and 19.1% (746/3906) in T2. 21.2% (62/292) prescribed antipsychotics in T1 had psychosis or bipolar disorder, 33.2% (97/292) had no mental ill health or problem behaviours, 20.6% (60/292) had problem behaviours but no psychosis or bipolar disorder. …”
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  3. 8403
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  5. 8405

    Water scarcity in semi-arid California compromises perennial alfalfa’s high yield and carbon sinking potentials by Tianxin Wang, Kanishka Mallick, Joseph Verfaille, Daphne Szutu, Dennis Baldocchi

    Published 2025-03-01
    “…Over the 7-year period, the average net ecosystem exchange (NEE) was −544 ± 201 g C m−2 y−1, accompanied by an average gross primary productivity (GPP) of −2281 ± 280 g C m−2 y−1 and an average of evapotranspiration (ET) of 861 ± 71 mm y−1. …”
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  13. 8413

    Lost microbes of COVID-19: Bifidobacterium, Faecalibacterium depletion and decreased microbiome diversity associated with SARS-CoV-2 infection severity by Eamonn MM Quigley, Thomas J Borody, Sabine Hazan, Neil Stollman, Huseyin S Bozkurt, Sonya Dave, Andreas J Papoutsis, Jordan Daniels, Brad D Barrows

    Published 2022-04-01
    “…Microbiome diversity and composition were compared between patients and exposed controls at all taxonomic levels.Results Compared with controls (n=20), severely symptomatic SARS-CoV-2-infected patients (n=28) had significantly less bacterial diversity (Shannon Index, p=0.0499; Simpson Index, p=0.0581), and positive patients overall had lower relative abundances of Bifidobacterium (p<0.0001), Faecalibacterium (p=0.0077) and Roseburium (p=0.0327), while having increased Bacteroides (p=0.0075). …”
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  14. 8414

    Impact of chemoradiotherapy for first primary lung cancer on the prognosis and re-chemoradiotherapy sensitivity of second primary lung cancer by Zhe Chen, Gaoming Wang, Nan Wang, Jiangjiang Liu, Yu Yao, Haitao Ma, Haitao Ma, Jing Luo, Kai Xie

    Published 2025-01-01
    “…Conversely, FPLC chemotherapy was linked to improved OS (HR=0.881, P=0.012) in this population. Patients with SPLC who received combined chemoradiotherapy for FPLC exhibited significantly reduced survival times (OS: HR=1.157, P=0.030; CSS: HR=1.198, P=0.018), a finding confirmed across multiple models. …”
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    Correlation between METTL3 overexpression and 18F-FDG uptake in patients with soft tissue sarcoma by Tong Wu, Jinghui Xie, Hongbo Feng, Hua Zhang, Juan Tao, Bo Chen

    Published 2025-01-01
    “…METTL3 expression positively correlated with the expression of CD163 (r = 0.502, p = 0.011), CD68 (r = 0.381, p = 0.017), and CD8 (r = 0.319, p = 0.048), and exhibited a trend toward correlation with CD4 expression (r = 0.310, p = 0.055). …”
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  19. 8419

    Comparison of Ziziphus jujube Mill. Syrup versus polyethylene glycol in children with functional constipation: a randomized clinical trial by Fatemeh Keihanian, Shohreh Maleknejad, Amin Saeidinia, Soheil Soltanipour, Amir Pirooz

    Published 2025-01-01
    “…There was no significant difference between the two groups in terms of age (P = 0.181), gender (P = 0.218), age at onset of constipation (P = 0.083), and weight (P = 0.199). …”
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