Model-based fed-batch cultivation of Viola odorata plant cells exhibiting antimalarial and anticancer activity by R. Babu, Manokaran Veeramani, Wallepure Aadinath, Vignesh Muthuvijayan, Shailja Singh, Smita Srivastava

“…In the current study, a modified stirred tank reactor and a balloon-type bubble column reactor were used to improve the biomass production at the batch reactor level. Sufficient nutrient feeding strategies were developed using first principle-based mathematical modelling to overcome substrate inhibition and achieve higher cell density in the reactor. …”
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Mixed methods evaluation of the Getting it Right First Time programme in elective orthopaedic surgery in England: an analysis from the National Joint Registry and Hospital Episode... by Stephen Morris, James Mason, Rosalind Raine, Peter Martin, Naomi J Fulop, Elena Pizzo, Andrew Hutchings, Helen Barratt, Jean Ledger, Raj Mehta, Sarah Jasim, Fiona Aspinal, Rafael Gafoor

“…Objective To evaluate the impact of the ‘Getting it Right First Time’ (GIRFT) national improvement programme in orthopaedics, which started in 2012.Design Mixed-methods study comprising statistical analysis of linked national datasets (National Joint Registry; Hospital Episode Statistics; Patient-Reported Outcomes); economic analysis and qualitative case studies in six National Health Service (NHS) Trusts.Setting NHS elective orthopaedic surgery in England.Participants 736 088 patients who underwent primary hip or knee replacement at 126 NHS Trusts between 1 April 2009 and 31 March 2018, plus 50 NHS staff.Intervention Improvement bundle including ‘deep dive’ visits by senior clinician to NHS Trusts, informed by bespoke set of routine performance data, to discuss how improvements could be made locally.Main outcome measures Number of procedures conducted by low volume surgeons; use of uncemented hip implants in patients >65; arthroscopy in year prior to knee replacement; hospital length of stay; emergency readmissions within 30 days; revision surgery within 1 year; health-related quality of life and functional status.Results National trends demonstrated substantial improvements beginning prior to GIRFT. …”
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Prevalence and influencing factors of non-suicidal self-injurious behaviour among Chinese college students: a Meta-analysis by TAO Silu, MAO Guoju, XIONG Yi, GUO Mengjia, WU Dongmei

“…Freshman year [OR=1.55, 95%CI(1.22, 1.97)], sophomore year [OR=1.74, 95%CI(1.36, 2.23)], bornin urban or town [OR=1.44, 95%CI(1.26, 1.64)], non-medical colleges or majors [OR=1.50, 95%CI(1.39, 1.61)], negative life events [OR=1.02, 95%CI(1.01, 1.04)], sexual abuse in primary school or earlier [OR=3.14, 95%CI(1.97, 5.02)], depression [OR=1.47, 95%CI(1.33, 1.63)], anxiety [OR=2.20, 95%CI(1.25, 3.87)], fantasies [OR=1.18, 95%CI(1.03, 1.35)], alcohol consumption [OR=1.60, 95%CI(1.40, 1.83)], and feelings of sadness and despair [OR=6.32, 95%CI(2.96, 13.51)] were the risk factors for prevalence of NSSI in Chinese college students.Conclusion The prevalence of NSSI among Chinese college students is high and closely related to a variety of factors. …”
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Probiotic administration aggravates dextran sulfate sodium salt-induced inflammation and intestinal epithelium disruption in weaned pig by Kunhong Xie, Weidong Cai, Lingjie Li, Bing Yu, Yuheng Luo, Zhiqing Huang, Xiangbing Mao, Jie Yu, Ping Zheng, Hui Yan, Hua Li, Jun He

“…Results Presence of A. muciniphila in DSS-challenged weaned pigs resulted in numerically increased diarrhea rate, blood neutrophilic granulocyte, serum C-reactive protein and immunoglobulin M levels, and numerically reduced final weight, average daily feed intake and average daily gain. The decrease in intestinal villus height, villous height: crypt depth ratio and digestibility was accompanied by lower expression of ZO1, ZO2, Claudin1, DMT1, CAT1, SGLT1 and PBD114 genes, as well as decreased enzyme activities of intestinal alkaline phosphatase, lactase, sucrase and maltase of piglets in DA group compared to piglets in DCON group. …”
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Usage, knowledge and attitudes towards electronic cigarettes use among nursing students in Croatia: a cross-sectional study by Leopold Kajan, Livia Puljak, Ivica Matić, Mario Marendić, Sanja Zoranić, Kata Ivanišević, Dijana Majstorović, Zrinka Puharić, Nataša Skitarelić, Marijana Neuberg, Ivana Barać, Snježana Čukljek, Marta Čivljak

“…Furthermore, 66% stated that they did not feel confident advising smokers about e-cigarettes. …”
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Fast In-House Next-Generation Sequencing in the Diagnosis of Metastatic Non-small Cell Lung Cancer: A Hospital Budget Impact Analysis by Ubong Silas, Maximilian Blüher, Antonia Bosworth Smith, Rhodri Saunders

“…The heterogeneity of hospital inputs and the cost of send-out NGS means context-specific inputs are needed. **Conclusion:** Using in-house NGS testing could reduce the testing turnaround time and increase the number of patients on targeted therapy. …”
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Distribution of Aeromonas bacterial population in water, sediment and Nile tilapia in fish culture pond, Guder, Ethiopia by Bekele Lema, Natarajan Pavanasam, Kassaye Balkew, Zufan Bedewi

“…The development of stress due to changes in physicochemical characters of water, and rich nutrient load in pond soil facilitate the growth of pathogenic bacteria which infect the culture fish O. niloticus. The detrivore feeding habits of O. niloticus is responsible for more number of bacterial populations in intestine than in other organs. …”
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Lived experiences of people with chronic kidney disease on maintenance dialysis: a systematic review and thematic synthesis of qualitative studies by Maya Annie Elias, Wim Van Damme, Grace Marie V Ku, Mahesh Kadammanavar, Edwin Wouters

“…The key internal factors influencing the lived experiences were personal beliefs and misconceptions about CKD, feelings of shame and guilt, financial constraints, and spirituality. …”
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Physicochemical and Sensory Properties of Broiler Chicken Breast Meat Stored Frozen and Thawed Using Various Methods by Anna Augustyńska-Prejsnar, Małgorzata Ormian, Zofia Sokołowicz

“…The current study has its practical implications due to the immense consumption of broiler chicken meat, the high proportion of deep frozen meat products in commerce, and the acceptability and popularity of frozen stored meat in households. …”
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Processability and Material Behavior of NiTi Shape Memory Alloys Using Wire Laser-Directed Energy Deposition (WL-DED) by Hediyeh Dabbaghi, Nasrin Taheri Andani, Mohammad Pourshams, Mahyar Sojoodi, Behrang Poorganji, Mohammad Elahinia

“…. %) SMA using the wire laser-directed energy deposition (WL-DED) technique, addressing the existing knowledge gap regarding the laser wire-feed metal additive manufacturing of NiTi alloys. …”
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The Impact of the COVID-19 Surge Response on Motivation Among Anesthesiology Residents and Fellows: A discussion of findings from semi-structured interviews at Montefiore Medical C... by Sujatha Ramachandran, Kateryna Slinchenkova, Jonathan Leff, David Adams, Sarang Koushik, Omar Viswanath, Naum Shaparin

“…# Background The American Board of Medical Specialties definition of medical professionalism cites the need to acquire, maintain, and advance a value system serving the patients' and public's interests above self-interests.^4^ Medical professionalism is a one of the core physician competencies assessed by both the ACGME training program evaluation and the ABA certification process. …”
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Utilization of Catfish Body Fat in the Diet of Tilapia Oreochromis niloticus by Mia Setiawati, C. Nuraeni, D. Jusadi

“…The results showed that lipid dosage in the diet insignificantly affected feed efficiency, (73.25-81.96%), protein retention (45.57-51.56%), daily growth rate (4.05-4.29%), and survival rate of fish (98.33-100%).  …”
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Comparison of Diaphragmatic Stretch Technique and Manual Diaphragm Release Technique on Diaphragmatic Excursion in Chronic Obstructive Pulmonary Disease: A Randomized Crossover Tri... by Aishwarya Nair, Gopala Krishna Alaparthi, Shyam Krishnan, Santhosh Rai, R. Anand, Vishak Acharya, Preetam Acharya

“…Both the interventions were performed in 2 sets of 10 deep breaths with 1-minute interval between the sets. …”
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Machine Learning in the Management of Patients Undergoing Catheter Ablation for Atrial Fibrillation: Scoping Review by Aijing Luo, Wei Chen, Hongtao Zhu, Wenzhao Xie, Xi Chen, Zhenjiang Liu, Zirui Xin

“…In terms of model type, deep learning, represented by convolutional neural networks, was most frequently applied (14/23, 61%). …”
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Spatiotemporal Characteristics of Extreme Precipitation and Its Future Trend Analysis in Huaihe River Basin by GUO Wei, YE Wen, ZHU Xuchao, WU Wei, WANG Lu, GAO Huamin, ZHANG Haiming, SHI Shaohui

“…This study can provide a deep understanding of extreme precipitation changes on a regional scale in the context of global warming, providing references for flood disaster prevention in the Huaihe River Basin in the future.…”
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Parkinson’s disease and other movement disorders in the context of the SARS-COV-2 pandemic by R. Kaladytė Lokominienė

“…., for adjusting or checking deep brain stimulation programming, battery failure, levodopa duodenal pump treatments, botulinum toxin therapy), and patients should be encouraged to use sports equipment available at home and /or play virtual reality games. …”
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Search for biocontrol agents among endophytic lipopeptidesynthesizing bacteria <i>Bacillus</i> spp. to protect wheat plants against Greenbug aphid (<i>Schizaphis graminum</i>) by S. D. Rumyantsev, V. Y. Alekseev, A. V. Sorokan, G. F. Burkhanova, E. A. Cherepanova, I. V. Maksimov, S. V. Veselova

“…One of the criteria for searching for new bacteria active against phloem-feeding insects can be the presence of lipopeptide synthetase genes in the bacterial genome.…”
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Quick sequential organ failure assessment score combined with other sepsis-related risk factors to predict in-hospital mortality: Post-hoc analysis of prospective multicenter study... by Ryo Ueno, Takateru Masubuchi, Atsushi Shiraishi, Satoshi Gando, Toshikazu Abe, Shigeki Kushimoto, Toshihiko Mayumi, Seitaro Fujishima, Akiyoshi Hagiwara, Toru Hifumi, Akira Endo, Takayuki Komatsu, Joji Kotani, Kohji Okamoto, Junichi Sasaki, Yasukazu Shiino, Yutaka Umemura

“…Following prior literature, an AUC >0.9 was deemed to indicate high accuracy; 0.7-0.9, moderate accuracy; 0.5-0.7, low accuracy; and 0.5, a chance result. …”
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Group Psychological Therapy Program in Adult Patients with Congenital Heart Disease and Anxious–Depressive Symptoms by Efrén Martínez-Quintana, Karen Codana-Alcántara, Hector M. Montesdeoca-Naranjo, Marta Isabel García-Suárez, María Pino Fleitas-Álvarez, María Alcántara-Castellano, Alejandro Ruiz-Castellano, Ana González-Isasi, Fayna Rodríguez-González, Esperanza Bosch-Casañas

“…<i>Methods</i>: We used non-pharmacological psychological group intervention, of six weekly sessions of 90 min each, administered by trained personnel, in adult patients with CHD. …”
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Evaluation of Changes in Macular Perfusion Detected by Optical Coherence Tomography Angiography following 3 Intravitreal Monthly Bevacizumab Injections for Diabetic Macular Edema i... by Ayman G. Elnahry, Ahmed A. Abdel-Kader, Karim A. Raafat, Khaled Elrakhawy

“…Pretreatment and posttreatment OCTA images were automatically aligned using a commercially available retina alignment software (i2k Align Retina software); then the fractal dimension (FD), vascular density (VD), and skeleton VD changes were obtained at the full retinal thickness (Full) and superficial (SCP) and deep (DCP) capillary plexuses after processing images using a semiautomated program. …”
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