Atg5 deficiency in basophils improves metabolism in lupus mice by regulating gut microbiota dysbiosis by Jiaxuan Chen, Quanren Pan, Lu Lu, Xiaorong Huang, Shuting Wang, Xiaoxian Liu, Jiaqi Lun, Xiaowei Xu, Hongyong Su, Fengbiao Guo, Lawei Yang, Liuyong You, Haiyan Xiao, Wenying Luo, Hua-feng Liu, Qingjun Pan

“…Abstract Autophagic activation in immune cells, gut microbiota dysbiosis, and metabolic abnormalities have been reported separately as characteristics of systemic lupus erythematosus (SLE). …”
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Enhancement of anti‐sarcoma immunity by NK cells engineered with mRNA for expression of a EphA2‐targeted CAR by Pui Yeng Lam, Natacha Omer, Josh K. M. Wong, Cui Tu, Louisa Alim, Gustavo R. Rossi, Maria Victorova, Hannah Tompkins, Cheng‐Yu Lin, Ahmed M. Mehdi, Amos Choo, Melissa R. Elliott, Elaina Coleborn, Jane Sun, Timothy Mercer, Orazio Vittorio, Lachlan J. Dobson, Alexander D. McLellan, Andrew Brooks, Zewen Kelvin Tuong, Seth W. Cheetham, Wayne Nicholls, Fernando Souza‐Fonseca‐Guimaraes

“…These cancers share common challenges, including high rates of metastasis, recurrence or treatment resistance, leading to a 5‐year survival rate of approximately 20% for patients with advanced disease stages. Despite the critical need, therapeutic advancements have been limited over the past three decades. …”
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Early Warning Model and Currency Crisis in the Iranian Economy A Probit Approach by Mohammadjavad Khosrosereshki, Yavar Dashtbany

“…Discussion and Conclusion In this article, in addition to examining the exchange rate seasonal growth and the central bank's foreign reserves' seasonal growth, the central bank's performance in the face of currency crises has been determined. Then, a model to predict currency crises with the Probit approach is also provided. …”
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A TRAILR2/CDH3 bispecific antibody demonstrates selective apoptosis and tumor regression in CDH3-positive pancreatic cancer by Peter Jung, Stefan P. Glaser, Jing Han, Alexandra Popa, Laura Pisarsky, Ningping Feng, Antonia Geyer, Franziska Haderk, Donat Alpar, Christopher Bristow, Susanne Schmittner, Paula-Elena Traexler, Mikhila Mahendra, Birgit Poehn, Poojabahen Gandhi, Roberto Fiorelli, Sanket Awate, Nicole Budano, Florian Martin, Christoph Albrecht, Barbara Drobits-Handl, Sathanandam S. Anand, Srinath Kasturirangan, Francesca Trapani, Norbert Schweifer, Joseph R. Marszalek, Ulrike Tontsch-Grunt, Mark Pearson, Timothy P. Heffernan, Norbert Kraut, Christopher P. Vellano, Juan Manuel García-Martínez

“…The limited clinical success of previous TRAILR2 agonistic agents, to date, has been ascribed to either poor efficacy or hepatotoxicity. …”
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Heterologous vaccination with subunit protein vaccine induces a superior neutralizing capacity against BA.4/5‐included SARS‐CoV‐2 variants than homologous vaccination of mRNA vacci... by Dandan Peng, Tingmei Zhao, Weiqi Hong, Minyang Fu, Cai He, Li Chen, Wenyan Ren, Hong Lei, Jingyun Yang, Aqu Alu, Yanghong Ni, Jian Liu, Jiong Li, Wei Wang, Guobo Shen, Zhiwei Zhao, Li Yang, Jinliang Yang, Zhenling Wang, Yoshimasa Tanaka, Guangwen Lu, Xiangrong Song, Xiawei Wei

“…In light of such situation, the vaccination against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is in desperate need of the third booster. It has been reported that heterologous boosters might produce more effective immunity against wild‐type SARS‐CoV‐2 and the variants. …”
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The combination of rAAV pseudo-lipid nanoparticle and triamcinolone acetonide enables multi-administration to liver by Chunmei Gan, Mi Leng, Yu Liu, Zhaoyue Zheng, Siwu He, Wen Qiao, Lin Xiao, Yao Xiao, Jingya Ye, Lixing Zhou, Jiao Zhou, Boduan Xiao, Wenxin Zhao, Jiamei Yang, Aohan Wu, Huiyuan Zhang, Hongbo Hu, Xiaobo Cen, Zhiyong Qian, Haohao Dong, C. Alexander Valencia, Lunzhi Dai, Hoi Yee Chow, Lei Zhang, Biao Dong

“…Herein, a novel strategy, named rAAV pseudo-lipid nanoparticle combined with triamcinolone acetonide (LNP-rAAV + TAC), has been described in mice. We showed successful but low efficient triple trafficking by LNP-rAAV2 carrying EGFP, human factor IX (hFIX), and luciferase (luc), due to its encapsulation characteristic. …”
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Development of a recombinant infectious bronchitis virus vaccine expressing infectious laryngotracheitis virus multiple epitopes by Guanming Shao, Jun Fu, Yun Pan, Shiying Gong, Chaoyi Song, Sheng Chen, Keyu Feng, Xinheng Zhang, Qingmei Xie

“…Infectious bronchitis virus (IBV) is considered a potential vector for vaccine development, but the issue of poor stability in recombinant IBV expressing foreign genes has not yet been resolved. In this study, we designed a multi-epitope cassette (gD-T/B) containing multiple T and B cell epitopes of ILTV gD protein. …”
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Immunisation schedule of the Pediatric Spanish Association: 2024 recommendations by Francisco José Álvarez García, Antonio Iofrío de Arce, Javier Álvarez Aldeán, Elisa Garrote Llanos, Lucía López Granados, María Luisa Navarro Gómez, Valentín Pineda Solas, Irene Rivero Calle, Jesús Ruiz-Contreras, Ignacio Salamanca de la Cueva, Pepe Serrano Marchuet, Francisco José Álvarez García, Antonio Iofrío de Arce, Javier Álvarez Aldeán, María Garcés-Sánchez, Elisa Garrote Llanos, Abián Montesdeoca Melián, María Luisa Navarro Gómez, Valentín Pineda Solas, Irene Rivero Calle, Jesús Ruiz-Contreras, Pepe Serrano Marchuet

“…The AEP 2025 Vaccination and Immunization Schedule recommended for children, adolescents and pregnant women residing in Spain features the following novelties:Due to the increase in measles cases and outbreaks in recent years, we recommend advancing the second dose of measles, mumps and rubella (MMR) vaccine to 2 years of age.As a consequence of the above, since many autonomous communities (ACs) use the quadrivalent vaccine for the second dose of MMR and varicella vaccines, we recommend, for all ACs, advancing the second dose of varicella vaccine to 2 years of age.Due to the very significant increase in cases of pertussis since late 2023 and especially in 2024, we recommend advancing the dose of Tdap given in adolescence to 10–12 years of age.To complete protection against meningococcal disease in adolescence, we recommend vaccination against MenB at age 12 years.We believe that vaccination against seasonal influenza should be routine up to age 18 years, but given the disappointing coverage in children aged 6–59 months, we currently consider that improving this coverage should be prioritised, extending vaccination to children and adolescents aged 5–18 years once this objective has been achieved.Among other aspects, the routine immunization tables for healthy individuals and risk groups, the use of the new extended-valence conjugate vaccines against pneumococcal disease, routine vaccination at 4 months of age with MenACWY and vaccination against SARS-CoV-2 for individuals aged more than 6 months with risk factors remain unchanged with respect to the 2024 schedule. …”
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Reactogenicity and Immunogenicity Against MPXV of the Intradermal Administration of Modified Vaccinia Ankara Compared to the Standard Subcutaneous Route by Valentina Mazzotta, Pierluca Piselli, Alessandro Cozzi Lepri, Giulia Matusali, Eleonora Cimini, Rozenn Esvan, Francesca Colavita, Roberta Gagliardini, Stefania Notari, Alessandra Oliva, Silvia Meschi, Rita Casetti, Giulia Micheli, Licia Bordi, Alessandro Giacinta, Germana Grassi, Saba Gebremeskel Tekle, Claudia Cimaglia, Jessica Paulicelli, Alessandro Caioli, Paola Gallì, Giulia Del Duca, Miriam Lichtner, Loredana Sarmati, Enrica Tamburrini, Claudio Mastroianni, Alessandra Latini, Paolo Faccendini, Carla Fontana, Emanuele Nicastri, Andrea Siddu, Alessandra Barca, Francesco Vaia, Enrico Girardi, Fabrizio Maggi, Andrea Antinori

“…Background: The recent resurgence of mpox in central Africa has been declared a new public health emergency of international concern (PHEIC) requiring coordinated international responses. …”
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Tenofovir and Doravirine Are Potential Reverse-Transcriptase Analogs in Combination with the New Reverse-Transcriptase Translocation Inhibitor (Islatravir) Among Treatment-Experien... by Alex Durand Nka, Yagai Bouba, Wilfried Rooker Tsapi Lontsi, Davy-Hyacinte Gouissi Anguechia, Georges Teto, Aude christelle Ka’e, Ezechiel Ngoufack Jagni Semengue, Collins Ambe Chenwi, Désiré Takou, Lum Forgwei, Tatiana Anim-Keng Tekoh, Aurelie Minelle Kengni Ngueko, Bernadette Bomgning Fokou, Jeremiah Efakika Gabisa, Michel Carlos Tommo Tchouaket, Willy Leroi TognaPabo, Derrick Tambe Ayuk Ngwese, Jacky Njiki Bikoi, Daniele Armenia, Vittorio Colizzi, Marcel Yotebieng, Nicaise Ndembi, Maria-Mercedes Santoro, Francesca Ceccherini-Silberstein, Carlo-Federico Perno, Alexis Ndjolo, Joseph Fokam

“…This study evaluated the predictive efficacy of ISL and identified potentially active antiretrovirals in combination among treatment-experienced patients in Cameroon, where NRTIs (3TC) have been the backbone of ART for decades now. Although ISL is a long-acting antiretroviral, it will provide other therapeutic options in combination with other reverse transcriptase inhibitors that remain effective. …”
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Multi-cancer early detection tests for general population screening: a systematic literature review by Ros Wade, Sarah Nevitt, Yiwen Liu, Melissa Harden, Claire Khouja, Gary Raine, Rachel Churchill, Sofia Dias

“…There were also concerns about the applicability of CancerSEEK, which has since been modified (now called Cancerguard™) and is undergoing further assessment. …”
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Carbon footprint reduction practices in the Olympic Games: a policy mobility approach by Wesselia Isa Ngoenha

“… Introduction The environmental impact of mega-events like the Olympic Games and the FIFA Men's World Cup has been widely criticized due to their significant contribution to greenhouse gas emissions, largely driven by infrastructure construction and resource use, and travel. …”
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IGJR issue 1/2018 by IF and FRFG

“…It is released biannually and employs a double-blind peer review process. Its editorial board consists of about 50 internationally renowned experts from ten different countries. …”
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Aetiology of chronic liver disease is a valuable factor for stratifying adverse outcomes of acute decompensation: prospective observational study by Jung Hee Kim, Sung-Eun Kim, Do Seon Song, Hee Yeon Kim, Eileen L. Yoon, Ji Won Park, Tae Hyung Kim, Young-Kul Jung, Ki Tae Suk, Hyung Joon Yim, Jung Hyun Kwon, Sung Won Lee, Seong Hee Kang, Moon Young Kim, Soung Won Jeong, Jae-Young Jang, Jeong Ju Yoo, Sang Gyune Kim, Young-Joo Jin, Gab Jin Cheon, Byung Seok Kim, Yeon Seok Seo, Hyoungsu Kim, Dong Hyun Sinn, Woo Jin Chung, Hwi Young Kim, Han Ah Lee, Seung Woo Nam, In Hee Kim, Ji Hoon Kim, Hee Bok Chae, Joo Hyun Sohn, Ju Yeon Cho, Yoon Jun Kim, Jin Mo Yang, Jung Gil Park, Won Kim, Hyun Chin Cho, Dong Joon Kim

“…However, limited research has been conducted to analyse these discrepancies across aetiologies.Methods The prospective Korean Acute-on-Chronic Liver Failure (KACLiF) cohort consisted of 1,501 patients who were hospitalized with AD of CLD from July 2015 to August 2018. …”
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Predictive value of TG/HDL-C and GFR-adjusted uric acid levels on cardiovascular mortality: the URRAH study by Elisa Russo, Francesca Viazzi, Roberto Pontremoli, Fabio Angeli, Carlo Maria Barbagallo, Bruno Berardino, Michele Bombelli, Federica Cappelli, Edoardo Casiglia, Rosario Cianci, Michele Ciccarelli, Arrigo F. G. Cicero, Massimo Cirillo, Pietro Cirillo, Lanfranco D’Elia, Giovambattista Desideri, Claudio Ferri, Ferruccio Galletti, Loreto Gesualdo, Cristina Giannattasio, Guido Grassi, Guido Iaccarino, Egidio Imbalzano, Luciano Lippa, Francesca Mallamaci, Alessandro Maloberti, Stefano Masi, Maria Masulli, Alberto Mazza, Alessandro Mengozzi, Maria Lorenza Muiesan, Pietro Nazzaro, Paolo Palatini, Gianfranco Parati, Fosca Quarti-Trevano, Marcello Rattazzi, Gianpaolo Reboldi, Giulia Rivasi, Massimo Salvetti, Valerie Tikhonoff, Giuliano Tocci, Andrea Ungar, Paolo Verdecchia, Agostino Virdis, Massimo Volpe, Claudio Borghi, Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension (SIIA)

“…The triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) ratio has been proposed as an easily obtainable marker for IR. …”
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Alteration, mineralization, geochemistry and fluid inclusion investigations in Joftrud prospect area, southwest of Birjand by Omid Shareipour, Azadeh Malekzadeh Shafaroudi, Maryam Javidi Moghaddam

“…For the first time, detailed studies of base metal mineralization and genesis of veins have been conducted. The purpose of this research is the geology, examine the geochemical and fluid inclusion data, and finally discus mineralization model of occurrence of ore veins in the Joftrud prospect area. …”
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Natural Resource Rent and Financial Development: Testing Financial Resource Curse Hypothesis in Iran by Majid Aghaei, Mahdieh Rezagholizadeh, mohammad abdi, rawa mosavi

“…Considering that the Iranian financial system is influenced by the banking system, and resource rents have been confirmed in the banking sector, this result can be justified as indicative of the greater flow of oil revenues into the Iranian banking system. …”
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Measurement Report: Changes in ammonia emissions since the 18th century in south-eastern Europe inferred from an Elbrus (Caucasus, Russia) ice-core record by M. Legrand, M. Legrand, M. Vorobyev, D. Bokuchava, S. Kutuzov, S. Kutuzov, A. Plach, A. Stohl, A. Khairedinova, V. Mikhalenko, M. Vinogradova, S. Eckhardt, S. Preunkert

“…Emission inventories indicate that NH<span class="inline-formula">₃</span> was predominantly emitted by agriculture over the 19th and 20th centuries but, up to now, these estimates have not been compared to long-term observations. To document past atmospheric NH<span class="inline-formula">₃</span> pollution in south-eastern Europe, ammonium (NH<span class="inline-formula"><math xmlns="http://www.w3.org/1998/Math/MathML" id="M4" display="inline" overflow="scroll" dspmath="mathml"><mrow><msubsup><mi/><mn mathvariant="normal">4</mn><mo>+</mo></msubsup></mrow></math><span><svg:svg xmlns:svg="http://www.w3.org/2000/svg" width="8pt" height="15pt" class="svg-formula" dspmath="mathimg" md5hash="310866e2e55ea172cf2d52bb7208ba35"><svg:image xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="acp-25-1385-2025-ie00001.svg" width="8pt" height="15pt" src="acp-25-1385-2025-ie00001.png"/></svg:svg></span></span>) was analysed along an ice core extracted from Mount Elbrus in the Caucasus, Russia. …”
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Presenting the entrepreneurial school model in Iran by tayebeh shahrostambeig, esmat Masoudi Nadushan, zahra taleb

“…In recent years, the development of entrepreneurship in schools has been placed on the agenda of education. The results of this study can help policymakers and education professionals in the development of entrepreneurial schools. …”
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Long-term trends in the prevalence of cardiovascular-kidney-metabolic syndrome in South Korea, 2011–2021: a representative longitudinal serial studyResearch in context by Yesol Yim, Jae E. Lee, Yejun Son, Soeun Kim, Hojae Lee, Sooji Lee, Wonwoo Jang, Hanseul Cho, Hayeon Lee, Kyeongmin Lee, Hyesu Jo, Jaeyu Park, Jiyeon Oh, Louis Jacob, Jiseung Kang, Hyunji Sang, Sang Youl Rhee, Dong Keon Yon

“…However, this syndrome has not been studied extensively outside of the United States. …”
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