Trifluridine-tipiracil in previously treated patients with oestrogen receptor-positive, HER2-negative metastatic breast cancer (BOOG 2019-01 TIBET trial): a single-arm, multicentre... by Niels A.D. Guchelaar, Ron H.J. Mathijssen, Maaike de Boer, Marlies L. van Bekkum, Joan B. Heijns, Birgit E.P.J. Vriens, Mandy M. van Rosmalen, Lonneke W. Kessels, Lisanne Hamming, Karin J. Beelen, Peter Nieboer, Susan M. van den Berg, Esther Oomen-de Hoop, Rhodé M. Bijlsma, Monique E.M.M. Bos

“…Findings: Fifty female patients were enrolled from September 2020 to July 2023, with a median of 3 (IQR, 2–3) previous endocrine therapy lines and 2 (IQR, 2–3) chemotherapy lines for MBC. The DCR rate at 8 weeks was 64.0% (n = 32, 95% CI: 50.1–75.9%; 80% CI: 55.0–72.1%), thereby meeting the primary endpoint of this study. …”
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Comparative genomics of Aspergillus nidulans and section Nidulantes by Sebastian Theobald, Tammi Vesth, Jane L. Nybo, Jens C. Frisvad, Inge Kjærbølling, Stephen Mondo, Kurt LaButti, Sajeet Haridas, Robert Riley, Alan A. Kuo, Asaf A. Salamov, Jasmyn Pangilinan, Anna Lipzen, Maxim Koriabine, Mi Yan, Kerrie Barry, Alicia Clum, Ellen K. Lyhne, Elodie Drula, Ad Wiebenga, Astrid Müller, Ronnie J.M. Lubbers, Roland S. Kun, Ana Carolina dos Santos Gomes, Miia R. Mäkelä, Bernard Henrissat, Blake A. Simmons, Jon K. Magnuson, Jakob B. Hoof, Uffe H. Mortensen, Paul S. Dyer, Michelle Momany, Thomas O. Larsen, Igor V Grigoriev, Scott E. Baker, Ronald P. de Vries, Mikael R. Andersen

“…Genetic dereplication of SMGC and subsequent synteny analysis provides evidence for horizontal gene transfer of a SMGC. Proteins that have been investigated in A. nidulans as well as its SMGC families are generally present in the section Nidulantes, supporting its role as model organism. …”
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Urethra-sparing prostate cancer radiotherapy: Current practices and future insights from an international survey by Jennifer Le Guévelou, Paul Sargos, Piet Ost, Filippo Alongi, Stefano Arcangeli, Alejandro Berlin, Pierre Blanchard, Anna Bruynzeel, Olivier Chapet, Alan Dal Pra, Robert T. Dess, Matthias Guckenberger, Andrew Loblaw, Amar U. Kishan, Barbara Alicja Jereczek-Fossa, David Pasquier, Mohamed Shelan, Shankar Siva, Alison C. Tree, Costantinos Zamboglou, Stephane Supiot, Vedang Murthy, Thomas Zilli

“…Purpose: In prostate cancer patients, high radiation doses to the urethra have been associated with an increased risk of severe genitourinary toxicity following dose-escalated radiotherapy. …”
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Association between fat-soluble vitamin co-exposure patterns and blood pressure in people with hypertension: a cross-sectional study by Suming Dai, Ping Wang, Sijia Wang, Sijia Wang, Hong Chen, Zhixin Cui, Wenhai Lu, Wenhai Lu, Ziyi Zhou, Ziyi Zhou, Nan Zhang, Zhuo Wang, Tengfei Lin, Tengfei Lin, Yun Song, Yun Song, Lishun Liu, Lishun Liu, Xiao Huang, Ping Chen, Genfu Tang, Yong Duan, Yong Duan, Hao Zhang, Binyan Wang, Binyan Wang, Binyan Wang, Yan Yang, Yan Yang, Yan Yang, Zezhong Tian

“…However, the potential relationship between the level of circulating multivitamins and blood pressure has not been explored. We aimed to investigate the association between multiple fat-soluble vitamin levels and blood pressure.MethodsA total of 2052 participants with essential hypertension were sampled nationwide. …”
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Association of inflammation cytokines with cognitive function in first-episode major depressive disorder by Yan Qing Xi, Yan Qing Xi, Yan Qing Xi, Zong Qi Wang, Zong Qi Wang, Zong Qi Wang, Guo Juan Li, Guo Juan Li, Guo Juan Li, Zhuo Qun Hao, Zhuo Qun Hao, Zhuo Qun Hao, Jia Hui Nie, Jin Xiang Li, Yu Ting Tan, Xiao Dong Hu, Xiao Dong Hu, Gen Wei Wang, Sha Liu, Sha Liu, Yan Fang Wang, Yan Fang Wang, Yan Fang Wang

“…In recent years, the relationship between the immune-inflammatory response and MDD has been a hot topic of research, but how the relationship between immunoinflammation and cognitive function is manifested in MDD is still unclear. …”
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Comparative evaluation of multimarker algorithms for early-stage HCC detection in multicenter prospective studies by Jinlin Hou, Thomas Berg, Arndt Vogel, Teerha Piratvisuth, Jörg Trojan, Enrico N. De Toni, Masatoshi Kudo, Katarina Malinowsky, Peter Findeisen, Johannes Kolja Hegel, Wenzel Schöning, Kairat Madin, Konstantin Kroeniger, Henry Lik-Yuen Chan, Ashish Sharma

“…Impact and implications: To improve the detection of early-stage hepatocellular carcinoma (HCC) from benign chronic liver disease (CLD), algorithms combining demographic characteristics and serum biomarkers, such as GAAD and GALAD, have been developed. GAAD combines gender (biological sex), age, alpha-fetoprotein (AFP), des-gamma carboxy-prothrombin (DCP); GALAD combines the same characteristics and biomarkers as GAAD with the addition of Lens culinaris agglutinin-reactive AFP (AFP-L3). …”
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Malícia honey (Mimosa quadrivalvis L.) produced by the jandaíra bee (Melipona subnitida D.) shows antioxidant activity via phenolic compound action in obese rats by Maria Luiza Rolim Bezerra, Maria Luiza Rolim Bezerra, Mirela Gouveia-Nhanca, Mirela Gouveia-Nhanca, Maria Letícia da Veiga Dutra, Maria Letícia da Veiga Dutra, Kamila Sabino Batista, Alana Natalícia Vasconcelos de Araújo, Alana Natalícia Vasconcelos de Araújo, Marcos dos Santos Lima, Marcos dos Santos Lima, Mateus Duarte Ribeiro, Mateus Duarte Ribeiro, Alexandre Sergio Silva, Alexandre Sergio Silva, Alexandre Sergio Silva, Adriano Francisco Alves, Tatiana Colombo Pimentel, Marciane Magnani, Marciane Magnani, Jailane de Souza Aquino, Jailane de Souza Aquino, Jailane de Souza Aquino

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La chirurgie cardiaque mini-invasive vidéo-assistée : une étude comparative à la voie conventionnelle [Less-invasive video-assisted cardiac surgery : a comparative study with the c... by Sami Bouchenafa, Ahmed Zaki Boukli-Hacene, Boukri Hamouda, Mohamed Atbi

“…English Abstract: Background-Vertical median sternotomy has been the best approach to cardiac surgery. While the conventional approach is traumatic, with many complications, using a video camera in surgery offers smaller incisions. …”
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Therapeutic benefit of the dual ALK/FAK inhibitor ESK440 in ALK-driven neuroblastoma by Seema Chugh, Jean C. Tien, Jennifer Hon, Carson Kenum, Rahul Mannan, Yunhui Cheng, Chi Chiang Li, Zainab I. Taher, Andrew D. Delekta, Pushpinder Singh Bawa, Ingrid J. Apel, Stephanie J. Miner, Xuhong Cao, Rohit Mehra, Saravana M. Dhanasekaran, Yuanyuan Qiao, Rajen Mody, Arul M. Chinnaiyan

“…Standard therapy involves highly toxic chemotherapy, surgery, radiation, and immunotherapy, and less toxic, more specific targeted therapies are urgently needed. Genomic studies have identified common driver aberrations in high-risk NB, such as MYCN amplification. …”
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Reproductive hormone profiles and gametogenesis in female of giant gouramy (Osphronemus gouramy) by Gratiana E. Wijayanti, . Soeminto, Sorta B.I. Simanjuntak

“…Eighteen broodstocks were naturally spawned; the day of spawning was referred as the first day (zero weeks) of post spawning. Nine (Group A) of those broodstocks were used to evaluate gonadotropin, estradiol, and progesterone profiles.  …”
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A humanized anti-MSLN×4-1BB bispecific antibody exhibits potent antitumour activity through 4-1BB signaling activation and fc function without systemic toxicity by Da-yan Zhang, Zhi-hua Zhang, Wen-ting Liu, Wei-ming Zhou, Peng-fei Zhou, Juan-juan Wei, Xue-jing Dai, Xiao-li Zeng, Yu-qiong Zhou, Han-wang Li, Heng Zhang, Ao-lin Shen, Lian-sheng Cheng, Guo-dong Shen, Yi-fu He

“…Abstract Background Agonistic monoclonal antibodies targeting 4-1BB/CD137 have shown preclinical promise, but their clinical development has been limited by severe liver toxicity or limited efficacy. …”
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CD36 enrichment in HER2-positive mesenchymal stem cells drives therapy refractoriness in breast cancer by Lorenzo Castagnoli, Alma Franceschini, Valeria Cancila, Matteo Dugo, Martina Bigliardi, Claudia Chiodoni, Paolo Toneguzzo, Viola Regondi, Paola A. Corsetto, Filippo Pietrantonio, Serena Mazzucchelli, Fabio Corsi, Antonio Belfiore, Antonio Vingiani, Giancarlo Pruneri, Francesca Ligorio, Mario P. Colombo, Elda Tagliabue, Claudio Tripodo, Claudio Vernieri, Tiziana Triulzi, Serenella M. Pupa

“…In particular, HER2 + BC has been defined as a "lipogenic disease" due to the functional and bi-directional crosstalk occurring between HER2-mediated oncogenic signaling and FA biosynthesis via FA synthase activity. …”
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Loop33 × 123 CAR-T targeting CD33 and CD123 against immune escape in acute myeloid leukemia by Haotian Ma, Zhifeng Yan, Runxia Gu, Yingxi Xu, Shaowei Qiu, Haiyan Xing, Kejing Tang, Zheng Tian, Qing Rao, Min Wang, Jianxiang Wang

“…Abstract Background Immunotherapy, such as chimeric antigen receptor T (CAR-T) cells targeting CD33 or CD123, has been well developed over the past decade for the treatment of acute myeloid leukemia (AML). …”
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Adherence to a digital therapeutic mediates the relationship between momentary self-regulation and health risk behaviors by Enzo G. Plaitano, Enzo G. Plaitano, Daniel McNeish, Sophia M. Bartels, Sophia M. Bartels, Kathleen Bell, Jesse Dallery, Michael Grabinski, Michaela Kiernan, Hannah A. Lavoie, Hannah A. Lavoie, Shea M. Lemley, Michael R. Lowe, David P. MacKinnon, Stephen A. Metcalf, Stephen A. Metcalf, Lisa Onken, Judith J. Prochaska, Cady Lauren Sand, Cady Lauren Sand, Emily A. Scherer, Luke E. Stoeckel, Haiyi Xie, Lisa A. Marsch

“…However, the role of momentary self-regulation in achieving behavior change has been infrequently examined. Using a novel momentary self-regulation scale, this study examined how targeting self-regulation through a digital therapeutic impacts adherence to the therapeutic and two different health risk behavioral outcomes.MethodsThis prospective interventional study included momentary data for 28 days from 50 participants with obesity and binge eating disorder and 50 participants who smoked regularly. …”
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Editorial by Ann-Kristin Kölln, Antony Mason, Jörg Tremmel, Markus Rutsche, Maria Lenk

“…The 16 year-old climate activist, who has also been nominated for a Nobel Peace Prize, started a movement that saw a multitude of student protests and school strikes around the world centred on action against climate change. …”
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Evaluation of dried blood spot sampling for real-time PCR malaria diagnostics in a rural setting in Angola by Alejandro Mediavilla, Begoña Febrer-Sendra, Aroa Silgado, Patricia Martínez-Vallejo, Beatriz Crego-Vicente, Arlette Nindia, Carles Rubio Maturana, Lidia Goterris, Joan Martínez-Campreciós, Sandra Aixut, Pedro Fernández-Soto, María Luisa Aznar, Antonio Muro, Inés Oliveira-Souto, Israel Molina, Elena Sulleiro

“…Real-time PCR diagnosis in endemic areas has not been implemented due to its high cost and the need for adequate infrastructure. …”
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A Neural Circuit From Paraventricular Nucleus of the Thalamus to the Nucleus Accumbens Mediates Inflammatory Pain in Mice by Xi Liu, Xi Zhang, Dongxu Wang, Ya Cao, Ling Zhang, Zhonghua Li, Qin Zhang, Yu Shen, Xian Lu, Keyu Fan, Mingxia Liu, Jingqiu Wei, Siping Hu, He Liu

“…In addition, compared to the control group, CFA‐induced inflammatory pain led to increased c‐Fos protein expression in PVT, which means that some of the neurons in this area of the brain region have been activated. Following the injection of retrograde transport fluorescent‐labeled virus into NAc, glutamatergic neurons projecting from the PVT to NAc were observed, confirming the projection relationship between PVT and NAc. …”
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The 0ν2β-decay CROSS experiment: preliminary results and prospects by The CROSS collaboration, I. C. Bandac, A. S. Barabash, L. Bergé, M. Brière, C. Bourgeois, P. Carniti, M. Chapellier, M. de Combarieu, I. Dafinei, F. A. Danevich, N. Dosme, D. Doullet, L. Dumoulin, F. Ferri, A. Giuliani, C. Gotti, P. Gras, E. Guerard, A. Ianni, H. Khalife, S. I. Konovalov, E. Legay, P. Loaiza, P. de Marcillac, S. Marnieros, C. A. Marrache-Kikuchi, C. Nones, V. Novati, E. Olivieri, C. Oriol, G. Pessina, D. V. Poda, T. Redon, V. I. Tretyak, V. I. Umatov, M. M. Zarytsky, A. S. Zolotarova

“…Rejection factors higher than 99.9% of α surface radioactivity have been demonstrated in a series of prototypes based on crystals of Li2MoO4 and TeO2. …”
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Assessment of platelet-to-white blood cell ratio on short-term mortality events in patients hospitalized with acute decompensated heart failure: evidence from a cohort study from J... by Xin Huang, Xin Huang, Xin Huang, Xin Huang, Maobin Kuang, Maobin Kuang, Maobin Kuang, Maobin Kuang, Jiajun Qiu, Jiajun Qiu, Jiajun Qiu, Jiajun Qiu, Chao Wang, Chao Wang, Chao Wang, Chao Wang, Guotai Sheng, Guotai Sheng, Yang Zou, Guobo Xie

“…ObjectivePlatelet-to-white blood cell ratio (PWR) as a comprehensive indicator of inflammatory response has been widely used to assess the prognosis of various diseases. …”
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Climate change rivals fertilizer use in driving soil nitrous oxide emissions in the northern high latitudes: Insights from terrestrial biosphere models by Naiqing Pan, Hanqin Tian, Hao Shi, Shufen Pan, Josep G. Canadell, Jinfeng Chang, Philippe Ciais, Eric A. Davidson, Gustaf Hugelius, Akihiko Ito, Robert B. Jackson, Fortunat Joos, Sebastian Lienert, Dylan B. Millet, Stefan Olin, Prabir K. Patra, Rona L. Thompson, Nicolas Vuichard, Kelley C. Wells, Chris Wilson, Yongfa You, Sönke Zaehle

“…Increases in atmospheric N2O have been attributed primarily to enhanced soil N2O emissions. …”
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