A UV to X-Ray View of Soft Excess in Type 1 Active Galactic Nuclei. I. Sample Selection and Spectral Profile by Shi-Jiang Chen, Jun-Xian Wang, Jia-Lai Kang, Wen-Yong Kang, Hao Sou, Teng Liu, Zhen-Yi Cai, Zhen-Bo Su

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Association of delayed asthma diagnosis with asthma exacerbations in children by Chung-Il Wi, MD, Euijung Ryu, PhD, Katherine S. King, MS, Jung Hyun Kwon, MD, PhD, Joshua T. Bublitz, BS, Miguel Park, MD, Sergio E. Chiarella, MD, Jason D. Greenwood, MD, MS, Thanai Pongdee, MD, Lynnea Myers, PhD, Björn Nordlund, PhD, Sunghwan Sohn, PhD, Elham Sagheb, MS, Bhavani Singh Agnikula Kshatriya, MS, Dave Watson, PhD, Hongfang Liu, PhD, Beverley J. Sheares, MD, MS, Carla M. Davis, MD, Wade Schulz, MD, PhD, Young J. Juhn, MD, MPH

“…Background: There is a significant delay between symptom onset and diagnosis of childhood asthma, but the impact of this delay on asthma outcomes has not been well understood. Objectives: We sought to study the association of delayed diagnosis of asthma with asthma exacerbations (AEs) in children. …”
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Étude archéozoologique du quartier portuaire romain de Saint-Lupien à Rezé/Ratiatum (Loire-Atlantique) : les vestiges fauniques en pied de berge by Aurélia Borvon

“…In the different parts of “area 4”, various taxa have been identified, both large-sized ones such as cattle, and very small-sized ones such as fish or shrimp. …”
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Hexane extract from Lindera communis roots: wound healing properties and membrane-disruptive activities against methicillin-resistant Staphylococcus aureus by Miaomiao Wang, Miaomiao Wang, Miaomiao Wang, Xian Hu, Xian Hu, Xian Hu, Liya Liu, Liya Liu, Liya Liu, Liya Liu, Yi Zhong, Yi Zhong, Yi Zhong, Wanlin Li, Wanlin Li, Wanlin Li, Qing Zhang, Qing Zhang, Qing Zhang, Congli Xu, Chunlin Long, Chunlin Long, Chunlin Long, Chunlin Long, Chunlin Long

“…(Lauraceae) in traditional Chinese medicine has been specifically employed for wound healing and treating skin diseases in cattle and horses, suggesting its potential antibacterial properties. …”
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Negative valuation of ambiguous feedback may predict near-term risk for suicide attempt in Veterans at high risk for suicide by Catherine E. Myers, Catherine E. Myers, Rokas Perskaudas, Rokas Perskaudas, Vibha Reddy, Chintan V. Dave, Chintan V. Dave, John G. Keilp, Arlene King, Kailyn Rodriguez, Kailyn Rodriguez, Lauren St. Hill, Rachael Miller, Alejandro Interian, Alejandro Interian

“…BackgroundLearning from feedback – adapting behavior based on reinforcing and punishing outcomes – has been implicated in numerous psychiatric disorders, including substance misuse, post-traumatic stress disorder, and depression; an emerging literature suggests it may also play a role in suicidality. …”
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PCSK9-antibodies fail to block PCSK9-induced inflammation in macrophages and cannot recapitulate protective effects of PCSK9-deficiency in experimental myocardial infarction by Simon Rauterberg, Simon Rauterberg, Carmen Härdtner, Jennifer Hein, Paola Schrepf, Remi Peyronnet, Christoph Koentges, Tamara A. Vico, Carolin Ehlert, Bianca Dufner, Diana Lindner, Constantin von zur Mühlen, Dennis Wolf, Dirk Westermann, Ingo Hilgendorf, Alexander von Ehr

“…Alirocumab treatment, while effective in lowering plasma cholesterol, did not replicate the survival benefits seen in PCSK9 KO mice and even worsened cardiac function post-MI. …”
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Association of immune-related adverse events with the outcomes of immune checkpoint inhibitors in patients with dMMR/MSI-H metastatic colorectal cancer by Chiara Cremolini, Sara Lonardi, Filippo Pietrantonio, Francesca Corti, Elisabetta Fenocchio, Massimiliano Salati, Margherita Ambrosini, Michael J Overman, Lisa Salvatore, Rossana Intini, Priya Jayachandran, Javier Ros, Maria Elena Elez, Marwan Fakih, Aakash Tushar Shah, Rosalba Miceli, Monica Niger, Vincenzo Nasca, Giacomo Mazzoli, Francesco Barretta

“…Prognostic/predictive markers are needed. Despite previous investigations in other tumor types, immune-related adverse events (irAEs) have not been well evaluated in patients with MSI-H cancers treated with ICIs.Methods We conducted an international cohort study at tertiary cancer centers collecting clinic-pathological features from 331 patients with MSI-H mCRC treated with ICIs. …”
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Roles of core nosZ denitrifiers in enhancing denitrification activity under long-term rice straw retention by Shijie Zhang, Shijie Zhang, Mengyao Hou, Mengyao Hou, Bing Li, Bing Li, Panfeng Guan, Panfeng Guan, Qing Chi, Qing Chi, Hao Sun, Hao Sun, Hangbo Xu, Hangbo Xu, Dongjie Cui, Dongjie Cui, Yupan Zhu, Yupan Zhu

“…The denitrification process is known to contribute to soil nitrogen (N) loss, which is strongly affected by fertilization strategies; however, the effects of distinct straw retention modes on soil denitrification activity have rarely been discriminated and the underlying mechanisms remain unclear. …”
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Exemples d’habitats aristocratiques sur les sites des rues Eugène-Desteuque et Ponsardin à Reims/Durocortorum by Magalie Cavé, Stéphane Sindonino, Sabine Groetembril

“…The domus question has long occupied an important place in the archaeological research of Reims and, with more than thirty years of research and the development of rescue archaeology, our knowledge of these urban houses has been substantially improved. It is, of course, still challenged by the inherent difficulties excavations face in stratified contexts, as well as the consequences of methodical and systematic recovery of building materials at the end of Antiquity, which render reading and interpreting plans of architectural remains difficult. …”
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Evaluating the controlled reopening of nightlife during the COVID-19 pandemic: a matched cohort study in Sitges, Spain, in May 2021 (Reobrim Sitges) by Mercè Marzo-Castillejo, Joan Colom, Betlem Salvador-González, Josep Basora, Oriol Cunillera Puértolas, Sara Contreras-Martos, Darío López Gallegos, Mateo Acedo Anta, Jesús Almeda Ortega

“…To attend the event, participants were required to be older than 17 years, with a negative rapid antigen diagnostic test (Ag-RDT) on the same afternoon, without a positive reverse-transcription PCR (RT-PCR) or Ag-RDT and/or symptoms associated with COVID-19 in the previous 7 days, to not having knowingly been in close contact with someone infected in the previous 10 days and to not have knowingly had close contact with someone with a suspicion of COVID-19 in the previous 48 hours. …”
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Life after prostate cancer diagnosis: protocol for a UK-wide patient-reported outcomes study by David H Brewster, Victoria Cairnduff, Eila Watson, Amy Downing, Adam W Glaser, Penny Wright, William Cross, Conan Donnelly, Anna Gavin, Carol Rivas, Richard Wagland, Peter Selby, Luke Hounsome, Therese Kearney, Rebecca Mottram, Majorie Allen, Oonagh McSorley, Hugh Butcher, Paul Kind, James W H Catto, Dyfed Huws, Emma McNair, Lauren Matheson, Johana Nayoan, Mike Horton, Jessica Corner, Julia Verne

“…A comprehensive patient-reported outcome measure has been developed using generic and specific instruments with proven psychometric properties and relevance in national and international studies. …”
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Editorial by Daniel Halliday

“…Similarly, proposals to tax or otherwise regulate inheritance need to be assessed not just in light of these background facts but in terms of what sort of legal reforms are defensible, how the relevant political narratives seem to evolve, and any likely impact on incentives in the jurisdiction in question. …”
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Intracalvariosseous injection: an approach for central nervous system drug delivery through skull bone marrow with a preclinical research in strokeResearch in context by Wenqian Liu, Mo Yang, Nanxing Wang, Xiangrong Liu, Chaoyu Wang, Kaibin Shi, Fu-Dong Shi, Yuesong Pan, Mingjun Zhang, Zhiwei Sun, Yongjun Wang, Yilong Wang

“…Researchers have discovered natural microchannels between the skull bone marrow and the dura mater, providing a pathway for drug delivery through the skull bone marrow. However, there has been no research on the feasibility, safety, and efficacy of this delivery method for drug treatment of stroke. …”
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Inflammation biomarkers and neurobehavioral performance in rural adolescentsKey PointsRelevance by Beemnet Amdemicael, Kun Yang, Briana N.C. Chronister, Caroline Mackey, Xin Tu, Sheila Gahagan, Danilo Martinez, Harvey Checkoway, David R. Jacobs, Jr., Jose Suarez-Torres, Suzi Hong, Jose R. Suarez-Lopez

“…Background: Systemic inflammation has been associated with lower neurobehavioral performance in diverse populations, yet the evidence in adolescents remains lacking. …”
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Longitudinal association between DNA methylation and type 2 diabetes: findings from the KORA F4/FF4 study by Liye Lai, Dave Laurence Juntilla, Monica Del, Monica Del C Gomez-Alonso, Harald Grallert, Barbara Thorand, Aiman Farzeen, Wolfgang Rathmann, Juliane Winkelmann, Holger Prokisch, Christian Gieger, Christian Herder, Annette Peters, Melanie Waldenberger

“…Abstract Background Type 2 diabetes (T2D) has been linked to changes in DNA methylation levels, which can, in turn, alter transcriptional activity. …”
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Evaluation of Learners’ Satisfaction with Open Flexible and Distance Learning Services at the University of Lagos Distance Learning Institute by Adenike Oladipo, Esther O. Oladele, Oladipupo Ajeyalemi, Folashade Afolabi, Peter O. Olayiwola, Johnson A. Adewara, Andrew Akala, Uchenna Udeani

“…Findings from this study revealed that DLI has been generally successful in satisfying learners at the pre-enrolment, process and product stages with mean response ratings of 7.27, 5.63, and 6.87 respectively. …”
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Early risk assessment in paediatric and adult household contacts of confirmed tuberculosis cases by novel diagnostic tests (ERASE-TB): protocol for a prospective, non-interventiona... by Ursula Panzner, Katharina Kranzer, Tsitsi Bandason, Kuda Mutasa, Sandra Rukobo, Charles Sandy, Bariki Mtafya, Andrea Rachow, Norbert Heinrich, Michael Hoelscher, Judith Bruchfeld, Olena Ivanova, Nyanda Elias Ntinginya, Doreen Pamba, Laura Olbrich, Issa Sabi, Simeon Mwanyonga, Elmar Saathoff, Willyhelmina Olomi, Junior Mutsvangwa, Hazel M Dockrell, Edson Tawanda Marambire, Denise Banze, Alfred Mfinanga, Theodora D Mbunda, Khosa Celso, Gunilla Kallenius, Claire J Calderwood, Christof Geldmacher, Kathrin Held, Tejaswi Appalarowthu, Friedrich Rieß, Anna Shepherd, Christopher Sundling, Mishelle Mugava, Martha Chipinduro, Lwitiho Sudi, Antelmo Haule, Emmanuel Sichone, Paschal Qwaray, Harrieth Mwambola, Lilian Minja, Peter Edwin, Dogo Ngalison, Stella Luswema, Celina Nhamuave, António Machiana, Carla Madeira, Emelva Manhiça, Nádia Sitoe, Jorge Ribeiro

“…Study findings will be presented at scientific conferences and published in peer-reviewed international journals.Trial registration number NCT04781257.Cite Now…”
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Compositional Design, Microstructure, and Thermal Processing of Aluminum-Based Complex Concentrated Alloys by Spyridon Chaskis, Constantinos Tiktopoulos, Evangelos Gavalas, Marianthi Bouzouni, Fotis Tsiolis, Spyros Papaefthymiou

“…Three lightweight aluminum-based complex concentrated alloys with chemical compositions that have not been previously studied were manufactured and studied: Al₅₂Mg_9.6Zn₁₆Cu_15.5Si_6.9 w.t.% or Al₆₃Mg₁₃Zn₈Cu₈Si₈ a.t.% (alloy A), Al₄₄Mg₁₈Zn₁₉Cu₁₉ w.t.% or Al₅₅Mg₂₅Zn₁₀Cu₁₀ a.t.% (alloy B), and Al₄₇Mg_21.4Zn₁₂Cu_9.7Si_9.7 w.t.% or Al_52.7Mg_26.6Zn_5.6Cu_4.6Si_10.4 a.t.% (alloy AM), with low densities of 3.15 g/cm³, 3.18 g/cm³ and 2.73 g/cm³, respectively. …”
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Eupalinolide B inhibits periodontitis development by targeting ubiquitin conjugating enzyme UBE2D3 by Wenhua Kuang, Ruishen Zhuge, Ping Song, Letai Yi, Shujie Zhang, Ying Zhang, Yin Kwan Wong, Ruixing Chen, Junzhe Zhang, Yuanbo Wang, Dandan Liu, Zipeng Gong, Peili Wang, Xiangying Ouyang, Jigang Wang

“…Abstract Periodontitis is a chronic periodontal inflammatory disease caused by periodontal pathogens commonly seen in adults. Eupalinolide B (EB) is a sesquiterpenoid natural product extracted from Eupatorium lindleyanum and has been reported as a potential drug for cancers and immune disorders. …”
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Correlation between immune signature and high‐density lipoprotein cholesterol level in stage II/III colorectal cancer by Yun Wang, Xiao‐qiang Sun, Hao‐cheng Lin, De‐shen Wang, Zhi‐qiang Wang, Qiong Shao, Feng‐hua Wang, Shu‐mei Yan, Jie‐ying Liang, Zhao‐lei Zeng, Huai‐qiang Ju, Rui‐hua Xu, Yu‐hong Li

“…However, the correlation between HDL‐C and the immune signature and the prognostic role of HDL‐C in stage II/III colorectal cancer (CRC) has not been previously reported. A total of 667 CRC patients were enrolled and divided into two groups based on the lower limit of normal HDL‐C values (0.78 mmol/L). …”
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