Pharmacological interventions for the management of anesthesia and sedation in patients with Duchenne muscular dystrophy: a systematic review and meta-analysis by Xianghong Lian, Xianghong Lian, Xianghong Lian, Yang Jing, Yang Jing, Yang Jing, Ting Luo, Ting Luo, Ting Luo, Yixin Guo, Yixin Guo, Yixin Guo, Yunzhu Lin, Yunzhu Lin, Yunzhu Lin

“…The neuromuscular blocking effects showed a significant age dependence in DMD patients, and the safe use of 2 mg/kg sugammadex to antagonize deep neuromuscular blockade and rapid recovery has been reported. …”
Get full text

HPGCN: A graph convolutional network-based prediction model for herbal heat/cold properties by Qikai Niu, Jing’ai Wang, Hongtao Li, Lin Tong, Haiyu Xu, Weina Zhang, Ziling Zeng, Sihong Liu, Wenjing Zong, Siqi Zhang, Siwei Tian, Huamin Zhang, Bing Li

“…Herbal properties are part of the fundamental theories of traditional Chinese medicine (TCM), which has been of great significance for herbal formulas and disease treatment in clinics for thousands of years. …”
Get full text

Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART): a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlle... by Jeremy Chataway, Suvankar Pal, Charis Wong, Elizabeth Elliott, Jenna M Gregory, Siddharthan Chandran, Judith Newton, Shuna Colville, Maria Stavrou, Christopher J Weir, Nigel Stallard, Malcolm R Macleod, Michelle Steven, Richard Anthony Parker, Arpan R Mehta, Robert J Swingler, Mahesh K B Parmar, Rachel S Dakin, Jill Williamson

“…(REC reference: 19/WS/0123) Results of the study will be submitted for publication in a peer-reviewed journal and a summary provided to participants.Trial registration numbers European Clinical Trials Registry (2019-000099-41); NCT04302870.…”
Get full text

Delay of Near-relativistic Electrons with Respect to Type III Radio Bursts throughout the Inner Heliosphere by J. G. Mitchell, E. R. Christian, G. A. de Nolfo, C. M. S. Cohen, M. E. Hill, A. Kouloumvakos, A. W. Labrador, R. A. Leske, D. J. McComas, R. L. McNutt Jr., D. G. Mitchell, M. Shen, N. A. Schwadron, M. E. Wiedenbeck, S. D. Bale, M. Pulupa

“…These results suggest that energetic electron delays with respect to type III radio bursts are not purely produced by a delayed injection/release as has been suggested, implying that transport processes play a role.…”
Get full text

Novel insights into palatal shelf elevation dynamics in normal mouse embryos by Jeremy P. Goering, Michael Moedritzer, Marta Stetsiv, Dona Greta Isai, Brittany M. Hufft-Martinez, An J. Tran, Zaid Umar, Madison K. Rickabaugh, Paul Keselman, Munish Chauhan, Pamela V. Tran, William M. Brooks, William M. Brooks, Kenneth J. Fischer, Andras Czirok, Andras Czirok, Irfan Saadi, Irfan Saadi

“…While earlier studies have implied that reorientation occurs rapidly, the precise timing has not been resolved. Time-restricted pregnancies with a 1-h resolution showed that in 97% of C57BL/6J embryos, the PS were unelevated at E14.0. …”
Get full text

mRNA-LNP vaccines combined with tPA signal sequence elicit strong protective immunity against Klebsiella pneumoniae by Ting Huang, Siyou Che, Zheng Lv, Danrui Hao, Runyu Wang, Qinxuan Yi, Ling Mei, Yang Yuan, Hang Zou, Yidong Guo, Xinrong Wang, Yiwen Chu, Kelei Zhao

“…Despite efforts having been created to develop different types of K. pneumoniae vaccines, there is no licensed vaccine for preventing K. pneumoniae infection. …”
Get full text

Assessing the feasibility of measuring residents’ quality of life in English care homes and the construct validity and internal consistency of measures completed by staff proxy: a... by Claire Goodman, Julienne Meyer, Karen Spilsbury, Barbara Hanratty, Rachael Carroll, Adam L Gordon, Gizdem Akdur, Anne Killett, Jennifer Burton, Ann-Marie Towers, Stacey Rand, Nick Smith, Sinead Palmer, Stephen Allan, Lucy Anne Webster

“…As there have not been any previous studies of the structural validity of the English language version of the QUALIDEM, ordinal exploratory factor analysis (EFA) was applied for this measure only. …”
Get full text

Community-based HPV self-collection versus visual inspection with acetic acid in Uganda: a cost-effectiveness analysis of the ASPIRE trial by Joel Singer, Angeli Rawat, Heather Armstrong, Josaphat Byamugisha, Gina S Ogilvie, Alex K Mezei, Heather N Pedersen, Stephen Sy, Catherine Regan, Sheona M Mitchell-Foster, Musa Sekikubo, Jane J Kim, Nicole G Campos

“…Community-based self-collected human papillomavirus (HPV) testing has been proposed to reduce barriers to screening.Objective Our objective was to evaluate the cost-effectiveness of the Advances in Screening and Prevention of Reproductive Cancers (ASPIRE) trial, conducted in Kisenyi, Uganda in April 2014 (n=500). …”
Get full text

Refined Mapping of Subsurface Water Ice on Mars to Support Future Missions by G. A. Morgan, N. E. Putzig, D. M. H. Baker, A. Pathare, C. M. Dundas, M. B. Russell, M. R. Perry, M. Chojnacki, H. G. Sizemore, A. M. Bramson, E. I. Petersen, S. Nerozzi, R. H. Hoover, Z. Bain

“…Motivated by science and the need to find suitable human landing sites, the Mars Subsurface Water Ice Mapping (SWIM) project has developed techniques to map out buried ice. …”
Get full text

Determination of Pharmaceutical Residues by UPLC-MS/MS Method: Validation and Application on Surface Water and Hospital Wastewater by Bui Van Hoi, Cam-Tu Vu, Lan-Anh Phung-Thi, Thao Thi Nguyen, Phuong Thanh Nguyen, Huong Mai, Phuong-Thu Le, Thanh-Hien Nguyen, Dao Thanh Duong, Hue Nguyen Thi, Dung Le-Van, Dinh Binh Chu

“…In this study, an analytical method for the simultaneous determination of 7 major pharmaceutical residues in Vietnam, namely, carbamazepine, ciprofloxacin, ofloxacin, ketoprofen, paracetamol, sulfamethoxazole, and trimethoprim, in surface water and hospital wastewater has been developed. The method includes enrichment and clean-up steps by solid phase extraction using mix-mode cation exchange, followed by identification and quantification using an ultrahigh-performance liquid chromatography and tandem mass spectrometry and employing electrospray ionization (UPLC-ESI-MS/MS). …”
Get full text

Évaluation de la prescription et de l’utilisation des benzodiazépines dans la ville de Sidi Bel-Abbès by Derouicha Matmour, Mounia Medjeber, Yassine Merad

“… Abstract Introduction-A high consumption of benzodiazepines (BZDs) has been noticed sometimes outside the rules of prescription recommendations, which makes their consumption a major public health problem. …”
Get full text

The protective roles of eugenol on type 1 diabetes mellitus through NRF2-mediated oxidative stress pathway by Yalan Jiang, Pingping He, Ke Sheng, Yongmiao Peng, Huilan Wu, Songwei Qian, Weiping Ji, Xiaoling Guo, Xiaoou Shan

“…However, the potential effects of EUG on T1DM had not been investigated. In this study, we established the streptozotocin (STZ)-induced T1DM mouse model in vivo and STZ-induced pancreatic β cell MIN6 cell model in vitro to investigate the protective effects of EUG on T1DM, and tried to elucidate its potential mechanism. …”
Get full text

Phase I study of pembrolizumab in combination with ibrutinib for the treatment of unresectable or metastatic melanoma by Yuan Yao, Yiyi Yan, Vera J. Suman, Allan B. Dietz, Courtney L. Erskine, Anastasios Dimou, Svetomir N. Markovic, Svetomir N. Markovic, Robert R. McWilliams, Heather N. Montane, Matthew S. Block, Matthew S. Block

“…BackgroundImmune checkpoint inhibitors (ICIs) have been transformative in the treatment of patients with metastatic melanoma, but primary and secondary resistance to ICI treatment is common. …”
Get full text

Human intestinal Caco-2 cell model to evaluate the absorption of 7-ketophytosterols and their effects on cholesterol transport by Mengmeng Wang, Min Yu, Amel Thanina Amrouche, Fan Jie, Shengyang Ji, Baiyi Lu

“…7-Ketophytosterols are the major oxidation products of phytosterols in foods, which have been associated with atherosclerosis. However, their absorption mechanism remains unclear. …”
Get full text

Cardiac repair using regenerating neonatal heart tissue-derived extracellular vesicles by Hanjing Li, Yining Liu, Yuqing Lin, Sijia Li, Chenlu Liu, Ao Cai, Wei Li, Wanyu Zhang, Xinlu Gao, Zhongyu Ren, Haoyu Ji, Yang Yu, Xiuxiu Wang, Wenya Ma, Ning Wang, Dan Zhao, Tianlong Li, Yu Liu, Benzhi Cai

“…Extracellular vesicles (EVs) have been shown to play vital cardioprotective roles in heart repair. …”
Get full text

Decrease in phase angle after Roux-en-Y gastric bypass is related to increase of anti-inflammatory status by Amanda Cristina Araújo Gomes, Amanda Machado Fiorotti, Amanda Motta de Bortoli, Beatriz Bobbio de Brito, João Arthur Souza Fiorido, Luciane Bresciani Salaroli, Andressa Bolsoni Lopes, Fabiano Kenji Haraguchi

“…Summary: Background & Aims: Phase angle (PhA) has been used as a prognostic indicator in various clinical conditions. …”
Get full text

Assessment of Health-Related Quality of Life after TBI: Comparison of a Disease-Specific (QOLIBRI) with a Generic (SF-36) Instrument by Nicole von Steinbuechel, Amra Covic, Suzanne Polinder, Thomas Kohlmann, Ugne Cepulyte, Herbert Poinstingl, Joy Backhaus, Wilbert Bakx, Monika Bullinger, Anne-Lise Christensen, Rita Formisano, Henning Gibbons, Stefan Höfer, Sanna Koskinen, Andrew Maas, Edmund Neugebauer, Jane Powell, Jaana Sarajuuri, Nadine Sasse, Silke Schmidt, Holger Mühlan, Klaus von Wild, George Zitnay, Jean-Luc Truelle

“…Until now, however, neither the discriminatory power of disease-specific (QOLIBRI) and generic (SF-36) HRQoL nor their correlates have been compared in detail. These aspects as well as some psychometric item characteristics were studied in a sample of 795 TBI survivors. …”
Get full text

Application of iron-rich slag to capture carbon dioxide gas through direct gas-solid carbonation by F. Abdul, R.F. Rahman, K.A. Purwanto, F.I. Ma'ruf, Y. Setiyorini, V.A. Setyowati, S. Pintowantoro

“…BACKGROUND AND OBJECTIVE: The nickel processing industry has always been related with the issue of carbón dioxide emission. …”
Get full text

Treatment of chronic hepatitis C by cepeginterferon alpha-2b in combination to ribavirin by M. V. Mayevskaya, O. O. Znoyko, Ye. A. Klimova, S. L. Maximov, S. N. Kizhlo, N. A. Petrochenkova, F. I. Nagimova, Yu. N. Linkova

“…The comparative analysis has demonstrated, that EVR at the 12-th week in group of Algeron 1,5 mkg/kg was observed in 100 % of patients with genotypes 2/3 and in 88,5% of patients with genotype 1. …”
Get full text

The temporal change of heat exposure and adaptation capacity in Chinese adults from 1994 to 2023 by Xiaohui Ji, Haomin Tan, Shaoli Huang, Zhongguo Huang, Jianxiong Hu, Jianxiong Hu, Guanhao He, Fengrui Jing, Ziqiang Lin, Mengen Guo, Tao Liu, Wenjun Ma, Wenjun Ma

“…Multivariate logistic regression model was used to analyze the risk factors of air conditioner ownership.ResultsMost respondents (94.6%) thought ambient temperature had been increasing, and 57.0% people thought climate change impacted their health. …”
Get full text