Effect of a high dose atorvastatin as adjuvant therapy to mesalamine in attenuating inflammation and symptoms in patients with ulcerative colitis: a randomized controlled pilot stu... by Sumaiah J. Alarfaj, Sahar M. El-Haggar, Sahar K. Hegazy, Sahar K. Hegazy, Maha M. Maher, Maha M. Maher, Monir M. Bahgat, Thanaa A. Elmasry, Sarah Alrubia, Amsha S. Alsegiani, Mostafa M. Bahaa

“…Activation of sphingosine 1 phosphate (S1P)/ tumor necrosis factor-alpha (TNF-α)/ interleukin-6 (IL-6) pathways has been confirmed in the pathogenesis of UC and preclinical studies proved the efficacy of atorvastatin on these pathways.AimTo investigate the role of atorvastatin on S1P/TNF-α/IL-6 pathway in UC.MethodsPatients with mild to moderate UC were allocated into two groups in this pilot study. …”
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Renin–angiotensin–aldosterone system activation in plasma as marker for prognosis in critically ill patients with COVID-19: a prospective exploratory study by Katharina Krenn, Felix Kraft, Luana Mandroiu, Verena Tretter, Roman Reindl-Schwaighofer, Theresa Clement, Oliver Domenig, Matthias G. Vossen, Gregor Riemann, Marko Poglitsch, Roman Ullrich

“…Abstract Background Acute respiratory distress syndrome (ARDS) associated with coronavirus infectious disease (COVID)-19 has been a challenge in intensive care medicine for the past three years. …”
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miR124a-3p inhibitor alleviates AFB1-induced hepatoxicity via targeting chicken glucocorticoid receptor mRNA by Mindie Zhao, Liang Chen, Yulan Zhao, Jie Liu, Huimin Chen, Ruqian Zhao

“…After a 3-day pre-feed, the AFB1 group was given 0.25 mg/kg of AFB1 for 18 days. …”
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Comparison of Field and Virtual Vegetation Surveys Conducted Using Uncrewed Aircraft System (UAS) Imagery at Two Coastal Marsh Restoration Projects by Aaron N. Schad, Molly K. Reif, Joseph H. Harwood, Christopher L. Macon, Lynde L. Dodd, Katie L. Vasquez, Kevin D. Philley, Glenn E. Dobson, Katie M. Steinmetz

“…., 1–30 m) satellite imagery, manned airborne data, and traditional field surveys, yet it has not been thoroughly evaluated in a virtual capacity as an alternative to traditional field vegetation plot surveys. …”
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Penerapan Covid Shooter Berbasis Android sebagai Game Edukasi Pencegahan Covid-19 pada Anak Usia Dini by Rocky Ardiansyah Yudistira Putra, Unzilla Savika Putri, Ginanjar Setyo Permadi, Dodik Arwin Dermawan

“…Abstract  Dissemination of information about the dangers of the Covid-19 outbreak need to be taught to the community so that together we prevent the spread of it. …”
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Principles, barriers and enablers to agroecological animal production systems: a qualitative approach based on five case studies by B. Dumont, C. Barlagne, P. Cassart, J.E. Duval, A. Fanchone, J-L. Gourdine, O. Huguenin-Elie, Y. Kazakova, J. Klötzli, A. Lüscher, E. Oteros-Rozas, D. Pomies, M.G. Rivera Ferre, W.A.H. Rossing, V. Stefanova, A. Swartebroeckx, C. Zagaria

“…Policy needs to go beyond the mere support of agroecological practices on livestock farms and adopt a systems approach looking downstream and upstream if it is to enable a large-scale agroecological transition with EU public policies. …”
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Episiotomies and obstetric anal sphincter injuries following a restrictive episiotomy policy in France: An analysis of the 2010, 2016, and 2021 National Perinatal Surveys. by Raphaele Houlbracq, Camille Le Ray, Béatrice Blondel, Nathalie Lelong, Anne Alice Chantry, Thomas Desplanches, ENP2021 Study Group

“…These results should be interpreted with caution given the low prevalence of OASI in some subgroups. Further research is needed to predict the optimal rate of episiotomy for instrumental deliveries. …”
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Progress in voluntary medical male circumcision for HIV prevention supported by the US President’s Emergency Plan for AIDS Relief through 2017: longitudinal and recent cross-sectio... by Carlos Toledo, Melissa Habel, Stephanie M Davis, Jonas Z Hines, Jonathan M Grund, Renee Ridzon, Brittney Baack, Jonathan Davitte, Anne Thomas, Valerian Kiggundu, Naomi Bock, Paran Pordell, Caroline Cooney, Irum Zaidi

“…The VMMC programme has achieved rapid scale-up but continues to face challenges, and new approaches may be needed to achieve the new Joint United Nations Programme on HIV/AIDS goal of 27 million additional circumcisions through 2020.…”
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Life course socioeconomic position and care dependency in later life: a longitudinal multicohort study from 17 countriesResearch in context by Ting Pan, Chenshuang Li, Ying Zhou

“…Socioeconomic disadvantage has been shown to be associated with elevated risks of care dependency, but how risks are modified by changes in socioeconomic position remains unclear. …”
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Shared mechanisms of enhanced plasmid maintenance and antibiotic tolerance mediated by the VapBC toxin:antitoxin system by Sarah Hollingshead, Gareth McVicker, Maria R. Nielsen, YuGeng Zhang, Giulia Pilla, Rebekah A. Jones, Jonathan C. Thomas, Sarah E. H. Johansen, Rachel M. Exley, Ditlev E. Brodersen, Christoph M. Tang

“…ABSTRACT Toxin:antitoxin (TA) systems are widespread in bacteria and were first identified as plasmid addiction systems that kill bacteria lacking a TA-encoding plasmid following cell division. TA systems have also been implicated in bacterial persistence and antibiotic tolerance, which can be precursors of antibiotic resistance. …”
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Reductive acetogenesis is a dominant process in the ruminant hindgut by Qiushuang Li, Jiabin Huo, Gaofeng Ni, Fan Zhang, Shizhe Zhang, Xiumin Zhang, Rong Wang, Jinzhen Jiao, Zhongtang Yu, Xuanxuan Pu, Yipeng Yue, Emilio M. Ungerfeld, Xiaoli Zhang, Jian Wu, Zhiliang Tan, Chris Greening, Min Wang

“…This gastrointestinal tract comprises a foregut (rumen) and hindgut (cecum and colon), which differ in structures and functions, particularly with respect to feed digestion and fermentation. While the rumen microbiome has been extensively studied, the cecal microbiome remains much less investigated and understood, especially concerning the assembling microbial communities and overriding pathways of hydrogen metabolism. …”
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Revealing the core suppression effects of various Di (2-ethylhexyl) phthalate exposure on early meiosis progression in postnatal male mice via single-cell RNA sequencing by Baoquan Han, Lei Hua, Shuai Yu, Wei Ge, Cong Huang, Yu Tian, Chunxiao Li, Jiamao Yan, Tian Qiao, Jiachen Guo, Dongliang Lu, Bin Wang, Diya Cai, Yunqi Zhang, Shaolin Liang, Jianjuan Zhao, Qi Hou, Wei Shen, Zhongyi Sun

“…The male reproductive system has been the subject of considerable attention in recent years due to the adverse effects of Di (2-ethylhexyl) phthalate (DEHP). …”
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Mejoramiento de procesos constructivos a partir de un módulo programable para captura de imágenes y simulación digital Improvement of constructive processes based on a programmable... by Adriana Gómez Cabrera, Juan Diego Echeverry Hoyos, María Ximena Giraldo Palma, Camilo Otálora Sanchez, Martha Lucía Cano Morales

“…<br>Civil projects executors are constantly dealing with the challenge of increasing productivity through resources optimization and their interaction; this has been addressed from different points of view using computational tools and manual tools. …”
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Emerging Resistance and Virulence Patterns in <i>Salmonella enterica</i>: Insights into Silver Nanoparticles as an Antimicrobial Strategy by Irina Gheorghe-Barbu, Ilda Czobor Barbu, Rareș-Ionuț Dragomir, Ioana Cristina Marinaș, Miruna Silvia Stan, Radu Pericleanu, Andreea Ștefania Dumbravă, Liviu-Iulian Rotaru, Simona Paraschiv, Leontina Mirela Bănică, Ionuț Pecete, Dan Oțelea, Violeta Corina Cristea, Mircea Ioan Popa, Marilena Monica Țânțu, Marius Surleac

“…Conclusions: The present findings revealed significant patterns in <i>Salmonella</i> isolates, subtypes, serovars, AR, and virulence, emphasising the need for continuous surveillance of <i>Salmonella</i> infections. …”
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Smartphone video games for cognitive functions and negative symptoms in male with chronic schizophrenia: A randomized controlled trial by Wenhui Wang, Mengting Ye, Yongjie Zhong, Miaomiao Zhang, Yue Wang, Chuanchuan Chen, Yitan Yao, Ziqiao Feng, Xiaoping Yuan, Shenya Shi, Xiaoqin Zhou, Kai Zhang

“…Background: Video games have been extensively examined as a promising and innovative approach for addressing various psychiatric disorders. …”
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Relationship between neutropenia caused by nanoliposomal irinotecan/fluorouracil/leucovorin and treatment outcomes in the NAPOLEON-2 study (NN-2301) by Tomonori Araki, Yuki Sonoda, Mototsugu Shimokawa, Taiga Otsuka, Kohei Hayashi, Takuya Honda, Kazuhiko Nakao, Taro Shibuki, Junichi Nakazawa, Shiho Arima, Keisuke Miwa, Yoshinobu Okabe, Futa Koga, Yujiro Ueda, Yoshihito Kubotsu, Hozumi Shimokawa, Shigeyuki Takeshita, Azusa Komori, Kazuo Nishikawa, Satoshi Otsu, Ayumu Hosokawa, Hisanobu Oda, Tatsunori Sakai, Shuji Arita, Machiko Kawahira, Hiroki Taguchi, Kengo Tsuneyoshi, Yasunori Kawaguchi, Toshihiro Fujita, Takahiro Sakae, Tsuyoshi Shirakawa, Toshihiko Mizuta, Kenji Mitsugi

“…Abstract The relationship between nanoliposomal irinotecan/fluorouracil/leucovorin (NFF) treatment outcomes and neutropenia in patients with pancreatic cancer has not been thoroughly examined. Thus, we conducted a retrospective analysis of data from patients with pancreatic cancer who were treated with NFF to investigate this relationship. …”
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Breeding bird communities of the pine forests in the forest-steppe zone by A. Atemasov, T. Atemasova

“…The avifauna of pine forests in the North-East of Ukraine has been poorly studied. Analysis of bird communities showed that the avifaunal complexes of pine forests are poorer and have minimal similarity to those in deciduous forests. …”
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The Effect of Adjuvant Radiotherapy on One- and Two-Stage Prosthetic Breast Reconstruction and on Autologous Reconstruction: A Multicenter Italian Study among 18 Senonetwork Breast... by Andrea Vittorio Emanuele Lisa, Marzia Salgarello, Alessandra Huscher, Fabio Corsi, Daniele Piovani, Federica Rubbino, Stefania Andreoletti, Giovanni Papa, Francesco Klinger, Corrado Tinterri, Alberto Testori, Marta Scorsetti, Paolo Veronesi, Maria Cristina Leonardi, Mario Rietjens, Umberto Cortinovis, Valeria Summo, Emanuele Rampino Cordaro, Pier Camillo Parodi, Paolo Persichetti, Mauro Barone, Giorgio De Santis, Matteo Murolo, Michele Riccio, Angelica Aquinati, Francesco Cavaliere, Nicola Vaia, Giulia Pagura, Erica Dalla Venezia, Franco Bassetto, Vincenzo Vindigni, Luigi Ciuffreda, Maria Alessandra Bocchiotti, Alberto Sciarillo, Nadia Renzi, Graziano Meneghini, Tajna Kraljic, Andrea Loreti, Lucio Fortunato, Valentina Pino, Valeriano Vinci, Marco Klinger

“…In modern breast cancer treatment, a growing role has been observed for breast reconstruction together with an increase in clinical indications for postmastectomy radiotherapy (PMRT). …”
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Évaluation de la prescription et de l’utilisation des benzodiazépines dans la ville de Sidi Bel-Abbès by Derouicha Matmour, Mounia Medjeber, Yassine Merad

“… Abstract Introduction-A high consumption of benzodiazepines (BZDs) has been noticed sometimes outside the rules of prescription recommendations, which makes their consumption a major public health problem. …”
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The interplay of geology, climate and tectonics on river incision: the example of the High Verdon Gorges, Southwestern French Alps by Cardinal, Thibaut, Petit, Carole, Rolland, Yann, Schwartz, Stéphane, Valla, Pierre Gaston, Scalabrino, Bruno, Audin, Laurence, Bertauts, Maxime, Zerathe, Swann, Thiéblemont, Denis, Braucher, Régis, Team, ASTER

“…This comparison allows us to propose that the downcutting of the Verdon Gorges started approximatively 1.5 to 2 Ma ago, even if the drainage network of the Verdon catchment area could have been shaped earlier, during the Messinian salinity crisis.…”
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