Cerebral microvascular density, blood-brain barrier permeability, and support for neuroinflammation indicate early aging in a Marfan syndrome mouse model by Tala Curry-Koski, Tala Curry-Koski, Liam P. Curtin, Mitra Esfandiarei, Mitra Esfandiarei, Mitra Esfandiarei, Theresa Currier Thomas, Theresa Currier Thomas, Theresa Currier Thomas, Theresa Currier Thomas

“…In a well-established mouse model of MFS (Fbn1C1041G/+), pre-mature aging of the aortic wall and the progression of aortic root aneurysm are observed by 6-month-of-age. TGF-β signaling has been implicated in cerebrovascular dysfunction, loss of blood-brain barrier (BBB) integrity, and age-related neuroinflammation. …”
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Protocol of an open-label safety and feasibility pilot study of ketamine-assisted psychotherapy for methamphetamine use disorder (the KAPPA trial) by Jonathan Brett, Celia Morgan, Nadine Ezard, Brendan Clifford, Krista J Siefried, Robert May, Liam Acheson, Kathryn Fletcher, Harriet MacDonald, Gillinder Bedi, Alexandre Guerin, Elizabeth Knock, Michael Millard, Jess Doumany

“…Safety and feasibility will be assessed over an 8-week period. Secondary outcomes (changes in methamphetamine use, cravings, withdrawal, quality of life and treatment satisfaction) will be assessed over a 24-week period.Ethics and dissemination This study has been approved by the St Vincent’s Hospital Human Research Ethics Committee, reference 2023/ETH00530. …”
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Accessible model predicts response in hormone receptor positive HER2 negative breast cancer receiving neoadjuvant chemotherapy by Luca Mastrantoni, Giovanna Garufi, Giulia Giordano, Noemi Maliziola, Elena Di Monte, Giorgia Arcuri, Valentina Frescura, Angelachiara Rotondi, Armando Orlandi, Luisa Carbognin, Antonella Palazzo, Federica Miglietta, Letizia Pontolillo, Alessandra Fabi, Lorenzo Gerratana, Sergio Pannunzio, Ida Paris, Sara Pilotto, Fabio Marazzi, Antonio Franco, Gianluca Franceschini, Maria Vittoria Dieci, Roberta Mazzeo, Fabio Puglisi, Valentina Guarneri, Michele Milella, Giovanni Scambia, Diana Giannarelli, Giampaolo Tortora, Emilio Bria

“…In patients receiving neoadjuvant chemotherapy (NACT), pathological complete response (pCR) is rare and multiple efforts have been made to predict disease recurrence. We developed a framework to predict pCR using clinicopathological characteristics widely available at diagnosis. …”
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Microbiological Analysis Conducted on Raw Milk Collected During Official Sampling in Liguria (North-West Italy) over a Ten-Year Period (2014–2023) by Sara Antonia Chiarlone, Andrea Gori, Serena Ravetta, Andrea Armani, Lisa Guardone, Francesca Pedonese, Salvatore Bavetta, Caterina Fiannacca, Nicola Pussini, Cristiana Maurella, Elisabetta Razzuoli

“…Milk has been consumed by humans for thousands of years for its nutritional properties. …”
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Evaluation of the efficiency of Russian universities: Do we need to change the paradigm? by E. V. Romanov

“…The principles of managerialism have been actively applied in the field of higher education and science in Russia in the last decade. …”
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Spontaneous high clonal expansion of Wilms’ tumor gene 1-specific cytotoxic T-lymphocytes in patients with Wilms’ tumor gene 1-expressing solid tumor by Soyoko Morimoto, Yukie Tanaka, Jun Nakata, Fumihiro Fujiki, Kana Hasegawa, Hiroko Nakajima, Sumiyuki Nishida, Akihiro Tsuboi, Naoki Hosen, Naoki Kagawa, Motohiko Maruno, Akira Myoui, Takayuki Enomoto, Shuichi Izumoto, Mitsugu Sekimoto, Naoya Hashimoto, Toshiki Yoshimine, Atsushi Kumanogoh, Yusuke Oji, Yoshihiro Oka, Haruo Sugiyama

“…Abstract Wilms’ tumor protein 1 (WT1)-targeted immunotherapy has been used in patients with leukemia and solid tumors. …”
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Norepinephrine use in cardiogenic shock patients is associated with increased 30 day mortality by Xin Lu, Xue Wang, Yanxia Gao, Joseph Harold Walline, Shiyuan Yu, Zengzheng Ge, Mubing Qin, Huadong Zhu, Yi Li

“…The survival benefit of norepinephrine therapy has not been demonstrated in clinical practice, however. …”
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Effects of autolytical fish protein hydrolysate on growth performance, survival rate, and hematological indices in farmed juvenile beluga, Huso huso by Ali Hosseinpour Zelaty

“…FPHs are produced from the enzymatic digestion of proteins in fish processing waste. They have been found to enhance fish growth, feed efficiency, immune responses, and disease resistance. …”
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Pro-inflammatory effects of inhaled Great Salt Lake dust particles by Jacob M. Cowley, Cassandra E. Deering-Rice, John G. Lamb, Erin G. Romero, Marysol Almestica-Roberts, Samantha N. Serna, Lili Sun, Kerry E. Kelly, Ross T. Whitaker, Jenna Cheminant, Alessandro Venosa, Christopher A. Reilly

“…Adverse health effects have been associated with exposure to windblown dust originating from dried lakebed sediments, but mechanistic studies evaluating the health effects of these dusts are limited. …”
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Protocol for an intervention development and pilot implementation evaluation study of an e-health solution to improve newborn care quality and survival in two low-resource settings... by Hassan Haghparast-Bidgoli, Michelle Heys, Caroline Crehan, Erin Kesler, Monica Lakhanpaul, Emma Wilson, Fabiana Lorencatto, Felicity Fitzgerald, Mario Cortina Borja, Msandeni Chiume, Hannah Gannon, Simbarashe Chimhuya, Gwendoline Chimhini, Tim Hull-Bailey, Tarisai Chiyaka, Yali Sassoon, Deliwe Nkhoma, Nushrat Khan, Alexander G. Stevenson, Kristina Curtis

“…Research ethics approvals have been obtained: Malawi College of Medicine Research and Ethics Committee (P.01/20/2909; P.02/19/2613); UCL (17123/001, 6681/001, 5019/004); Medical Research Council Zimbabwe (MRCZ/A/2570), BRTI and JREC institutional review boards (AP155/2020; JREC/327/19), Sally Mugabe Hospital Ethics Committee (071119/64; 250418/48). …”
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The Expression Pattern and Functional Analysis of Extracellular Vesicle Long Non-Coding RNAs from Uterine Fluid During Implantation in Pig by Yijun Shang, Qiuping Zhang, Yue Ding, Yongzhong Wang, Shengchen Gu, Xupeng Zang, Zheng Xu, Sixiu Huang, Zicong Li, Zhenfang Wu, Ting Gu, Linjun Hong, Gengyuan Cai

“…However, the specific roles of lncRNAs carried by UF-EVs during the embryo implantation period have not been thoroughly reported in the literature. In the present study, high-throughput sequencing and biological tools were applied to analyse lncRNAs in UF-EVs on days 9, 12, and 15 of pregnancy to identify key regulatory lncRNAs in UF-EVs during the porcine embryonic implantation period and to explore their expression patterns and functional roles. …”
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The Effect of Chewing Simulation on Flexural Strength of Different Lithium Disilicate Ceramics by Alsulimani O, Yousief SA, Al-Dabbagh RA, Attar EA, Bukhary DM, Algamaiah H, Musawa K, Subahi A, Abuzinadah SH, Alhaddad AJ, Alqahtani WMS, Emam ANM, Alqhtani MA, Elmarakby AM

“…Osamah Alsulimani,1 Salah A Yousief,2,3 Raghad A Al-Dabbagh,4 Esraa A Attar,4 Dalea M Bukhary,4 Hamad Algamaiah,5 Khadija Musawa,6 Awatif Subahi,6 Samar H Abuzinadah,7 Abdulrahman J Alhaddad,4 Waleed MS Alqahtani,8 Abdel Naser M Emam,9 Mohammad A Alqhtani,9 Ahmed M Elmarakby2,10 1Department of Oral Diagnostic Sciences, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia; 2Department of Restorative and Prosthetic Dental Sciences, College of Dentistry, Dar Al Uloom University, Riyadh, 13313, Saudi Arabia; 3Department of Crown and Bridge, Faculty of Dental Medicine, Al-Azhar University, Assuit, Egypt; 4Department of Oral and Maxillofacial Prosthodontics, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia; 5Department of Restorative Dental Science, King Saud University, College of Dentistry, Riyadh, Saudi Arabia; 6BDS, General Dentist, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia; 7Department of Restorative Dentistry, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia; 8Department of Prosthetic Dentistry, College of Dentistry, King Khalid University, Abha, Saudi Arabia; 9Department of Prosthetic Dental Science, Faculty of Dentistry, Najran University, Najran, Saudi Arabia; 10Department of Operative Dentistry, Faculty of Dental Medicine, Al-Azhar University, Assuit, EgyptCorrespondence: Salah A Yousief, Department of Restorative and Prosthetic Dental Sciences, College of Dentistry, Dar Al Uloom University, Riyadh, 13313, Saudi Arabia, Tel +966598045800, Email Salah.a@dau.edu.saBackground: Improved Lithium Disilicate Ceramic has been highly valued in dentistry for over two decades, owing to its durability and aesthetic qualities, making it a preferred choice for both anterior and posterior crowns.Objective: This study aimed to evaluate the flexural strength of two types of lithium disilicate blocks post-chewing simulation.Materials and Methods: Seventy-six lithium disilicate specimens were utilized in this study. …”
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miR-1458 is inhibited by low concentrations of Vitamin B6 and targets TBX6 to promote the formation of spermatogonial stem cells in Rugao Yellow Chicken by Qingqing Geng, Cai Hu, Ziduo Zhao, Zhe Wang, Fufu Cheng, Jing Chen, Qisheng Zuo, Yani Zhang

“…It should be noted that most of the germline findings related to miRNAs were obtained by in vitro studies, and in vivo studies are needed to validate our results for clinical applications.…”
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Controlling the cannibalism of African catfish juvenile by 17β‒estradiol hormone administration and the stocking density determination by Khoirotun Nisa Siregar, Fajar Maulana, Muhammad Zairin Jr., Alimuddin Alimuddin, Widanarni Widanarni

“…The hormonal treatment has been conducted as an effort to control cannibalism. …”
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The use of ambon banana (Musa paradisiaca var. sapientum) stems flour in grouper (Epinephelus lanceolatus ♂× Epinephelus fuscoguttatus ♀) floating net cage nursery by Dinamella Wahjuningrum, Diah Ayu Lestari, Aldy Mulyadin, Irzal Effendi

“…The addition of Ambon banana stems flour in feed in the first 14 days (B) can improve health status but has not been able to increase production performance and morphometric grouper.   …”
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Studying the Beneficial Indicators of Intercropping of Safflower (Carthamus tinctorius L.) with Chickpea (Cicer arietinum L.), Lentil (Lens culinaris Medik), and Bitter Vetch (Lath... by Amin Yari, Farzad Mondani, Alireza Bagheri, Hamid Reza Chaghazardi

“…The advantage of intercropping has been reported in many studies, especially those in which one of the components of intercropping is legume species, and the results of the current research are consistent with them. …”
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Ethnic and racial discrimination in maternal health care in Mexico: a neglected challenge in the search for universal health coverage by Edson Serván-Mori, Sergio Meneses-Navarro, Rocío García-Díaz, Diego Cerecero-García, David Contreras-Loya, Octavio Gómez-Dantés, Arachu Castro

“…Abstract Background Ethnic and racial discrimination in maternal health care has been overlooked in academic literature and yet it is critical for achieving universal health coverage (UHC). …”
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Impact of iron chelation with deferasirox on telomere length and oxidative stress in hemodialysis patients: A randomized study by Blanca Olivia Murillo Ortiz, Joel Ramírez Emiliano, Marcos Javier Romero Vázquez, Lauro Fabián Amador Medina, Sandra Martínez Garza, Edna Montserrat Ramos Rodríguez

“…Background: Recent studies have demonstrated the effectiveness, safety, and tolerability of deferasirox in patients in peritoneal dialysis, however, its effect has not been studied in patients undergoing hemodialysis. …”
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Galectin-3 secreted by triple-negative breast cancer cells regulates T cell function by Annat Raiter, Yael Barhum, Julia Lipovetsky, Chen Menachem, Sharona Elgavish, Shmuel Ruppo, Yehudit Birger, Shai Izraeli, Orna Steinberg-Shemer, Rinat Yerushalmi

“…However, the substantial variation in immune response prompts an urgent need for new immune-targeting agents. This requires a comprehensive understanding of TNBC's tumor microenvironment. …”
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Instance maps as an organising concept for complex experimental workflows as demonstrated for (nano)material safety research by Benjamin Punz, Maja Brajnik, Joh Dokler, Jaleesia D. Amos, Litty Johnson, Katie Reilly, Anastasios G. Papadiamantis, Amaia Green Etxabe, Lee Walker, Diego S. T. Martinez, Steffi Friedrichs, Klaus M. Weltring, Nazende Günday-Türeli, Claus Svendsen, Christine Ogilvie Hendren, Mark R. Wiesner, Martin Himly, Iseult Lynch, Thomas E. Exner

“…Nanosafety assessment, which seeks to evaluate the risks from exposure to nanoscale materials, spans materials synthesis and characterisation, exposure science, toxicology, and computational approaches, resulting in complex experimental workflows and diverse data types. …”
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