Super-enhancers in tumors: unraveling recent advances in their role in Oncogenesis and the emergence of targeted therapies by Yumeng Ji, Baixue Li, Rongjin Lin, Jing Yuan, Yang Han, Yuping Du, Yang Zhao

“…In tumor samples, super enhancers have been identified as crucial players in the development and progression of tumor cells, opening up new avenues for cancer research and treatment. …”
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Wnt signaling inhibits casein kinase 1α activity by modulating its interaction with protein phosphatase 2A by Chen Shen, Wenhui Lu, Siva B. Merugu, Aradhana Bharti, Said M. Afify, Lauren Schnitkey, Daniel T. Wynn, Fan Yang, Thomas M. Rohwetter, Anmada Nayak, Nawat Bunnag, Carolina Cywiak, Hsin-Yao Tang, Brent T. Harris, Christopher Albanese, Chukwuemeka Ihemelandu, Melanie H. Cobb, Arminja Kettenbach, Ethan Lee, Yashi Ahmed, David J. Robbins

“…Summary: The mechanism by which Wnt signaling, an essential pathway controlling development and disease, stabilizes β-catenin has been a subject of debate over the last four decades. …”
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Male sex ratio of red tilapia Oreochromis sp. after soaking in different concentrations of coconut milk at larvae stadia by Fajar Maulana, Agus Oman Sudrajat, Andre Permana, Lina Mulyani, Harton Arfah

“…Masculinization can be carried out to produce monosexual tilapia seeds to accelerate fish growth. As the use of the 17α-methyltestosterone synthetic hormone for masculinization activities has been limited, natural ingredients are required as a substitute, namely coconut milk. …”
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Genetic variability and performance of Asian swamp eel Monopterus albus (Zuiew, 1793) from West Java cultured in saline water medium by Dinar Tri Soelistyowati, Ahmad Fahrul Syarif, Ridwan Affandi, Dendi Hidayatullah

“…The production is limited depend on the catches of natural population. The cultivation of eel has been carried out to increase the production for sustainability. …”
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Study on the Therapeutic Effects of Bisdemethoxycurcumin on a Cerebral Amyloid Angiopathy Mouse Model Established via Chronic Treatment With Five Vascular Risk Factors by Shudong Lin, Guanghua Zhu, Juan Xie, Xuanwei Wen, Limin Deng, Sijing Li, Guozhi Liu, Feiyan Wang, Shuangxi Chen, Zijian Xiao

“…Bisdemethoxycurcumin (BDMC) has been demonstrated to exhibit pharmacological effects with anti‐Aβ toxicity properties. …”
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Systematic identification of secondary bile acid production genes in global microbiome by Yuwei Yang, Wenxing Gao, Ruixin Zhu, Liwen Tao, Wanning Chen, Xinyue Zhu, Mengping Shen, Tingjun Xu, Tingting Zhao, Xiaobai Zhang, Lixin Zhu, Na Jiao

“…Although certain organisms involved in bile acid metabolism have been identified, a global, comprehensive elucidation of the microbes, metabolic enzymes, and bile acid remains incomplete. …”
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Clinical and cost-effectiveness of Knee Arthroplasty versus Joint Distraction for Osteoarthritis (KARDS): protocol for a multicentre, phase III, randomised control trial by Deborah D Stocken, Dennis G McGonagle, David Murray, Catherine Reynolds, Catherine Fernandez, David R Ellard, Andrew Metcalfe, Hemant Sharma, Paul Harwood, Hamish Simpson, Hemant Pandit, Susanne Arnold, Cerys Joyce Tassinari, Ruchi Higham, Isabelle Louise Smith, Ruben Mujica-Mota, Thomas William Hamilton, Julie Croft

“…With more young people presenting with knee OA and increasing life expectancy, there is an unmet need to postpone time to first KR. Knee joint distraction (KJD), the practice of using external fixators to open up knee joint space, is proposed as potentially effective to preserve the joint following initial studies in the Netherlands, however, has not been researched within an NHS setting. …”
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Three-dimensional omnidirectional characterization methods of rock anisotropic wave velocity and acoustic emission location optimization by Shengjun MIAO, Wenxuan YU, Mingchun LIANG, Pengjin YANG, Conghao LI, Zejing LIU

“…Rock failure and instability have been key research topics in rock mechanics domestically and internationally. …”
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Microtubule inhibition as a proposed mechanism for the anthelmintic effect of phytochemicals isolated from Cicerbita alpina by Mark James Horgan, Ines Sigg, Ioanna Poulopoulou, Francisco J. Rodriguez-Mejias, Eva Albertini, Pietro Fusani, Florian Fischer, Eftychia Martinidou, Daniela Schuster, Stefan Martens, Pidder Jansen Dürr, Matthias Gauly, Hermann Stuppner, Alexander Weiss, Veronika Temml, Bianka Siewert

“…., when grown as a sprout, is known as a bitter-tasting culinary delicacy. Recently it has also been reported to have anthelmintic activity, prompting further investigation into its mechanism of action. …”
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Feasibility of implementing a decision aid for advanced cancer patients in a comprehensive cancer centers' outpatient setting: Valuable lessons learned by K. Laryionava, R. Boekels, J. Schildmann, M. Wensing, U. Wedding, B. Surmann, K. Mehlis, C. Gebel, M. Cinci, K. Krug, E. C. Winkler

“…Abstract Background Decision aids (DAs) have been proposed as tools to empower patients in decision‐making. …”
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Gambaran Glukosa Darah Setelah Latihan Fisik pada Tikus Wistar Diabetes Melitus yang Diinduksi Aloksan by Ahmad Syukri Harahap, Rahmatina B. Herman, Eti Yerizel

“…<br />Kata kunci: latihan fisik, glukosa darah, diabetes melitus</p><p>Abstract<br />Diabetes Melitus has been categorized as a global disease which have increasing prevalence and the mine cause of morbidity and mortality. …”
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Impact of Granulocyte Colony-Stimulating Factor (G-CSF) on Clinical Outcomes in Allogeneic Hematopoietic Cell Transplantation: Does Speeding Up Neutrophil Engraftment Make a Differ... by Ahmed Alnughmush, MD, Ayman Sayyed, MD, Mats Remberger, PhD, Eshrak AL-Shaibani, MD, Carol Chen, BSc, Caden Chiarello, Ivan Pasic, MD, Igor Novitzky-Basso, MD, Arjun Datt Law, MD, Wilson Lam, MD, Dennis (Dong Hwan) Kim, MD, Armin Gerbitz, MD, Auro Viswabandya, MD, Rajat Kumar, MD, Fotios V. Michelis, MD, Jonas Mattsson, MD, PhD

“…The theoretical impacts of growth factors have been challenged in numerous studies. Methods. In this retrospective cohort study conducted at the Princess Margaret Cancer Centre, we analyzed the clinical outcomes of 509 patients who underwent allogeneic HCT between May 1, 2019, and May 31, 2022. …”
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Abnormal dynamic functional networks during pain-free periods: Resting-state co-activation pattern analysis in primary dysmenorrhea by Huiping Liu, Xing Su, Meiling Shang, Ling Ma, Weixian Bai, Hui Wang, Lu Quan, Youjun Li, Zigang Huang, Jiaxi He, Wanghuan Dun, Yuchen Zhang

“…Primary dysmenorrhea (PDM) is a form of chronic visceral pain, which has been identified spatial alterations in brain functional networks using static functional connectivity analysis methods. …”
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Hsp70/Bmi1-FoxO1-SOD Signaling Pathway Contributes to the Protective Effect of Sound Conditioning against Acute Acoustic Trauma in a Rat Model by Guoxia Zhu, Yongxiang Wu, Yang Qiu, Keyong Tian, Wenjuan Mi, Xinqin Liu, Yuanyuan Chen, Jinwen Jia, Jiasheng Luo, Lianjun Lu, Jianhua Qiu

“…Although the protective effect of SC in mammals is generally understood, the exact mechanisms involved have not yet been elucidated. To confirm the protective effect of SC against noise exposure (NE) and the stress-related signaling pathway of its rescue, we observed target molecule changes caused by SC of low frequency prior to NE as well as histology analysis in vivo and verified the suggested mechanisms in SGNs in vitro. …”
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Weight loss for overweight and obese patients with prostate cancer: a study protocol of a randomised trial comparing clinic-based versus Telehealth delivered EXercise and nutrition... by Robert U Newton, Daniel A Galvão, Dennis R Taaffe, Suzanne K Chambers, David Joseph, Amanda Devine, Colin I Tang, Nigel Spry, Emily Jeffery, Dickon Hayne, Pedro Lopez, P Lyons-Wall, Christine Kudiarasu

“…Exercise will consist of supervised resistance and aerobic exercise performed three times a week plus additional self-directed aerobic exercise performed 4 days/week for the first 6 months. …”
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Classification of risk for transmission of vaccine-preventable diseases in Brazilian municipalities: comparative analysis before and after the national movement for vaccination and... by Ana Catarina de Melo Araújo, Thales Philipe Rodrigues da Silva, Janaina Fonseca Almeida Souza, Krishna Mara Rodrigues Freire, Fernanda Penido Matozinhos, Eder Gatti Fernandes

“…Conclusion The study concludes that VC surveillance, in conjunction with the Microplanning for High-Quality Vaccination Activities methodology developed by the Ministry of Health in 2023, played a crucial role in resuming immunization efforts that had been hindered by science denialism and the COVID-19 pandemic.…”
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Use of thymidine kinase 1 autoantibody, thymidine kinase antigen, extracellular protein kinase A autoantibody, and C‐reactive protein for early detection of malignant tumors in dog... by Yoonhee Kim, Wonhee Lee, Byunggak Kim, Bonghwan Jang, Kyung‐Rok Yu, Hong Sook Kim, Minok Ryu, Yein Oh, Kyoungwon Seo, Chul Park, Ulsoo Choi, Dongha Bhang, Hwayoung Youn

“…Abstract Background Although the importance of early diagnosis of malignant tumors is a major concern, an easily accessible in‐house method has not been established. Objectives To investigate the most optimal model by combining thymidine kinase 1 (TK1) autoantibody, extracellular protein kinase A (ECPKA) autoantibody, TK1 antigen, C‐reactive protein (CRP), age, breed, and sex. …”
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Automated Video Assistant Referee in Lead Climbing by Eliane Künzler, David Roder, Urs Stöcker, Peter Wolf

“…RTMO: Towards high-performance one-stage real-time multi-person pose estimation. 2024 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR), 1491–1500. https://doi.org/10.1109/CVPR52733.2024.00148 …”
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Seasonal analysis of indoor and outdoor ratios of PM2.5 and PM10 in Bangkok and Chiang Mai: A comparative study of haze and non-haze episodes by Wissanupong Kliengchuay, Sarima Niampradit, Narut Sahanavin, William Mueller, Susanne Steinle, Miranda Loh, Helinor Jane Johnston, Sotiris Vardoulakis, San Suwanmanee, Walaiporn Phonphan, John W. Cherrie, Kraichat Tantrakarnapa

“…Particulate matter (PM) air pollution has been identified as one cause of human health impact with the estimated global 8.8 million attributable deaths. …”
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Evaluating the Benefit of Home Support Provider Services for Positive Airway Pressure Therapy in Patients With Obstructive Sleep Apnea: Protocol for an Ambispective International R... by Sarah Alami, Manuella Schaller, Sylvie Blais, Henry Taupin, Marta Hernández González, Frédéric Gagnadoux, Paula Pinto, Irene Cano-Pumarega, Lieven Bedert, Ben Braithwaite, Hervé Servy, Stéphane Ouary, Céline Fabre, Fabienne Bazin, Joëlle Texereau

“…However, no robust evaluation of the impact of these differences on clinical and patient outcomes has been performed. ObjectiveThe AWAIR study aims to evaluate and compare the impact of different home support provider service levels on PAP adherence and persistence in 4 European countries. …”
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