Identification of therapeutic target genes for age-related hearing loss through systematic genome-wide mendelian randomization of druggable genes by Kun Zhang, Bo Hou, Tao Yan, Ruru Qiao, Peng Qu, Xinbo Xu, Hanbing Zhang

“…Mendelian randomization (MR) has been used to repurpose existing drugs and identify new therapeutic targets. …”
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Use of Indocyanine Green (ICG) to Assess Myocardial Perfusion and Territorial Distribution of Vein Grafts Implanted on Coronary Arteries in an Ex-vivo Porcine Model. A Potential Ad... by Cristiano Spadaccio, Antonio Nenna, Diletta Corrado, Carter Glenn, Antonio Panza, Russell Vester, Grzegorz Laskawski, David Rose, Louis Louis

“…Background: The fluorescent dye indocyanine green (ICG) has been used to identify anatomical structures intraoperatively in coronary artery bypass grafting (CABG). …”
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Prevalence and associated factors of multidimensional poverty among rural households in East Gojjam zone, Northern Ethiopia: a community-based cross-sectional study by Amare Wubishet Ayele, Yeshiwas Ewinetu, Asefa Delesho, Yirsie Alemayehu, Hayimro Edemealem

“…Various socio-demographic, agro-ecological, and related factors have been identified to rural MP. To address this issue, stakeholders should prioritize to promote climate-resilient agriculture and strengthening drought coping mechanisms. …”
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PretoxTM: a text mining system for extracting treatment-related findings from preclinical toxicology reports by Javier Corvi, Nicolás Díaz-Roussel, José M. Fernández, Francesco Ronzano, Emilio Centeno, Pablo Accuosto, Celine Ibrahim, Shoji Asakura, Frank Bringezu, Mirjam Fröhlicher, Annika Kreuchwig, Yoko Nogami, Jeong Rih, Raul Rodriguez-Esteban, Nicolas Sajot, Joerg Wichard, Heng-Yi Michael Wu, Philip Drew, Thomas Steger-Hartmann, Alfonso Valencia, Laura I. Furlong, Salvador Capella-Gutierrez

“…Scientific Contribution While text mining solutions have been widely used in the clinical domain to identify adverse drug reactions from various sources, no similar systems exist for identifying adverse events in animal models during preclinical testing. …”
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Use of Augmented Reality for Training Assistance in Laparoscopic Surgery: Scoping Literature Review by Francisco Javier Celdrán, Javier Jiménez-Ruescas, Carlos Lobato, Lucía Salazar, Juan Alberto Sánchez-Margallo, Francisco M Sánchez-Margallo, Pascual González

“…After applying the exclusion criteria, 76 articles were selected, with 25 (33%) later excluded for not meeting quality standards, leaving 51 (67%) in the final review. …”
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Effectiveness of Video Teletherapy in Treating Obsessive-Compulsive Disorder in Children and Adolescents With Exposure and Response Prevention: Retrospective Longitudinal Observati... by Jamie D Feusner, Nicholas R Farrell, Mia Nunez, Nicholas Lume, Catherine W MacDonald, Patrick B McGrath, Larry Trusky, Stephen Smith, Andreas Rhode

“…Assessments were conducted at baseline, after 7-11 weeks, and after 13-17 weeks. Additionally, longitudinal assessments of OCD symptoms were performed at weeks 18-30, 31-42, and 43-54. …”
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Satellite Cells: Regenerative Mechanisms and Applicability in Muscular Dystrophy by Gustavo Torres de Souza, Rafaella de Souza Salomão Zanette, Danielle Luciana Aurora Soares do Amaral, Francisco Carlos da Guia, Claudinéia Pereira Maranduba, Camila Maurmann de Souza, Ernesto da Silveira Goulart Guimarães, João Vitor Paes Rettore, Natana Chaves Rabelo, Antônio Márcio Resende do Carmo, Fernando de Sá Silva, Carlos Magno da Costa Maranduba

“…In spite of the significant amount of variation amongst the satellite cell populations, it seems that their activity is tightly bound to the paired box 7 transcription factor expression, which is, therefore, used as a canonical marker for these cells. …”
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Predictors of Poor Outcome of Anti-MDA5-Associated Rapidly Progressive Interstitial Lung Disease in a Chinese Cohort with Dermatomyositis by Yuhui Li, Yimin Li, Jian Wu, Miao Miao, Xiaojuan Gao, Wenxin Cai, Miao Shao, Xuewu Zhang, Yan Xu, Lu Cong, Jing He, Xiaolin Sun

“…Antimelanoma differentiation-associated protein 5 (anti-MDA5) autoantibody has been reported in dermatomyositis (DM) to be associated with rapidly progressive interstitial lung disease (RP-ILD). …”
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Pemanfaatan Aplikasi Pengiriman Makanan Pasca Penurunan Level Pembatasan Kegiatan Masyarakat Akibat Covid-19 Di Indonesia by Wan Ahmad Gazali Kodri, Dwiza Riana, Sri Hadianti

“…Abstract The use of food delivery applications is increasing very quickly, especially during the COVID-19 Pandemic, when people's movements were restricted, making everyone try to use Food Delivery Applications (FDA) to meet their meal needs. The decrease in the number of COVID-19 cases has caused the Indonesian government to lower the level of Enforcement of Restrictions on Community Activities (PPKM) so that people can return to common social activities. …”
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Health Economic Evaluation of Patients With Colorectal Liver Metastases Randomized to ALPPS or TSH: Analysis From the LIGRO Trial by Kristina Hasselgren, MD, PhD, Martin Henriksson, PhD, Bård I. Røsok, MD, PhD, Peter N. Larsen, MD, PhD, Ernesto Sparrelid, MD, PhD, Gert Lindell, MD, PhD, Nicolai A. Schultz, MD, PhD, Bjorn A. Bjørnbeth, MD, PhD, Bengt Isaksson, MD, PhD, Magnus Rizell, MD, PhD, Anna Lindhoff Larsson, RN, Per Sandström, MD, PhD, Bergthor Björnsson, MD, PhD

“…Further research, exploring cost and health outcomes beyond 2 years is needed.…”
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TaSnRK3.23B, a CBL-interacting protein kinase of wheat, confers drought stress tolerance by promoting ROS scavenging in Arabidopsis by Feiyan Dong, Yide Liu, Huadong Zhang, Yaqian Li, Jinghan Song, Sheng Chen, Shuailei Wang, Zhanwang Zhu, Yan Li, Yike Liu

“…Abstract Background Sucrose non-fermenting-1-related protein kinases (SnRKs) have been implicated in plant growth and stress responses. …”
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A case-control genome-wide association study of estimated breeding values for resistance to gastrointestinal nematodes in two local dairy sheep breeds by C. Persichilli, S. Biffani, G. Senczuk, M. Di Civita, M.K. Bitew, A. Bosco, L. Rinaldi, S. Grande, G. Cringoli, F. Pilla

“…The presence of overlapping functional pathways related to different genes in the two breeds seems to reinforce the idea of the polygenicity of this trait, and further studies are needed in order to make selection schemes an effective tool to contrast GINs.…”
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Dendritic cell maturation is induced by p53-armed oncolytic adenovirus via tumor-derived exosomes enhancing systemic antitumor immunity by Tomoko Ohtani, Shinji Kuroda, Nobuhiko Kanaya, Yoshihiko Kakiuchi, Kento Kumon, Masashi Hashimoto, Chiaki Yagi, Ryoma Sugimoto, Satoru Kikuchi, Shunsuke Kagawa, Hiroshi Tazawa, Yasuo Urata, Toshiyoshi Fujiwara

“…Recently, oncolytic virus therapy has been recognized as a systemic immune stimulator. …”
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Single or multiple treatments with lusutrombopag in subjects with thrombocytopenia and chronic liver disease needing an invasive procedure by Davide Scalabrini, Paolo Sciuto, Cristina Felicani, Antonia Rudilosso, Pietro Andreone

“…In these cases, generally, an infusion of platelets is performed, albeit in recent years has been replaced by a cycle of second generation thrombopoietin receptor (TpoR) agonists. …”
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Body Composition in Crohn’s Disease and Ulcerative Colitis: Correlation with Disease Severity and Duration by Dawesh P. Yadav, Saurabh Kedia, Kumble Seetharama Madhusudhan, Sawan Bopanna, Sandeep Goyal, Saransh Jain, Naval K. Vikram, Raju Sharma, Govind K. Makharia, Vineet Ahuja

“…Results on body composition in Crohn’s disease (CD) and ulcerative colitis (UC) have been heterogeneous and are lacking from Asia. Present study assessed body composition in CD/UC and correlated it with disease severity/duration. …”
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P Wave Duration/P Wave Voltage Ratio Plays a Promising Role in the Prediction of Atrial Fibrillation: A New Player in the Game by E. Karacop, A. Enhos, N. Bakhshaliyev, R. Ozdemir

“…Prolonged P wave duration and decreased P wave voltage have been shown to be independent predictors of AF. The present study aimed to investigate the role of P wave duration/P wave voltage in predicting new-onset AF. …”
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Extraction of collagen from by-products of Amazonian fish tambaqui, Colossoma macropomum and pirarucu Arapaima gigas by Alexandre Augusto Barai, Antônio José Inhamuns, Tiago Cabral Nóbrega, Cristiane Cunha Guimarães, Lígia dos Santos Mourão, Antonio Fabio Lopes de Souza, Fagnaldo Braga Pontes, Flávia Dayane Félix Farias, Joana Maia Mendes, João Paulo Ferreira Rufino, Adriano Teixeira de Oliveira

“…Several high-value commercial products, such as collagen, have been developed from by-products of the fish processing industry due to their wide range of applications and importance for human health. …”
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Effect of Al and Ta Impurities on Si Adsorption on (001) and (111) Surfaces of B1-TiN by Yury M. Koroteev, Leonid A. Svyatkin, Sergey O. Ognev, Vyacheslav M. Silkin

“…In the present work, with the help of first-principles calculations of electronic and atomic structure of (001) and (111) surfaces of the Ti_1−x−yAl<i>_x</i>Ta<i>_y</i>N system with adsorbed Si atom and the interatomic bond study apparatus based on the calculation of a crystal orbital Hamilton population and a crystal orbital bond index, the nature of the bonds between adsorbed Si and the N, Ti, Al, and Ta atoms of the Ti_1−x−yAl<i>_x</i>Ta<i>_y</i>N surface system has been studied. It was found that the binding energy of Si with the Ti_1−x−yAl<i>_x</i>Ta<i>_y</i>N surface system can be both higher and lower than the binding energy of its bonding with the surface of the binary TiN compound depending on the position of the Al and Ta substitution atoms in the surface layers. …”
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Effectiveness and Side Effect Incidence in a Real-World Digital Weight-Loss Service Using Compounded Semaglutide: A Retrospective Comparative Study by Louis Talay, Matt Vickers

“…When Semaglutide has become commercially unavailable, digital weight-loss services (DWLSs) have prescribed a compounded form of the medication—a practice in which health professionals formulate a replica of the commercial medication to serve ongoing patient needs. Although compounding has been relatively common over the past century, prominent medical bodies have argued that compounding a relatively novel medication such as Semaglutide represents a major safety risk. …”
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Cardiovascular Disease Multimorbidity and Decreased Health‐Related Quality of Life in Haiti: A Cross‐Sectional Study by Shalom Sabwa, Vanessa Rouzier, Rodney Sufra, Reichling St. Sauveur, Nour Mourra, Rehana Rasul, Joseph Inddy, Lily D. Yan, Madeline Sterling, Laura Pinheiro, Marie Deschamps, Jean William Pape, Margaret L. McNairy

“…Health‐related quality of life (HRQOL) has been inversely associated with multimorbidity but is understudied in lower‐ and middle‐income countries. …”
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