A new peptide inhibitor of C1QBP exhibits potent anti‐tumour activity against triple negative breast cancer by impairing mitochondrial function and suppressing homologous recombina... by Xingxing Li, Yue Wu, Min Zhang, Fengliang Wang, Hong Yin, Yanrong Zhang, Shuli Zhao, Jiehua Ma, Mingming Lv, Cheng Lu

“…Nevertheless, to date, no pharmacological agents capable of directly targeting and inducing the degradation of C1QBP have been identified. In this study, we have unveiled a new peptide, PDBAG1, derived from the precursor protein GPD1, employing a peptidomics‐based drug screening strategy. …”
Get full text

The prevalence and distribution of malaria in Mpumalanga Province before and during COVID-19 (2017 - 2022) by I Kleinhans, S Mahanjana, F Els, M Mabona, L A Pitso, G Malatje, G Kok, J Raman

“…Additionally, the ongoing COVID-19 pandemic and the emergence of drug and insecticide resistance have been identified as potential stumbling blocks in the achievement of this goal. …”
Get full text

Validation of the Polish version of the Functional Oral Intake Scale against flexible endoscopic evaluation of swallowing and the International Dysphagia Diet Standardization Initi... by Magdalena Milewska, Barbara Jamroz, Mariusz Panczyk, Joanna Chmielewska-Walczak, Tomasz Czernicki, Marta Dabrowska-Bender, Marcin Folwarski, Marcin Folwarski, Dorota Szostak-Wegierek

“…Despite its frequent use, a validated version for the Polish population has been lacking.MethodsThis study aimed to validate the Polish adaptation of FOIS (FOIS-PL) by examining its concordance with Fiberoptic Endoscopic Evaluation of Swallowing (FEES) outcomes and the International Dysphagia Diet Standardization Initiative Functional Diet Scale (IDDSI-FDS) scores across patients with diverse clinical profiles. …”
Get full text

Difficultés diagnostiques de la tuberculose cérébrale by Chahrazed Benrabah

“…In our country and in recent years, an upsurge in extrapulmonary tuberculosis has been observed. The objective of this article was to present an atypical case of cerebral tuberculosis whose diagnosis was late, made by anatomopathological examination with a review of the literature. …”
Get full text

The Interpretation is the Message. Komposition als angewandte Interpretation bei György Kurtág by Tom Rojo Poller

“…Diese Arbeitshypothese wird in zwei methodischen Schritten verfolgt: Zunächst wird die Kategorie von Interpretation in Hinblick auf prominente Aspekte in Kurtágs Schaffen begrifflich aufgefächert. …”
Get full text

Difficultés diagnostiques de la tuberculose cérébrale by Chahrazed Benrabah

“…In our country and in recent years, an upsurge in extrapulmonary tuberculosis has been observed. The objective of this article was to present an atypical case of cerebral tuberculosis whose diagnosis was late, made by anatomopathological examination with a review of the literature. …”
Get full text

Therapy for Dupuytren’s Disease (II): Collagenase Therapy vs. Limited Fasciectomy—A Long-Term Comparative Study by Nikolaus Wachtel, Francesca Romana Dingler, Constanze Kuhlmann, Sinan Mert, Elisabeth Maria Haas-Lützenberger, Verena Alt, Nicholas Moellhoff, Riccardo Giunta, Wolfram Demmer

“…Conclusions: The two therapy options should be seen as complementary for the treatment of DD. Collagenase therapy seems a sensible option for DD with an earlier Tubiana stage and contractures that predominantly affect the MCP joint. …”
Get full text

Optimal selection of satellite XCO₂ images for urban CO₂ emission monitoring by A. Danjou, G. Broquet, A. Schuh, F.-M. Bréon, T. Lauvaux, T. Lauvaux

“…Emission estimation methods have been widely tested and applied to actual or synthetic images. …”
Get full text

Delayed completion of pneumococcal conjugate vaccination among children 4–48 months in rural Uganda: a socio-demographic inquiry by Herbert Malemo, Andrew Tamale, Paul Kakwangire, Matthew C. Igwe, Dickens R. Mwine, Isa Asiimwe, Solomon A. Mbina, Mary G. Abalinda

“…In Uganda, the 3 + 0 PCV regimen has been reported to have a steady decline in the completion rate and the reasons for the delayed completion are unidentified. …”
Get full text

Geodynamics of basins above subducted slabs: An integrated modelling study of tectonics, sedimentation, and magmatism in the Timok Magmatic Complex by Stojadinović Uroš, Toljić Marinko, Trivić Branislav, Pantović Radoje, Srećković-Batoćanin Danica, Krstekanić Nemanja, Kostić Bojan, Velojić Miloš, Stefanović Jelena, Ranđelović Nikola, Maleš Maja

“…The new model of the TMC basin’s geodynamic evolution will quantitatively advance the strategy of prospecting and exploration of world‐class porphyry copper‐ gold deposits, which have been actively exploited in this region for more than a century. …”
Get full text

Electrical and Viscoelastic Parameters of Erythrocytes as a Part of Diagnostic Models for Differentiating Fatty Liver Disease of Mixed Genesis from Non-Alcoholic and Alcohol-Relate... by M. V. Kruchinina, M. F. Osipenko, M. V. Parulikova, A. A. Gromov

“…Two indicators of red blood cells have been established that statistically significantly distinguish the mixed-genesis FLD from the AFLD (Volcano plot); these are the index of red blood cells destruction at a frequency of 5 ×105 Hz, which was higher with AFLD (p = 0.0007), and the capacity of cell membranes, the value of which prevailed in mixed-genesis FLD (p = 0.011). …”
Get full text

JNK and NADPH Oxidase Involved in Fluoride-Induced Oxidative Stress in BV-2 Microglia Cells by Ling Yan, Shengnan Liu, Chen Wang, Fei Wang, Yingli Song, Nan Yan, Shuhua Xi, Ziyou Liu, Guifan Sun

“…In CNS, activated microglial cells can release more reactive oxygen species (ROS), and NADPH oxidase (NOX) is the major enzyme for the production of extracellular superoxide in microglia. ROS have been characterized as an important secondary messenger and modulator for various mammalian intracellular signaling pathways, including the MAPK pathways. …”
Get full text

Maternal neonicotinoid pesticide exposure impairs glucose metabolism by deteriorating brown fat thermogenesis by Wenwen Zhu, Jiali Fang, Chenbo Ji, Hong Zhong, Tianying Zhong, Xianwei Cui

“…Methods: 100 pregnant women who completed a 75 g oral glucose tolerance test (OGTT) at 24–28 weeks of gestation were enrolled. Urinary concentrations of seven widely used NEOs were quantified using ultra-high performance liquid chromatography multiple reaction monitoring mass spectrometry (UHPLC-MRM-MS/MS). …”
Get full text

Deciphering the role of IL17RA in psoriasis and chronic mucocutaneous candidiasis: shared pathways and distinct manifestations by Ayat Kadhi, Ayat Kadhi, Ayat Kadhi, Edward Eid, Michel J. Massaad, Inaam El-Rassy, Dana Maria Khoury, Yutaka Shimomura, Nelly Rubeiz, Mazen Kurban, Mazen Kurban, Mazen Kurban, Georges Nemer, Georges Nemer

“…Despite this intriguing clinical observation, their genetic etiologies have been studied separately, neglecting the shared inflammatory mediator, interleukin 17A-F (IL17A-F). …”
Get full text

Sorafenib Prevents Escape from Host Immunity in Liver Cirrhosis Patients with Advanced Hepatocellular Carcinoma by Hidenari Nagai, Takanori Mukozu, Daigo Matsui, Takenori Kanekawa, Masahiro Kanayama, Noritaka Wakui, Kouichi Momiyama, Mie Shinohara, Kazunari Iida, Koji Ishii, Yoshinori Igarashi, Yasukiyo Sumino

“…Purpose. It has been reported that Th2 cytokines downregulate antitumor immunity, while activation of type T cells promotes antitumor immunity. …”
Get full text

Liver Metastases in Pancreatic Acinar Cell Carcinoma Treated with Selective Internal Radiation Therapy with Y-90 Resin Microspheres by Felipe Nasser, Joaquim Maurício Motta Leal Filho, Breno Boueri Affonso, Francisco Leonardo Galastri, Rafael Noronha Cavalcante, Diego Lima Nava Martins, Vanderlei Segatelli, Lilian Yuri Itaya Yamaga, Rene Claudio Gansl, Bernardino Tranchesi Junior, Antônio Luiz de Vasconcellos Macedo

“…Liver-directed therapy with Y-90 selective internal radiation therapy (SIRT) has been used to treat hepatic metastases from pancreatic tumors. …”
Get full text

Prevalence and Determinants of Diarrheal Diseases among Under-Five Children in Horo Guduru Wollega Zone, Oromia Region, Western Ethiopia: A Community-Based Cross-Sectional Study by Kefalew Alemayehu, Lemessa Oljira, Melake Demena, Abdi Birhanu, Dasselegn Workineh

“…Although efforts have been made to reduce the morbidity and mortality resulting from diarrheal diseases, there is scarce information on the progress of the interventions against the burdens. …”
Get full text

Erratum to ‘Cost differences between autologous and nonautologous cranioplasty implants: A propensity score–matched value driven outcomes analysis’ [World Neurosurgery: X (22C) (20... by Matthew Findlay, Sawyer Z. Bauer, Diwas Gautam, Matthew Holdaway, Robert B. Kim, Walid K. Salah, Spencer Twitchell, Sarah T. Menacho, Gurpreet S. Gandhoke, Ramesh Grandhi

“…More reliable synthetic implants have been developed, but they are significantly more expensive than autologous bone. …”
Get full text

Silk Protein Gene Engineering and Its Applications: Recent Advances in Biomedicine Driven by Molecular Biotechnology by Ji X, Li Y, Wang J, Wang G, Ma B, Shi J, Cui C, Wang R

“…Given the limited production and restricted properties of natural silk proteins, molecular biotechnology has been extensively applied in silk protein genetic engineering to produce novel silk proteins with specific properties. …”
Get full text

Kangtaizhi Granule Alleviated Nonalcoholic Fatty Liver Disease in High-Fat Diet-Fed Rats and HepG2 Cells via AMPK/mTOR Signaling Pathway by Jiaxin Zhang, Haixia Du, Menglan Shen, Zhengqi Zhao, Xinmiao Ye

“…Kangtaizhi granule (KTZG) is a Chinese medicine compound prescription and has been proven to be effective in nonalcoholic fatty liver disease (NAFLD) treatment clinically. …”
Get full text