Antileishmanial Effect of 5,3′-Hydroxy-7,4′-dimethoxyflavanone of Picramnia gracilis Tul. (Picramniaceae) Fruit: In Vitro and In Vivo Studies by Sara M. Robledo, Wilson Cardona, Karen Ligardo, Jéssica Henao, Natalia Arbeláez, Andrés Montoya, Fernando Alzate, Juan M. Pérez, Victor Arango, Iván D. Vélez, Jairo Sáez

“…Species of Picramnia genus are used in folk medicine to treat or prevent skin disorders, but only few species have been studied for biological activity and chemical composition. …”
Get full text

Extracellular vesicles from fifth-stage larval Angiostrongylus cantonensis upregulate cholesterol biosynthesis and suppress NLRP2-associated inflammatory responses in mouse astrocy... by Chien-Ju Cheng, Lian-Chen Wang, Lichieh Julie Chu, Kuang-Yao Chen, Ching-Yun Huang, Kuo-Lun Lan, Kuo-Yang Huang

“…Extracellular vesicles (EVs) derived from helminthes have been implicated in regulating host survival and immune response. …”
Get full text

Threshold responses of freshwater fish community size spectra to invasive species by Bradley Novak, Brent A. Murry, Jeff S. Wesner, Vojsava Gjoni, Caroline C. Arantes, Erin Shepta, Justin P. F. Pomeranz, James R. Junker, Kathrine Zipfel, Andrew Stump, Levi E. Solomon, Kristopher A. Maxson, Jason A. DeBoer

“…Abstract Aquatic invasive species (AIS) threaten biodiversity and ecosystem services around the world, but their management has been hampered by the lack of quantifiable control targets. …”
Get full text

Energy management education for persons living with long COVID-related fatigue (EMERGE): protocol of a two-parallel arms target trial emulation study in a multicentre outpatient in... by Emilia Riggi, Marco Barbero, Gian Luca Di Tanna, Ruth Hersche, Andrea Weise

“…Disease-related and productivity cost data will be collected, and a cost-effectiveness profile of the EME intervention will be compared with standard care.Ethics and dissemination Ethical approval has been obtained from the competent Swiss ethics commission.Findings will be reported (1) to the study participants; (2) to patient organisations and hospitals supporting EMERGE; (3) to funding bodies; (4) to the national and international occupational therapy community and healthcare policy; (5) will be presented at local, national, and international conferences and (6) will be disseminated by peer-review publications.…”
Get full text

Confirmation of the Luminous Blue Variable Status of MWC 930 by A. S. Miroshnichenko, N. Manset, S. V. Zharikov, J. Zsargó, J. A. Juárez Jiménez, J. H. Groh, H. Levato, M. Grosso, R. J. Rudy, E. A. Laag, K. B. Crawford, R. C. Puetter, D. E. Reichart, K. M. Ivarsen, J. B. Haislip, M. C. Nysewander, A. P. LaCluyze

“…For the last ~7 years it has been exhibiting a continuous optical and near-IR brightening along with a change of the emission-line spectrum appearance and cooling of the star’s photosphere. …”
Get full text

Presenting a Leadership Empowerment Model through Sense-making by Using the Cognitive and Behavioral Scripts by Hamid Zare, Aliasghar Pourezzat, Hasan Zareei Matin, Arezoo Salmani

“…Objective Leadership has consistently been recognized as a fundamental element in any group of individuals, playing a critical role whether in defining their roles within society or within the structural confines of an organization. …”
Get full text

Association of socioeconomic status with diabetic microvascular complications: a UK Biobank prospective cohort study by Yikeng Huang, Zhi Zheng, Haibing Chen, Chufeng Gu

“…Abstract Background Prior studies on the link between socioeconomic status (SES) and diabetic microvascular complications have been inconclusive. This study aimed to explore whether SES is associated with the risk of diabetic retinopathy (DR), nephropathy (DN) and diabetic peripheral neuropathy (DPN) using large prospective cohort. …”
Get full text

MAZ-mediated tumor progression and immune evasion in hormone receptor-positive breast cancer: Targeting tumor microenvironment and PCLAF+ subtype-specific therapy by Gaofeng Ni, Yuwei Sun, Hongling Jia, Zhikai Xiahou, Yumeng Li, Fu Zhao, Hongyan Zang

“…Background: Breast cancer had been the most frequently diagnosed cancer among women, making up nearly one-third of all female cancers. …”
Get full text

Predicting Iran Cooperative Development Bank's Profit/Loss: Two-stage Collective Learning by Seyed Bagher Fattahi, Seyed Mozafar Mirbargkar, Ebrahim Chirani, Mohammadreza Vatanparast

“…The results of data analysis reveal that the average ratio of the net profit or loss of the bank to its total assets has been computed in a manner that reflects the average profitability of the bank branches over the research period.…”
Get full text

Rhoifolin Suppresses Cell Proliferation and Induces Apoptosis in Hepatocellular Carcinoma Cells In Vitro and In Vivo by Ruolan Chen, Zufa Sabeel, Lu Ying, Youfeng Liang, Rui Guo, Mingxuan Hao, Xiaoyang Chen, Wenjing Zhang, Jian Dong, Yan Liu, Changyuan Yu, Zhao Yang

“…Rhoifolin (ROF), a flavonoid constituent, has previously been shown to suppress the proliferation of breast and pancreatic cancer cells. …”
Get full text

Solar Flares Triggered by a Filament Peeling Process Revealed by High-resolution GST Hα Observations by Mia Mancuso, Ju Jing, Haimin Wang, Wenda Cao

“…High-resolution H α observations reveal details of the flares and some striking features, such as a filament peeling process: individual strands of thin flux tubes are separated from the main filament, followed shortly thereafter by a flare. …”
Get full text

Single, double, and triple-hit strategies to establish a long-term premature rabbit model of bronchopulmonary dysplasia by Chiara Catozzi, Francesca Stretti, Enrica Scalera, Matteo Storti, Angelo Modena, Giorgio Aquila, Gino Villetti, Erica Ferrini, Andrea Grandi, Franco Fabio Stellari, Francesca Ravanetti, Luisa Ragionieri, Roberta Ciccimarra, Matteo Zoboli, Christina Brandenberger, Henri Schulte, Xabier Murgia, Maurizio Civelli, Francesca Ricci

“…The BPD rabbit model exposed to 95% oxygen has been used in recent years for drug testing. However, the toxicity of the strong hyperoxic hit precludes a longer-term follow-up due to high mortality after the first week of life. …”
Get full text

Pola Tekanan Darah Pada Lansia di Posyandu Lansia Kelurahan Padang Pasir Padang Januari 2014 by Saskia Konita, Syaiful Azmi, Erkadius .

“…Setbacks structure and function of organs also occur in the cardiovascular system, one of which is the arterial wall has been thickened and stiff due to arteriosclerosis so that blood is forced through narrow vessels than usual and cause a rise in blood pressure and cause life-threatening complications. …”
Get full text

Candidate SNP-markers altering TBP binding affinity for promoters of the Y-linked genes CDY2A, SHOX, and ZFY are lowering many indexes of reproductive potential in men by M. P. Ponomarenko, E. B. Sharypova, I. A. Drachkova, L. K. Savinkova, I. V. Chadaeva, D. A. Rasskazov, P. M. Ponomarenko, L. V. Osadchuk, A. V. Osadchuk

“…Female reproductive potential has been investigated in great detail, whereas the male reproductive potential (MRP) has not received the equal amount of attention as yet. …”
Get full text

Investigation of Novel Aronia Bioactive Fraction-Alginic Acid Nanocomplex on the Enhanced Modulation of Neuroinflammation and Inhibition of Aβ Aggregation by Bong-Keun Jang, Soo Jung Shin, Hyun Ha Park, Vijay Kumar, Yong Ho Park, Jeom-Yong Kim, Hye-Yeon Kang, Sunyoung Park, Youngsun Kwon, Sang-Eun Shin, Minho Moon, Beom-Jin Lee

“…Results: The AANCP readily formed nanoparticles, 209.6 nm in size, with a negatively charged zeta potential. The AANCP exhibited better stability in four plasma samples (human, dog, rat, and mouse) and was slowly released in different pH conditions (pH 2.0, 7.4, and 8.0) compared with non-complexedABF. …”
Get full text

Metode Deteksi Pokok Pohon Secara Automatis pada Citra Perkebunan Sawit Menggunakan Model Convolutional Neural Network (CNN) pada Perangkat Lunak Sistem Informasi Geografis by Samuel Samuel, Kestrilia Rega Prilianti, Hendry Setiawan, Prasetyo Mimboro

“…Therefore, innovation breakthroughs are needed so that the monitoring process can be carried out efficiently but still accurately. …”
Get full text

Effects of pesticide dichlorvos on liver injury in rats and related toxicity mechanisms by Pengcheng Zhang, Zixian Zhou, Jiaqi Yao, Yuhong Jiang, Hang Lei, Zhijun Xie, Juan Li, Xianlin Zhao, Lv Zhu, Meihua Wan, Ling Liu, Wenfu Tang

“…Additionally, the regulatory mechanisms underlying DDVP-induced liver injury have not been thoroughly investigated. In this study, we utilized Wistar rats and BRL-3A cells to establish in vivo and in vitro models for examining the effects of DDVP exposure on liver damage. …”
Get full text

Development of an Efficient and Generalized MTSCAM Model to Predict Liquid Chromatography Retention Times of Organic Compounds by Mengdie Fan, Chenhui Sang, Hua Li, Yue Wei, Bin Zhang, Yang Xing, Jing Zhang, Jie Yin, Wei An, Bing Shao

“…Recently, machine learning and artificial intelligence algorithms have been applied to retention time prediction, which show unparalleled advantages over traditional experimental methods. …”
Get full text

Smoking and secondhand smoke exposure and carotid intima-media thickness: Baseline data from the Aidai Cohort Study in Japan by Makoto Saito, Yoshihiro Miyake, Keiko Tanaka, Chisato Nagata, Hidenori Senba, Yasuko Hasebe, Toyohisa Miyata, Takashi Higaki, Eizen Kimura, Bunzo Matsuura, Osamu Yamaguchi, Ryuichi Kawamoto

“…Introduction Epidemiological evidence regarding the relationship between smoking and secondhand smoke (SHS) exposure and carotid intima-media thickness (CIMT) has been limited in Asian populations. Employing baseline data from the Aidai Cohort Study, Japan, we evaluated the evidence in this cross-sectional study. …”
Get full text

Application of a methodological framework for the development and multicenter validation of reliable artificial intelligence in embryo evaluation by D. Gilboa, Akhil Garg, M. Shapiro, M. Meseguer, Y. Amar, N. Lustgarten, N. Desai, T. Shavit, V. Silva, A. Papatheodorou, A. Chatziparasidou, S. Angras, J. H. Lee, L. Thiel, C. L. Curchoe, Y. Tauber, D. S. Seidman

“…Abstract Background Artificial intelligence (AI) models analyzing embryo time-lapse images have been developed to predict the likelihood of pregnancy following in vitro fertilization (IVF). …”
Get full text