Efficacy and Safety of Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting Transforming Growth Factor-β and Programmed Death-Ligand 1, Plus Chemotherapy in Patients With Stage... by Christian Rolfo, MD, PhD, Laurent Greillier, MD, PhD, Remi Veillon, MD, PhD, Firas Badin, MD, MBA, Francois Ghiringhelli, MD, PhD, Nicolas Isambert, MD, PhD, Astrid Paulus, MD, PhD, Surendra Pal Chaudhary, MD, Yulia Vugmeyster, PhD, Masashi Sato, MSc, Sandrine Hiret, MD, PhD

“…On the basis of an interim analysis, the data were considered mature, and no further analysis has been planned. Conclusion: Bintrafusp alfa with chemotherapy was found to have a manageable safety profile and encouraging clinical activity in patients with stage IV NSCLC.…”
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Comparative effectiveness of urine drug screening strategies alongside opioid agonist treatment in British Columbia, Canada: a population-based observational study protocol by Malcolm Maclure, M Eugenia Socías, Evan Wood, Paul Gustafson, Robert W Platt, Bohdan Nosyk, Jeong Eun Min, Micah Piske, Julie Bruneau, U Siebert, P Todd Korthuis, Paxton Bach, B Carolina Guerra-Alejos, Megan Kurz, Laura M Dale, X Joan Hu, Kyle Kampman, Tom Loughin

“…Results will be disseminated to local advocacy groups and decision-makers, national and international clinical guideline developers, presented at international conferences and published in peer-reviewed journals electronically and in print.…”
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Fatigue in patients with chronic obstructive pulmonary disease: protocol of the Dutch multicentre, longitudinal, observational FAntasTIGUE study by Mirjam A G Sprangers, Martijn A Spruit, Emiel F M Wouters, Daisy J A Janssen, Jean W M Muris, Judith B Prins, Yvonne M J Goërtz, Milou Looijmans, Melissa S Y Thong, Jeannette B Peters, Chris Burtin, Yvonne Meertens-Kerris, Arnold Coors, Jan H Vercoulen

“…This manuscript describes the protocol of the FAntasTIGUE study and gives an overview of the possible strengths, weaknesses and clinical implications.Methods and analysis A 2-year longitudinal, observational study, enrolling 400 patients with clinically stable COPD has been designed. Fatigue, the primary outcome, will be measured by the subjective fatigue subscale of the Checklist Individual Strength (CIS-Fatigue). …”
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A lignin-based controlled/sustained release hydrogel by integrating mechanical strengthening and bioactivities of lignin by Bowei Wang, Dingkun Qiu, Yihui Gu, Zhu Shan, Ruonan Shi, Jing Luo, Shuang Qi, Yilin Wang, Bo Jiang, Yongcan Jin

“…The favorable antioxidant and antimicrobial activities of lignin have been shown to promote wound healing. However, the accumulation of lignin in high concentrations in the body brings about varying degrees of biotoxicity. …”
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Potential Effect of Exosomes Derived from Cancer Stem Cells and MSCs on Progression of DEN-Induced HCC in Rats by Faisal A. Alzahrani, Mohammed A. El-Magd, Ahmed Abdelfattah-Hassan, Ayman A. Saleh, Islam M. Saadeldin, Eman S. El-Shetry, Abdelnaser A. Badawy, Saleh Alkarim

“…Cross talk, mediated by exosomes, between normal stem cells and cancer stem cells (CSCs) in the tumor microenvironment has been given less attention so far. In addition, no publications are available in the literature that address the in vivo impact of exosomes derived from CSCs and mesenchymal stem cells (MSCs) on progression of long-term hepatocellular carcinoma (HCC). …”
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The prevalence and influencing factors of COVID-19 in pregnant women post-relaxation of epidemic control measures in Hunan Province, China by Yingxia Wang, Yixu Liu, Kehan Zou, Min Yang, Yinglan Wu, Donghua Xie

“…A farmer/worker occupation type (OR = 0.62, 95% CI: 0.48, 0.79) was a protective factor.ConclusionA high prevalence of COVID-19 in pregnant women following relaxation of control measures has been observed at provincial scale in China. Most cases were mild, and few effects on newborns were observed. …”
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Multiple Gene Deletion Mutants of Equine Herpesvirus 1 Exhibit Strong Protective Efficacy Against Wild Virus Challenge in a Murine Model by Stephanie S. Pradhan, Vekataramireddy Balena, Bidhan Chandra Bera, Taruna Anand, Rhushikesh Khetmalis, Aashwina Madhwal, Supriya Kandasamy, Selvaraj Pavulraj, Manju Bernela, Priya Mor, Bhupendra Nath Tripathi, Nitin Virmani

“…Conclusions: These studies are suggestive of vToH-QMV EHV1 being a potential vaccine candidate against EHV1 infection, which needs to be finally tested in the main host, i.e., horses.…”
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Candidate SNP markers of changes in the expression levels of the human <i>SCN9A</i> gene as a hub gene for pain generation, perception, response and anesthesia by P. A. Dotsenko, K. A. Zolotareva, R. A. Ivanov, I. V. Chadaeva, N. L. Podkolodnyy, V. A. Ivanisenko, P. S. Demenkov, S. A. Lashin, M. P. Ponomarenko

“…It was found that SCN9A as a hub gene for pain generation, perception, pain response and anesthesia is acted on by natural selection against its downregulation, to keep the nervous system highly informed on the status of the organism and the environment.…”
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Molecular Detection of Carbapenemase-Encoding Genes in Multidrug-Resistant Acinetobacter baumannii Clinical Isolates in South Africa by Yaw Adjei Anane, Teke Apalata, Sandeep Vasaikar, Grace Emily Okuthe, Sandile Songca

“…Carbapenem-resistant Acinetobacter baumannii has been responsible for an increasing number of hospital-acquired infections globally. …”
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Unveiling the nutraceutical potential of indigenous and exotic eggplant for bioactive compounds and antioxidant activity as well as its suitability to the nutraceutical industry by Yvonne Angel Lyngdoh, Yvonne Angel Lyngdoh, Partha Saha, Partha Saha, Bhoopal Singh Tomar, Rakesh Bhardwaj, Laxman L. Nandi, Mohita Srivastava, Bishal Gurung, Jeetendra Kumar Ranjan, Paresh Chaukhande

“…Wide diversity exists in eggplant in terms of biochemical content; however, extensive research work has not been undertaken to gain more in-depth knowledge on its antioxidant capacity to improve the quality of the existing popular cultivated varieties and develop/identify nutrient-rich germplasms. …”
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Protocol for process evaluation of SMART Mental Health cluster randomised control trial: an intervention for management of common mental disorders in India by Anushka Patel, David Peiris, Pallab K Maulik, Graham Thornicroft, Shekhar Saxena, Sudha Kallakuri, Amanpreet Kaur, Siddhardha Devarapalli, Mercian Daniel, Beverley M Essue, Shashi Kant, D Praveen, Usha Raman, Rajesh Sagar, Ankita Mukherjee

“…Findings of the study will be disseminated through peer-reviewed publications, stakeholder meetings, digital and social media platforms.Trial registration number CTRI/2018/08/015355.…”
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Left ventricular remodeling and its association with mineral and bone disorder in kidney transplant recipients by Li Sun, Dongliang Zhang, Jiawen Liu, Xiang Gao, Chuanjian Suo, Shuang Fei, Zhengkai Huang, Zijie Wang, Hao Chen, Jun Tao, Zhijian Han, Xiaobing Ju, Zengjun Wang, Min Gu, Ruoyun Tan

“…Background The assessment of left ventricular (LV) remodeling and its association with mineral and bone disorder (MBD) in kidney transplant recipients (KTRs) have not been systematically studied. We aimed to evaluate LV remodeling changes one year after kidney transplantation (KT) and identify their influencing factors.Methods Ninety-five KTRs (68 males; ages 40.2 ± 10.8 years) were followed before and one year after KT. …”
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Determining the status of ecosystem degradation trends and their implications for ecological integrity in the southern African grassland biome by L.R. Vukeya, T.M. Mokotjomela, N. Pillay

“…Overall, 39.2 % (365,629 km2) of the grassland biome has been permanently modified, while 60.8 % of the basic ecosystems remain unchanged. …”
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Treatment outcomes and its associated factors among neonates admitted with sepsis in Hiwot Fana Comprehensive Specialized University Hospital, Harar, Ethiopia by Betelhem Gezahegn, Ahmed Abdella, Fentahun Meseret, Ahmed Mohammed, Mulualem Keneni, Tesfaye Asfaw, Diribsa Tizazu, Assefa Desalew

“…Although efforts have been made to advance the outcomes of neonates admitted to hospitals, there is a paucity of data regarding neonatal sepsis treatment outcomes in the study setting. …”
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Absent in melanoma 2: a potent suppressor of retinal pigment epithelial-mesenchymal transition and experimental proliferative vitreoretinopathy by Yu Chen, Mingyuan Jiang, Liping Li, Shanshan Yang, Zuimeng Liu, Shiwen Lin, Wanxiao Wang, Jinyang Li, Feng Chen, Qiang Hou, Xiaoyin Ma, Ling Hou

“…Although absent in melanoma 2 (AIM2) has been linked to inflammatory disorders, autoimmune diseases, and cancers, its role in the EMT of the retinal pigment epithelium (RPE-EMT) and retinal diseases remains unclear. …”
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Formation of a Novel Antagonistic Bacterial Combination to Enhance Biocontrol for Cucumber <i>Fusarium</i> Wilt by Fan Yang, Xin Wang, Huayan Jiang, Xiaoke Chang, Weiwei Chen, Gongyao Shi, Baoming Tian, Qiuju Yao

“…For further investigation, the strain has been combined with two other <i>Bacillus strains</i> (<i>Bacillus velezensis</i> VJH504 and <i>Bacillus subtilis</i> JNF2) to enhance biocontrol ability, which formed high-efficiency microbial agents in the current study. …”
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Chemotherapy in synergy with innate immune agonists enhances T cell priming for checkpoint inhibitor treatment in pancreatic cancer by Nan Niu, Keyu Li, Junke Wang, Vanessa Funes, Birginia Espinoza, Pan Li, Jianxin Wang, Melissa Lyman, Mengni He, Brian Herbst, Michael Wichroski, Ruslan Novosiadly, Sami Shoucair, Yiping Mou, Lei Zheng

“…Abstract Background The combination of conventional chemotherapy and immune checkpoint inhibitors (ICIs) has been unsuccessful for pancreatic ductal adenocarcinoma (PDAC). …”
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Metabolomics mechanism of traditional soy sauce associated with fermentation time by Li Zhu, Siyu He, Ying Lu, Jianhong Gan, Ningping Tao, Xichang Wang, Zaoli Jiang, Yuanxiang Hong, Changhua Xu

“…Therefore, a better understanding to the influence of fermentation time on soy sauce had been proposed. As the formation and conversion of amino acids and sugars might be mainly responsible for flavor formation in CTFSS, the ratio of these two reactions rate led the metabolism to be divided into three steps, degradation, conversion and balance.…”
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MicroRNA-122 protects against interferon-α-induced hepatic inflammatory response via the Janus kinase–signal transducer and activator of transcription pathway by Fanwei Liu, Bowen Liu, Shanshan Xu, Yinhua Ni, Xiaoli Liu

“…Significant overlap in the epidemiology and coinfection of chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) has been identified, which accelerates the development of severe liver cirrhosis and hepatocellular carcinoma worldwide. …”
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Effects of polymethylmethacrylate nanoplastics on the swimming behaviour and gut microbiome of the freshwater amphipod Gammarus pulex by Sareh Yaripour, Mandar Bandekar, Jiri Vihavainen, Kuldeep More, Aslak Eronen, Manuela Faria Durão, Mikhail Daneliya, Tuure Houni, Tia Halonen, Jari T.T. Leskinen, Jaakko Haverinen, Hannu Huuskonen, Ulrika Candolin, Jukka Kekäläinen, Raine Kortet

“…Nanoplastic particles (NPs: <1000 nm) have been drawing attention for their potential toxicological implications on organisms. …”
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