Blockades of effector T cell senescence and exhaustion synergistically enhance antitumor immunity and immunotherapy by Xia Liu, Emily Shaw, Fusheng Si, Guangyong Peng, Yan Tao, Feiya Ma, David Bagley, Yuanqin Zhang

“…In addition to exhaustion, cellular senescence in tumor-infiltrating T cells (TILs) has recently been identified as an important T cell dysfunctional state induced by various malignant tumors. …”
Get full text

Adaptation of VegSyst-DSS for N, P and K recommendations for grafted tomato grown in perlite in Mediterranean greenhouses by M. Gallardo, J.M. Cedeño, J.J. Magán, M.D. Fernández, R.B. Thompson

“…Unlike substrate-growing systems with recirculation of drainage, very few tools and strategies have been developed to optimize nutrient management for free-draining substrate. …”
Get full text

Assessing the Causal Relationship Between Various Immune Cells and Attention Deficit Hyperactivity Disorder: Mendelian Randomization Study by Qian Ge, Zhongyan Li, Weijing Meng, Chen Cai, Mengdi Qiu, Yafei Liu, Haibo Zhu

“…ABSTRACT Background Immune system modulation has been shown to have a significant impact on attention deficit hyperactivity disorder (ADHD). …”
Get full text

High-Density Lipoprotein Reduction Differentially Modulates to Classical and Nonclassical Monocyte Subpopulations in Metabolic Syndrome Patients and in LPS-Stimulated Primary Human... by Johanna L. Grün, Aaron N. Manjarrez-Reyna, Angélica Y. Gómez-Arauz, Sonia Leon-Cabrera, Felix Rückert, José M. Fragoso, Nallely Bueno-Hernández, Sergio Islas-Andrade, Guillermo Meléndez-Mier, Galileo Escobedo

“…The effect of metabolic syndrome on human monocyte subpopulations has not yet been studied. Our main goal was to examine monocyte subpopulations in metabolic syndrome patients, while also identifying the risk factors that could directly influence these cells. …”
Get full text

Ethnobotanical studies on rice landraces under on-farm conservation in Xishuangbanna of Yunnan Province, China by Fei Wang, Tao Sun, Shuai Yu, Chunhui Liu, Zhuo Cheng, Jianxin Xia, Longzhi Han

“…Despite the diverse rice resources in this region, a comprehensive and systematic study has not been undertaken. Methods From October to November 2023, we collected rice landraces under the on-farm conservation in 18 townships including Menghai, Mengla and Jinghong in Xishuangbanna. …”
Get full text

The interaction network and potential clinical effectiveness of dimensional psychopathology phenotyping based on EMR: a Bayesian network approach by Jianqing Qiu, Ting Zhu, Ke Qin, Wei Zhang

“…The Research Domain Criteria (RDoC) framework serves as a recognized approach to addressing this heterogeneity, and several assessment and translation techniques have been proposed. Among these methods, transforming RDoC scores from electronic medical records (EMR) using Natural Language Processing (NLP) has emerged as a suitable technique, demonstrating clinical effectiveness. …”
Get full text

Practice and factors affecting informed consent among healthcare workers for major surgical procedures at Gurage zone hospitals, South Ethiopia, 2022: a facility-based cross-sectio... by Haimanot Abebe, Bitew Tefera Zewudie, Yibeltal Mesfin, Shegaw Geze Tenaw, Daniel Tsega, Bogale Chekole, Zebene Mekonnen, Shegaw Tesfa Mengist, Agere Aynalem, Tadele Lankrew, Yihenew Sewale, Muche Argaw, Tadesse Sahle

“…Objective This study aimed to assess the informed consent practice process and associated factors among healthcare workers for major surgical procedures at Gurage zone hospitals, in 2022.Methods and materials Institution-based cross-sectional study was employed.Settings This study was conducted in Gurage zone hospitals.Participants All healthcare workers who have been working in Gurage zone hospitals of surgical, operation rooms and obstetrics/gynaecology wards had exposure to patients who had undergone surgery during the study periodOutcome The primary outcome of the study was the practice of informed consent practice among healthcare workers in Gurage zone hospitals.Result A total of 448 study participants were involved in this study giving a response rate of 98%. …”
Get full text

Characteristics of Land Use Change and Evaluation of Ecological Sensitivity in Chongqing by XIE Xianjian, GOU Qiantao, WU Han

“…[Results] (1) In the study area, the landscape matrix was predominantly composed of farmland, accounting for more than 45% of the total area. There had been a significant reduction in both cropland and grassland, while the areas of forest land and urban-rural construction land had increased markedly from 2000 to 2020. (2) Over the course of 20 years, the average value of the comprehensive ecological sensitivity index rose from 1.037 to 1.045, indicating an overall improvement in the ecological environment of the study area. …”
Get full text

High nature value farming systems in Europe: A dataset encompassing the environmental impact assessment of farms and extensive ruminant food productsFigshare by M. Torres-Miralles, P. Jeanneret, M. Lamminen, F. Joly, B. Dumont, H. Tuomisto, I. Herzon

“…Additionally, we utilised the LCA inventory Agribalyse 3.0 database to estimate the environmental footprint of four pivotal HNV products: goat cheese, cow milk, lamb, and beef. The main outcome is a unique and novel dataset for HNV farming systems, addressing critical gaps in available information. …”
Get full text

Analisis Sentimen Berbahasa Inggris Dengan Metode Lstm Studi Kasus Berita Online Pariwisata Bali by Ngakan Made Krisna Sedana, I Nyoman Saputra Wahyu Wijaya, I Ketut Resika Arthana

“…Sentiment analysis is carried out using the LSTM (Long-Term Memory) machine learning model, with news data that has been labeled with sentiment by experts according to the content of the news. …”
Get full text

Aux origines gauloises de Tours (Indre-et-Loire) : état des connaissances by Sandrine Linger-Riquier

“…Thus, the settlement possesses all the attributes of a major city and is considered to be the only site in the area likely to have been the capital. Various discoveries in Tours during the 1980s and especially in 2001, however, testify to a prior Gallic occupation. …”
Get full text

Protocol on establishing a prospective enhanced surveillance of vaccine preventable diseases in residential aged care facilities in Central Queensland, Australia: an observational... by Mohammad Rashidul Hashan, Robert Booy, Michael Kirk, Gulam Khandaker, Gwenda Chapman, Jacina Walker, Sonya Jayne Davidson, Jill Auriac, Nicolas Smoll, Delwar Akbar

“…Descriptive statistics, univariate and multivariate regression analysis will be conducted to identify the predictors of morbidity and clinical outcomes following infection.Ethics and dissemination The study has been approved by the CQHHS Human Research Ethics Committee (HREC) (reference number HREC/2021/QCQ/74305). …”
Get full text

Modeling the advective supply of Calanus finmarchicus to Stellwagen Bank as an indicator of sand lance foraging habitat, and the climate vulnerability of a National Marine Sanctuar... by Cameron R. S. Thompson, Cameron R. S. Thompson, Isabel A. Honda, Isabel A. Honda, Jacob P. Kritzer, Jackie Motyka, Jeffrey A. Runge, Rubao Ji

“…The northern sand lance (Ammodytes dubius), a key species in the food web supporting the Stellwagen Bank National Marine Sanctuary (SBNMS), feeds primarily on the lipid-rich copepod Calanus finmarchicus. …”
Get full text

Release Profile and Antibacterial Activity of <i>Thymus sibthorpii</i> Essential Oil-Incorporated, Optimally Stabilized Type I Collagen Hydrogels by Caglar Ersanli, Ioannis Skoufos, Konstantina Fotou, Athina Tzora, Yves Bayon, Despoina Mari, Eleftheria Sarafi, Konstantina Nikolaou, Dimitrios I. Zeugolis

“…Although the strong antimicrobial activity of various EOs has already been studied and revealed, their characteristic high sensitivity and volatility drives the need towards a more efficient drug administration method via a biomaterial system. …”
Get full text

Genetic Association and Expression Correlation between Colony-Stimulating Factor 1 Gene Encoding M-CSF and Adult-Onset Still’s Disease by Yi-Ming Chen, Wei-Ting Hung, Wan-Chun Chang, Chia-Wei Hsieh, Wen-Hung Chung, Joung-Liang Lan, Ning-Rong Gung, Yun-Shien Lee, Der-Yuan Chen, Shuen-Iu Hung

“…Adult-onset Still’s disease (AOSD) is a rare and inflammatory disorder characterized by spiking fever, rash, arthritis, and multisystemic involvement. HLA has been shown to be associated with AOSD; however, it could not explain the innate immunity and autoinflammatory characteristics of AOSD. …”
Get full text

Brain radiotherapy and dorsal vagal complex irradiation: A new organ at risk to decrease radiation-induced nausea and vomiting? by Valentine Caspar, Nicolas Giraud, Thomas Charleux, Arnaud Beddok, Brieuc Bernard, Maelle Martin, Juliette Thariat, Aymeri Huchet, Véronique Vendrely, Charles Dupin

“…The dorsal vagal complex (DVC) located in the brainstem (BS) has been identified as the center of nausea and vomiting. …”
Get full text

MiR-128-3p mediates MRP2 internalization in estrogen-induced cholestasis through targeting PDZK1 by Yue Zu, Qianyan Gao, Yisheng He, Qiao Deng, Guodong Li, Xiping Li, Tianze Shang, Xinwei Cheng, Chenglong Zhu, Jianqiao Wang, Dong Liu, Chengliang Zhang

“…Estrogens have been reported to cause dysfunction in biliary transport systems, thereby inducing cholestasis. …”
Get full text

Host protein PRPS2 interact with the non-structural protein p17 of Avian Reovirus and promote viral replication by Hu Xiaomiao, Zhao Ruihong, Li Wei, Pan Xiaocheng, Dai Yin, Wu Huimin, Wu Yantao, Zhang Chengcheng

“…Avian reovirus (ARV) is highly prevalent in healthy poultry flocks and has been linked to viral arthritis/tendonitis, dwarf syndrome, chronic respiratory disease, and immunosuppression in avian species, resulting in significant economic losses within the poultry industry. …”
Get full text

 Increasing the resolution of malaria early warning systems for use by local health actors by Michelle V. Evans, Felana A. Ihantamalala, Mauricianot Randriamihaja, Vincent Herbreteau, Christophe Révillion, Thibault Catry, Eric Delaitre, Matthew H. Bonds, Benjamin Roche, Ezra Mitsinjoniala, Fiainamirindra A. Ralaivavikoa, Bénédicte Razafinjato, Oméga Raobela, Andres Garchitorena

“…Many of these models have been operationalized into malaria early warning systems (MEWSs), which provide predictions of malaria dynamics several months in advance at national and regional levels. …”
Get full text

CT-based skeletal muscle loss predicts long term prognosis in patients with distal cholangiocarcinoma undergone pancreaticoduodenectomy by Guangzhen Qu, Shao-Cheng Lyu, Yong Zhang, Kun Gao, Chuanguo Zhou

“…However, the impact of skeletal muscle changes on tumor prognosis has not been systematically elaborated. We aimed to explore the value of skeletal muscle changes in the prognosis of distal cholangiocarcinoma (DCC) patients undergone pancreaticoduodenectomy (PD). …”
Get full text