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Tumor microenvironment-responsive hyperbranched polymers for controlled drug delivery
Published 2024-12-01Get full text
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17304
Glycopatterns of Urinary Protein as New Potential Diagnosis Indicators for Diabetic Nephropathy
Published 2017-01-01Get full text
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17305
Network Medicine‐Based Strategy Identifies Maprotiline as a Repurposable Drug by Inhibiting PD‐L1 Expression via Targeting SPOP in Cancer
Published 2025-01-01“…Experimental validation revealed that MAP reduced PD‐L1 expression by targeting E3 ubiquitin ligase speckle‐type zinc finger structural protein (SPOP), and the combination of MAP and anti‐CTLA4 in vivo significantly enhanced the antitumor effect, providing a new alternative for the clinical treatment of colorectal and lung cancer.…”
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Anti-PD-1 exacerbates bleomycin-induced lung injury in mice via Caspase-3/GSDME-mediated pyroptosis
Published 2025-01-01“…Consistent with the findings in the animal model, immunofluorescence and RNA sequencing of lung tissue from ICI-LI patients revealed upregulation of the expression of genes related to the GSDME-related pyroptosis pathway. …”
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Effects of aminooxyacetic acid on learning and memory function and neurochemical changes in chronic alcoholism
Published 2025-02-01“…Conclusion: AOAA may alleviate cognitive deficits associated with chronic alcoholism by inhibiting CBS expression, reducing H₂S levels, and enhancing 5-HT release in the prefrontal cortex. These findings suggest AOAA as a potential therapeutic strategy for alcohol-induced cognitive impairments.…”
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Traditional pediatric massage enhanced the skeletal muscle mass in OVA-exposed adolescent rats via regulating SCFAs-FFAR2-IGF-1/AKT pathway
Published 2025-01-01“…Pulmonary function (PF) was detected by whole body plethysmograph, including enhanced pause and minute ventilation. Airway allergic inflammation (AAI) status was assessed by concentrations of OVA-specific immunoglobulin E in plasma, interleukin (IL)-4 and IL-1β in bronchoalveolar lavage fluid via ELISA assay. …”
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Subsurface drip irrigation mitigated greenhouse gas emission and improved root growth and yield in apple in semi-arid region
Published 2025-03-01“…In summary, SDI can enhance apple yield, foster deep root development, and reduce GHG emissions. The research findings offer empirical evidence for the sustainable growth and ecological preservation of the apple industry.…”
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Integration of Transcriptomics and Metabolomics Provides Insight into the Growth-Promoting Functions of <i>Solanum khasianum</i> Endophyte in <i>Medicago sativa</i>
Published 2025-01-01“…By integrating the results of transcriptome and metabolome analysis, <i>A. alstroemeriae</i> may promote plant growth by regulating genes associated with the biosynthetic pathways of flavonoids, anthocyanins, and proanthocyanidins in plants. These research findings provide a theoretical basis for future verification of the molecular response mechanisms and metabolic regulation of <i>A. alstroemeriae</i>-promoted plant growth. …”
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The Role of EGFR/PI3K/Akt/cyclinD1 Signaling Pathway in Acquired Middle Ear Cholesteatoma
Published 2013-01-01Get full text
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Technicolor Middle Ages: (Ex)changes and Transformations from Medieval to Present Day Perception of Colour
Published 2011-09-01“…Dans chacun d’eux, l’action se situe au moyen-âge. Il s’agit de The Adventures of Robin Hood (1938), Ivanhoe (1952) et The Knights of the Round Table (1953). …”
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Folklore et écriture vernaculaire dans The Autobiography of Miss Jane Pittman
Published 2006-05-01“…Elle parvient à « éliminer » un adversaire des plus symboliques, le contremaître noir, en le réduisant à néant dans une réplique emblématique du pouvoir du signifyin(g) (« You ain’t nothing but Nothing » p. 11). La veille femme, sage mais non résignée, devient trickster à la fin du récit. …”
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Regulatory signatures involved in the cell cycle pathway contribute to egg production heterosis in chicken
Published 2025-02-01“…Conclusion Our study characterized the dynamic profile of genome-wide gene expression in ovary and highlighted the role of dominant expression of cell cycle pathway genes in heterosis. These findings provided new insights for the molecular mechanism of egg production heterosis, which would facilitate the rational choice of suitable parents for producing crossbred chickens with higher egg production.…”
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Comparative Analysis of Carbon Density Simulation Methods in Grassland Ecosystems: A Case Study from Gansu Province, China
Published 2025-01-01“…In contrast, the SOC estimates followed an opposite trend, with the overall approach yielding a higher <i>R</i><sup>2</sup> value of 0.92. (4) Generally, variable selection significantly enhanced model accuracy, with spatial and non-parametric models demonstrating superior precision and stability in estimating the four carbon density components of grassland. These findings provide methodological guidance for converting sample point carbon density data into regional-scale estimates of grassland carbon storage.…”
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