Grem1 inhibits osteogenic differentiation of MBMSCs in OVX rats through BMP/Smad1/5 signaling pathway by Shan-shan Yang, Min LinHu, Xiao-hua Hu, Si-si Jiang, Wen-yue Hu, Xiao-hong Yang

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In silico approaches for developing sesquiterpene derivatives as antagonists of human nicotinic acetylcholine receptors (nAChRs) for nicotine addiction treatment by Taufik Muhammad Fakih, Aden Dhana Rizkita, Sintia Ayu Dewi, Muchtaridi Muchtaridi

“…Among the 55 compounds examined, Dihydroxyeudesmene, Gibberodione, and Germacrene-E exhibited the highest binding affinities. These compounds demonstrated robust interactions with the nAChRÿ3 receptor, as evidenced by elevated molecular mechanics general surface area (MM/GBSA) values (ΔG Bind = Dihydroxyeudesmene: −36.45 kcal/mol, Gibberodione: −36.51 kcal/mol, and Germacrene-E: −36.51 kcal/mol). …”
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Identification and Clinical Validation of High HSP60 Expression Predicts Poor Prognosis in Patients with Ovarian Cancer by Zheng M, Li S, Deng J, Huang C, Zhang H

“…Min Zheng,1,* Shaoxing Li,1,* Jie Deng,1 Chaolin Huang,1 Hua Zhang2 1Department of Gynecology and Obstetrics, Clinical Medical College and The First Affiliated Hospital of Chengdu Medical College, Chengdu, People’s Republic of China; 2Department of Rehabilitation Medicine, Clinical Medical College and The First Affiliated Hospital of Chengdu Medical College, Chengdu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hua Zhang; Chaolin Huang, Department of Gynecology and Obstetrics, Clinical Medical College and The First Affiliated Hospital of Chengdu Medical College, No. 278, The Middle Section of Baoguang Avenue, Xindu District, Chengdu City, Sichuan Province, 610500, People’s Republic of China, Email 2508034576@qq.com; huangchaolin1006@163.comObjective: This study aimed to investigate the clinical significance of heat shock protein 60 (HSP60) expression in ovarian cancer and evaluate its correlation with patient survival outcomes.Methods: A total of 260 ovarian cancer patients diagnosed between 2017 and 2019 were enrolled. …”
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Predicting early diagnosis of intensive care unit-acquired weakness in septic patients using critical ultrasound and biological markers by Ling Lei, Liang He, Tongjuan Zou, Jun Qiu, Yi Li, Ran Zhou, Yao Qin, Wanhong Yin

“…Inclusion criteria were as follows: age over 18 years; expected ICU stay longer than 3 days; and voluntary informed consent. …”
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The relationship between body appreciation and weight-related health behaviors among Chinese adolescents by Yuyuan Zhong, Ying Chen, Ying Chen, Meng Wang, Bian Lu, Ting Shen, Jing Hu, Fengyang Jiang, Hongmei Wang

“…Notably, this study provided novel evidence linking body appreciation with positive weight-related behavioral outcomes in both physical activity and dietary behaviors (such as sufficient fruit and vegetable consumption and reduced fried food intake) among Chinese adolescents. …”
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Spatial-temporal distribution and evolution of medical and health talents in China by Lei Zhang, Jie Tang, Qianqian Zhou, Yu Song, Dayong Zhang

“…Moreover, the global and local Moran’s I indices reveal varying spatial autocorrelation for TAD, TAS, TAI, and TAE. The Dagum Gini coefficients of TAD, TAS, TAI, and TAE show different patterns of decomposition.…”
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The Influences of Key Strata Compound Breakage on the Overlying Strata Movement and Strata Pressure Behavior in Fully Mechanized Caving Mining of Shallow and Extremely Thick Seams: A Case Study by Junmeng Li, Yanli Huang, Jixiong Zhang, Meng Li, Ming Qiao, Fengwan Wang

“…In order to analyze the impact of compound breakage of key strata on overlying strata movement and strata pressure behavior during the fully mechanized caving mining in shallow and extremely thick seams, this paper took the 1322 fully mechanized caving face in Jindi Coal Mine in Xing County as the engineering background. …”
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Mechanisms and thresholds of land use affecting surface water quality in Hangzhou City’s residential areas by Qianhu Chen, Jinye Huang

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Carbono acumulado en raíces de especies vegetales en sistemas silvopastoriles en el Norte de Colombia by José Luis Contreras-Santos, Judith Martínez-Atencia, Cindy Katherine Falla-Guzman

Subjects: “…Densidad de longitud; gramínea; propiedades fisicoquímicas; raíces finas; suelo.…”
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Intranasal Insulin Diminishes Postoperative Delirium and Elevated Osteocalcin and Brain Derived Neurotrophic Factor in Older Patients Undergoing Joint Replacement: A Randomized, Do... by Yang M, Zhou L, Long G, Liu X, Ouyang W, Xie C, He X

“…Mi Yang, Lei Zhou, Ge Long, Xing Liu, Wen Ouyang, Chang Xie, Xi He Department of Anesthesia, The Third Xiangya Hospital of Central South University, Changsha, People’s Republic of ChinaCorrespondence: Xi He, Email hexitougao@163.comBackground: Brain energy metabolism disorders, including glucose utilization disorders and abnormal insulin sensitivity, are linked to the pathogenesis of postoperative delirium. …”
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Erbin Regulates Tissue Factors Through Ras/Raf Pathway in Coagulation Disorders in Sepsis by Yang C, Lei C, Jing G, Xia Y, Zhou H, Wu D, Zuo J, Gong H, Wang X, Dong Y, Aidebaike D, Wu X, Song X

“…Cheng Yang,1,* Chuntian Lei,1,* Guoqing Jing,1 Yun Xia,1 Huimin Zhou,1 Die Wu,1 Jing Zuo,1 Hailong Gong,1 Xing Wang,1 Yingyue Dong,1 Delida Aidebaike,1 Xiaojing Wu,2 Xuemin Song1 1Research Centre of Anesthesiology and Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, 430062, People’s Republic of China; 2Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaojing Wu; Xuemin Song, Email RM000851@whu.edu.cn; xueminsong@whu.edu.cnBackground: Sepsis, as a clinically critical disease, usually induces coagulation disorders. …”
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Development and Characterization of a Hydrogel Containing Chloramphenicol-Loaded Binary Ethosomes for Effective Transdermal Permeation and Treatment Acne in Rat Model by Liu RJ, Li M, Zhu Q, Liu HY, Zhang XX, Han XY, Yu MJ, Zhou JW, Han CY

“…Run jia Liu,1 Miao Li,1 Qian Zhu,1 Hui ying Liu,1 Xing xiu Zhang,1 Xiang yuan Han,1 Meng jun Yu,1 Jian wen Zhou,2 Cui yan Han1 1School of Pharmacy, Qiqihar Medical University, Qiqihar, People’s Republic of China; 2Institute of Medicine and Drug Research, Qiqihar Medical University, Qiqihar, People’s Republic of ChinaCorrespondence: Cui yan Han, School of Pharmacy, Qiqihar Medical University, Qiqihar, People’s Republic of China, Tel/Fax +86-24-2663822, Email hcymuphar@qmu.edu.cnPurpose: Acne is a serious disfiguring follicular sebaceous gland disorder that negatively affects patients’ quality of life and self-image. …”
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Variation in Nutritional Quality of By-Products from Nine Organic Apple Cultivars by Elisabeta Elena Popa, Laurentiu Mihai Palade, Violeta Alexandra Ion, Andreea Barbu, Oana Crina Bujor, Vlad Ioan Popa, Paul Alexandru Popescu, Amalia Carmen Mitelut, Mihaela Cristina Draghici, Mihaela Geicu-Cristea, Mona Elena Popa

“…Novelty and scientific contribution. In this study, nine varieties of organic apples were analysed and the nutritional parameters were determined. …”
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Exploring similarities and differences in anti-atherosclerotic potential bioactives among Dendrobium species by UPLC-Q-Exactive Orbitrap MS by Yu Zhang, Xi Chen, Oushan Tang, Keyun Cheng, Lijun Ge, Weibo Lu, Jing Zheng, Yeshun Wu, Si-wei Wang, Xi-xi Zeng, Jing Xue, Yiwei Cui, Liting Ji, Qing Shen

“…Molecular docking experiments assessed the binding affinity of the identified compounds with target proteins. …”
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Metformin Ameliorates Ulcerative Colitis Through Inhibiting NLRP3 Inflammasome Activation by Cao R, Jing J, Ma Y, Qi W, Huang X, Zhang C, Lu Z, He J, Wang G, Ma Y, Zhang H

“…Run Cao,1,* Jing Jing,1,* Yuting Ma,1,2,* Wenqing Qi,1 Xinyu Huang,1 Chaofang Zhang,1 Zhizhuo Lu,1 Jiayi He,1 Guiling Wang,1 Yuanfang Ma,1 Hailong Zhang1 1Joint National Laboratory for Antibody Drug Engineering, the First Affiliated Hospital, Henan University, Kaifeng, Henan, People’s Republic of China; 2Xuzhou Central Hospital, Xuzhou, Jiangsu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hailong Zhang; Yuanfang Ma, Joint National Laboratory for Antibody Drug Engineering, the First Affiliated Hospital, Henan University, Kaifeng, Henan, People’s Republic of China, Email hailong6891@163.com; mayf@henu.edu.cnPurpose: Metformin (Met) is widely used to treat a variety of diseases, but its role in ulcerative colitis (UC) has not been fully elucidated. …”
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Comparative transcriptome analysis on candidate genes involved in lipid biosynthesis of developing kernels for three walnut cultivars in Xinjiang by Wenqiang Wang, Hao Wen, Qiang Jin, Wenjun Yu, Gen Li, Minyu Wu, Hongjin Bai, Lirong Shen, Cuiyun Wu

“…In order to explore the biosynthesis molecular mechanism of oil accumulation and fatty acid (FA) synthesis in walnut, the samples at different development periods of three walnut cultivars, ‘Zhipi’ (ZP), ‘Xinwu 417’ (W417) and ‘Xinwen 81’ (W81) were collected for transcriptomic analysis. …”
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Thyroid Dysfunction After Intensity-Modulated Radiotherapy and PD⁃1 Inhibitor Treatment for Locally Advanced Nasopharyngeal Carcinoma by Shang K, He Q, Xu X, Luo X, Zhao C, Liu L, Li Z, Li Y, Jin F

“…Kai Shang,1,2,* Qianyong He,1– 3,* Xinyu Xu,2 Xunyan Luo,2 Chaofen Zhao,1,3 Lina Liu,1– 3 Zhuoling Li,1– 3 Yuanyuan Li,1– 3 Feng Jin1,3 1Department of Oncology, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, People’s Republic of China; 2School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, People’s Republic of China; 3Department of Oncology, the Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Feng Jin, Department of Oncology, the Affiliated Hospital of Guizhou Medical University, 28 Guiyi Street, Guiyang, Guizhou, 550004, People’s Republic of China, Tel +851-86512802, Email tjzlk2023@163.comPurpose: Analyze the incidence and risk factors of thyroid dysfunction in patients with advanced nasopharyngeal carcinoma (LA-NPC) after intensity-modulated radiotherapy (IMRT) and PD⁃1 inhibitor treatment and their relationship with treatment efficacy and prognosis.Methods: Eighty-five LA-NPC patients treated with IMRT and PD-1 inhibitors were retrospectively collected from March 1, 2019, to May 30, 2022. …”
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Solid Self-Microemulsifying Drug Delivery System for Improved Oral Bioavailability of Relugolix: Preparation and Evaluation by Li ZL, Deng GX, Fang CZ, Zhao YQ, Yuan J, Chen L, Zhong HJ, Guo F

“…Zi-Lin Li,1,* Guo-Xing Deng,1,* Chuan-Zhou Fang,1,* Yue-Qi Zhao,1 Jing Yuan,2 Liang Chen,3 Hai-Jun Zhong,1 Feng Guo1 1School of Pharmacy, Jiangxi Medical College, Nanchang University, Nanchang, 330006, People’s Republic of China; 2College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, 471000, People’s Republic of China; 3Jiangxi Prozin Pharmaceutical Co., LTD, Jian, 343100, People’s Republic of China*These authors contributed equally to this workCorrespondence: Feng Guo; Hai-JunZhong, School of Pharmacy, Jiangxi Medical College, Nanchang University, Nanchang, 330006, People’s Republic of China, Tel +86 0791 86361839, Email fengguo@ncu.edu.cn; zhonghj@ncu.edu.cnPurpose: To improve the oral absorption of relugolix (RLGL), which has low oral bioavailability due to its low solubility and being a substrate of P-glycoprotein (P-gp). …”
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Rhein Mitigates Lung Injury in Severe Acute Pancreatitis Through the Inhibition of MARK4-Mediated Microtubule Destabilization by Sun Z, Liu J, Ge P, Cao Y, Liu J, Wen H, Luo X, Pei B, Jin Z, Li H, Xun L, Luo Y, Yang Q, Chen H

“…Zhenxuan Sun,1– 3,* Jie Liu,1– 3,* Peng Ge,1– 3,* Yinan Cao,4 Jin Liu,1– 3 Haiyun Wen,1– 3 Xinyu Luo,1– 3 Boliang Pei,1– 3 Zuocang Jin,1,3 Huijuan Li,3 Lu Xun,1– 3 Yalan Luo,5 Qi Yang,6 Hailong Chen1– 3 1Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116011, People’s Republic of China; 2Institute (College) of Integrative Medicine, Dalian Medical University, Dalian, Liaoning, 116011, People’s Republic of China; 3Laboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116011, People’s Republic of China; 4Day Surgery Center, Dalian Municipal Central Hospital, Dalian, Liaoning, 116033, People’s Republic of China; 5Department of Gastroenterology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116011, People’s Republic of China; 6Department of Traditional Chinese Medicine, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116023, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hailong Chen, Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Zhongshan Road 222, Dalian, Liaoning, 116011, People’s Republic of China, Tel +86 411 83635963, Fax +86 411 83622844, Email chenhailong@dmu.edu.cnPurpose: Explore the therapeutic effect and molecular mechanism of rhein on severe acute pancreatitis associated acute lung injury (SAP-ALI).Methods: The SAP-ALI rat model was constructed by retrograde injection of 5% sodium taurocholate into the pancreaticobiliary duct, and pulmonary microvascular endothelial cell (PMVEC) injury model was induced by LPS. …”
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