Fluorescence Correlation Spectroscopy in Drug Discovery: Study of Alexa532-Endothelin 1 Binding to the Endothelin ETA Receptor to Describe the Pharmacological Profile of Natural Products by Catherina Caballero-George, Thomas Sorkalla, Daniel Jakobs, Jessica Bolaños, Huzefa Raja, Carol Shearer, Eldredge Bermingham, Hanns Häberlein

“…A similar effect was observed for the fungal extract, which completely displaced Alexa532-ET1 from its binding to the “inactive” receptor state. These findings suggest that both BQ-123 and the fungal extract act as inverse agonists.…”
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Spatial Differentiation and Influencing Factors of Second-Hand Housing Prices: A Case Study of Binhu New District, Hefei City, Anhui Province, China by Song Xu, Zhen Zhang

“…This paper studies the price characteristics of second-hand residential transactions in Binhu New District taking advantage of the hedonic price model and MGWR model and draws the following conclusions. (1) There are obvious spatial positive correlation and spatial heterogeneity in the price of second-hand housing in Binhu New District. (2) The number of bedrooms, area, age of the house, and the distance to the nearest school have small effect on the scale, so they have strong spatial heterogeneity. …”
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Protocol for odorant-binding protein 2A gene knockdown by dual siRNA transfection in a three-dimensional human epidermal equivalent model by Shinobu Nakanishi

“…Here, we present a protocol for the knockdown of the odorant-binding protein 2A (OBP2A) gene in a three-dimensional human epidermal equivalent model (3DE-model). …”
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SPECIES COMPOSITION AND DENSITY FLUCTUATION OF THE CITRUS LEAFMINER PHYLLOCNISTIS CITRELLA STAINTON (LEPIDOPTERA: PHYLLOCNISTIDAE) ON XOAN ORANGES IN DONG PHU DISTRICT, BINH PHUOC PROVINCE by Nguyen Thi Viet, Duong Thi Hong Thuy, Vu Thi Anh

“…The study on the composition of insect pests on Xoan Orange trees in Dong Phu District, Binh Phuoc Province, identified 28 species belonging to 25 families and 7 orders. …”
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Inhibition of inflammatory cell infiltration by antagonistic peptides that specifically bind to CCR5 via regulation of the NF-kB signaling pathway in rats with colitis by Yang-Da Song, Yi-Hang Song, Si-Xue Liu, Hua-Rong Huang, Ying-Qiang Zhong

“…Aim of the study was to further investigate the effect and mechanism of CCR5 binding peptides in rat colitis. Material and methods Experimental colitis was induced by 5% TNBS. …”
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NLS-binding deficient Kapβ2 reduces neurotoxicity via selective interaction with C9orf72-ALS/FTD dipeptide repeats by Kevin M. Kim, Amandeep Girdhar, Maria E. Cicardi, Vaishnavi Kankate, Miyuki Hayashi, Ruoyu Yang, Jenny L. Carey, Charlotte M. Fare, James Shorter, Gino Cingolani, Davide Trotti, Lin Guo

“…Abstract Arginine-rich dipeptide repeat proteins (R-DPRs) are highly toxic proteins found in patients with C9orf72-linked amyotrophic lateral sclerosis and frontotemporal dementia (C9-ALS/FTD). …”
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The value of exosomes suppressor of cytokine signaling 1， speckled protein 140 and calcyclin binding protein expressions in peritoneal dialysis effluent in the diagnosis of peritoneal fibrosis by Han Xiao-li, Wang Jia-wei, Wei Zhi-feng, Wang Lin-lin, Guo Bao-zhu, Cao Yan-chun, Jin Yu-jie, Liu Sheng-jun

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Binding Investigation of Some Important Metal Ions Copper (I), Nickel (II), and Aluminium (III) with Bovine Serum Albumin Using Valid Spectroscopic Techniques by Hassan A. Alhazmi, Md Shamsher Alam, Mohammed Albratty, Asim Najmi, Ahmed A. Abdulhaq, Rym Hassani, Waquar Ahsan, Abdulrahman N. Qramish

“…These findings were similar to our previous findings using affinity capillary electrophoresis (ACE). …”
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Human Antibodies Can Cross Guinea Pig Placenta and Bind Its Neonatal Fc Receptor: Implications for Studying Immune Prophylaxis and Therapy during Pregnancy by Evi Budo Struble, Li Ma, Lilin Zhong, A. Lesher, Joel Beren, Pei Zhang

“…We also observe that human IgG binds to an engineered soluble variant of the guinea pig neonatal Fc receptor in vitro in a manner similar to that demonstrated for the human variant, suggesting that this transplacental transport mirrors the receptor-based mechanism seen in humans. …”
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RNA‐Binding Protein Hnrnpa1 Triggers Daughter Cardiomyocyte Formation by Promoting Cardiomyocyte Dedifferentiation and Cell Cycle Activity in a Post‐Transcriptional Manner by Chuling Li, Yijin Chen, Qiqi Chen, Haoxiang Huang, Michael Hesse, Yilin Zhou, Ming Jin, Yu Liu, Yifei Ruan, Xiang He, Guoquan Wei, Hao Zheng, Senlin Huang, Guojun Chen, Wangjun Liao, Yulin Liao, Yanmei Chen, Jianping Bin

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Molecular docking reveals fibrinogen binding sites on SARS-CoV-2 spike protein: A potential mechanism for COVID-19-related coagulation by Onur Ozturk, Evren Kilinc, Batuhan Gorkem Irez, Emel Timucin

“…Coagulation disorders, particularly those leading to thromboinflammation, have been linked to severe complications in COVID-19 cases. …”
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MERS-CoV spike vaccine-induced N-terminal domain-specific antibodies are more protective than receptor binding domain-specific antibodies by Olubukola M. Abiona, Nianshuang Wang, Sarah R. Leist, Alexandra Schäfer, Adam S. Cockrell, Lingshu Wang, Sandhya Bangaru, Laura Stevens, Rachel L. Graham, Jacob F. Kocher, Yaroslav Tsybovsky, Masaru Kanekiyo, Azad Kumar, Kaitlyn M. Morabito, Osnat Rosen, Wei Shi, Anne Werner, Yi Zhang, Cynthia Ziwawo, Christian K.O. Dzuvor, Charis Palandjian, Connor Eastman, Hannah R. Matthews, Jeswin Joseph, James D. Chappell, Wing-Pui Kong, John R. Mascola, Andrew B. Ward, Mark R. Denison, Ralph Baric, Jason S. McLellan, Barney S. Graham, Kizzmekia S. Corbett-Helaire

“…Vaccination with MERS S-2P elicited both receptor-binding domain (RBD)- and non-RBD-specific antibodies, including N-terminal domain (NTD)-specific G2-and CDC2-A2-like antibodies. …”
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Mechanistic insights into Y-Box binding protein-1 mediated regulation of lipid metabolism and oxidative stress in NAFLD via INHBE/TNF-β pathway by Zhi Ren, Rui Wang, Jun Wei, Zhenzeng Ma, Xiquan Ke

Subjects: “…Y-box binding protein-1…”
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An allelic atlas of immunoglobulin heavy chain variable regions reveals antibody binding epitope preference resilient to SARS-CoV-2 mutation escape by Weiqi Deng, Weiqi Deng, Xuefeng Niu, Ping He, Ping He, Qihong Yan, Qihong Yan, Huan Liang, Yongping Wang, Yongping Wang, Lishan Ning, Lishan Ning, Zihan Lin, Zihan Lin, Yudi Zhang, Xinwei Zhao, Xinwei Zhao, Liqiang Feng, Linbing Qu, Ling Chen, Ling Chen

“…We observed an association between Ig alleles and antibody binding epitopes. Different allelic genotypes binding to the same RBD epitope on the spike show different neutralizing potency and breadth. …”
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Shrimp White Spot Viral Infections Are Attenuated by Organic Acids by Regulating the Expression of HO-1 Oxygenase and β-1,3-Glucan-Binding Protein by Ioan Pet, Igori Balta, Nicolae Corcionivoschi, Tiberiu Iancu, Ducu Stef, Lavinia Stef, Iuliana Cretescu

“…In vivo, in a shrimp challenge test, 2% Aq significantly downregulated the expression of proteins involved in WSSV virulence, such as the lipopolysaccharide-β-1,3-glucan-binding protein (LGBP) and the TLR signalling pathway (LvECSIT), and increased the expression of HO-1 oxygenase. …”
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Vitamin D binding protein genetic isoforms, serum vitamin D, and cancer risk in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. by Stephanie J Weinstein, Dominick Parisi, Alison M Mondul, Tracy M Layne, Jiaqi Huang, Rachael Z Stolzenberg-Solomon, Regina G Ziegler, Mark P Purdue, Wen-Yi Huang, Christian C Abnet, Neal D Freedman, Kai Yu, Demetrius Albanes

“…Associations between vitamin D biochemical status and cancer may be modified by vitamin D binding protein isoforms which are encoded by GC (group-specific component). …”
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Investigation on the Binding and Conformational Change of All-trans-Retinoic Acid with Peptidyl Prolyl cis/trans Isomerase Pin1 Using Spectroscopic and Computational Techniques by GuoFei Zhu, ShaoLi Lyu, Yang Liu, Chao Ma, Wang Wang

“…Binding and conformational change of all-trans-retinoic acid (ATRA) with peptidyl prolyl cis/trans isomerase Pin1 were investigated systematically by spectroscopic and computational techniques under experimentally optimized physiological conditions. …”
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RNA binding protein ALYREF regulates ferroptosis to facilitate LUAD growth and metastasis via promoting SLC7A11 mRNA stability by Yanni Chen, Ting Zhao, Hao Chen, Jun Chen, Weili Han

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MsCL-P1: A multifunctional C-type lectin from largemouth bass (Micropterus salmoides) with broad microbe binding and agglutination activities by Siyi She, Ying Ye, Fengyao Guo, Shun Yang, Mengmeng Huang, Hui Fei

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Intuiciones visuales para pueblos olvidados. La utilización del cine en las Misiones Pedagógicas de la Segunda República Española by María García Alonso

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