Hydroxysafflor Yellow A Inhibits LPS-Induced NLRP3 Inflammasome Activation via Binding to Xanthine Oxidase in Mouse RAW264.7 Macrophages by Xiaolong Xu, Yuhong Guo, Jingxia Zhao, Ning Wang, Junying Ding, Qingquan Liu

“…Moreover, we proved that HSYA markedly inhibited LPS-induced cleaved caspase-1 activation via suppressing the sensitization of NLRP3 inflammasome and prevented the mature IL-1β formation from pro-IL-1β form. These findings suggest that XO may be a potential target of HSYA via direct binding inhibition and the combination of HSYA-XO suppresses LPS-induced ROS generation, contributing to the depression of NLRP3 inflammasome and inhibition of IL-1β secretion in macrophages.…”
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Elevated Circulating Adipocyte-Fatty Acid Binding Protein Levels Predict Incident Ischemic Cardiovascular Events in a Longitudinal and Prospective AMI Aging Study by Zhao X, Zhao H, Chen R, Zhou J, Li N, Li J, Yan S, Liu C, Zhou P, Chen Y, Song L, Yan H

“…Xiaoxiao Zhao,1 Hanjun Zhao,1 Runzhen Chen,1 Jinying Zhou,1 Nan Li,1 Jiannan Li,1 Shaodi Yan,2 Chen Liu,1 Peng Zhou,1 Yi Chen,1 Li Song,1 Hongbing Yan2 1Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College & Chinese Academy of Medical Sciences, BeiJing, People’s Republic of China; 2Department of Cardiology, Fuwai Hospital Chinese Academy of Medical Sciences, ShenZhen, People’s Republic of ChinaCorrespondence: Hongbing Yan, Department of Cardiology, Fuwai Hospital Chinese Academy of Medical Sciences, ShenZhen, 12 Langshan Road, Shenzhen, 518000, People’s Republic of China, Tel +86-13701339287, Email hbyanfuwai2018@163.com Hanjun Zhao, Department of Cardiology, Fuwai Hospital, Chinese Academy of Medical Sciences, No. 167, Beijing, 100037, People’s Republic of China, Tel +86-15210020808, Email 15210020808@163.comBackground: The protein known as Fatty Acid-Binding Protein 4 (FABP4), predominantly found in adipocytes, macrophages, and endothelial cells, has emerged as a pivotal biomarker linking inflammation and metabolism in the context of cardiovascular diseases.Aim: The present investigation sought to elucidate the influence of FABP4 on the prognostic ramifications for patients experiencing ischemic vascular events, which encompass ischemic cerebrovascular occurrences, myocardial infarctions, and cardiovascular mortality.Methods: A total of 1102 consecutive patients diagnosed with acute myocardial infarction (AMI) and aged over 55 years were prospectively enrolled from March 2017 to January 2020. …”
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Recognition of Staphylococcus aureus by the pattern recognition molecules langerin, mannan-binding lectin, and surfactant protein D: the influence of capsular polysaccharides and wall teichoic acid by Kirstine Mejlstrup Hymøller, Kirstine Mejlstrup Hymøller, Stig Hill Christiansen, Stig Hill Christiansen, Anders Grønnegaard Schlosser, Uffe B. Skov Sørensen, Jean C. Lee, Steffen Thiel, Steffen Thiel

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Remboîtage of a Binding: Authenticity and Conservation of "Fifty-two Plates Engraved from Portraits by Van Dyck and Others, 16th - 17th Century" by Malina Belcheva

“…The present study of the album Fifty-two Plates Engraved from Portraits by Van Dyck and Others, 16th - 17th Century, includes commentaries on the conservation research, the album provenance, bibliographical information, acquisition; details of the conservation treatment: the binding, text block, and graphic works consolidation; and it underlines the conservation integration of the historical repairs through contemporary conservation materials applied for stabilization of the album condition and enhancement of the binding flexibility and solidity.…”
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RNA binding protein ILF3 increases CEP55 mRNA stability to enhance malignant potential of breast cancer cells and suppress ferroptosis by Sheng Chen, Yangyong Luo, Simin Ruan, Guosen Su, Guoxing Huang

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Fluorescence Correlation Spectroscopy in Drug Discovery: Study of Alexa532-Endothelin 1 Binding to the Endothelin ETA Receptor to Describe the Pharmacological Profile of Natural Products by Catherina Caballero-George, Thomas Sorkalla, Daniel Jakobs, Jessica Bolaños, Huzefa Raja, Carol Shearer, Eldredge Bermingham, Hanns Häberlein

“…A similar effect was observed for the fungal extract, which completely displaced Alexa532-ET1 from its binding to the “inactive” receptor state. These findings suggest that both BQ-123 and the fungal extract act as inverse agonists.…”
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Le lien entre le paysage des cinq sens (gokan no fūkei 五感の風景) et la vie quotidienne du furusato by Tanaka Naoto

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Spatial Differentiation and Influencing Factors of Second-Hand Housing Prices: A Case Study of Binhu New District, Hefei City, Anhui Province, China by Song Xu, Zhen Zhang

“…This paper studies the price characteristics of second-hand residential transactions in Binhu New District taking advantage of the hedonic price model and MGWR model and draws the following conclusions. (1) There are obvious spatial positive correlation and spatial heterogeneity in the price of second-hand housing in Binhu New District. (2) The number of bedrooms, area, age of the house, and the distance to the nearest school have small effect on the scale, so they have strong spatial heterogeneity. …”
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Protocol for odorant-binding protein 2A gene knockdown by dual siRNA transfection in a three-dimensional human epidermal equivalent model by Shinobu Nakanishi

“…Here, we present a protocol for the knockdown of the odorant-binding protein 2A (OBP2A) gene in a three-dimensional human epidermal equivalent model (3DE-model). …”
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Inhibition of inflammatory cell infiltration by antagonistic peptides that specifically bind to CCR5 via regulation of the NF-kB signaling pathway in rats with colitis by Yang-Da Song, Yi-Hang Song, Si-Xue Liu, Hua-Rong Huang, Ying-Qiang Zhong

“…Aim of the study was to further investigate the effect and mechanism of CCR5 binding peptides in rat colitis. Material and methods Experimental colitis was induced by 5% TNBS. …”
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Binding Investigation of Some Important Metal Ions Copper (I), Nickel (II), and Aluminium (III) with Bovine Serum Albumin Using Valid Spectroscopic Techniques by Hassan A. Alhazmi, Md Shamsher Alam, Mohammed Albratty, Asim Najmi, Ahmed A. Abdulhaq, Rym Hassani, Waquar Ahsan, Abdulrahman N. Qramish

“…These findings were similar to our previous findings using affinity capillary electrophoresis (ACE). …”
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Human Antibodies Can Cross Guinea Pig Placenta and Bind Its Neonatal Fc Receptor: Implications for Studying Immune Prophylaxis and Therapy during Pregnancy by Evi Budo Struble, Li Ma, Lilin Zhong, A. Lesher, Joel Beren, Pei Zhang

“…We also observe that human IgG binds to an engineered soluble variant of the guinea pig neonatal Fc receptor in vitro in a manner similar to that demonstrated for the human variant, suggesting that this transplacental transport mirrors the receptor-based mechanism seen in humans. …”
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Molecular docking reveals fibrinogen binding sites on SARS-CoV-2 spike protein: A potential mechanism for COVID-19-related coagulation by Onur Ozturk, Evren Kilinc, Batuhan Gorkem Irez, Emel Timucin

“…Coagulation disorders, particularly those leading to thromboinflammation, have been linked to severe complications in COVID-19 cases. …”
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Penggabungan Best Worst Method, Moora Dan Copeland Score Pada Sistem Pendukung Keputusan Kelompok Penentuan Penerima Bantuan Pada Dinas Sosial by Willy Bima Alfajri, Dinar Mutiara Kusumo Nugraheni, Bayu Surarso

“…Hasil perhitungan dengan metode ini dapat dijadikan sebagai acuan dalam proses pengambilan keputusan bagi Dinas Sosial, sebab ketepatan pilihan penerima bantuan sosial memiliki pengaruh langsung terhadap pencapaian tujuan perlindungan sosial.   …”
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Shrimp White Spot Viral Infections Are Attenuated by Organic Acids by Regulating the Expression of HO-1 Oxygenase and β-1,3-Glucan-Binding Protein by Ioan Pet, Igori Balta, Nicolae Corcionivoschi, Tiberiu Iancu, Ducu Stef, Lavinia Stef, Iuliana Cretescu

“…In vivo, in a shrimp challenge test, 2% Aq significantly downregulated the expression of proteins involved in WSSV virulence, such as the lipopolysaccharide-β-1,3-glucan-binding protein (LGBP) and the TLR signalling pathway (LvECSIT), and increased the expression of HO-1 oxygenase. …”
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PENINGKATAN PENDAPATAN MASYARAKAT SEKITAR HUTAN ADAT BULUH CINA DI KABUPATEN KAMPAR MELALUI POLA DIVERSIFIKASI PERKEBUANAN, TANAMAN PANGAN DAN TERNAK by LATIFA SISWATI, ANTO ARIYANTO

“… ABSTRAK Penelitian ini adalah untuk mencari pola diversifikasi optimum untuk usahatani perkebunan karet, perkebunan sawit, tanaman pangan dan ternak kepada petani yang tinggal di sekitar hutan adat Buluh Cina di Kecamatan Siak Hulu Propinsi Riau. …”
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Geografías de la mirada en el cine documental no institucional: el cuerpo o la cuestión del alejamiento (España 1951-1974) by Sonia Kerfa

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Investigating Whether Consuming Meals in a Dining Room Impacts Patients’ Mood, Level of Interaction, and Subsequent Nutrient Intake in a Stroke Rehabilitation Ward. by Sali Abouhajar, Grace Bennett, Linda Dooley, Tracy Waldron, Katie Walsh, Sile Murphy, Aoibheann McMorrow, Joseph Harbison, Suzanne L Doyle

“…All 19 patients enjoyed eating in the dining room and 14 out of the 19 patients preferred eating in the dining room. …”
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Investigation on the Binding and Conformational Change of All-trans-Retinoic Acid with Peptidyl Prolyl cis/trans Isomerase Pin1 Using Spectroscopic and Computational Techniques by GuoFei Zhu, ShaoLi Lyu, Yang Liu, Chao Ma, Wang Wang

“…Binding and conformational change of all-trans-retinoic acid (ATRA) with peptidyl prolyl cis/trans isomerase Pin1 were investigated systematically by spectroscopic and computational techniques under experimentally optimized physiological conditions. …”
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MsCL-P1: A multifunctional C-type lectin from largemouth bass (Micropterus salmoides) with broad microbe binding and agglutination activities by Siyi She, Ying Ye, Fengyao Guo, Shun Yang, Mengmeng Huang, Hui Fei

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