Protection against Mitochondrial and Metal Toxicity Depends on Functional Lipid Binding Sites in ATP13A2 by Shaun Martin, Sarah van Veen, Tine Holemans, Seyma Demirsoy, Chris van den Haute, Veerle Baekelandt, Patrizia Agostinis, Jan Eggermont, Peter Vangheluwe

“…Here, we analyzed stable human SHSY5Y cell lines overexpressing wild-type (WT) or ATP13A2 mutants in which three N-terminal lipid binding sites (LBS1–3) were mutated. …”
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EFFECT OF COMPLIANCE COST AND TAX BURDEN ON TAX COMPLIANCE OF SMALL AND MEDIUM-SCALE ENTERPRISES IN BENUE STATE, NIGERIA by Okpe Caleb John, Aliyu Nuraddeen Shehu, Bello A. Ahmad, Ahmed Aliyu Abdullahi, Mohammed Musa Abdulkarim

“… Tax compliance is critical for small and medium-scale enterprises (SMEs) in Benue State, Nigeria, significantly affecting their growth and sustainability. …”
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SURVIVING HUMANITARIAN CRISIS IN NIGERIA: COPING STRATEGIES OF INTERNALLY DISPLACED PERSONS (IDP) IN BENUE STATE, NORTHCENTRAL, NIGERIA by ISAAC OLAWALE ALBERT, JOEL ABAH

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Parametric Yield-Driven Resource Binding in High-Level Synthesis with Multi-Vth/Vdd Library and Device Sizing by Yibo Chen, Yu Wang, Yuan Xie, Andres Takach

“…During the resource binding process, voltage level converters are inserted between resources when required. …”
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Biogenic Waste from Two Varieties of Plantain in Ghana Contain Pectin with Potential Binding Properties in Conventional Tablets by Desmond Asamoah Bruce Otu, Frederick William Akuffo Owusu, Mariam El Boakye-Gyasi, Raphael Johnson, Prince George Jnr Acquah, Yayra Edzor-Agbo, Marcel Tunkumgnen Bayor, Mary-Ann Archer

“…It has found widespread use in the pharmaceutical sector, particularly as a binding agent in tablet formulations. This study aimed to evaluate pectin from two popular plantain varieties, Apem (M) and Apantu (T) at different ripening stages, for pharmaceutical use as a binding agent in immediate-release tablets. …”
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In-Silico Evaluation of Binding Interaction and ADME Properties of Novel Pyrazoline and Pyrimidine Derivatives Targeting Cyclooxygenase-2 Enzyme by Sarmad Abbas Fadhil, Karima Fadhil Ali, Wesen Adel Mehde

“…Through in-silico methods, the binding affinity of these derivatives to the COX-2 receptor was predicted using computer simulations and compared with the reference drug, meloxicam. …”
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Dual modality feature fused neural network integrating binding site information for drug target affinity prediction by Haohuai He, Guanxing Chen, Zhenchao Tang, Calvin Yu-Chian Chen

“…The model introduces a binding site-focused graph construction approach to extract binding information, enabling more balanced and efficient modeling of drug-target interactions. …”
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Binge Eating Disorder Mediates Links between Symptoms of Depression, Anxiety, and Caloric Intake in Overweight and Obese Women by Roseann E. Peterson, Shawn J. Latendresse, Lindsay T. Bartholome, Cortney S. Warren, Nancy C. Raymond

“…Despite considerable comorbidity between mood disorders, binge eating disorder (BED), and obesity, the underlying mechanisms remain unresolved. …”
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Human epididymis protein 4-annexin II binding promotes aberrant epithelial-fibroblast crosstalk in pulmonary fibrosis by Weishuai Zheng, Menglin Zou, Xingxing Hu, Han Gao, Weiwei Song, Qinhui Hou, Yuan Liu, Zhenshun Cheng

“…The HE4 and ANXA2 binding site is located after the 30th amino acid at the N terminus of the HE4 molecule. …”
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Hoe Christenonderwysers ’n bydrae kan maak tot die morele herstel binne Suid-Afrikaanse Skole by Ruan Lambrechts

“…The argument is that Christian educators can influence the younger generation to embrace better moral values through their lifestyle. Since many teachers lack the confidence to live out a Christian lifestyle within South African schools due to the challenges posed by legislation and the societal dynamics of the South African youth, this article delves into these issues. …”
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Mannose-Binding Lectin Promoter Polymorphisms and Gene Variants in Pulmonary Tuberculosis Patients from Cantabria (Northern Spain) by J.-Gonzalo Ocejo-Vinyals, Lucía Lavín-Alconero, Pablo Sánchez-Velasco, M.-Ángeles Guerrero-Alonso, Fernando Ausín, M.-Carmen Fariñas, Francisco Leyva-Cobián

“…Mannose-binding lectin is a central molecule of the innate immune system. …”
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A nociceptor-specific RNAi screen in Drosophila larvae identifies RNA-binding proteins that regulate thermal nociception by Amber Dyson, Gita Gajjar, Katherine C. Hoffman, Dakota Lewis, Sara Palega, Erik Rangel Silva, James Auwn, Andrew Bellemer

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Invasion of pancreatic ductal epithelial cells by Enterococcus faecalis is mediated by fibronectin and enterococcal fibronectin-binding protein A by Munefumi Shimosaka, Jumpei Kondo, Mamika Sonoda, Rui Kawaguchi, Emika Noda, Kaho Nishikori, Asuka Ogata, Shinji Takamatsu, Ken Sasai, Hirofumi Akita, Hidetoshi Eguchi, Yoshihiro Kamada, Shigefumi Okamoto, Eiji Miyoshi

“…Mechanistically, bacterial expression of enterococcal fibronectin-binding protein A (EfbA) was correlated with adhesive potential of E. faecalis strains. …”
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Binge-like sucrose consumption reduces the dendritic length and complexity of principal neurons in the adolescent rat basolateral amygdala. by Masroor Shariff, Paul Klenowski, Michael Morgan, Omkar Patkar, Erica Mu, Mark Bellingham, Arnauld Belmer, Selena E Bartlett

“…Additionally, we found that long-term binge-like sucrose consumption caused a significant reduction in the length and complexity of apical dendrites. …”
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Study of Erythrocyte Indices, Erythrocyte Morphometric Indicators, and Oxygen-Binding Properties of Hemoglobin Hematoporphyrin Patients with Cardiovascular Diseases by Victor V. Revin, Antonina A. Ushakova, Natalia V. Gromova, Larisa A. Balykova, Elvira S. Revina, Vera V. Stolyarova, Tatiana A. Stolbova, Ilya N. Solomadin, Alexander Yu. Tychkov, Nadezhda V. Revina, Oksana G. Imarova

“…The current study investigates the functional state of erythrocytes and indices of the oxygen-binding capacity of hemoglobin in blood samples from healthy donors and from patients with coronary artery disease and myocardial infarction before and after treatment. …”
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Binding affinity screening of polyphenolic compounds in Stachys affinis extract (SAE) for their potential antioxidant and anti-inflammatory effects by Hun Hwan Kim, Se Hyo Jeong, Min Yeong Park, Pritam Bhangwan Bhosale, Abuyaseer Abusaliya, Sang Joon Lee, Jeong Doo Heo, Hyun Wook Kim, Je Kyung Seong, Dong Il Kim, Kwang Il Park, Gon Sup Kim

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HA198 mutations in H9N2 avian influenza: molecular dynamics insights into receptor binding by Rui Zhu, Rui Zhu, Rui Zhu, Jie Wu, Ruiying Chen, Mo Zhou, Mo Zhou, Mo Zhou, Shinuo Cao, Shinuo Cao, Shinuo Cao, Zhi Wu, Zhi Wu, Zhi Wu, Ligang Wang, Lei Zhang, Shanyuan Zhu, Shanyuan Zhu, Shanyuan Zhu

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A novel label-free method to determine equilibrium dissociation constants of antibodies binding to cell surface proteins by Eilyn R. Lacy, Rupesh Nanjunda, Scott L. Klakamp, Deborah Kwok, Jennifer F. Nemeth, Gordon D. Powers, H. Hugo Caicedo, Steven A. Jacobs

“…This report describes a novel electrochemiluminescence-based method, called MSD-CAT, for the affinity analysis of antibodies binding to cell-surface receptors. MSD-CAT was used to evaluate the binding of monoclonal antibodies, Fab fragments, and bispecific antibodies targeting the cell-surface receptor interleukin 3 receptor alpha (CD123) and the results were compared to data obtained using surface plasmon resonance (SPR). …”
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Biparatopic binding of ISB 1442 to CD38 in trans enables increased cell antibody density and increased avidity by Jeremy Loyau, Thierry Monney, Marco Montefiori, Fedir Bokhovchuk, Jeremy Streuli, Matthew Blackburn, Arnaud Goepfert, Lydia N. Caro, Samitabh Chakraborti, Stefania De Angelis, Camille Grandclément, Stanislas Blein, M. Lamine Mbow, Ankita Srivastava, Mario Perro, Stefano Sammicheli, Eugene A. Zhukovsky, Michael Dyson, Cyrille Dreyfus

“…The predicted antibody-antigen stoichiometries at different CD38 surface densities were experimentally validated by surface plasmon resonance and cell binding assays. The specific design and structural features of ISB 1442 enable: 1) enhanced trans binding to adjacent CD38 molecules to increase Fc density at the cancer cell surface; 2) prevention of avid cis binding to monomeric CD38 to minimize blockade by soluble shed CD38; and 3) greater binding avidity, with a slower off-rate at high CD38 density, for increased specificity. …”
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Low Levels of Sex Hormone-Binding Globulin Constitute an Independent Risk Factor for Arterial Stiffness in Korean Women by Kunhee Han, Hyejin Chun, Moon-Jong Kim, Doo-Yeoun Cho, Soo-Hyun Lee, Bo Youn Won, Kwang-Min Kim, Nam-Seok Joo, Young-Sang Kim

“…The association between sex hormone-binding globulin (SHBG) and arterial stiffness in women is not conclusive. …”
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