Structural modeling of NAD+ binding modes to PARP-1 by N. V. Ivanisenko, D. A. Zhechev, V. A. Ivanisenko

“…The structure of complex of human poly (ADP-ribose) polymerase-1 with NAD+ can be a starting point for rational design of small molecule inhibitors based on NAD+ derivatives. …”
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<i>Klebsiella pneumoniae</i> Phage M198 and Its Therapeutic Potential by Lika Leshkasheli, Ia Kusradze, Darejan Bolkvadze, Lia Askilashvili, Maria Chichashvili, Giorgi Tsertsvadze, Elisabed Zaldastanishvili

“…The rapid worldwide spread of antibiotic resistance is quickly becoming an increasingly concerning problem for human healthcare. Non-antibiotic antibacterial agents are in high demand for many Gram-negative bacterial pathogens, including <i>Klebsiella pneumoniae</i>. …”
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Theoretical Study of Sphingomyelinases from <i>Entamoeba histolytica</i> and <i>Trichomonas vaginalis</i> Sheds Light on the Evolution of Enzymes Needed for Survival and Colonizati... by Fátima Berenice Ramírez-Montiel, Sairy Yarely Andrade-Guillen, Ana Laura Medina-Nieto, Ángeles Rangel-Serrano, José A. Martínez-Álvarez, Javier de la Mora, Naurú Idalia Vargas-Maya, Claudia Leticia Mendoza-Macías, Felipe Padilla-Vaca, Bernardo Franco

“…Our group has shown that the parasitic protist <i>Entamoeba histolytica</i> encodes for 14 sphingomyelinases (SMases); one of them (acid sphingomyelinase 6, aSMase6) is involved in repairing membrane damage and exhibits hemolytic activity. The enzymatic characterization of aSMase6 has been shown to be activated by magnesium ions but not by zinc, as shown for the human aSMase, and is strongly inhibited by cobalt. …”
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Ekoterroryzm zagrożeniem dla polityki zrównoważonego rozwoju. Aspekt ideologiczny i praktyczny by Mariusz Ciszek

“…The ideology of some ecological radicals’ formations, their methods of working ( the practical aspect) show, however, that in fact such seen the comprehended development of human civilizations is with their point of sight too moderated and not to accept. …”
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ANTHROPOLOGICAL ASPECTS OF HIGH-TECH FACILITIES OP-ERATION SUPPORT by Olexandr O. Matusevych, Olecsii O. Matusevich

“…The authors highlighted proposals for psychocorrective work among the personnel of the facilities. The problem of further development of continuous improvement of the equipment maintenance systems, based on integrated approach taking into account the human factor, is also not overlooked. …”
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Self-Assembled Peptide Hydrogels PPI45 and PPI47: Novel Drug Candidates for <i>Staphylococcus aureus</i> Infection Treatment by Quanlong Wu, Mengyin Deng, Ruoyu Mao, Na Yang, Ya Hao, Manli Cao, Da Teng, Jianhua Wang

“…In vitro safety assessments indicated minimal hemolytic activity on murine red blood cells and low cytotoxicity on human immortalized epidermal cells (HaCaT). …”
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Genetic diversity of VIR Raphanus sativus L. collections on aluminum tolerance by A. B. Kurina, I. A. Kosareva, A. M. Artemyeva

“…Radish and small radish (Raphanus sativus L.) are popular and widely cultivated root vegetables in the world, which occupy an important place in human nutrition. Edaphic stressors have a significant impact on their productivity and quality. …”
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Improvement in XIa Selectivity of Snake Venom Peptide Analogue BF9-N17K Using P2′ Amino Acid Replacements by Li Ding, Zhiping Zhai, Tianxiang Qin, Yuexi Lin, Zhicheng Shuang, Fang Sun, Chenhu Qin, Hongyi Luo, Wen Zhu, Xiangdong Ye, Zongyun Chen, Xudong Luo

“…With the snake venom Kunitz-type peptide BF9 as the scaffold, we obtained a highly active XIa inhibitor BF9-N17K in our previous work, but it also inhibited the hemostatic target plasmin. …”
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Exploring the relationship between Total Athleticism score and CrossFit® Open Performance in amateur athletes: single measure involving body fat percentage, aerobic capacity, muscl... by Ramires Alsamir Tibana, Fábio Hech Dominski, Alexandro Andrade, Nuno Manuel Frade de Sousa, Fabricio Azevedo Voltarelli, Ivo Vieira de Sousa Neto

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GPIHBP1 increase accounts for rheumatic arthritis-related hypotriglyceridemia by facilitating lipids uptake of white adipose tissues by Meng-Ke Song, Meng-Fan Gu, Ling Liu, Lian-Jun He, Peng Ye, Kui Yang, Dan-Dan Wang, Opeyemi Joshua Olatunji, Qin Yin, Jian Zuo

“…Abstract Background Metabolism alteration is a common complication of rheumatic arthritis (RA). This work investigated the reason behind RA-caused triglyceride (TG) changes. …”
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Study on current climate change issues and response strategies by Li Jiayu, Tao Chongshuo, Zhang Yixian

“…Today, human activities are generating massive emissions of greenhouse gases, intensifying the issue of global climate change. …”
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An unconstrained four pool model analysis of proton relaxation and magnetization transfer in ex vivo white matter by Niklas Wallstein, André Pampel, Roland Müller, Carsten Jäger, Markus Morawski, Harald E. Möller

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Presenting the professional thinking model of employees based on the dimensions of ambivalence and psychological empowermen by Abdolmajid Kord, Mansur Garkaz, Alireza Maetoofi, Ali khuzin, Alireza Hasan Maleki

“…Economic enterprises are formed with the aim of earning and profiting and continue their activities. Audit institutions also need income to continue their activity. …”
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The Mitochondria-Targeted Antioxidant SkQ1 Downregulates Aryl Hydrocarbon Receptor-Dependent Genes in the Retina of OXYS Rats with AMD-Like Retinopathy by M. L. Perepechaeva, A. Yu. Grishanova, E. A. Rudnitskaya, N. G. Kolosova

“…It has been shown that SkQ1 reduces clinical signs of retinopathy in senescence-accelerated OXYS rats, which are a known animal model of human age-related macular degeneration (AMD). The aim of this work was to test whether SkQ1 affects transcriptional activity of AhR (aryl hydrocarbon receptor) and Nrf2 (nuclear factor erythroid 2-related factor 2), which are considered as AMD-associated genes in the retina of OXYS and Wistar rats. …”
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Theoretical approaches to improving the terminological apparatus of psychodiagnostic research in the system of the Ministry of Internal Affairs of Ukraine by V. I. Barko, V. V. Barko, O. O. Yevdokimova

“…It is proposed to understand individual (individual psychological) properties as generalised characteristics of temperament, character, abilities, orientation, i.e. stable mental phenomena which influence human activity, characterise a personality from the psychological and social aspects and are implemented in society. …”
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Investigating the intrinsic top-down dynamics of deep generative models by Lorenzo Tausani, Alberto Testolin, Marco Zorzi

“…This capability can be linked to current theories in computational neuroscience, which propose that spontaneous brain activity at rest is the manifestation of top-down dynamics of generative models detached from action-perception cycles. …”
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Specific Immune Responses and Oncolytic Effects Induced by EBV LMP2A-Armed Modified Ankara-Vaccinia Virus Vectored Vaccines in Nasopharyngeal Cancer by Liying Sun, Chao Liu, Junping Peng

“…Conclusions: Thus, the MVA-LMP2A recombinant virus effectively induces strong LMP2A-specific cellular and humoral immune responses and anti-tumor activity. This work provides a promising therapeutic strategy for developing NPC candidate vaccines, as well as a reference for the treatment of EBV LMP2-associated malignancies.…”
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The STELLA Robotic Observatory on Tenerife by Klaus G. Strassmeier, Thomas Granzer, Michael Weber, Manfred Woche, Emil Popow, Arto Järvinen, Janos Bartus, Svend-Marian Bauer, Frank Dionies, Thomas Fechner, Wilbert Bittner, Jens Paschke

“…Not only that the telescopes are automated, but the entire observatory operates like a robot, and does not require any human presence on site.…”
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Placental ischemia during pregnancy induces hypertension, cerebral inflammation, and oxidative stress in dams postpartum by Savanna Smith, Jonna Smith, Kylie Jones, Angie Castillo, Natalia Wiemann, Ahfiya Howard, Mark Cunningham

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Bioactive compounds in the aboveground part of hemiephemeroid onions (Allium L.) by T. I. Fomina, T. A. Kukushkina

“…Representatives of the genus Allium L. are valuable food and medicinal plants that have long been used for nutrition and human health. Modern research has proved their high biological activity. …”
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