In-silico screening and analysis of missense SNPs in human CYP3A4/5 affecting drug-enzyme interactions of FDA-approved COVID-19 antiviral drugs by Amro A. Abdelazim, Mohamad Maged, Ahmed I. Abdelmaksoud, Sameh E. Hassanein

“…Abstract Single nucleotide polymorphisms (SNPs) represent the prevailing form of genetic variations observed in the human population. Such variations could alter the encoded enzymes’ activities. …”
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Dismissing class by Cotal San Martin Vladimir

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Acefylline Derivatives as a New Class of Anticancer Agents: Synthesis, Molecular Docking, and Anticancer, Hemolytic, and Thrombolytic Activities of Acefylline-Triazole Hybrids by Irum Shahzadi, Ameer Fawad Zahoor, Bushra Parveen, Azhar Rasul, Zohaib Raza, Sajjad Ahmad, Ali Irfan, Gamal A. El-Hiti

“…The synthesized acefyllines demonstrated moderate activity (cell viability = 22.55 ± 0.95% − 57.63 ± 3.65%) compared with the starting drug acefylline (cell viability = 80 ± 3.87%) against the human liver carcinoma (Hep G2 cell line). …”
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Establishing Personalized and Sparse Spinal Reflex Circuitry From Locomotion Data by Huawei Wang, Arvid Q. L. Keemink, Massimo Sartori

“…This may limit the generalizing capabilities of such circuits and prevent a better understanding of the dominant reflex loops in human locomotion. In this work we propose an identification framework that can identify personalized sparse-structure reflex circuitry directly from experimental data. …”
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Optogenetic Inhibition of Striatal Neuronal Activity Improves the Survival of Transplanted Neural Stem Cells and Neurological Outcomes after Ischemic Stroke in Mice by Yifan Lu, Lu Jiang, Wanlu Li, Meijie Qu, Yaying Song, Xiaosong He, Zhijun Zhang, Guo-Yuan Yang, Yongting Wang

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Heart Rate Variability: A Psychophysiological Factor Related to Both Regular Physical Activity and Eudaimonic Well‐Being Among Young Adults by Yoshino Murakami, Daisuke Goto, Hayato Tsukamoto, Kazuho Yamaura, Takeshi Hashimoto

“…ABSTRACT Introduction Eudaimonic well‐being (EWB), which refers to optimal human functioning, is associated with psychophysiological outcomes, such as reduced inflammation and a lower risk of depression. …”
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«Which of You Is Ready to Take a Leap to the Emptiness Today»? by Yu. A. Lukin

“…The further discussion of M.V.  Lomonosov’s life and work became the statement of the system-forming role  of the motivational component in the structure of any kind of human activity  (including educational). …”
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Decoding Subjective Understanding: Using Biometric Signals to Classify Phases of Understanding by Milan Lazic, Earl Woodruff, Jenny Jun

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Workplace envy through the lens of leader–member exchange: evidence from higher educational institutions by Sunali Bindra, Bhumika Achhnani, Netra Neelam

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Discharge Estimation for an Ungauged Inland River in an Arid Area Related to Anthropogenic Activities: A Case Study of Heihe River Basin, Northwestern China by Shuang Liu, Zhenghui Xie, Yujin Zeng

“…In the arid areas, the discharge in some reaches is unsurveyed, which makes related works trapped. It is important to estimate a long-term discharge in an ungauged river using available fragmentary data including those on human activities. …”
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The features of Tat protein of human immunodeficiency virus type 1 (Retroviridae: <i>Lentivirus: Lentivirus humimdef1</i>) non-A6 variants, characteristic for the Russian Federatio... by Anna I. Kuznetsova, Anastasiia A. Antonova, Aleksey V. Lebedev, Ekaterina N. Ozhmegova, Anastasia V. Shlykova, Ilya A. Lapovok, Oxana V. Galzitskaya

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The Bioethics-CSR Divide by Caio Caesar Dib

“…There are three main responsibilities that fall under bioethics: (i) activism in biopolicy, through the engagement in the creation of laws, jurisprudence, and public policies; (ii) the exercise of bioethics expertise, be it through the specialized knowledge in philosophical thought, its ability to juggle multiple languages related to various disciplines related to bioethics, or its capacity to combat and avoid misinformation and epistemic distortion; (iii) and, intellectual exchange, by exercising awareness that it is necessary to work with specialists from different backgrounds to achieve its goals.[34] All of those suggest the need for bioethics to improve its dialogue with CSR and business and human rights. …”
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Acute stimulation of PBMCs drives switch from dopamine-induced anti- to proinflammatory phenotype of monocytes only in women by Leonie Fleige, Silvia Capellino

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Démarche qualité en primatologie by Jean-Marie Héliès

“…Specifically, institutions providing livestock for the study of non-human primates can find an interest in setting up a quality system to optimise their activities without necessarily attempting to apply for a certification. …”
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Multiple sclerosis and neuropsychiatric disorders during the COVID-19 pandemic. Literature review by K. Brasas, V. Lileikytė, D. Mickevičienė

“…However, a decrease in human contact and visits to doctors has led to another problem in patients with chronic diseases, especially those with multiple sclerosis, such as worsening of neuropsychological status, depression, increased stress levels, insomnia, and decreased physical activity. …”
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Tumour Cell Lines HT-29 and FaDu Produce Proinflammatory Cytokines and Activate Neutrophils In Vitro: Possible Applications for Neutrophil-Based Antitumour Treatment by Antonio Brú, Juan-Carlos Souto, Sonia Alcolea, Rosa Antón, Angel Remacha, Mercedes Camacho, Marta Soler, Isabel Brú, Amelia Porres, Luis Vila

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Common features of environmentally and socially engaged community programs addressing the intersecting challenges of planetary and human health: mixed methods analysis of survey an... by Linda J. M. Thomson, Linda J. M. Thomson, Ailsa Critten, Victoria Hume, Helen J. Chatterjee, Helen J. Chatterjee

“…Two of the 10 subthemes: ‘Connection to nature in children’ and ‘Relationship with natural world’ within the major theme: ‘Connection to nature’ addressed planetary and human health directly through practices recognizing environmental and human interdependency. …”
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Biological properties of Moringa oleifera: A systematic review of the last decade [version 2; peer review: 2 approved, 1 approved with reservations] by Andrea Catalina Gómez, Javier Andrés Soto, C. A. Zuniga-Gonzalez, Karen Shirley Molina, Andrea Natalia Barreto, Maryeli Vásquez

“…Moringa oleifera is a plant well known for the properties of its phytocomponents and its role has been analyzed in a variety of fields, from medicine to biotechnology. Methods In this work, the biological activity of Moringa oleifera in human health was explored through a review of 129 original articles published between 2010 and 2021 related to antitumor activity and its potential uses against chronic and infectious diseases. …”
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Biological properties of Moringa oleifera: A systematic review of the last decade [version 1; peer review: 2 approved, 1 approved with reservations] by Andrea Catalina Gómez, Javier Andrés Soto, C. A. Zuniga-Gonzalez, Karen Shirley Molina, Andrea Natalia Barreto, Maryeli Vásquez

“…Moringa oleifera is a plant well known for the properties of its phytocomponents and its role has been analyzed in a variety of fields, from medicine to biotechnology. Methods In this work, the biological activity of Moringa oleifera in human health was explored through a review of 129 original articles published between 2010 and 2021 related to antitumor activity and its potential uses against chronic and infectious diseases. …”
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Specificity of psychological readiness for changes and psychological resilience in the employees of the State Criminal-Executive Service of Ukraine by O. V. Mitroshkina

“…The work focuses on the study of psychological readiness for change and psychological resilience among employees of the State Criminal-Executive Service of Ukraine. …”
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