Hyperinsulinemia Induced Altered Insulin Signaling Pathway in Muscle of High Fat- and Carbohydrate-Fed Rats: Effect of Exercise by Anu Joseph, S. Parvathy, Koyikkal Karthikeya Varma

“…The present work investigates the molecular mechanisms of high carbohydrate and fat diet in inducing prediabetic hyperinsulinemia and effect of exercise on InsR signaling events, muscular AChE, and lactate dehydrogenase activity. Adult male Wistar rats were divided into the control (C) diet group, high-carbohydrate diet (HCD) group, high-fat diet (HFD) group, and HCD and HFD groups with exercise (HCD Ex and HFD Ex, respectively). …”
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Impact of Varicocele on The Expression of Testicular Enzymes Involved in The Transsulfuration Pathway by Azam Shiasi, Marziyeh Tavalaee, Ramesh Monajemi, Dattilo M, Mohammad Hossein Nasr-Esfahani

“…We aimed to investigate the underlying mechanisms.Therefore, the expression of the main enzyme proteins involved in the generation of endogenous antioxidant power,cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), heme oxygenase (HO-1), and also, some ofthe metabolites (methionine, homocysteine, taurine and vitamin B6) reporting on their activity was investigatedusing a surgical varicocele model in rats.Materials and Methods: In this experimental study, thirty male Wistar rats (7-8 weeks old, weighing 180-220 g)were divided into three groups: control, sham, and varicocele. …”
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Stem Cells and Platelet-Rich Plasma Enhance the Healing Process of Tendinitis in Mice by Rosangela Alquieri Fedato, Júlio César Francisco, Gabriel Sliva, Lúcia de Noronha, Márcia Olandoski, Jose Rocha Faria Neto, Priscila Elias Ferreira, Rossana Baggio Simeoni, Eltyeb Abdelwahid, Katherine Athayde Teixeira de Carvalho, Luiz César Guarita-Souza

“…Methods. Fourty-one male Wistar rats received collagenase injections into their bilateral Achilles tendons (collagenase-induced tendinopathy model). …”
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Effect of cubebin against streptozotocin-induced diabetic nephropathy rats via inhibition TNF-α/NF-κB/TGF-β: in vivo and in silico study by Rahamat Unissa Syed, Sivakumar S. Moni, Weiam Hussein, Taghreed Mohammad Saad Alhaidan, Sondos Mohammed Y. Abumilha, Lama Khalid Alnahdi, Ling Shing Wong, Vetriselvan Subramaniyan, Vinoth Kumarasamy

“…DN is a well-identified complication of diabetes mellitus (DM) characterized by renal hypertrophy that progressively declines kidney function. Wistar rats were randomly divided into groups- normal, STZ control (65 mg/kg/body weight), and STZ + cubebin (10 and 20 mg/kg). …”
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Malondialdehyde and carbonyl levels in skeletal muscle tissues after intermittent hypobaric hypoxia exposures by Syarifah Dewi, Alexander Rafael Satyadharma, Albertus Raditya Danendra, Wardaya

“…Methods: Twenty-five Wistar rats were allocated into five groups, including one control group and four hypoxic groups (I-IV). …”
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Metformin and Probiotics Interplay in Amelioration of Ethanol-Induced Oxidative Stress and Inflammatory Response in an In Vitro and In Vivo Model of Hepatic Injury by Farhin Patel, Kirti Parwani, Dhara Patel, Palash Mandal

“…Human HepG2 cells and male Wistar rats were exposed to ethanol and simultaneously treated with probiotic V or Met alone as well as in combination. …”
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Histological Structure of Spleen White Rat (Rattus norvegicus L.) After Induced of Nanochitosan Preparation of Neem Leaf (Azadirachta indica A. Juss) Ethanol Extract by Putri Lestari Ningtias, Teguh Suprihatih, Agung Janika Sitasiwi

“…The purpose of this study was to analyze the effect of induced of a nanochitosan ethanol extract of neem leaves on the histological structure of the spleen tissue of female Wistar white rats. This study used a randomized design (CRD) which was divided into 3 treatment groups with 4 repetitions. …”
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Application of stem cells alone and in combination with low-level laser therapy for sciatic nerve repair in rats by Mohsen Shalalvand, Hamidreza Mahaseni Aghdam, Ahmad Asghari, Siamak Nehzat, Fatemeh Shahsavari, Rojin Ardalani

“…In this animal study, the right sciatic nerve of 30 male Wistar rats, each weighing 250–300 g, was surgically excised to a length of 8 mm. …”
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Modulation of Blood Coagulation and Hematological Parameters by Crassocephalum crepidioides Leaf Methanol Extract and Fractions in STZ-Induced Diabetes in the Rat by Opeyemi O. Ayodele, Funmilayo D. Onajobi, Omolaja R. Osoniyi

“…This study investigated the effects of C. crepidioides leaf methanol extract and fractions on blood coagulation profile of diabetic Wistar rats. The effect of 100 mg/kg body weight of the methanol extract and partitioned fractions of C. crepidioides on blood coagulation profile of STZ-induced diabetic rats were initially evaluated, while graded concentrations (50–200 mg/kg body weight) of the aqueous and hexane fractions were further tested in diabetic rats against standard drugs aspirin (anticoagulant) and metformin (antidiabetic). …”
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The Effect of Varied Time Interval and Micro-Current (Direct) on the Level of Biomarker (IL-6) and Rate of Tooth Movement: An Animal Study by Parnita Dwivedi, Ashish Agrawal, Subash Chandra Gupta, Tehmin Chou

“…Material and Method: 20 female Wistar rats (Rattus norvegicus) were randomly selected and divided into control (group 1–4 rats) with orthodontic appliance (OA) and experimental groups (OA + Micro-current (MC). …”
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SOURCES OF PRODUCTION OF REACTIVE OXYGEN AND NITROGEN SPECIES IN TISSUES OF PERIODONTIUM AND SALIVARY GLANDS OF RATS UNDER MODELED SYSTEMIC INFLAMMATION by A.M. Yelins’ka, O.O. Shvaykovs’ka, V.O. Kostenko

“…The study was carried out on 20 white male rats of the Wistar line weighing 180-220 g, divided into 2 groups: the 1st included intact animals, the 2nd was made up of the animals with induced systemic inflammation. …”
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Assessment of the Effects of Chemotherapy on Ovarian Reserve in Rats by Ahmet Mete Ergenoğlu, Özgür Yeniel, Volkan Turan, Gülşah Demirtaş, Levent Akman, Mustafa Coşan Terek, Gülinnaz Ercan, Osman Zekioğlu

“…STUDY DESIGN: Thirty Wistar rats were divided into three groups. Cisplatin was administered at a dose of 5 mg/kg (Cisplatin group, n=10), cyclophosphamide was administered at a dose of 6 mg/kg (Cyclophosphamide group, n=10) and control group was only given sterile saline (Control group, n=10) in Ege University Faculty of Medicine. …”
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Black Chokeberry (<i>Aronia melanocarpa</i>) Juice Supplementation Affects Age-Related Myocardial Remodeling in Rats by Elena Daskalova, Mina Pencheva, Slavi Delchev, Lyudmila Vladimirova-Kitova, Spas Kitov, Stoyan Markov, David Baruh, Petko Denev

“…Methods: Healthy male Wistar rats (n = 24) were divided into three groups: (1) young controls (CY)—age 2 months; (2) old controls (CO)—age 27 months; (3) AMJ group—27-month-old animals, supplemented with <i>Aronia melanocarpa</i> juice (AMJ) at a dose of 10 mL∙kg⁻¹ for 105 days. …”
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Metformin reverts aortic calcifications and elastin loss induced by an experimental metabolic syndrome by Lucas Streckwall, Nancy Martini, Claudia Sedlinsky, León Schurman, María Virginia Gangoiti, Antonio Desmond McCarthy

“…Here, we evaluate the in vivo efficacy of oral MET to reduce AC in a model of MetS. Twenty young male Wistar rats were divided into two groups: one received water and the other received water plus 20% fructose to induce MetS. …”
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Growth of the prefrontal cortical glioblastoma altered cognitive and emotional behaviors via mediating miRNAs and GABA-A receptor signaling pathways in rats by Sepide Nateghi, Ameneh Rezayof, Fatemeh Kouhkan, Ladan Delphi, Yavar Bagheri Davisaraei, Fatemeh Rostami, Fatemeh Tirgar, Houri Sepehri

“…The implantation of C6 cells into the mPFC induced GBM in this brain region (referred to as the mPFC-GBM) in male Wistar rats via stereotaxic surgery, as confirmed by Magnetic Resonance Imaging (MRI), and Hematoxylin and Eosin (H&E) staining. …”
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New Paradigm in Cell Therapy Using Sperm Head to Restore Brain Function and Structure in Animal Model of Alzheimer’s Disease: Support for Boosting Constructive Inflammation vs. Ant... by Nafiseh Pakravan, Ardeshir Abbasi, Zuhair Mohammad Hassan

“…To do so, SVF, sperm, or sperm head (from Wistar rat) was administered via intra-cerebro-ventricular route to Sprague Dawley rat AD model. …”
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Clerodendrum volubile Ethanol Leaf Extract: A Potential Antidote to Doxorubicin-Induced Cardiotoxicity in Rats by Olufunke Esan Olorundare, Adejuwon Adewale Adeneye, Akinyele Olubiyi Akinsola, Daniel Ayodele Sanni, Mamoru Koketsu, Hasan Mukhtar

“…Thus, cardioprotective potential and mechanism(s) of CVE in DOX-induced cardiotoxicity were investigated using cardiac and oxidative stress markers and histopathological endpoints. 50–400 mg/kg/day CVE in 5% DMSO in distilled water were investigated in Wistar rats intraperitoneally injected with 2.5 mg/kg DOX on alternate days for 14 days, using serum troponin I and LDH, complete lipid profile, cardiac tissue oxidative stress marker assays, and histopathological examination of DOX-treated cardiac tissue. …”
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Toxicological Characterization of Six Plants of the Beninese Pharmacopoeia Used in the Treatment of Salmonellosis by Boris Legba, Victorien Dougnon, Esther Deguenon, Jerrold Agbankpe, Maximin Senou, Alidah Aniambossou, Carène Gbaguidi, Kevin Sintondji, Lamine Baba-Moussa, Jacques Dougnon

“…The acute toxicity of aqueous and ethanolic extracts of Psidium guajava, Vernonia amygdalina, Cajanus cajan, Phyllanthus amarus, Uvaria chamae, and Lantana camara was evaluated according to OECD Guideline 423 at a single dose of 2000 mg/kg body weight on Wistar rats. Histological sections were performed on the liver and kidneys to confirm hematological and biochemical data. …”
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THE EFFECTIVENESS OF ZINC AND RISEDRONATE ON BONE TURNOVER IN RAT MODEL OF OSTEOPOROSIS ASSESSED WITH THE EXPRESSION OF β-CROSSLAPS by Adam Fajar, Mohammad Rizal Chaidir, Dicky Mulyadi, Ahmad Ramdan, Yoyos Dias Ismiarto

“…Methods: This research is conducted as experimental comparative method used 25 female Galur Wistar rat that divided into Non-ovariectomy and Ovariectomy group to induce osteoporosis. …”
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Effect of vasopressin on the expression of genes for key enzymes of interstitial hyaluronan turnover and concentration ability in WAG rat kidneys by L. N. Ivanova, A. V. Babina, G. S. Baturina, L. E. Katkova

“…The expression of the genes encoding hyaluronan synthase-2 (Has2) and hyaluronidase-1, 2 (Hyal1, Hyal2) in the kidneys of Wistar Albino Glaxo (WAG) was studied. Has2 mRNA content was the highest in the kidney papilla of the hydrated rats. …”
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