Intrapericardial injection of hydrogels with ASC and their secretome to treat dilated cardiomyopathies by Tácia Tavares Aquinas Liguori, Gabriel Romero Liguori, Viktor Sinkunas, Cristiano Jesus Correia, Raphael dos Santos Coutinho e Silva, Fernando Luiz Zanoni, Vera Demarchi Aiello, Martin Conrad Harmsen, Luiz Felipe Pinho Moreira

“…DOX-IC was induced in Wistar male rats through ten weekly intra-peritoneal injections of doxorubicin (cumulative dose: 18 mg/kg). …”
Get full text

Prenatal Exposure to Nicotine in Pregnant Rat Increased Inflammatory Marker in Newborn Rat by Yosouf Mohsenzadeh, Asghar Rahmani, Javad Cheraghi, Maryam Pyrani, Khairollah Asadollahi

“…During this experimental study, 32 pregnant healthy Wistar rats were divided into 4 equal groups, including a control and 3 nicotine exposure groups. …”
Get full text

Cardiac and testicular alterations induced by acute exposure to titanium dioxide nanoparticles: Histopathological study by Amin Al‐Doaiss, Bashir Jarrar, Ali Shati, Mohammed Al‐Kahtani, Mohammad Alfaifi

“…The current study was carried out to find out the acute damage that might be induced by TiO2 NPs in the heart and testis. Three groups of Wistar albino rats (Rattus norvegicus) were subjected to a single dose TiO2 NPs (126, 252, 378 mg/kg bw). …”
Get full text

Differential Effects of Alcoholic and Non-Alcoholic Beer Intake on Renin–Angiotensin System Modulation in Spontaneous Hypertensive Rats by María Dolores Mayas, Cristina Cueto-Ureña, María Jesús Ramírez-Expósito, José Manuel Martínez-Martos

“…This study investigates the effects of alcoholic (AB) and non-alcoholic beer (NAB) consumption on blood pressure and the activity of enzymes regulating the renin–angiotensin system (RAS) in Wistar–Kyoto (WKY) and spontaneously hypertensive rats (SHRs), with WKY rats used as normotensive controls for SHRs. …”
Get full text

Anti-inflammatory activity of Alpinia officinarum hance on rat colon inflammation and tissue damage in DSS induced acute and chronic colitis models by Vijayabharathi Rajendiran, Vidhya Natarajan, Sivasithamparam Niranjali Devaraj

“…Acute and chronic colitis were induced in Male Wistar rats by administration of Dextran Sulfate Sodium (DSS) in drinking water. …”
Get full text

Antidiabetic Activity of Benzopyrone Analogues in Nicotinamide-Streptozotocin Induced Type 2 Diabetes in Rats by Yogendra Nayak, Venkatachalam Hillemane, Vijay Kumar Daroji, B. S. Jayashree, M. K. Unnikrishnan

“…Type 2 diabetes (T2D) was induced in Wistar rats by streptozotocin (60 mg/kg, i.p.) followed by nicotinamide (120 mg/kg i.p.). …”
Get full text

Neuroprotective Effects of Bone Marrow Mesenchymal Stem Cells on Bilateral Common Carotid Arteries Occlusion Model of Cerebral Ischemia in Rat by Bagher Pourheydar, Sara Soleimani Asl, Mostafa Azimzadeh, Adel Rezaei Moghadam, Asghar Marzban, Mehdi Mehdizadeh

“…Herein, we discuss the neuroprotective effects of bone marrow mesenchymal stem cells (BMSCs) on rat hippocampal cells following intravenous injection of these cells in an ischemia-reperfusion model. Adult male Wistar rats were divided into 5 groups: control, sham (surgery without blockage of common carotid arteries), ischemia (common carotid arteries were blocked for 30 min prior to reperfusion), vehicle (7 days after ischemia PBS was injected via the tail vein), and treatment (injections of BMSC into the tail veins 7 days after ischemia). …”
Get full text

Dietary Fiber with Functional Properties Counteracts the Thwarting Effects of Copper Nanoparticles on the Microbial Enzymatic Activity and Short-Chain Fatty Acid Production in the... by Jerzy Juśkiewicz, Bartosz Fotschki, Anna Stępniowska, Ewelina Cholewińska, Dorota Napiórkowska, Aleksandra Marzec, Łucja Brzuzan, Joanna Fotschki, Ewa Żary-Sikorska, Katarzyna Ognik

“…The present study aimed to scrutinize the hypothesis that the dietary addition of fiber with functional properties would prevent the thwarting effects of copper nanoparticles (Cu-NP) on fecal microbial metabolic activity. The Wistar rats were fed for 6 weeks with diets with two different contents of Cu-NP (a recommended dose of 6.5 mg/kg or doubled) and four sources of dietary fiber: control – cellulose; and experimental – pectin, inulin, and psyllium. …”
Get full text

Neuroprotective Effect of Intrastriatal Caffeic Acid Phenethyl Ester Treatment in 6-OH Dopamine Model of Parkinson’s Disease in Rats by Burak Cem Soner, Eda Acikgoz, Salim Yalcin Inan, Sule Ayla, Ayse Saide Sahin, Gulperi Oktem

“…We aimed to determine the effect of intrastriatal CAPE administration as a neuroprotective agent on 6-hydroxydopamine (6-OHDA)-induced PD model. Adult male Wistar rats weighing 280–320 g were used. The PD model was induced with unilateral intrastriatal 6-OHDA injection. …”
Get full text

Reversal of acetaminophen-generated oxidative stress and concomitant hepatotoxicity by a phytopharmaceutical product by Afolabi C. Akinmoladun, Kehinde O. Oguntunde, Lawrence O. Owolabi, Omotayo B. Ilesanmi, Joan O. Ogundele, M.Tolulope Olaleye, Afolabi A. Akindahunsi

“…In this study, Trévo™, a nutraceutical and phytopharmaceutical product, was evaluated for beneficial effects in acetaminophen-induced hepatic toxicity in Wistar rats. Animals received Trévo™ (1.5 mL/kg, 3.0 mL/kg or 4.5 mL/kg) orally for 14 days. …”
Get full text

Chrysoeriol ameliorates hyperglycemia by regulating the carbohydrate metabolic enzymes in streptozotocin-induced diabetic rats by Baskaran Krishnan, Abirami Ramu Ganesan, Ravindran Balasubramani, Dinh Duc Nguyen, Soon Woong Chang, Shaoyun Wang, Jianbo Xiao, Balamuralikrishnan Balasubramanian

“…The present study aimed to evaluate the effects of chrysoeriol from Cardiospermum halicacabum in streptozotocin induced Wistar rats. Thirty rats were categorized as control, diabetic control supplemented with 0, 20 mg/kg chrysoeriol and 600 μg/kg BW of glibenclamide for 45-day trial period. …”
Get full text

In Vivo and Ex Vivo Evaluation of 1,3-Thiazolidine-2,4-Dione Derivatives as Euglycemic Agents by Diana Alemán-González-Duhart, Samuel Álvarez-Almazán, Miguel Valdes, Feliciano Tamay-Cach, Jessica Elena Mendieta-Wejebe

“…The aim of this study was to determine whether C40, C81, and a new compound, C4, act as euglycemic and antioxidant agents in male Wistar rats with streptozotocin-induced diabetes. …”
Get full text

Effect of platelet activating factor antagonist treatment on gentamicin nephrotoxicity by A. Rodriguez-Barbero, E. Bosque, L. Rivas-Cabaero, M. Arévalo, J. M. López-Novoa

“…Experiments were completed in 21 Wistar rats divided into three groups: group GENTA was injected with gentamicin 100 mg kg−1 body wt/day s.c. for 6 days. …”
Get full text

Vegetation Activity Trend and Its Relationship with Climate Change in the Three Gorges Area, China by Guifeng Han, Yongchuan Yang, Shuiyu Yan

“…Vegetation activity presents a distinctive uptrend during the study period, especially in Fengjie, Yunyang, Wushan, Wuxi, and Badong counties located in the midstream of the Three Gorges Reservoir. …”
Get full text

Early Maternal Deprivation Enhances Voluntary Alcohol Intake Induced by Exposure to Stressful Events Later in Life by Sara Peñasco, Virginia Mela, Jose Antonio López-Moreno, María-Paz Viveros, Eva M. Marco

“…In the present study, we aimed to assess the impact of early life stress, in the form of early maternal deprivation (MD, 24 h on postnatal day, pnd, 9), on voluntary alcohol intake in adolescent male and female Wistar rats. During adolescence, from pnd 28 to pnd 50, voluntary ethanol intake (20%, v/v) was investigated using the two-bottle free choice paradigm. …”
Get full text

Effects of Kalsis, A Dietary Supplement, on Bone Metabolism in the Ovariectomized Rats by Mercedes Montero, Manuel Díaz-Curiel, David Guede, Jose Ramón Caeiro, Marta Martín-Fernández, Mercedes Rubert, Daisy Navarro, Concepción de la Piedra

“…We studied the ability of Kalsis, a food supplement that contains selenium, citric acid, and vitamin E, to prevent the effects of ovariectomy on bone loss. Six-month-old, Wistar female rats were studied. Groups (n=12): SHAM: sham-operated rats; OVX: ovariectomized rats, treated with vehicle; OVX + Kalsis: ovariectomized rats treated with Kalsis (25 mg/kg/day) for 3 months. …”
Get full text

The Regenerative Potential of Facial Nerve Motoneurons following Chronic Axotomy in Rats by Yusu Ni, Diyan Chen, Yi Jiang, Danhong Qiu, Wen Li, Huawei Li

“…The potential of facial nerve regeneration and probable mechanisms involved following chronic facial nerve injury should be further studied. Methods. Adult male Wistar rats were used to model either (i) facial nerve injury (axotomy) or (ii) reinjury (chronic axotomy followed by a second axotomy within 5 months). …”
Get full text

Leptin Inhibits the Proliferation of Vascular Smooth Muscle Cells Induced by Angiotensin II through Nitric Oxide-Dependent Mechanisms by Amaia Rodríguez, Javier Gómez-Ambrosi, Victoria Catalán, Ana Fortuño, Gema Frühbeck

“…This study was designed to investigate whether leptin modifies angiotensin (Ang) II-induced proliferation of aortic vascular smooth muscle cells (VSMCs) from 10-week-old male Wistar and spontaneously hypertensive rats (SHR), and the possible role of nitric oxide (NO). …”
Get full text

Protective Effect of Vitamins C and E on Depot-Medroxyprogesterone Acetate-Induced Ovarian Oxidative Stress In Vivo by Atik Ismiyati, I. Wayan Arsana Wiyasa, Dwi Yuni Nur Hidayati

“…A study was designed to investigate ameliorates effect of combined vitamins C and E able to against depot-medroxyprogesterone acetate- (DMPA-) induced ovarian oxidative stress in rat. Twenty-five female Wistar rats were divided into the following groups (n=5 rats each): control (untreated) (C); depot-medroxyprogesterone acetate (DMPA); DMPA plus green vitamin C (at dose of 0.2 mg/gram; 0.4 mg/gram; 0.8 mg/gram) and vitamin E (0.04 IU/gram). …”
Get full text

‘One man’s meat is another man’s poison’. The Rhetoric of Dissent in John Henry Cardinal Newman’s Apologia pro Vita Sua (1864) by Bertrand Lentsch

“…His thereafter feeling impelled to deliver Apologia pro Vita Sua, to rebut the charge of deluding himself and beguiling the throng of well-wishers, raised eyebrows. The diary of his conversion is yet no anticlimax, since he wilfully enshrined his apology in apologetics. …”
Get full text