ADAM19: A Novel Target for Metabolic Syndrome in Humans and Mice by Lakshini Weerasekera, Caroline Rudnicka, Qing-Xiang Sang, Joanne E. Curran, Matthew P. Johnson, Eric K. Moses, Harald H. H. Göring, John Blangero, Jana Hricova, Markus Schlaich, Vance B. Matthews

“…Secondly, we examined the expression of ADAM19 in liver and gonadal white adipose tissue using an in vivo diet induced obesity mouse model. Finally, we investigated the effect of neutralising ADAM19 on diet induced weight gain, insulin resistance in vivo, and liver TNF-α levels. …”
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How Much Time Should Be Waited and What Are the Main Findings to Evaluate the Hepatocellular Carcinoma Response to Regorafenib? A Real-Life Experience by Gustavo Hideki Kawanami, Leopoldo Katsuda, Thiara Barcelos Rocha, Fabio da Silva Yamashiro, Leonardo Pelafsky, Xingshun Qi, Fernando Gomes Romeiro

“…In addition, some clinical and imaging findings can be deemed as predictors of good response to tyrosine kinase inhibitors.…”
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Biochemical Composition and Seasonal Variations of the Madagascar Algae <i>Eucheuma denticulatum</i> (<i>Solieriaceae</i>, Rhodophyta) by Elando Fréda Zamanileha, Anne-Sophie Burlot, Thomas Latire, Christel Marty, Philippe Douzenel, Laurent Vandanjon, Nathalie Bourgougnon, Pierre Ravelonandro, Gilles Bedoux

“…Seaweed extracts showed antioxidant activity by the in vitro method ranging from 2026 ± 2 to 2998 ± 4 μg.mL⁻¹ in 2021, and from 1904 ± 2 to 2876 ± 4 μg.mL⁻¹ in 2022. Finally, the principal component analysis (PCA) showed a correlation between protein content and environmental parameters. …”
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Peningkatan keterampilan membaca memindai melalui strategi the power of two pada siswa by Eti Sunarsih, Masweni Masweni, Fitri Fitri

“…Hal tersebut terjadi karena minat belajar siswa yang masih dalam pembelajaran membaca dan siswa juga kesulitan dalam memahami materi dikarenakan metode yang digunakan guru masih konvensional. …”
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Poly-L-Arginine Induces Apoptosis of NCI-H292 Cells via ERK1/2 Signaling Pathway by Ya-Ni Wang, Ling-Ling Zhang, Xiao-Yun Fan, Sha-Sha Wu, Sheng-Quan Zhang

“…The expressions of the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2), Bcl-2/Bax, and cleaved caspase-3 were assessed by western blot. …”
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Harnessing Non-Antibiotic Strategies to Counter Multidrug-Resistant Clinical Pathogens with Special Reference to Antimicrobial Peptides and Their Coatings by Shyam Kumar Mishra, Tanzina Akter, Umme Laila Urmi, George Enninful, Manjulatha Sara, Jiawei Shen, Dittu Suresh, Liangjun Zheng, Elias Shiferaw Mekonen, Binod Rayamajhee, Francesco M. Labricciosa, Massimo Sartelli, Mark Willcox

“…Furthermore, we discuss various approaches for attaching and functionalising these peptides on surfaces. Finally, we recommend comprehensive in vivo studies to evaluate the efficacy of AMPs and their mimetics, investigate their synergistic combinations with other molecules and assess their potential as coatings for medical devices.…”
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The impact of abandoned iron ore on the endophytic bacterial communities and functions in the root systems of three major crops in the local area by Shuyi Chen, Jie Tang, Junqiang Xu, Lianxin Peng, Peng Wu, Qiang Li

“…The mining environment resulted in functional enrichment of histidine kinases and oxidoreductases in the bacterial community. …”
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MyVivarium: A cloud-based lab animal colony management application with realtime ambient sensing by Robinson Vidva, Mir Abbas Raza, Jaswant Prabhakaran, Ayesha Sheikh, Alaina Sharp, Hayden Ott, Amelia Moore, Christopher Fleisher, Hailey Netherton, Evan Goldstein, Pothitos M. Pitychoutis, Tam V. Nguyen, Aaron Sathyanesan

“…Lab administrators can assign tasks to users with reminders for experiments or cage maintenance. Finally, we designed a low-cost system to sense ambient humidity, temperature, vivarium worker activity, and room illuminance. …”
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A Hybrid Retrieval Method for an &#x03A9;-Class Bianisotropic Metamaterial Using Scattering Parameter Method by Gokhan Ozturk, Ugur Cem Hasar, Yunus Kaya, Huseyin Korkmaz, Ivaylo Stoyanov

“…Then, it is applied for extracting the electromagnetic properties of two bianisotropic MM slabs in the form of square split-ring-resonators and <inline-formula> <tex-math notation="LaTeX">$\Omega $ </tex-math></inline-formula>-shape using their S-parameters simulated by a full wave simulation program. Finally, its accuracy is examined by comparing simulated S-parameters with those reconstructed by using extracted electromagnetic parameters. …”
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Dysregulated Circulating Dendritic Cell Function in Ulcerative Colitis Is Partially Restored by Probiotic Strain Lactobacillus casei Shirota by Elizabeth R. Mann, Jialu You, Verena Horneffer-van der Sluis, David Bernardo, Hafid Omar Al-Hassi, Jon Landy, Simon T. Peake, Linda V. Thomas, Cheng T. Tee, Gui Han Lee, Ailsa L. Hart, Parveen Yaqoob, Stella C. Knight

“…LcS treatment conditioned control-DC to induce CLA on T cells in conjunction with β7, generating a multihoming profile, but had no effects on UC-DC. Finally, LcS treatment enhanced DC ability to induce TGFβ production by T cells in controls but not UC patients. …”
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Case report: A panorama gene profile of ovarian cancer metastasized to axillary lymph node by Yu Xia, Yu Huang, Zheng Liu, Siyuan Song, Yi Wang, Yi Wang, Jing Luo

“…Further analysis of NGS identified two novel missense mutations, D326E in BTK (Bruton’s tyrosine kinase) at SH2 domain and D251E in EPHA5 (EPH receptor A5), along with other known cancer- associated mutations. …”
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Nonprofessional Phagocytosis Can Facilitate Herpesvirus Entry into Ocular Cells by Vaibhav Tiwari, Deepak Shukla

“…Similar inhibition was seen by blocking phosphoinositide 3 kinase signaling, which is required for microbial phagocytosis. …”
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Symptom-based depression subtypes: brain dynamic specificity and its association with gene expression profiles by Qunjun Liang, Zhifeng Zhou, Shengli Chen, Shiwei Lin, Xiaoshan Lin, Ying Li, Yingli Zhang, Bo Peng, Gangqiang Hou, Yingwei Qiu

“…The loading weight in CCA showed that dynamics in transmodal networks contributed the most to the correlation in the subtypes characterized by typical depression symptoms, whereas unimodal networks contributed the most to subtypes characterized by anxiety and insomnia. Finally, gene expression underlying the CCA model, along with its biological encoding process, performed using a postmortem gene expression atlas revealed distinct gene enrichments for different subtypes. …”
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Empowering Security Operation Center With Artificial Intelligence and Machine Learning&#x2014;A Systematic Literature Review by Mohamad Khayat, Ezedin Barka, Mohamed Adel Serhani, Farag Sallabi, Khaled Shuaib, Heba M. Khater

“…Moreover, this systematic review emphasizes the benefits of these technologies for enhancing security operations. Finally, a case study is presented to describe the function of ML- and AI-powered SOC components to achieve optimum security. …”
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Berberine-induced browning and energy metabolism: mechanisms and implications by Aslıhan Alpaslan Ağaçdiken, Zeynep Göktaş

“…While the precise mechanisms behind this effect remain unclear, the adenosine monophosphate-activated protein kinase (AMPK) pathway is known to play a crucial role. …”
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Triglycerides mediate the relationships of per- and poly-fluoroalkyl substance (PFAS) exposure with nonalcoholic fatty liver disease (NAFLD) risk in US participants by Wenying Qiao, Jiashuo Li, Lijia Luo, Wenjuan Peng, Xi Wang, Ronghua Jin, Junnan Li

“…It further highlighted significant mediation effects of TG, with the mediated proportion ranging from 10.4 % to 42.9 %. Finally, sensitivity and stratified analyses were performed, confirming the reliability of these findings. …”
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Insulin-Like Growth Factor I Prevents Cellular Aging via Activation of Mitophagy by Xuwei Hou, Zhaohui Li, Yusuke Higashi, Patrice Delafontaine, Sergiy Sukhanov

“…IGF-1 increased mitophagy in aged cells, and this was associated with decreased expression of cyclin-dependent kinase inhibitors p16 and p21 and elevated levels of Nrf2 and Sirt3, regulators of mitophagy and mitochondrial biogenesis. …”
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Modeling dynamic changes in type 1 diabetes progression:Quantifying $\beta$-cell variation after the appearance ofislet-specific autoimmune responses by Patrick Nelson, Noah Smith, Stanca Ciupe, Weiping Zou, Gilbert S. Omenn, Massimo Pietropaolo

“…Our model is able to describe changes in the ratio of pathogenic T cells and regulatory T cells after the appearance of islet antibodies in the pancreas. Finally, we discuss the robustness of the model and its ability to assist experimentalists in designing studies to test complicated theories about the disease.…”
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Drug repurposing screen for the rare disease ataxia-telangiectasia by Namrata Jayanth, Gurvan Mahé, Matthew Campbell, Mike Lipkin, Shushant Jain, Rhea van de Bospoort, Jennifer Thornton, Brad Margus, David F. Fischer

“…It is caused by bi-allelic mutations impacting a gene encoding a serine/threonine kinase ATM (Ataxia Telangiectasia Mutated), which plays a crucial role in DNA repair and maintenance of genomic stability. …”
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Selenoprotein S Attenuates Tumor Necrosis Factor-α-Induced Dysfunction in Endothelial Cells by Siyuan Cui, Lili Men, Yu Li, Yingshuo Zhong, Shanshan Yu, Fang Li, Jianling Du

“…Moreover, SelS overexpression regulates TNF-α-induced inflammatory factors including interleukin-1β, interleukin-6, interleukin-8, and monocyte chemotactic protein-1 and attenuates the TNF-α-induced activation of p38 mitogen-activated protein kinase (MAPK) and nuclear factor-κB (NF-κB) pathways. …”
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