Wnt5a Increases Properties of Lung Cancer Stem Cells and Resistance to Cisplatin through Activation of Wnt5a/PKC Signaling Pathway by Jiali Yang, Kangjian Zhang, Jing Wu, Juan Shi, Jing Xue, Jing Li, Juan Chen, Yongzhao Zhu, Jun Wei, Jinxi He, Xiaoming Liu

“…The role of noncanonical Wnt signaling in the regulation of properties of lung cancer stem cells and chemoresistance was interrogated, by accessing capacities of cell proliferation, migration, invasion, and clonogenicity as well as the apoptosis in A549 cell lines and cisplatin-resistant A549 cells treated with Wnt5a conditional medium or protein kinase C (PKC) inhibitor GF109203X. Results showed that the noncanonical Wnt signaling ligand, Wnt5a, could promote the proliferation, migration, invasion, and colony formation in A549 lung adenocarcinoma cells and cisplatin-resistant A549/DDP cells and increase the fraction of ALDH-positive cell in A549/DDP cells. …”
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Longevity Recipe - Lifestyle Influences on the Quantity and Quality of Life by Katarzyna Piotrowicz, Hubert Piotrowicz, Jacek Kurzeja, Agnieszka Bajkacz, Wojciech Kraśnik, Olga Jankowska, Anna Rogala, Joanna Osmólska

“…Why are social relationships an important protective element? Finally, it considers whether there is a cure for longevity. …”
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Significant Contribution of Mouse Mast Cell Protease 4 in Early Phases of Experimental Autoimmune Encephalomyelitis by Louisane Desbiens, Catherine Lapointe, Marjan Gharagozloo, Shaimaa Mahmoud, Gunnar Pejler, Denis Gris, Pedro D’Orléans-Juste

“…In addition, higher levels of spinal myelin were found in mMCP-4 KO as compared with WT mice. Finally, whereas EAE triggered significant increases in brain levels of mMCP-4 mRNA and immunoreactive ET-1 in WT mice, the latter peptide was reduced to basal levels in mMCP-4 KO congeners. …”
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Centrosome amplification and aneuploidy driven by the HIV-1-induced Vpr•VprBP•Plk4 complex in CD4+ T cells by Jung-Eun Park, Tae-Sung Kim, Yan Zeng, Melissa Mikolaj, Jong Il Ahn, Muhammad S. Alam, Christina M. Monnie, Victoria Shi, Ming Zhou, Tae-Wook Chun, Frank Maldarelli, Kedar Narayan, Jinwoo Ahn, Jonathan D. Ashwell, Klaus Strebel, Kyung S. Lee

“…Mechanistically, Vpr forms a cooperative ternary complex with an E3 ligase subunit, VprBP, and polo-like kinase 4 (Plk4). Unexpectedly, however, the complex enhances Plk4’s functionality by promoting its relocalization to the procentriole assembly and induces centrosome amplification. …”
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Enhanced Proliferation of Porcine Bone Marrow Mesenchymal Stem Cells Induced by Extracellular Calcium is Associated with the Activation of the Calcium-Sensing Receptor and ERK Sign... by Jingjing Ye, Wei Ai, Fenglin Zhang, Xiaotong Zhu, Gang Shu, Lina Wang, Ping Gao, Qianyun Xi, YongLiang Zhang, Qingyan Jiang, Songbo Wang

“…Moreover, Ca2+o-induced promotion of pBMSCs proliferation, the changes of proliferative genes expression levels, and the activation of ERK1/2 signaling pathway were effectively blocked by U0126, a selective ERK kinase inhibitor. In conclusion, our findings provided evidence that the enhanced pBMSCs proliferation in response to Ca2+o was associated with the activation of CaSR and ERK1/2 signaling pathway, which may be useful for the application of pBMSCs in future clinical studies aimed at tissue regeneration and repair.…”
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Diagnosis and Management of Atypical Chronic Myeloid Leukemia with a t(2;13)(q33;q12) Translocation by John S. Wang, Omar Elghawy, Brett R. Kurpiel, Michael G. Douvas

“…After clinical progression, he was treated with sorafenib, a multiprotein kinase inhibitor more commonly used in the treatment of hepatocellular and renal cell carcinoma due to its off target FLT3 inhibition. …”
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Discrete vulnerability to pharmacological CDK2 inhibition is governed by heterogeneity of the cancer cell cycle by Vishnu Kumarasamy, Jianxin Wang, Michelle Roti, Yin Wan, Adam P. Dommer, Hanna Rosenheck, Sivasankar Putta, Alec Trub, John Bisi, Jay Strum, Patrick Roberts, Seth M. Rubin, Costakis Frangou, Karen McLean, Agnieszka K. Witkiewicz, Erik S. Knudsen

“…Abstract Cyclin dependent kinase 2 (CDK2) regulates cell cycle and is an emerging target for cancer therapy. …”
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Using computer modeling to find new LRRK2 inhibitors for parkinson’s disease by María C. García, Sebastián A. Cuesta, José R. Mora, Jose L. Paz, Yovani Marrero-Ponce, Frank Alexis, Edgar A. Márquez

“…The dataset was constructed using pIC50 values of various compounds targeting the inhibition of leucine-rich repeat kinase 2 (LRRK2). The best ensemble model showed exceptional predictive performance, with five-fold cross-validation and external validation metrics exceeding 0.8 (Q2cv = 0.864 and Q2ext = 0.873). …”
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The Enigmatic Upper Ordovician of the Naturtejo UNESCO Global Geopark (Portugal) by Sofia Pereira, Jorge Colmenar, Cristiana Esteves, Ícaro Dias da Silva, Miguel Pires, Carlos Neto de Carvalho

“…In the Vila Velha de Ródão Syncline, the Barroca da Senhora stream fossil site constitutes a new geosite within the protected area of Portas de Ródão Natural Monument, presenting the most complete Upper Ordovician sequence of this structure. Finally, the stratigraphic and paleontologic record of the Vale Feitoso estate offers all the conditions to propose a new theme geotrail, diversifying the tourism in the Monfortinho village (Penha Garcia Syncline).…”
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Protective Effects of Ophiocordyceps lanpingensis on Glycerol-Induced Acute Renal Failure in Mice by Yanyan Zhang, Yaxi Du, Hong Yu, Yongchun Zhou, Feng Ge

“…Rhabdomyolysis was monitored using creatine kinase (CK) level. Oxidative stress was determined using kidney tissue glutathione (GSH), malondialdehyde (MDA), and superoxide dismutase (SOD) levels. …”
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Chordoma Spontaneous Regression After COVID-19 by Luis Fernando Moura da Silva Junior, Gyl Eanes Barros Silva, Marcos Adriano Garcia Campos, Antonio Augusto Lima Teixeira Júnior, Ramon Moura Santos, Orlando José dos Santos, Natalino Salgado Filho

“…Six months after COVID-19, she finally came back for endoscopic endonasal resection of the tumor and pre-operative MRI surprisingly showed 98.9% regression of the tumor volume. …”
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Research on Density Peak Clustering Color-Separation Algorithm Based on SOM Neural Network by Xin Ru, Yanhao Wang, Ran Chen, Zhifa Zeng, Laihu Peng, Wei Tang, Weimin Shi, Hui Wang

“…To solve these problems, In this paper, we propose a density peak clustering color-separation algorithm based on self-organizing mapping (SOM) neural network, which firstly uses enhanced super-resolution generative adversarial network (Real-ESRGAN) blind super-resolution reconstruction network to clarify the degraded image and obtain a high-resolution image with clear boundaries; secondly, we carry out the initial clustering through the SOM neural network to simplify the image information; and then we use an improved density peak clustering (DPC) algorithm to calculate clustering centers under the conditions of conforming to the perception of human eyes, and carry out secondary clustering on the image; finally, carry out image post-processing through the variegated spots merging algorithm based on the connected component analysis. …”
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Clinical Evidence in the Treatment of Obstructive Sleep Apnoea with Oral Appliances: A Systematic Review by Andrea Rossi, Antonino Lo Giudice, Camilla Di Pardo, Alberto Teodoro Valentini, Francesca Marradi, Nicola Vanacore, Cristina Grippaudo

“…After removing duplicates and studies that did not comply with the inclusion criteria, 32 full-text articles were assessed for eligibility, and 17 RCTs were finally included in the qualitative synthesis. The 17 selected studies were very heterogeneous in the type of included RCTs in terms of patient inclusion criteria, sample size, distribution of the two genders in the various groups, duration of treatment, and definition of primary and secondary outcomes, without any restriction on the definition of the control group. …”
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Legionella pneumophila response to shifts in biofilm structure mediated by hydrodynamics by Ana Rosa Silva, C. William Keevil, Ana Pereira

“…Water structures in the biofilm seem to be key to Legionella migration across the biofilm. Finally, shear conditions favoured the transition of L. pneumophila to VBNC states (∼94 %), despite the high viable cell counts (∼8 log10 CFU/cm2) found throughout the experiments. …”
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Experimental Study on Flow Characteristics of Aeolian Sand in Fractures by Jiarui Chen, Wenhu Gu, Jihua Zhang, Jitao Tang, Zhengzheng Cao, Jingke Wu, Jianxiong Liu, Weizhong He, Fang Shi

“…With the increase of fracture opening, the sand burst rate increases logarithmically. Finally, according to the test results, the relation equation which can simultaneously describe the influence of fracture opening and fracture inclination on the rate of the sand burst is fitted. …”
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Efficiency analysis and performance modelling of a photovoltaic system for cruise ship cabins with battery storage using direct current distribution networks by Patrick Schwager, Laura Tiede, Thomas Scholz, Kai Gehrke, Martin Vehse

“…The integration into a 350 VDC distribution grid per deck and fire zone was found to be the most advantageous. Finally, synthetic load and irradiance profiles were used to simulate ship operation within a fire zone deck to determine the size of battery storage required for that area. …”
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Applications and Challenges of High-Throughput Phenotyping of Crops at Ground and Aviation Scales by Longyue CHEN, Dandan DUAN, Weibing XU, Zuolin LI, Chong ZHAO, Yi JIANG, Yonggang GAO, Wenqing ZUO

“…However, there is potential for the improvement of its application performance. Finally, the challenges, optimization solutions, broad prospects and future development trends of HTP phenotyping of crops were discussed. …”
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The Rapid Effect of Bisphenol-A on Long-Term Potentiation in Hippocampus Involves Estrogen Receptors and ERK Activation by Xiaowei Chen, Yu Wang, Fang Xu, Xiaofei Wei, Junfang Zhang, Chuang Wang, Hua Wei, Shujun Xu, Peiyun Yan, Wenhua Zhou, Istvan Mody, Xiaohong Xu, Qinwen Wang

“…The rapid facilitatory effect of low-dose BPA on hippocampal LTP required membrane-associated estrogen receptor (ER) and involved activation of the extracellular signal-regulated kinase (ERK) signaling pathway. Coadministration of 17β-estradiol (E2, the primary estrogen hormone) and BPA (100 nM) abolished both the BPA-induced enhancement of LTP and the E2-induced enhancement of baseline fEPSP, suggesting a complex interaction between BPA- and E2-mediated signaling pathways. …”
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Evolution of Magnetohydrodynamic Turbulence in the Expanding Solar Wind: Residual Energy and Intermittency by Chen Shi, Nikos Sioulas, Zesen Huang, Marco Velli, Anna Tenerani, Victor Réville

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CDK14 regulates the development and repair of lung by Jian-wei Chen, Yu-xiang Wang, Rong-rong Gao, Lan-yue Ma, Jing Zhong, Jia-xin Yang, Zhao-hua Deng, Yu-yan Li, Xiao-ling Li, Ya-hai Shu, Wen-jing Guo, Zi-yuan Zhou, Xiao Yu Tian, Jinjin Ma, Yang Liu, Qi Chen

“…Abstract Cyclin-dependent kinases (CDK) 14 regulates cell cycle, tumor expansion by influencing the downstream targets of the canonical Wnt signaling pathway. …”
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