Periodic Catatonia Marked by Hypercortisolemia and Exacerbated by the Menses: A Case Report and Literature Review by Samantha Zwiebel, Alejandro G. Villasante-Tejanos, Jose de Leon

“…Through 4 catatonic episodes (one lasting 17 months) there were menstrual exacerbations of catatonia and increases in 4 biological variables: (1) creatine kinase (CK) up to 4,920 U/L, (2) lactate dehydrogenase (LDH) up to 424 U/L, (3) late afternoon cortisol levels up to 28.0 mcg/dL, and (4) white blood cell (WBC) counts up to 24,200/mm3 with neutrophilia without infections. …”
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Neuroprotective and Antiapoptotic Activity of Lineage-Negative Bone Marrow Cells after Intravitreal Injection in a Mouse Model of Acute Retinal Injury by Anna Machalińska, Dorota Rogińska, Ewa Pius-Sadowska, Miłosz P. Kawa, Edyta Paczkowska, Michał Rudnicki, Renata Lejkowska, Bartłomiej Baumert, Barbara Wiszniewska, Bogusław Machaliński

“…Furthermore, transplanted Lin−BMCs differentiated locally into cells with a macrophage-like phenotype. Finally, Lin−BMCs treatment was associated with generation of two distinct transcriptomic patterns. …”
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Haptoglobin Genotype-Dependent Anti-Inflammatory Signaling in CD163+ Macrophages by R. Clive Landis, Pandelis Philippidis, Jan Domin, Joseph J. Boyle, Dorian O. Haskard

“…We describe an anti-inflammatory signalling pathway involving phosphatidylinositol-3-kinase activation upstream of Akt phosphorylation (pSer473Akt) and IL-10 secretion. …”
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Analgesic and Antioxidant Activities of 4-Phenyl-1,5-benzodiazepin-2-one and Its Long Carbon Chains Derivatives by Terence Nguema Ongone, Redouane Achour, Mostafa El Ghoul, Latyfa El Ouasif, Meryem El Jemli, Laila Chemlal, Yahia Cherrah, Katim Alaoui, Amina Zellou

“…Additionally, a significant scavenging activity in DPPH and reducing power was observed in testing antioxidant assays. Finally, we carried out a study of the antioxidant activity of these derivatives. …”
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Failure of a Solar Filament Eruption Caused by Magnetic Reconnection with Overlying Coronal Loops by Leping Li, Hongqiang Song, Yijun Hou, Guiping Zhou, Baolin Tan, Kaifan Ji, Yongyuan Xiang, Zhenyong Hou, Yang Guo, Ye Qiu, Yingna Su, Haisheng Ji, Qingmin Zhang, Yudi Ou

“…It slowly rose, quickly erupted, rapidly decelerated, then finally stopped, with an untwisting motion. As a failed eruption, the event is associated with an M4.4 flare but no coronal mass ejection. …”
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Future changes in compound explosive cyclones and atmospheric rivers in the North Atlantic by F. Lopez-Marti, F. Lopez-Marti, M. Ginesta, D. Faranda, A. Rutgersson, A. Rutgersson, P. Yiou, L. Wu, G. Messori, G. Messori, G. Messori

“…Notably, we identify a significant and systematic future increase in the cyclones and atmospheric river concurrences. Finally, under the high-emission scenario, the explosive cyclone and atmospheric river concurrences show an increase and model agreement over western Europe. …”
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Impacts of high CDW levels on the chemical, microstructural, and mechanical behavior of cement-based mortars by M.L. Peixoto, S.D. Jesus, H.S. Cavalcante, B.S. Teti, R.C. Manta, N.B. Lima, H.C.B. Nascimento, S. Fucale, N.B.D. Lima

“…Further, the XRD results revealed diffraction peaks associated with Quartz, Portlandite, and Ettringite phases, corroborating the technical feasibility of using CDW. Finally, high partial replacements of fine natural aggregate by fine recycled concrete aggregate have technical and sustainable. …”
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ATP-Binding Pocket-Targeted Suppression of Src and Syk by Luteolin Contributes to Its Anti-Inflammatory Action by Jeong-Oog Lee, Deok Jeong, Mi-Yeon Kim, Jae Youl Cho

“…Luteolin displayed potent NO-inhibitory activity and also suppressed the nuclear translocation of NF-κB (p65 and p50) via blockade of Src and Syk, but not other mitogen-activated kinases. Overexpression of wild type Src and point mutants thereof, and molecular modelling studies, suggest that the ATP-binding pocket may be the luteolin-binding site in Src. …”
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Ultrasound-Guided Analgesia in Cardiac and Breast Surgeries: A Cadaveric Comparison of SPIP Block with Single and Double Injections vs. DPIP Block by Carmelo Pirri, Debora Emanuela Torre, Astrid Ursula Behr, Veronica Macchi, Andrea Porzionato, Raffaele De Caro, Carla Stecco

“…Adequate volume facilitates proper spread and diffusion across the fascial plane, ensuring more comprehensive fascia coverage and thus enhancing the block’s effectiveness. Finally, precise volume management is key to maximizing both efficacy and safety.…”
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Effective Connectivity Study Guiding the Neuromodulation Intervention in Figurative Language Comprehension Using Optical Neuroimaging by Tania Alexandra Couto, Shiyang Xu, Paulo Armada da Silva, Chenggang Wu, Karl Neergaard, Meng-Yun Wang, Juan Zhang, Yutao Xiang, Zhen Yuan

“…Moreover, the interhemispheric directional flow suggests a right hemisphere engagement in decoding unfamiliar literal sentences and fine-grained integration guided by the left hemisphere to reduce ambiguity in meaningless words. Finally, bottom-up mechanisms seem activated by logographic-semantic processing in literal meanings and memory storage centres in meaningless comprehension. …”
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Immune Dysfunction in Rett Syndrome Patients Revealed by High Levels of Serum Anti-N(Glc) IgM Antibody Fraction by Anna Maria Papini, Francesca Nuti, Feliciana Real-Fernandez, Giada Rossi, Caterina Tiberi, Giuseppina Sabatino, Shashank Pandey, Silvia Leoncini, Cinzia Signorini, Alessandra Pecorelli, Roberto Guerranti, Solange Lavielle, Lucia Ciccoli, Paolo Rovero, Claudio De Felice, Joussef Hayek

“…Rett syndrome (RTT), a neurodevelopmental disorder affecting exclusively (99%) female infants, is associated with loss-of-function mutations in the gene encoding methyl-CpG binding protein 2 (MECP2) and, more rarely, cyclin-dependent kinase-like 5 (CDKL5) and forkhead box protein G1 (FOXG1). …”
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Inhibition of Src signaling induces autophagic killing of Toxoplasma gondii via PTEN-mediated deactivation of Akt. by Alyssa Hubal, Anusha Vendhoti, Charles N Shaffer, Sarah Vos, Yalitza Lopez Corcino, Carlos S Subauste

“…Src knockdown or treatment with the Src family kinase inhibitor, Saracatinib, impaired these events, leading to PTEN accumulation around the PV and a reduction in activated Akt recruitment at this site. …”
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Metagenomic exploration and computational prediction of novel enzymes for polyethylene terephthalate degradation by Donya Afshar Jahanshahi, Mohammad Reza Rezaei Barzani, Mohammad Bahram, Shohreh Ariaeenejad, Kaveh Kavousi

“…To overcome the scarcity of known PET-degrading enzymes, we used a Generative Adversarial Network (GAN) model for dataset augmentation and a pretrained deep Evolutionary Scale Language Model (ESM) to generate sequence embeddings for classification. Finally, 21 novel PET-degrading enzymes were identified. …”
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Numerical Method of Flexible Pavement considering Moisture and Stress Sensitivity of Subgrade Soils by Jue Li, Jianlong Zheng, Yongsheng Yao, Junhui Zhang, Junhui Peng

“…Subsequently, the validity of FEM model was verified by the laboratory tank model. Finally, the effect of moisture contents on the dynamic response of pavement structures was studied by tensile stress and vertical compressive strain. …”
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Therapeutic Adherence in Patients with Arterial Hypertension by Liens Hernández Quintero, Diana Amelia Crespo Fernández, Liliet Trujillo Cruz, Liliana María Hernández Quintero, Marcia Azcuy Pérez

“…<br /><strong>Objective:</strong> to determine the level of therapeutic adherence in patients with arterial hypertension in office 22 belonging to the Turcios Lima Comunitary Polyclinic of the Pinar del Río municipality. <br /><strong>Method:</strong> a descriptive, cross-sectional study was carried out in patients with arterial hypertension from office 22, belonging to the Turcios Lima Comunitary Polyclinic from December 2018 to June 2019. …”
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Lightweight AES Design for IoT Applications: Optimizations in FPGA and ASIC With DFA Countermeasure Strategies by Salman Ahmed, Nabihah Ahmad, Nasir Ali Shah, Ghulam E. Mustafa Abro, Ardhi Wijayanto, Abdinasir Hirsi, Abdul Rehman Altaf

“…This study identifies critical gaps in lightweight AES and security challenges while discussing countermeasures that balance security with design efficiency. Finally, this study provides valuable insights for finding research directions to strengthen the robustness of AES in lightweight IoT environments.…”
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ISOA‐DBN: A New Data‐Driven Method for Studying the Operating Characteristics of Air Conditioners by Mengran Zhou, Qiqi Zhang, Feng Hu, Ling Wang, Guangyao Zhou, Weile Kong, Changzhen Wu, Enhan Cui

“…The results show that ISOA performs better than SOA in the test of 14 standard functions. Finally, the ISOA is used to adjust the DBN parameters finely. …”
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Predictive value of preoperative pan-immune-inflammation value index in the prognosis of oral cancer patients undergoing radical resection by Weihai Huang, Yulan Lin, Enling Xu, Yanmei Ji, Jing Wang, Fengqiong Liu, Fa Chen, Yu Qiu, Bin Shi, Lisong Lin, Baochang He

“…Randomized survival forest (RSF) was used to assess the relative importance of preoperative PIV in prognostic prediction. Finally, a Nomogram model was plotted to predict the prognosis of oral cancer patients. …”
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The Human IL-22 Receptor Is Regulated through the Action of the Novel E3 Ligase Subunit FBXW12, Which Functions as an Epithelial Growth Suppressor by Joseph Franz, Jacob Jerome, Travis Lear, Qiaoke Gong, Nathaniel M. Weathington

“…FBXW12 shRNA increases human epithelial cell growth and cell cycle progression with enhanced constitutive activity of map kinases JNK and ERK. These findings indicate that the heretofore-undescribed protein FBXW12 functions as an E3 ligase constituent to ubiquitinate and degrade IL-22R and that therapeutic FBXW12 inhibition may enhance IL-22 signaling and bolster mucosal host defense and infection containment.…”
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Establishment of a Nomogram for Predicting Early Death in Viral Myocarditis by Xuejun Sun, Naxin Xie, Mengling Guo, Xuelian Qiu, Hongwei Chen, Haibo Liu, Hongmu Li

“…Combined with the actual clinical situation, the heart failure (HF) (OR: 2.13, 95% CI: 2.76–5.95), electrocardiogram (ECG) (OR: 6.11, 95% CI: 1.05–8.66), pneumonia (OR: 3.62, 95% CI: 1.43–9.85), brain natriuretic peptide (BNP) (OR: 4.66, 95% CI: 3.07–24.06), and lactate dehydrogenase (LDH) (OR: 1.90, 95% CI: 0.19–9.39) were finally used to construct the nomogram. The nomogram’s C-index was 0.908 in the training cohort and 0.924 in the validation cohort. …”
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