Halofuginone prevents inflammation and proliferation of high-altitude pulmonary hypertension by inhibiting the TGF-β1/Smad signaling pathway by Jiangtao Wang, Lina Guan, Jian Yu, Bohua Ma, Huihua Shen, Guozhu Xing, Yawei Xu, Qiufang Li, Juan Liu, Qin Xu, Wenhui Shi, Jia He, Yixuan Huang, Dongfeng Yin, Wu Li, Rui Wang

“…We further detected the expression levels of inflammatory factors interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α) and proliferative/antiproliferative indicators proliferating cell nuclear antigen (PCNA), cyclin-dependent kinase 6 (CDK6), Cyclin D1, p21 in lung tissue, and found that HF could attenuate the lung tissue inflammatory response and proliferative response in HAPH rats. …”
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Comparison of CRISPR-Cas13b RNA base editing approaches for USH2A-associated inherited retinal degeneration by Lewis E. Fry, Lauren Major, Ahmed Salman, Lucy A. McDermott, Jun Yang, Andrew J. King, Michelle E. McClements, Robert E. MacLaren

“…We develop and characterize a mouse model of Usher syndrome carrying the c.11840 G > A mutation designed for the evaluation of base editors for inherited retinal disease. Finally, we compare Cas13 effectors delivered via AAV for the repair of Ush2a in photoreceptors. …”
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Field Development Optimization for Low-Productivity Gas Wells under Intermittent Production by Wei Tian, Yi Liu, Xuri Li, Youliang Jia, Yixuan Wang, Li Li, Zhengyan Zhao, Weihong Ding, Wenxin Zhou, Wenyue Sun

“…The test results show that the trained model accurately predicted all selected key cycle parameters, with R2 values ranging from 0.91 to 0.99. Finally, the optimization method was applied to 100 wells in the gas field for real-time validation. …”
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Sulforaphane enhances Nrf2-mediated antioxidant responses of skeletal muscle induced by exhaustive exercise in HIIT mice by Yangwenjie Wang, Yang Xiang, Ruiqi Wang, Xiangning Li, Jianxiong Wang, Siwang Yu, Ying Zhang

“…Importantly, SFN treatment improved antioxidative capacity of skeletal muscle in response to the acute exhaustive exercise by increasing mRNA and nucleoprotein expression of Nrf2 and these genes involved in antioxidant generation and decreasing blood creatine kinase (CK) and 4-hydroxy-2-nonenal (4-HNE)-modified protein levels in the HIIT mice.…”
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Interleukin-29 Enhances Synovial Inflammation and Cartilage Degradation in Osteoarthritis by Lingxiao Xu, Qiuyue Peng, Wenhua Xuan, Xiaoke Feng, Xiangqing Kong, Miaojia Zhang, Wenfeng Tan, Meilang Xue, Fang Wang

“…Furthermore, recombinant IL-29 augmented the mRNA expression of IL-1β, IL-6, IL-8, and matrix-metalloproteinase-3 (MMP-3) in OA FLS and increased cartilage degradation when ex vivo OA cartilage explant was coincubated with OA FLS. Finally, in OA FLS, IL-29 dominantly activated MAPK and nuclear factor-κB (NF-κB), but not Jak-STAT and AKT signaling pathway as examined by western blot. …”
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A prognostic model of 8-T/B cell receptor-related signatures for hepatocellular carcinoma by Xuan Zuo, Hui Li, Shi Xie, Mengfen Shi, Yujuan Guan, Huiyuan Liu, Rong Yan, Anqi Zheng, Xueying Li, Jiabang Liu, Yifan Gan, Haiyan Shi, Keng Chen, Shijie Jia, Guanmei Chen, Min Liao, Zhanhui Wang, Yanyan Han, Baolin Liao

“…Both the CIBERSORT algorithm and the TB tools were used to analyze the features and heterogeneity of the tumor microenvironment. Results Finally, an 8-gene prognostic model was successfully established and achieved the validation in both the International Cancer Genome Consortium and Nanfang Hospital cohorts. …”
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Association of Glycemic Indices (Hyperglycemia, Glucose Variability, and Hypoglycemia) with Oxidative Stress and Diabetic Complications by Eleftheria Papachristoforou, Vaia Lambadiari, Eirini Maratou, Konstantinos Makrilakis

“…In particular, hyperglycemia promotes the creation of advanced glycation end-products (AGEs), the activation of protein kinase C (PKC), and the hyperactivity of hexosamine and sorbitol pathways, leading to the development of insulin resistance, impaired insulin secretion, and endothelial dysfunction, by inducing excessive ROS production and OS. …”
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Treatment Options for Nosocomial Ventriculitis/Meningitis: A Case Report and Review of the Literature by Marios Karvouniaris, Zoi Aidoni, Eleni Gkeka, Stella Niki Primikyri, Konstantinos Pagioulas, Elena Argiriadou

“…Although she was considered cured, she had a prolonged intensive care unit stay and finally died in the ward two months after the completion of treatment. …”
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From α-to β-diversity: Understanding the historical, present, and future diversity patterns of Fagaceae in Southwestern China by Bikram Pandey, Fengying Zhang, Basu Dev Poudel, Rong Li, Mohammed A. Dakhil, Bishal Gurung, Zhaxi Luobu, Yawen Gan, Ziyan Liao, Lin Zhang

“…We integrated climate variables along with topographic and plant trait predictors to understand the species diversity. Finally, simultaneous autoregression (SAR) model was used to evaluate the effects of predictor variables on the α- and β-diversity patterns. …”
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Anti-inflammatory Property of Galectin-1 in a Murine Model of Allergic Airway Inflammation by Yunxiang Lv, Mengyuan Dai, Muzi Wang, Fangfang Chen, Rongyu Liu

“…These immunomodulatory effects in the allergic lung were correlated with the activation of extracellular signal-regulated kinase (ERK) signaling pathway and downregulation of endogenous Gal-1. …”
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Relato de Experiência das Relações Antagônicas entre a Psicologia e o Direito na Prisão by Arlindo da Silva Lourenço, Ellen Taline de Ramos, Gustavo Martineli Massola

“…Defende-se a interface entre a Psicologia e o Direito como fundamental, inclusive como possibilidade de superação desses antagonismos que, em sua reprodução pura e simples, minam as possibilidades de desenvolvimento, seja de uma como da outra ciência. …”
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A Master–Slave Game-Based Strategy for Trading and Allocation of Virtual Power Plants in the Electricity Spot Market by Na Yang, Liuzhu Zhu, Bao Wang, Rong Fu, Ling Qi, Xin Jiang, Chengyang Sun

“…This method ensures the rational allocation of electricity consumption among distributed energy resources within the VPP and derives the optimized bidding prices and quantities for both the VPP and its internal members. Finally, the case study shows that the proposed trading strategy provides effective bidding strategies for distributed energy resources participating in the joint market for energy and frequency regulation ancillary services. …”
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Stabilization effect and mechanism of heavy metals by microbial consortium of phosphate-solubilizing bacteria and urease-producing bacteria by Xuezhe Zhu, Xuezhe Zhu, Xuezhe Zhu, Xuezhe Zhu, Xuezhe Zhu, Xuezhe Zhu, Yupin Zhou, Yupin Zhou, Yupin Zhou, Yupin Zhou, Yupin Zhou, Yupin Zhou, Zhenghao Yan, Yongfang Yan, Shuangquan Li, Shuangquan Li, Shuangquan Li, Shuangquan Li, Shuangquan Li, Mingjiao Yu, Mingjiao Yu, Mingjiao Yu, Mingjiao Yu, Mingjiao Yu, Xiao Yan, Xiao Yan, Xiao Yan, Xiao Yan, Xiao Yan, Mingjiang Zhang, Mingjiang Zhang, Mingjiang Zhang, Mingjiang Zhang, Mingjiang Zhang

“…An in-depth analysis showed that the composite metals were precipitated as dense precipitate encased in carbonate and phosphate, and additionally could be stabilized in the form of biosorption. Finally, the stabilization mechanism of heavy metals based on biomineralization and biosorption is proposed. …”
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Targeting EGFR-binding protein SLC7A11 enhancing antitumor immunity of T cells via inducing MHC-I antigen presentation in nasopharyngeal carcinoma by Haihua Wang, Songqing Fan, Yuting Zhan, Yue Xu, Yao Du, Jiadi Luo, Hongjing Zang, Shuping Peng, Weiyuan Wang

“…We discovered that EGFR, operating in a kinase-independent manner, played a role in stabilizing the expression of SLC7A11, which subsequently inhibited MHC-I antigen presentation. …”
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Gene Expression Profiling of IL-17A-Treated Synovial Fibroblasts from the Human Temporomandibular Joint by Toshio Hattori, Naomi Ogura, Miwa Akutsu, Mutsumi Kawashima, Suguru Watanabe, Ko Ito, Toshirou Kondoh

“…Furthermore, signal inhibitor experiments indicated that IL-17-mediated induction of IL-6 was transduced via activation of NFκB and phosphatidylinositol 3-kinase/Akt. These results suggest that IL-17A is associated with the inflammatory progression of TMD.…”
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Study on the regulation of tea polyphenols on the structure and gel properties of myofibrillar protein from Neosalanx taihuensis by Xiangxiang Ni, Mengting Li, Zhiwei Huang, Yinyin Wei, Chaoyi Duan, Ruixi Li, Yajie Fang, Xiu Wang, Mingfeng Xu, Rongrong Yu

“…The research results indicated that the WHC of the EGCG group had increased by 17.06 % compared to the oxidized group, and the decrease in amino content reached as much as 40.09 %. Finally, molecular docking simulations were performed to explore the ways in which TP and MP interact. …”
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Optimal configuration strategy of energy storage considering flexible response of high energy-consuming industrial and mining loads in independent microgrid by Cuomu Yixi, Xiaoming Liu, Yu Li, Jingming Tan, Zhihong Liu, Basang Danzeng, Lei Wang

“…The model is then linearized into a mixed-integer programming problem. Finally, through case study simulations of an actual microgrid in Southwest China, the feasibility and effectiveness of the proposed ES optimization strategy are verified. …”
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Naringenin inhibits lipid accumulation by activating the AMPK pathway in vivo and vitro by Xiaoyu Cai, Songxue Wang, Huali Wang, Suwen Liu, Guishan Liu, Huibin Chen, Ji Kang, Hao Wang

“…Meanwhile, naringenin increased the AMPK (AMP-activated protein kinase) activity and the expression of AMPK phosphorylated protein in 3T3 mature adipocytes. …”
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New Insights on the Seismic Activity of Ostuni (Apulia Region, Southern Italy) Offshore by Pierpaolo Pierri, Marilena Filippucci, Vincenzo Del Gaudio, Andrea Tallarico, Nicola Venisti, Vincenzo Festa

“…Our results show right-lateral transtensional kinematics of the seismogenic faults along approximately E-W striking planes, with a tension, T, with a trend of about 60° (NE-SW direction) and a plunge of 20°. Finally, we have tried to correlate the location of the four best constrained earthquakes with their seismogenic structures.…”
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Fucosylated haptoglobin promotes inflammation via Mincle in sepsis: an observational study by Taylor Roh, Sungeun Ju, So Young Park, Yeonghwan Ahn, Jiyun Chung, Miyako Nakano, Gyoungah Ryu, Young Jae Kim, Geumseo Kim, Hyewon Choi, Sung-Gwon Lee, In Soo Kim, Song-I Lee, Chaeuk Chung, Takashi Shimizu, Eiji Miyoshi, Sung-Soo Jung, Chungoo Park, Sho Yamasaki, Seung-Yeol Park, Eun-Kyeong Jo

“…Moreover, the Hp fucosylation (AAL) level significantly correlates with the levels of inflammatory cytokines in sepsis patients, suggesting that Fu-Hp is clinically relevant. Finally, Fu-Hp treatment significantly enhances the levels of inflammatory cytokines in the plasma and various tissues of mice. …”
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