GATA2 mutated allele specific expression is associated with a hyporesponsive state of HSC in GATA2 deficiency syndrome by Laetitia Largeaud, Vincent Fregona, Laura A. Jamrog, Camille Hamelle, Stéphanie Dufrechou, Naïs Prade, Esmaa Sellam, Pauline Enfedaque, Manon Bayet, Sylvie Hébrard, Mathieu Bouttier, Christine Didier, Bastien Gerby, Eric Delabesse, Marlène Pasquet, Cyril Broccardo

“…Defects in the CMP mature compartment, along with the inflammatory molecular signature, explain the loss of heterogeneity in HPC compartment observed in patients. Finally, our study provides a valuable model that recapitulates the ASE-related pathology observed in GATA2 deficiency, shedding light on the mechanisms contributing to the disease’s natural progression.…”
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Transient activation of YAP/TAZ confers resistance to morusin-induced apoptosis by Hoyeon Lee, Sang Woo Cho, Hyo Sun Cha, Kun Tae, Cheol Yong Choi

“…Abstract Background The Hippo signaling pathway involves a kinase cascade that controls phosphorylation of the effector proteins YAP and TAZ, leading to regulation of cell growth, tissue homeostasis, and apoptosis. …”
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The Physics Case for an Electron-Muon Collider by Meng Lu, Andrew Michael Levin, Congqiao Li, Antonios Agapitos, Qiang Li, Fanqiang Meng, Sitian Qian, Jie Xiao, Tianyi Yang

“…With this in mind, one can imagine a lepton collider complex, starting from colliding order 10 GeV electron and muon beams for the first time in history and to probe charged lepton flavor violation, then to be upgraded to a collider with 50-100 GeV electron and 1-3 TeV muon beams to measure Higgs properties and search for new physics and finally to be transformed to a TeV-scale muon-muon collider. …”
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Increased Insular Connectivity and Enhanced Empathic Ability Associated with Dance/Music Training by Li Gujing, He Hui, Li Xin, Zhang Lirong, Yao Yutong, Ye Guofeng, Lu Jing, Zhou Shulin, Yang Lei, Luo Cheng, Yao Dezhong

“…These results indicated that dance/music training might enhance insular subnetwork function, which would facilitate integration of intero/exteroceptive information and result in better affective sensitivity. Those changes might finally facilitate the subjects’ empathic ability.…”
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Аpplicability of microsatellite loci designed for cosmopolitan species for the investigation of endemic species: a case study of Silene sendtneri Boiss. by Jasna Hanjalić, Lejla Ušanović, Lejla Lasić, Abdurahim Kalajdžić, Belma Kalamujić Stroil, Adisa Ahmić, Naris Pojskić

“…(Caryophyllaceae) is the Dinaric endemic plant species with white, decorative and scented flowers. …”
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Arap Şiirinde Şairin Kendisine Mers̱iye Söylemesi: Mālik b. er-Rayb’ın el-Ḳaṣīdetu’l-Yāʾiyye’si Örneği by Mücahit Küçüksarı, Muhammed Ali Söylemez

“…Çalışmanın sonunda, el-Ḳaṣīdetu’l-Yāʾiyye’nin, muhtevası itibariyle klasik mers̱iye planından farklı olduğu görülmüştür. Ayrıca şairin, kināye, istiʿāre, iltifāt ve ṭıbāḳ gibi sanatlar sayesinde soyut kavramlara somutluk; cansız varlıklara canlılık kazandırarak anlatımın netliğini ve gerçeklik boyutunu artırdığı tespit edilmiştir.…”
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MicroRNA-132 Interact with p250GAP/Cdc42 Pathway in the Hippocampal Neuronal Culture Model of Acquired Epilepsy and Associated with Epileptogenesis Process by Jinxian Yuan, Hao Huang, Xin Zhou, Xi Liu, Shu Ou, Tao Xu, Ruohan Li, Limin Ma, Yangmei Chen

“…In addition, we verified the effect of miR-132 in vivo and found that silencing miR-132 inhibited the aberrant formation of dendritic spines and chronic spontaneous seizure in a lithium-pilocarpine-induced epileptic mouse model. Finally, we confirmed that silencing miR-132 has a neuroprotective effect on cultured epileptic neurons; however, this effect did not occur through the p250GAP pathway. …”
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Importance of Cheese Whey Processing: Supplements for Sports Activities – a Review by Patricia Fassina, Gabriela Quadros Nunes, Fernanda Scherer Adami, Márcia Inês Goettert, Claucia Fernanda Volken de Souza

“…Compared to WPC and WPI, WPH improved peak torque associated with strength training without reducing the creatine kinase (CK) and tumor necrosis factor alpha (TNF-α) levels in this type of physical activity, and the decreases in CK and lactate dehydrogenase (LDH) associated with aerobic exercise were significant. …”
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Rapamycin Improves Palmitate-Induced ER Stress/NF κ B Pathways Associated with Stimulating Autophagy in Adipocytes by Jiajing Yin, Liping Gu, Yufan Wang, Nengguang Fan, Yuhang Ma, Yongde Peng

“…In present study, we examined the activity of rapamycin, a mTOR kinase inhibitor, against endoplasmic reticulum stress and inflammation in adipocytes. …”
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Schwann Cell‐Specific Ablation of Beclin 1 Impairs Myelination and Leads to Motor and Sensory Neuropathy in Mice by Lisa Gambarotto, Loris Russo, Silvia Bresolin, Luca Persano, Rachele D'Amore, Giulia Ronchi, Federica Zen, Luisa Muratori, Alice Cani, Samuele Negro, Aram Megighian, Sonia Calabrò, Paola Braghetta, Dario Bizzotto, Matilde Cescon

“…Abstract The core component of the class III phosphatidylinositol 3‐kinase complex, Beclin 1, takes part in different protein networks, thus switching its role from inducing autophagy to regulating autophagosomal maturation and endosomal trafficking. …”
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Gut microbial 3α‐hydroxysteroid dehydrogenase promotes depression in males via degrading testosterone by Di Li, Jingru Cheng, Wei Zhang, Pengfei Cheng, Yuan He, Jinghan Jia, Chao Wang, Zhongchun Liu, Zhou Sun, Jinxi Wang

“…Testosterone supplementation improves depression‐like behavior in mice induced by gavage of Escherichia coli heterologously expressing 3α‐HSD. Finally, the universality of 3α‐HSD in gut of male patients with depression was higher than that of healthy controls. …”
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Selenium-enriched oolong tea (Camellia sinensis) extract exerts anti-inflammatory potential via targeting NF-κB and MAPK pathways in macrophages by Qi Wang, Juqing Huang, Yafeng Zheng, Xuefang Guan, Chenchun Lai, Huiying Gao, Chi-Tang Ho, Bin Lin

“…Furthermore, Se-TE could block mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-κB) signaling pathways through the inhibition of the phosphorylation of key proteins (IκB-α, p65, p38, ERK, and JNK) and the translocation of the p65 subunit into the nucleus. …”
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Saline–CO₂ Solution Effects on the Mechanical Properties of Sandstones: An Experimental Study by Motao Duan, Haijun Mao, Guangquan Zhang, Junxin Liu, Sinan Zhu, Di Wang, Hao Xie

“…The failure mode of the sample gradually changed from /-shaped failure to V-shaped composite failure, then to local /-shaped failure, and finally to X-shaped composite failure. On this basis, the process of sandstone was divided into the dissolution stage, precipitation stage and secondary dissolution stage, and the rock microstructure change model under a salt–CO₂ environment was established. …”
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In the coevolution of cotton and pathogenic fungi, resistant cotton varieties lead to an escalation in the virulence of Verticillium dahliae by Yalin Zhang, Lifang Cui, Ruibing Liu, Zili Feng, Hongjie Feng, Jinglong Zhou, Lihong Zhao, Feng Wei, Heqin Zhu

“…Additionally, the transcriptome analysis revealed that the 4th and 6th generations of strains differentially expressed genes (DEGs) accumulated a significant number of response genes associated with pathogen pathogenicity differentiation, including the mitogen-activated protein kinase (MAPK) signaling pathway, amino and antibiotic biosynthesis, phenylpropanoid metabolism. …”
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Prevalence of behavioral risk factors among Ukrainians during war amid existing stress factors by Olena Kolesnikova, Olena Vysotska, Anastasiia Radchenko, Olga Zaprovalna, Nataliya Emelyanova

“…Furthermore, we identified differences in the prevalence of BRFs based on indicators such as reduced quality of life, social maladjustment, work-related factors, and traumatic experiences. Finally, we offered recommendations for a screening strategy for BRFs. …”
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Compound events in Germany in 2018: drivers and case studies by E. Xoplaki, E. Xoplaki, F. Ellsäßer, F. Ellsäßer, J. Grieger, K. M. Nissen, J. G. Pinto, M. Augenstein, T.-C. Chen, T.-C. Chen, H. Feldmann, P. Friederichs, D. Gliksman, D. Gliksman, L. Goulier, K. Haustein, K. Haustein, J. Heinke, L. Jach, F. Knutzen, S. Kollet, J. Luterbacher, J. Luterbacher, N. Luther, S. Mohr, S. Mohr, C. Mudersbach, C. Müller, E. Rousi, F. Simon, L. Suarez-Gutierrez, L. Suarez-Gutierrez, L. Suarez-Gutierrez, S. Szemkus, S. M. Vallejo-Bernal, S. M. Vallejo-Bernal, S. M. Vallejo-Bernal, O. Vlachopoulos, F. Wolf

“…We provide new insights into the drivers of spatially and temporally compound events, such as heat and drought, and heavy precipitation combined with extreme winds, and their adverse effects on ecosystems and society, using large-scale atmospheric patterns. …”
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Fungal Biocontrol Agents in the Management of Postharvest Losses of Fresh Produce—A Comprehensive Review by Phathutshedzo Ramudingana, Ndivhuho Makhado, Casper Nyaradzai Kamutando, Mapitsi Silvester Thantsha, Tshifhiwa Paris Mamphogoro

“…We therefore hypothesize that the use of fungal antagonists for prevention of postharvest loss of fresh produce is more effective compared to physical and chemical methods. Finally, particular attention is given to the gaps observed in establishing beneficial microbes as BCAs and factors that hamper their development, particularly in terms of shelf life, efficacy, commercialization, and legislation procedures.…”
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Intrinsic p53 activation restricts gammaherpesvirus driven germinal center B cell expansion during latency establishment by Shana M. Owens, Jeffrey M. Sifford, Gang Li, Steven J. Murdock, Eduardo Salinas, Darby Oldenburg, Debopam Ghosh, Jason S. Stumhofer, Intawat Nookaew, Mark Manzano, J. Craig Forrest

“…We identify the B cell-specific latency gene M2, a viral promoter of germinal center B cell differentiation, as a viral protein sufficient to elicit a p53-dependent anti-proliferative response caused by Src-family kinase activation. We further demonstrate that Epstein-Barr virus-encoded latent membrane protein 1 similarly triggers a p53 response in primary B cells. …”
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Zebrafish Fins as a Model System for Skeletal Human Studies by Manuel Marí-Beffa, Jesús A. Santamaría, Carmen Murciano, Leonor Santos-Ruiz, José A. Andrades, Enrique Guerado, José Becerra

“…Despite the tissue dissimilarity, this empirical evidence might finally lead to clinical applications to skeletal disorders in humans.…”
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Local structural–functional coupling with counterfactual explanations for epilepsy prediction by Jiashuang Huang, Shaolong Wei, Zhen Gao, Shu Jiang, Mingliang Wang, Liang Sun, Weiping Ding, Daoqiang Zhang

“…Then, we extract subgraphs from these multimodal brain networks and select them based on their frequencies to generate local SC–FC coupling patterns. Finally, we employ these patterns to identify brain disorders while refining abnormal patterns to generate counterfactual explanations. …”
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