The ERK1/2 Inhibitor U0126 Attenuates Diabetes-Induced Upregulation of MMP-9 and Biomarkers of Inflammation in the Retina by Ghulam Mohammad, Mohammad Mairaj Siddiquei, Mohammad Imtiaz Nawaz, Ahmed M. Abu El-Asrar

“…This study was conducted to determine the expression of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in a time-dependent manner and the effect of extracellular-signal-regulated kinases-1/2 (ERK1/2) inhibition on the expressions of MMP-9, TIMP-1, and inflammatory biomarkers in the retinas of diabetic rats. …”
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Rapid and non-destructive classification of rice seeds with different flavors: an approach based on HPFasterNet by Helong Yu, Helong Yu, Zhenyang Chen, Shaozhong Song, Shaozhong Song, Shaozhong Song, Chunyan Qi, Junling Liu, Chenglin Yang

“…In this experiment, 19 categories of japonica rice seeds were selected, and a total of 36735 images were finally obtained. The lightweight network High Precision FasterNet (HPFasterNet) proposed in this study combines the Ghost bottleneck and FasterNet_T0 and introduces group convolution to compare the model performance. …”
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Exploration of the mechanism of 5-Methylcytosine promoting the progression of hepatocellular carcinoma by Qiyao Zhang, Zhen Cao, Yuting He, Ziwen Liu, Wenzhi Guo

“…Immune, metabolic, and tumor-related pathways in HCC subtypes with differences in methylation status were analyzed and a prognostic model based on m5C-related genes was constructed. Finally, using RIP and molecular interaction analysis, we demonstrated that YBX1 binds to TPM3 in an m5C dependent manner and regulates HCC progression. …”
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Waste heat recovery cycles integration into a net-Zero emission solar-thermal multi-generation system; Techno-economic analysis and ANN-MOPSO optimization by Pradeep Kumar Singh, Ali Basem, Rebwar Nasir Dara, Mohamed Shaban, Sarminah Samad, Raymond Ghandour, Ahmad Almadhor, Samah G. Babiker, Iskandar Shernazarov, Ibrahim A. Alsayer

“…To optimize the system's performance, an artificial neural network is integrated with a multi-objective particle swarm optimization algorithm to reduce computational time from approximately 16 h to 4 min. Finally, under optimal conditions, the system achieves an exergy efficiency of 31.69 %, freshwater production of 19.53 kg/s, cooling production of 441.6 kW, and a total cost rate of $87.2/h.…”
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Additive manufacturing of continuous carbon fiber reinforced PETG with ultra-high interlaminar shear strength by Wenbo Wang, Yong Hu, Lei Yang, Yudong Lin, Lei Zhou, Jiayun Ma, Bing Liu, Xuan Cai, Chunze Yan, Yusheng Shi, Xiyong Chen

“…After the optimization, the maximum interlaminar shear strength and the maximum relative density of the produced samples reach 27.41 MPa and 99.47% with the parameters of hatch spacing 0.8 mm and printing speed 2 mm/s. Finally, the mechanism analysis of the above improvement and parameter optimization is carried out by relative density and surface morphology. …”
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A novel virtual inductor optimization methodology of virtual synchronous generators for enhanced power decoupling by Xin Zhang, Lijiao Gong, Yanjun Zhang, Xiaolei Ma, Lianshan Han, Santao Jiang, Weiji Zhou

“…This content achieves precise adjustment of the system’s stability, dynamic and decoupling performance. Finally, a series of comparative experiments is conducted to demonstrate its superior dynamic, static performance and enhanced power decoupling characteristics. …”
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G Protein-Coupled Estrogen Receptor-Selective Ligands Modulate Endometrial Tumor Growth by Whitney K. Petrie, Megan K. Dennis, Chelin Hu, Donghai Dai, Jeffrey B. Arterburn, Harriet O. Smith, Helen J. Hathaway, Eric R. Prossnitz

“…Moreover, our findings shed light on the potential mechanisms of SERM/SERD side effects reported in many clinical studies. Finally, our results provide the first demonstration that pharmacological inhibition of GPER activity in vivo prevents estrogen-mediated tumor growth.…”
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Antifibrotic Effect of Combination of Nilotinib and Stem Cell-Conditioned Media on CCl4-Induced Liver Fibrosis by Gamal Shiha, Ahmed Nabil, Ahmed Lotfy, Reham Soliman, Ayman A. Hassan, Islam S. Ali, Doaa F. Gad, Faten Zahran

“…Nilotinib is a second-generation tyrosine kinase inhibitor, which showed antifibrotic efficacy. …”
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Improved differential protection for two-terminal weak feed AC system considering negative sequence control coordination strategy by Junjie Hou, Qiangqiang Gao, Yanfang Fan, Guobing Song, Xiaofang Wu, Wentao Yang, Runbin Cao, Faxi Peng

“…Secondly, based on the problem of the traditional negative sequence control strategy, an improved control strategy is introduced and the operation performance of differential protection under the improved control strategy is studied. Finally, an improved differential protection scheme based on the change of current amplitude is proposed. …”
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MicroRNA-155 modulates methotrexate-induced spatial memory impairment by disruption of the blood-brain barrier integrity by Yu-Chieh Chen, Li-Tung Huang, Hong-Ren Yu, Jiunn-Ming Sheen

“…Tight junction proteins expression were also examined. Finally, we tested whether anti-miR155 pretreatment can reversed the MTX effect. …”
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Characterization of older adults' sexual life in a health area by Juan Miguel Benítez García, Julio César Camero Machín, Jesús Cuello Ávila, Juan Carlos Curbelo Fajardo

“…<br /><strong>Methods:</strong> a descriptive and cross-sectional study was carried out in office 163 of the Raúl Sánchez University Polyclinic, in Pinar del Río in the period between September 2020 and September 2021. …”
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Clinical Features and Risk Factors of Active Tuberculosis in Patients with Behçet’s Disease by Yaxu Liu, Lifan Zhang, Ziyue Zhou, Luxi Sun, Baotong Zhou, Xiaoqing Liu, Wenjie Zheng

“…The control group was selected by random number sampling from the remaining BD patients, including those with latent tuberculosis infection, previous tuberculosis, or without tuberculosis. Finally, we reviewed 386 BD patients and identified 21 (5.4%) ATB cases, including four (19.0%) microbiologically confirmed and 17 (81.0%) clinically diagnosed. …”
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Cross-Linking Mast Cell Specific Gangliosides Stimulates the Release of Newly Formed Lipid Mediators and Newly Synthesized Cytokines by Edismauro Garcia Freitas Filho, Elaine Zayas Marcelino da Silva, Camila Ziliotto Zanotto, Constance Oliver, Maria Célia Jamur

“…The effect of cross-linking the gangliosides on the MAP kinase pathway was then investigated. Cross-linking the gangliosides induced the phosphorylation of ERK1/2, JNK1/2, and p38 as well as activating both NFκB and NFAT in a Syk-dependent manner. …”
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Inflammatory Response Mechanisms Exacerbating Hypoxemia in Coexistent Pulmonary Fibrosis and Sleep Apnea by Ayodeji Adegunsoye, Jay Balachandran

“…Adipocytes may induce hypoxia inducible factor (HIF) 1α production; GERD is associated with increased levels of lactate dehydrogenase (LDH), alkaline phosphatase (ALP), and tumor necrosis factor alpha (TNF-α); pulmonary artery myocytes often exhibit increased cytosolic free Ca2+. Protein kinase C (PKC) mediated upregulation of TNF-α and IL-1β also occurs in the pulmonary arteries. …”
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Oncogenic PIK3CA corrupts growth factor signaling specificity by Ralitsa R Madsen, Alix Le Marois, Oliwia N Mruk, Margaritis Voliotis, Shaozhen Yin, Jahangir Sufi, Xiao Qin, Salome J Zhao, Julia Gorczynska, Daniele Morelli, Lindsay Davidson, Erik Sahai, Viktor I Korolchuk, Christopher J Tape, Bart Vanhaesebroeck

“…Abstract Technical limitations have prevented understanding of how growth factor signals are encoded in distinct activity patterns of the phosphoinositide 3-kinase (PI3K)/AKT pathway, and how this is altered by oncogenic pathway mutations. …”
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Field Monitoring-Based and Theoretical Analysis of Baota Mountain Landslide Stability by Yaming Tang, Heping Shu, Qiang Xue, Jiayun Wang, Wei Feng, Hongna Ma, Yan’e Li, Jin Luo, Hamid Reza Pourghasemi

“…The theoretical factor of safety was also calculated for the landslide. Finally, the theoretical results were validated by monitoring data in the field. …”
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Inhibitory effects of oxyresveratrol on ERK and Smad1/2 phosphorylation and HSC activation in preventing carbon tetrachloride-induced rat liver fibrosis by Guliang Yang, Jianfeng Zhan, Yiwen Yang, Li Yuan, Peilei Wang, Chi-Tang Ho, Shiming Li

“…Furthermore, the mRNA transcription levels of α-smooth muscle actinn (α-SMA), desmin, and two MMPs (MMP2 and MMP9) were reduced and the expression levels of transforming growth factor β1 (TGF-β1), p- small mother against decapen-taplegic protein (Smad)1/2 and p-extracellular signal-regulated kinases (ERK)1/2 in the liver tissue down-regulated dramatically. …”
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Functional state of the nigrostriatal system of Krushinsky – Molodkina rats during audiogenic seizure expression by N. A. Dorofeeva, L. S. Nikitina, D. V. Zosen, M. V. Glazova, E. V. Chernigovskaya

“…In the current work, we studied the role of extracellular signal-regulated kinase (ERK1/2) in the regulation of the nigrostriatal glutamate, GABA and dopamine neurons of Krushinsky – Molodkina rats at clonus-tonus and ataxia stages of audiogenic seizure. …”
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Long-Term Statistical Analysis of Severe Weather and Climate Events in Greece by Vassiliki Kotroni, Antonis Bezes, Stavros Dafis, Dimitra Founda, Elisavet Galanaki, Christos Giannaros, Theodore Giannaros, Athanasios Karagiannidis, Ioannis Koletsis, George Kyros, Konstantinos Lagouvardos, Katerina Papagiannaki, Georgios Papavasileiou

“…The main results show that between 2010 and 2023, Greece experienced: nearly one heatwave per summer; heavy rainfall events, most common in winter and autumn, showing a significant increase, particularly in the eastern Aegean and western continental Greece; dry spells, which are longest in southern Greece; thunderstorm and hail events peaking in spring and summer; fire weather conditions and risk peaking in southern Greece. Finally, societal impacts from weather hazards have increased in Greece over the past 14 years, with flash floods being the most frequent and damaging events, while public preparedness and effective risk communication remain low.…”
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Inhibition of STING-mediated type I IFN signaling by African swine fever virus DP71L by Lakmal Ranathunga, Sachini Abesinghe, Ji-Won Cha, Niranjan Dodantenna, Kiramage Chathuranga, Asela Weerawardhana, D. K. Haluwana, Nuwan Gamage, Jong-Soo Lee

“…Consequently, this interaction disrupted the binding between STING and TANK-binding kinase 1 (TBK1), thereby inhibiting downstream signaling including phosphorylation of TBK1, STING and IRF3 for antiviral signaling. …”
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