Remimazolam Combined with Andrographolide Improve Postoperative Cognitive Dysfunction in Rats after Cardiopulmonary Bypass through the AMPK/SIRT1 Signaling Pathway by Chong Chen, Lixia Lan, Kai Xu

“…The adenosine monophosphate-activated protein kinase/silent information regulator of transcription 1 (AMPK/SIRT1) signaling pathway was activated by the combination of Re and AP. …”
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Genome-Wide Identification and Characterization of the LRR-RLK Gene Family in Two Vernicia Species by Huiping Zhu, Yangdong Wang, Hengfu Yin, Ming Gao, Qiyan Zhang, Yicun Chen

“…Leucine-rich repeat receptor-like kinases (LRR-RLKs) make up the largest group of RLKs in plants and play important roles in many key biological processes such as pathogen response and signal transduction. …”
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Tear Film Proteome of Healthy Domestic Cats by Jéssica Fontes Veloso, Paula Elisa Brandão Guedes, Luciana Carvalho Lacerda, Juliano Oliveira Santana, Irma Yuliana Mora-Ocampo, Carlos Priminho Pirovani, Arianne Pontes Oriá, Alexandre Dias Munhoz, Renata Santiago Alberto Carlos

“…Others were considered novel in tear film samples of all species: cyclin-dependent protein kinase, serine/arginine repetitive matrix protein, apelin receptor, secretory protein related to C1q/TNF, Wee1, α-1,4 glucan phosphorylase, and WD repeat domain 1. …”
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Stress and Strain: Differentiating the Responses to High and Moderate Heat Loads and Subsequent Recovery in Grain-Fed Feedlot Steers—Metabolic Hormones by Gene Wijffels, Megan L. Sullivan, Sally Stockwell, Suzie Briscoe, Roger Pearson, Stephen T. Anderson, Yutao Li, Cintia C. de Melo Costa, Russell McCulloch, John B. Gaughan

“…The Challenge simulated a strong heatwave. Finally, the steers were maintained in outdoor pens for 38 d. …”
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Increasing the concentration of plasma molecules improves the biological activity of platelet-rich plasma for tissue regeneration by Mikel Sánchez, Jon Mercader Ruiz, Daniel Marijuán Pinel, Pello Sánchez, Nicolás Fiz, Jorge Guadilla, Juan Azofra, Maider Beitia, Diego Delgado

“…Regarding cell migration capacity, it was found that the process is platelet-dependent. Finally, the anti-inflammatory effect of BPCP was evaluated by inducing an inflammatory environment in M1-type macrophages. …”
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Effect of Contact Time and Gas Component on Interfacial Tension of CO2/Crude Oil System by Pendant Drop Method by Xin Wang, Lifeng Liu, Zengmin Lun, Chengyuan Lv, Rui Wang, Haitao Wang, Dong Zhang

“…The dynamic interfacial tension of CO2/original oil, CO2/remaining oil, and CO2/produced oil systems is large at the initial contact and decreases gradually after that, and then finally it reaches dynamic balance. In addition, the higher the pressure is, the larger the magnitude of changing of CO2/crude oil interfacial tension with time will reduce. …”
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Effect of Iota-Carrageenan and Its Hydrolysates on the Stability of Milk Ice Cream Mixes by Anna Kot, Ewa Jakubczyk, Magdalena Buniowska-Olejnik, Anna Kamińska-Dwórznicka

“…The iota-carrageenan after commercial lactase treatment improved the stability of milk ice cream mixes by increasing the consistency index to 0.104 and a flow behaviour index to 0.702. Finally, it may be concluded that the stabilisers used – iota-carrageenan and its hydrolysates – significantly influenced the physical properties of milk ice cream mixes and, hence, can be used as beneficial ingredients in the recipe of milk ice cream mixes.…”
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PARP inhibition-associated heterochromatin confers increased DNA replication stress and vulnerability to ATR inhibition in SMARCA4-deficient cells by Kimiyoshi Yano, Megumi Kato, Syoju Endo, Taichi Igarashi, Ryoga Wada, Takashi Kohno, Astrid Zimmermann, Heike Dahmen, Frank T. Zenke, Bunsyo Shiotani

“…Elevated RS levels increase the vulnerability of cancer cells to ataxia telangiectasia and Rad3-related kinase inhibitors (ATRis). Here, we screened for DNA damage response inhibitors that enhance ATRi-induced cytotoxicity using SWI/SNF complex-deficient cells and identified a potent synergy between ATRi and poly(ADP-ribose) polymerase inhibitor (PARPi), particularly in SMARCA4-deficient cells. …”
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Prediction of circRNA-miRNA Associations Based on Network Embedding by Wei Lan, Mingrui Zhu, Qingfeng Chen, Jianwei Chen, Jin Ye, Jin Liu, Wei Peng, Shirui Pan

“…Furthermore, the network embedding algorithm is used to extract potential features of circRNA and miRNA from the heterogeneous network, respectively. Finally, the associations between circRNAs and miRNAs are predicted by using neighborhood regularization logic matrix decomposition and inner product. …”
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Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson’s Disease by Dmitri Leonoudakis, Anand Rane, Suzanne Angeli, Gordon J. Lithgow, Julie K. Andersen, Shankar J. Chinta

“…In addition, securinine inhibited the activation of the inflammatory mediator NF-κB, as well as mitogen-activated protein kinases in lipopolysaccharide- (LPS-) stimulated BV2 cells. …”
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Frk positively regulates innate antiviral immunity by phosphorylating TBK1 by Xiaomei Zhang, Ying You, Tingrong Xiong, Tingrong Xiong, Xiaokai Zhang, Haibo Wang, Jinxia Geng, Miao Wang, Yanyan Xu, Shanshan Gao, Shanshan Gao, Xiaoyan Wu, Yue Zheng, Xianhua Wen, Haoyu Yang, Yu Wang, Yu Wang, Xiaohua Wen, Congcong Zhao

“…In this study, we validated the function of Fyn-related kinase (Frk) in the antiviral innate immune response and identified the direct target molecule of Frk in the IFN-β signaling pathway. …”
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A Spiritual Care Program for Patients With Cancer and Psychosomatic Disorders in Iran: A Protocol Study by Rahmatollah Marzband, Seyed Hamzeh Hosseini, Zeinab Hamzehgardeshi, Mahmood Moosazadeh, Mohammad Eslamijouybari, Tahereh Yaghoubi, Marzieh Azizi, Fereshteh Araghian Mojarad, Ehsan Abedini

“…Then, the opinions of a panel of experts will be used to finalize the content and assess the quality of the designed program using the appraisal of guidelines for research and evaluation instrument II (AGREE II) tool. …”
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Hydroxytyrosol Protects against Myocardial Ischemia/Reperfusion Injury through a PI3K/Akt-Dependent Mechanism by Ying-hao Pei, Jiao Chen, Liang Xie, Xiao-min Cai, Run-Hua Yang, Xing Wang, Jian-bin Gong

“…Prereperfusion administration of HT was associated with a significantly smaller area of myocardial infarction and remarkably decreased level of myocardial apoptosis and necrosis, as evidenced by a lower apoptotic index, reduced cleaved caspase-3, and the serum activities of lactate dehydrogenase and creatinine kinase MB. Moreover, HT also attenuated the impairment of cardiac systolic function. …”
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Long Term Survival and Continued Complete Response of Vemurafenib in a Metastatic Melanoma Patient with BRAF V600K Mutation by K. Sahadudheen, Md. Rafiqul Islam, M. Iddawela

“…Introduction. BRAF kinase inhibitors such as Vemurafenib have shown improvement in overall survival, progression-free survival, and response rates in patients with metastatic melanoma with BRAF V600K mutation. …”
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A multilayered regulatory network mediated by protein phosphatase 4 controls carbon catabolite repression and de-repression in Magnaporthe oryzae by Zhicheng Huang, Qing Wang, Yan Li, Pengyun Huang, Jian Liao, Jing Wang, Hui Li, Yingying Cai, Jiaoyu Wang, Xiaohong Liu, Fu-Cheng Lin, Jianping Lu

“…We demonstrate that the protein phosphatase 4 complex (Pp4c and Smek1 subunits), the AMP-activated protein kinase (AMPK) Snf1, and the transcriptional regulators CreA (repressor) and Crf1 (activator) collaboratively regulate the utilization of non-preferred carbon sources. …”
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Serum Lipids Alterations in Patients Under Systemic JAK Inhibitors Treatments in Dermatology: Clinical Aspects and Management by Giovanni Paolino, Mario Valenti, Andrea Carugno, Matteo Bianco, Dario Didona, Matteo Riccardo Di Nicola, Pier Luigi Acutis, Carmen Cantisani, Vittoria Giulia Bianchi, Nicola Zerbinati, Alessandra Narcisi, Antonio Costanzo, Santo Raffaele Mercuri

“…<i>Background and Objectives</i>: Janus kinase inhibitors (JAKi) have significantly advanced the treatment of various dermatological conditions by modulating the JAK-STAT signalling pathway. …”
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Network Diffusion Framework to Simulate Spreading Processes in Complex Networks by Michał Czuba, Mateusz Nurek, Damian Serwata, Yu-Xuan Qiu, Mingshan Jia, Katarzyna Musial, Radosław Michalski, Piotr Bródka

“…First, a survey of the existing approaches and toolkits for simulating spreading phenomena is shown, and then, an overview of the framework functionalities. Finally, we report four case studies conducted with the package to demonstrate its usefulness: the impact of sanitary measures on the spread of COVID-19, the comparison of information diffusion on two temporal network models, and the effectiveness of seed selection methods in the task of influence maximisation in multilayer networks. …”
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Sickle Cell Disease Activates Peripheral Blood Mononuclear Cells to Induce Cathepsins K and V Activity in Endothelial Cells by Philip M. Keegan, Sindhuja Surapaneni, Manu O. Platt

“…Inhibition of c-Jun N-terminal kinase (JNK) significantly reduced cathepsins K and V activation by 60% and 51%, respectively. …”
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The Problem of Spurious Emissions in 5G FR2 Phased Arrays, and a Solution Based on an Upmixer With Embedded LO Leakage Cancellation by Arun Paidimarri, Yujiro Tojo, Caglar Ozdag, Alberto Valdes-Garcia, Bodhisatwa Sadhu

“…The LO cancellation results in better than &#x2212;57-dBc LO leakage across all candidate frequencies. Finally, we present extensive over-the-air (OTA) measurement validation of the LO suppression across frequencies, signal levels, and 64-element beam steering across a 60 beam steering range.…”
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Diagnosis of the vegetation cover in the wetlands of La Caimanera Swamp, Colombia and Casitas Wetland, Mexico by means of Landsat and Sentinel-2A images during last four decades by Gastón Ballut-Dajud, Erick Arturo Betanzo-Torres, Luis Carlos Sandoval Herazo

“…In terms of water content, NDWI positive values ranged from 0.06 to 0.72, reflecting water presence in both wetlands. Finally, it can be said that the mangrove area is preserved and has not suffered significant damage from human activities.…”
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