End-to-end dataflow engineering framework of honey manufacturing from intermediates to process by TAS1R2@AuNPs/SPCE biosensor coupled with quality transfer principle by Xiaoyan Hu, Jingqi Zeng, Lijuan Ma, Xiaomeng Wang, Jing Du, Lu Yao, Zhisheng Wu

“…Furthermore, a hypersensitized TAS1R2@AuNPs/SPCE biosensor was developed to identify biological quality attributes of honey, the powerful affinities between honey intermediates and the TAS1R2 receptor were discovered (KD < 1 × 10−8 M), and the abnormal batches of B2, B23 and C23 were diagnosed by TAS1R2@AuNPs/SPCE biosensor and multivariable algorithm. Finally, the end-to-end dataflow containing physical, chemical and biological critical quality attributes was successfully established to interpret the quality transfer principle of honey manufacturing, which revealed that the front-end refining process was relatively unstable and the back-end refining process was a negligible influence on the quality of honey manufacturing. …”
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Pigmented Maize (Zea mays L.) Contains Anthocyanins with Potential Therapeutic Action Against Oxidative Stress - A Review by Jesús Miguel Magaña Cerino, Héctor Arturo Peniche Pavía, Axel Tiessen, Carmen Magdalena Gurrola Díaz

“…Furthermore, the biosynthesis, bioavailability, and stability are also summarized. Finally, many in vitro and in vivo studies of maize anthocyanins are discussed that demonstrated their nutraceutical potential, antioxidant capacity, and other biological effects. …”
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Geometrical comparison of inline and staggered stack wire mesh absorbers for solar volumetric receivers by Daniel Sanchez-Señoran, Miguel A. Reyes-Belmonte, Michael P. Kinzel, Marina Casanova, Antonio L. Avila-Marin

“…Conversely, the IL arrangement demonstrates superior hydrodynamic performance. Finally, the results are corroborated with existing literature, which further validates the reliability of the numerical model and its conclusions.…”
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Kaempferol improves glucose uptake in skeletal muscle via an AMPK-dependent mechanism by William T. Moore, Jing Luo, Dongmin Liu

“…The effect of kaempferol on glucose uptake was blunted by inhibition of glucose transporter 4, phosphoinositide 3-kinase (PI3K), or AMPK. In addition, kaempferol induced AMPK phosphorylation, and inhibition of AMPK prevented kaempferol-stimulated Akt phosphorylation. …”
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Fine tuning enzyme activity assays for monitoring the enzymatic hydrolysis of PET by Krisztina Boros, Blanka Eszter Nagy, Raluca Bianca Tomoiagă, Róbert Tőtős, Monica Ioana Toșa, Csaba Paizs, László Csaba Bencze

“…The other predominantly employed UV-spectroscopy assay was also improved in terms of employed wavelength and medium extinction coefficient of the three aromatic degradation products, while being cross-validated by the improved HPLC method. Finally, both methods were used for monitoring the product formation within the leaf-branch compost cutinase (LCC)-mediated PET-hydrolysis and provided individual time-productivity profiles for each aromatic degradation product.…”
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Geographical origin traceability of kiwifruit products using stable isotope and multi-element analysis with multivariate modeling: Feature extraction, selection of model and variab... by Wang Shuanhui, Chen Chang, Tian Jing, Liu Zhi, Mei Xianxian, Zhou Jialu, Wang Dongguang, Zhu Shaohua

“…Supervised methods, partial least squares-discriminant analysis (PLS-DA) and its derivative algorithm (OPLS-DA), linear discriminant analysis (LDA), enhanced identification performance and finally elevated the accuracies to 100 % for all kiwifruit origins. …”
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Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM. by Frances M Bashore, Vittorio L Katis, Yuhong Du, Arunima Sikdar, Dongxue Wang, William J Bradshaw, Karolina A Rygiel, Tina M Leisner, Rod Chalk, Swati Mishra, C Andrew Williams, Opher Gileadi, Paul E Brennan, Jesse C Wiley, Jake Gockley, Gregory A Cary, Gregory W Carter, Jessica E Young, Kenneth H Pearce, Haian Fu, Emory-Sage-SGC TREAT-AD Center, Alison D Axtman

“…RNA sequencing and genetic data support spleen tyrosine kinase (SYK) and high affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) as putative targets to be modulated for Alzheimer's disease (AD) therapy. …”
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A Citrus bergamia Extract Decreases Adipogenesis and Increases Lipolysis by Modulating PPAR Levels in Mesenchymal Stem Cells from Human Adipose Tissue by Debora Lo Furno, Adriana Carol Eleonora Graziano, Rosanna Avola, Rosario Giuffrida, Vincenzo Perciavalle, Francesco Bonina, Giuliana Mannino, Venera Cardile

“…Moreover, the expression of peroxisome proliferator-activated receptor gamma (PPAR-γ), adipocytes fatty acid-binding protein (A-FABP), adipose triglyceride lipase (ATGL), hormone-sensitive lipase (HSL), monoglyceride lipase (MGL), 5′-adenosine monophosphate-activated protein kinase (AMPK)α1/2, and pAMPKα1/2 was evaluated by Western blot analysis and the release of glycerol by colorimetric assay. …”
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Teratogenic Effects of Coadministration of Fluoxetine and Olanzapine on Rat Fetuses by Azam Bakhtiarian, Nasrin Takzare, Mehdi Sheykhi, Narges Sistany, Farahnaz Jazaeri, Mario Giorgi, Vahid Nikoui

“…The sixth group received 9 mg/kg fluoxetine and 3 mg/kg olanzapine. Finally, the seventh group was administrated with fluoxetine and olanzapine at 18 mg/kg and 6 mg/kg, respectively. …”
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Detection of The TNFSF Members BAFF, APRIL, TWEAK and Their Receptors in Normal Kidney and Renal Cell Carcinomas by Vassiliki Pelekanou, George Notas, Katerina Theodoropoulou, Marilena Kampa, Dimitrios Takos, Vassilia-Ismini Alexaki, Jelena Radojicic, Frank Sofras, Andreas Tsapis, Efstathios N. Stathopoulos, Elias Castanas

“…Therapeutic modalities targeting VEGF, PDGF, and c-kit using tyrosine kinase inhibitors and m-TOR using specific biologic factors are in development. …”
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ACCIDENTS AND OCCUPATIONAL ILLNESS ASSESSMENTS FOR 400/220/110/20 kV URECHESTI POWER SUBSTATION by Nicolae Daniel FÎȚĂ, Mila Ilieva OBRETENOVA, Florin MURESAN – GRECU, Gheorghe Eugen SAFTA, Adrian Mihai SCHIOPU, Dan Cristian LAZAR

“…Prevention of occupational risks is the only way to improve the safety and health conditions of the participants in the work process, as well as a reliable source for reducing costs, increasing labor productivity, quality of production and, finally, quality of social life. Risk management facilitates a structured and systematic approach to decision-making. …”
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Case report: Exploring efficacy of tofacitinib in modulating interferon response in five case of anti-MDA5+ dermatomyositis with interstitial lung disease by Jie Zhao, Yan Bao, Ying Gao, Keliang Xie

“…In an attempt to stem the relentless progression, tofacitinib, a Janus kinase (JAK) inhibitor, was applied into her treatment regimen. …”
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Design of Efficient Off-Grid Solar Photovoltaic Water Pumping System Based on Improved Fractional Open Circuit Voltage MPPT Technique by Ali Hmidet, Umashankar Subramaniam, Rajvikram Madurai Elavarasan, Kannadasan Raju, Matias Diaz, Narottam Das, Kashif Mehmood, Alagar Karthick, M. Muhibbullah, Olfa Boubaker

“…This association avoids the use of a speed sensor/encoder and a current sensor for the IM. Finally, the effectiveness of the proposed off-grid SPVWPS and its control system for both steady-state and dynamic conditions of insolation change is verified using a 1KVA rated prototype. …”
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Metformin-induced mitophagy suppresses auditory hair cell apoptosis via AMPK pathway by Yifan Lai, Jiawei Qiu, Kuang Zheng, Xiang Li, Yinuo Lin, Zhengzheng Li, Haiqiu Sun

“…Mechanistically, we discovered that metformin activates AMP-activated protein kinase (AMPK) signaling in HEI-OC1 cells stimulated by TBHP, thereby triggering mitophagy. …”
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Involvement of Toll Like Receptor 2 Signaling in Secondary Injury during Experimental Diffuse Axonal Injury in Rats by Yonglin Zhao, Junjie Zhao, Ming Zhang, Yahui Zhao, Jiaxi Li, Xudong Ma, Tingqin Huang, Honggang Pang, Bo Wang, Jinning Song

“…Intracerebral knockdown of TLR2 significantly downregulated TLR2 expression, attenuated cortical apoptosis, lessened glial response, and reduced the secondary axonal and neuronal injury in the cortex by inhibiting phosphorylation of mitogen-activated protein kinases (MAPK) including Erk, JNK, and p38, translocation of NF-κB p65 from the cytoplasm to the nucleus, and decreasing levels of proinflammatory cytokines including interleukin-6, interleukin-1β, and tumor necrosis factor-α. …”
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PGE2 Desensitizes β-Agonist Effect on Human Lung Fibroblast-Mediated Collagen Gel Contraction through Upregulating PDE4 by Qiuhong Fang, Yingmin Ma, Jing Wang, Joel Michalski, Stephen I. Rennard, Xiangde Liu

“…Pretreatment with PGE2 abolished the inhibitory effect of salmeterol, but it potentiated the inhibitory effect of cilomilast on fibroblast-mediated collagen gel contraction. Finally, indomethacin slightly inhibited PDE4C expression, while PGE2 stimulated the expression of PDE4A and -4C in human lung fibroblasts. …”
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An Investigation of the Anticancer Mechanism of <i>Caesalpinia sappan</i> L. Extract Against Colorectal Cancer by Integrating a Network Pharmacological Analysis and Experimental Va... by Mibae Jeong, Jaemoo Chun, Sang-Min Park, Heerim Yeo, Se Won Na, In Jin Ha, Bonglee Kim, Mi-Kyung Jeong

“…Western blot analyses confirmed the modulation of critical signaling pathways, including STAT3, AKT, and mitogen-activated protein kinases. Furthermore, CSE significantly suppressed tumor growth in MC38 CRC-bearing mice. …”
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A szakértői elfogultság a büntetőügyekben II. rész by Márton Lontai, Horolma Pamzsav, Dávid Petrétei

“…Érték: A tanulmány átfogó képet nyújt Itiel Dror munkásságán keresztül a szakértői elfogultság problémájáról, továbbá használható megoldási javaslatokat kínál. …”
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Cytokine-armed oncolytic herpes simplex viruses: a game-changer in cancer immunotherapy? by Howard L Kaufman, Hongbin Wang, Dipongkor Saha, Samuel D Rabkin, Mia Borlongan, Uyen Le, Hans J Nauwynck

“…In this review, we highlight preliminary data with several cytokines and chemokines, including GM-CSF, interleukin 12, FMS-like tyrosine kinase 3 ligand, tumor necrosis factor α, interleukin 2, interleukin 15, interleukin 18, chemokine (C-C motif) ligand 2, chemokine (C-C motif) ligand 5, chemokine (C-X-C motif) ligand 4, or their combinations, and show how these payloads can further enhance the antitumor immunity of oHSV. …”
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Drug-induced bone disorders: A systematic review by Anshita Aggarwal, Meha Sharma, Indira Maisnam, Soumitra Ghosh, Sameer Aggarwal, Saptarshi Bhattacharya, Deep Dutta

“…Anti-epileptics, proton pump inhibitors, glucocorticoids, immunosuppressants (calcineurin inhibitors), anticoagulants, glitazones, SGLT2 inhibitors, somatostatin analogs, anticancer medications, and protein kinase inhibitors are some of the commonly used medications associated with bone mineral loss. …”
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