Active Suspension Based on a Motor-Driving Compacted Double-Gas-Chamber Hydro-Pneumatic Strut by Ruihong Li, Bing Ma, Fan Yang, Dezhao Lin, Weiqiang Zhang

“…The controller is built based on the quarter-car model with the MDHPS model and the optimal values are identified through the Ziegler-Nichols method and Genetic Algorithm (GA). Finally, to investigate the attitude control effect of MDHPS, the full-car model is established based on the co-simulation of Carsim and Matlab/Simulink. …”
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Protection Effect of Endomorphins on Advanced Glycation End Products Induced Injury in Endothelial Cells by Jing Liu, Liping Yan, Ruilan Niu, Limin Tian, Qi Zhang, Jinxing Quan, Hua Liu, Suhong Wei, Qian Guo

“…The expression of p38 mitogen-activated protein kinase (p38 MAPK) was detected by immunofluorescence assay. …”
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Mechanisms Underlying the Antidepressant Response of Acupuncture via PKA/CREB Signaling Pathway by Huili Jiang, Xuhui Zhang, Yu Wang, Huimin Zhang, Jing Li, Xinjing Yang, Bingcong Zhao, Chuntao Zhang, Miao Yu, Mingmin Xu, Qiuyun Yu, Xingchen Liang, Xiang Li, Peng Shi, Tuya Bao

“…Protein kinase A (PKA)/cAMP response element-binding (CREB) protein signaling pathway, contributing to impaired neurogenesis parallel to depressive-like behaviors, has been identified as the crucial factor involved in the antidepressant response of acupuncture. …”
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Growth profile of Bacteroidetes strains under low molecular weight alginate fractions produced by non-thermal processing techniques by Pedro Rivero-Ramos, Pedro J. Fernandez-Julia, Dolores Rodrigo, María Benlloch-Tinoco, Jose Munoz-Munoz

“…Higher M/G ratios significantly enhanced the growth of B. thetaiotaomicron VPI-5482 (p < 0.05, r = 0.9685). Finally, D. mossii DSMZ22836 was found to employ three enzymes (Aly, GH88, GH92) to degrade the low Mw alginate fractions. …”
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Comparative transcriptomics analysis of Zygosaccharomyces mellis under high-glucose stress by Gongliang Liu, Xinyu Bi, Changli Tao, Yongtao Fei, Sujuan Gao, Jinglong Liang, Weidong Bai

“…The result revealed that transcriptional changes in multiple metabolic pathways occur in response to high-glucose stress. q-RT PCR analysis further confirmed that several stress response pathways, such as the high osmolarity glycerol mitogen-activated protein kinase (HOG-MAPK) signal transduction pathway, trehalose synthesis pathway and oxidative stress response are closely related to high-glucose tolerance in Z. mellis. …”
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Postdigital Bystanding: Youth Experiences of Sexual Violence Workshops in Schools in England, Ireland, and Canada by Jessica Ringrose, Debbie Ging, Faye Mishna, Betsy Milne, Tanya Horeck, Kaitlynn Mendes

“…We analyse how the intersectional community, cultural, and identity-specific factors in particular schooling environments shape responses to bystanding in postdigital environments, including how factors of sexism, defensive masculinity, elitism, racism, and a reluctance to report digital issues played out in the responses to the workshops. Finally, following young people’s suggestions, we recommend that schools need to cultivate better safety and support strategies for youth in order to make postdigital bystander interventions more responsive and therefore effective in challenging and preventing sexual violence in society.…”
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The Increased Expression of HLA-DR and ICAM-1 Molecules by Human Bronchial Epithelial Cells, Induced by Activated Mononuclear Cells, is Downregulated by Nedocromil Sodium by O. Sacco, S. Lantero, L. Scarso, V. Frangova, V. Ottolini, G. A. Rossi

“…A similarly dose-dependent inhibitory effect was also observed with dexamethasone, which, however, was less active than nedocromil on HL-ADR expression and more active on ICAM-1 expression. Finally, nedocromil and dexamethasone showed a significant synergistic effect on the expression of both cell surface molecules at the lowest concentrations tested.…”
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Targeting AI-2 quorum sensing: harnessing natural products against Streptococcus suis biofilm infection by Shuji Gao, Shuo Yuan, Yingying Quan, Wenjie Jin, Yamin Shen, Rishun Li, Baobao Liu, Yuxin Wang, Li Yi, Shaohui Wang, Xiaogai Hou, Yang Wang

“…Using LC‒MS/MS, we further analysed the impact of SAA and RH on the metabolic activity of S. suis, revealing the potential medicinal value of these compounds. Finally, the efficacy of SAA and RH against S. suis infection was validated in Galleria mellonella larvae, confirming their significant anti-infection effects.…”
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Environmental behavior of per- and polyfluoroalkyl substances (PFASs) and the potential role of biochar for its remediation: a review by Haiyan Wang, Haiyan Zhang, Lizhi He, Jie Wang, Shuo Wang, Xiaoyu Shi, Xiaokai Zhang, Hailong Wang, Feng He

“…Furthermore, this review discusses the ability of biochar to reduce the likelihood of PFASs entering the food chain through water and soil and evaluates the feasibility and limitations of using biochar for PFASs removal. Finally, we identify future research directions to support the safe and effective use of biochar for PFASs remediation, so as to promote the advancement of green remediation technologies. …”
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Toward an integrated pantropical ocean observing system by Gregory R. Foltz, Yassir A. Eddebbar, Janet Sprintall, Antonietta Capotondi, Antonietta Capotondi, Sophie Cravatte, Sophie Cravatte, Peter Brandt, Peter Brandt, Adrienne J. Sutton, Tamaryn Morris, Juliet Hermes, Juliet Hermes, Clive R. McMahon, Michael J. McPhaden, Lev B. Looney, Lev B. Looney, Lev B. Looney, Franz Philip Tuchen, Franz Philip Tuchen, Mathew Koll Roxy, Fan Wang, Fei Chai, Regina R. Rodrigues, Belen Rodriguez-Fonseca, Belen Rodriguez-Fonseca, Aneesh C. Subramanian, Marcus Dengler, Cheyenne Stienbarger, Kathleen Bailey, Weidong Yu

“…Common gaps, needs, and recommendations are identified, and interbasin differences driven by socioeconomic disparities are discussed, building on the concept of an integrated pantropical observing system. Finally, recommendations for improved observations of tropical basin interactions, through oceanic and atmospheric pathways, are presented, emphasizing the benefits that can be achieved through closer interbasin coordination and international partnerships.…”
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TOM1L Is Involved in a Novel Signaling Pathway Important for the IL-2 Production in Jurkat T Cells Stimulated by CD3/CD28 CoLigation by Ahmed Elmarghani, Hanan Abuabaid, Peter Kjellen

“…The ability of TOM1L to activate Fyn was further shown in a kinase assay using angiotensin II as a substrate. …”
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Formulation, characterization, and evaluation of curcumin-loaded ginger-derived nanovesicles for anti-colitis activity by Shengjie Huang, Min Zhang, Xiaoge Li, Jierong Pei, Zhirong Zhou, Peng Lei, Meng Wang, Peng Zhang, Heshui Yu, Guanwei Fan, Lifeng Han, Haiyang Yu, Yuefei Wang, Miaomiao Jiang

“…The study achieved a high loading capacity (94.027% ± 0.094%) and encapsulation efficiency (89.300% ± 0.344%). Finally, the drugs' in vivo distribution and anti-colitis activity were investigated in mice. …”
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PPARG Could Work as a Valid Therapeutic Strategy for the Treatment of Lung Squamous Cell Carcinoma by Shunbin Shi, Guiping Yu, Bin Huang, Yedong Mi, Yan Kang, Julia Pia Simon

“…After that, a gene set enrichment analysis (GSEA) was conducted to study the functionalities of PPARG and PPARG-driven triggers within the molecular pathways. Finally, another mega-analysis was constructed to test the expression changes of PPARG and its driven targets. …”
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Assistive Devices Analysis for Visually Impaired Persons: A Review on Taxonomy by Sadia Zafar, Muhammad Asif, Maaz Bin Ahmad, Taher M. Ghazal, Tauqeer Faiz, Munir Ahmad, Muhammad Adnan Khan

“…In the second stage, state of the art machine learning techniques process these signals and extract useful information. Finally, feedback is provided to the user through auditory and/or vibratory means. …”
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N-Cadherin Upregulation Promotes the Neurogenic Differentiation of Menstrual Blood-Derived Endometrial Stem Cells by Yanli Liu, Fen Yang, Shengying Liang, Qing Liu, Sulei Fu, Zhenyu Wang, Ciqing Yang, Juntang Lin

“…In vivo studies clearly showed that N-cad knockdown via in utero electroporation perturbed the migration and maturation of mouse neural precursor cells (NPCs). Finally, a further transfection assay also confirmed that N-cad upregulation in MenSCs results in the expression of S100. …”
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Altered ERK1/2 Signaling in the Brain of Learned Helpless Rats: Relevance in Vulnerability to Developing Stress-Induced Depression by Yogesh Dwivedi, Hui Zhang

“…Extracellular signal-regulated kinase 1/2- (ERK1/2-) mediated cellular signaling plays a major role in synaptic and structural plasticity. …”
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New insights into microbial bile salt hydrolases: from physiological roles to potential applications by Zixing Dong, Shuangshuang Yang, Cunduo Tang, Dandan Li, Dandan Li, Yunchao Kan, Yunchao Kan, Lunguang Yao, Lunguang Yao

“…Meanwhile, we also present the potential applications of BSHs and BSH-producing probiotics in various fields. Finally, we describe several important questions that need to be addressed by further investigations. …”
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A Green Approach to the Production of Hybrid Diindolylmethane-Phenylboronic Acids via a 3MCR: Promising Antineoplasic Molecules by Mónica Zarco Juarez, Joel Omar Martínez, Olivia Noguez Cordova, María Inés Nicolás Vazquez, Teresa Ramírez-Apan, Javier Pérez Flores, René Miranda Ruvalcaba, Gabriel Arturo Arroyo Razo

“…Moreover, the activity of these target molecules was evaluated in the presence of six cancer cell lines (U251 = glia of the central nerve system, PC-3 = prostate, K562 = leukemia, HCT-15 = colon, MCF-7 = breast, and SKLU-1 = lung), which resulted in the meta-regioisomer being the most active. Finally, the products were also analyzed using computational chemistry in order to determine their most stable geometries and reactivities by computing the respective molecular electrostatic potentials.…”
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Parchment Glutamine Index (PQI): A novel method to estimate glutamine deamidation levels in parchment collagen obtained from low-quality MALDI-TOF data by Nair, Bharath, Palomo, Ismael Rodríguez, Markussen, Bo, Wiuf, Carsten, Fiddyment, Sarah, Collins, Matthew James

“…After pre-processing raw spectra, we used weighted least-squares linear regression to estimate Q deamidation levels from the convoluted isotopic envelope for seven collagen-peptide markers. Finally, we employed a linear mixed effect model to predict the overall deamidation level of a parchment sample termed Parchment Glutamine Index (PQI). …”
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STK3 Suppresses Ovarian Cancer Progression by Activating NF-κB Signaling to Recruit CD8+ T-Cells by Xiangyu Wang, Fengmian Wang, Zhi-Gang Zhang, Xiao-Mei Yang, Rong Zhang

“…Serine/threonine protein kinase-3 (STK3) is a critical molecule of the Hippo pathway but little is known about its biological functions in the ovarian cancer development. …”
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