Progress in Pathogenesis of Proteinuria by Aihua Zhang, Songming Huang

“…The close relationships of slit diaphragm (SD) molecules such as nephrin, podocin, CD2-associated protein (CD2AP), a-actinin-4, transient receptor potential cation channel 6 (TRPC6), Densin and membrane-associated guanylate kinase inverted 1 (MAGI-1), α3β1 integrin, WT1, phospholipase C epsilon-1 (PLCE1), Lmx1b, and MYH9, and mitochondrial disorders and circulating factors in the pathogenesis of glomerular proteinuria were also gradually discovered. …”
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The transcriptional response of cortical neurons to concussion reveals divergent fates after injury by Mor R. Alkaslasi, Eliza Y. H. Lloyd, Austin S. Gable, Hanna Silberberg, Hector E. Yarur, Valerie S. Tsai, Mira Sohn, Gennady Margolin, Hugo A. Tejeda, Claire E. Le Pichon

“…We found that the axon injury responsive dual leucine zipper kinase (DLK) is required for the layer V neuron death. …”
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Declining precipitation frequency may drive earlier leaf senescence by intensifying drought stress and enhancing drought acclimation by Xinyi Zhang, Xiaoyue Wang, Constantin M. Zohner, Josep Peñuelas, Yang Li, Xiuchen Wu, Yao Zhang, Huiying Liu, Pengju Shen, Xiaoxu Jia, Wenbin Liu, Dashuan Tian, Prajal Pradhan, Adandé Belarmain Fandohan, Dailiang Peng, Chaoyang Wu

“…The enhanced drought acclimation, showing a more rapid response to drought, also explains the positive relationship between precipitation frequency and foliar senescence date. Finally, we find 30 current state-of-art Earth system models largely fail to capture the sensitivity of DFS to changes in precipitation frequency and incorrectly predict the direction of correlations for approximately half of the northern global lands, in both historical simulations and future predictions. …”
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Small cell lung cancer with EML4-ALK fusion: report of a case responding to ALK TKI and literature review by Mingyue Wang, Hongzhi Liu, Ruixin Zhang, Runyu Li, Xiaoyu Qin, Fangling Ning, Lijun Tian

“…Abstract Purpose With the continuous development and progress of next-generation gene sequencing technology, many types of anaplastic lymphoma kinase (ALK) rearrangement have been discovered. However, in small cell lung cancer (SCLC), ALK rearrangement is extremely rare and there is no standard treatment protocol. …”
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Development and Evaluation of a Rehabilitation Wheelchair with Multiposture Transformation and Smart Control by Wujing Cao, Hongliu Yu, Xinyu Wu, Sujiao Li, Qiaoling Meng, Chunjie Chen

“…This work describes the functional requirements, mechanical structure, and control system and the overall evaluation of ReChair including the kinematic simulation of the multiposture transformation and passive lower limb rehabilitation training to quantitatively verify the motion capability of ReChair, the voice control system evaluation that shows how the voice recognition system is suitable for home environment, the sensorless speed detection test results that indicate how the wheel speeds measured by sensorless method are appropriate for travelling control, and the passive and balance training test results that show how the lower limb rehabilitation training in daily life by ReChair is convenient. Finally, the experimental results show that ReChair meets the patients’ requirements and has practical significance. …”
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The EGFR-ADAM17 Axis in Chronic Obstructive Pulmonary Disease and Cystic Fibrosis Lung Pathology by Marta Stolarczyk, Bob J. Scholte

“…In addition to intracellular kinases, the extracellular glutathione-dependent redox potential controls ADAM17 shedding. …”
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Inverse design of nanophotonic devices enabled by optimization algorithms and deep learning: recent achievements and future prospects by Kim Junhyeong, Kim Jae-Yong, Kim Jungmin, Hyeong Yun, Neseli Berkay, You Jong-Bum, Shim Joonsup, Shin Jonghwa, Park Hyo-Hoon, Kurt Hamza

“…Additionally, we summarize the open-source inverse design tools and commercial foundries. Finally, we provide our perspectives on the current challenges of inverse design, while offering insights into future directions that could further advance this rapidly evolving field.…”
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Array Three-Dimensional SAR Imaging via Composite Low-Rank and Sparse Prior by Zhiliang Yang, Yangyang Wang, Chudi Zhang, Xu Zhan, Guohao Sun, Yuxuan Liu, Yuru Mao

“…Then, the framework that integrates variable splitting and alternative minimization (VSAM) is presented to solve the imaging optimization problem, which is suitable for high-dimensional imaging scenes. Finally, the performance of the method is validated through extensive simulation and real data experiments. …”
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Preserved egg white alleviates DSS-induced colitis in mice through the reduction of oxidative stress, modulation of infl ammatory cytokines, NF-κB, MAPK and gut microbiota composit... by Lingyu Li, Ning Qiu, Yaqi Meng, Chenyan Wang, Yoshinori Mine, Russell Keast, Vincent Guyonnet

“…In addition, western blotting results showed that PEW significantly suppressed DSS-induced phosphorylation levels of nuclear factor-kappa B (NF-κB) p65 and p38 mitogen-activated protein kinase (MAPK) in colon tissues of mice with colitis. …”
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Molecular Features and Methylation Status in Early Onset (≤40 Years) Colorectal Cancer: A Population Based, Case-Control Study by Giulia Magnani, Daniela Furlan, Nora Sahnane, Luca Reggiani Bonetti, Federica Domati, Monica Pedroni

“…Early onset colorectal cancer disclosed an average number of methylated genes significantly lower when compared to the controls (p=0.02). Finally both of the two groups were highly methylated in ESR1, GATA5, and WT1 genes and were similar for LINE-1 hypomethylation. …”
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Autoinflammatory Reaction in Dogs Treated for Cancer via G6PD Inhibition by Jonathan W. Nyce

“…The autoinflammatory reaction observed closely resembles mevalonate kinase deficiency (MKD), a rare autosomal recessive disease in humans characterized by recurrent febrile attacks, arthralgia, skin rash, and aphthous ulcers of mucocutaneous tissues. …”
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Formation of advanced glycation end products in raw and subsequently boiled broiler muscle: biological variation and effects of postmortem ageing and storage by Suhong Huang, Xiaoli Dong, Yali Zhang, Yuru Chen, Yajie Yu, Ming Huang, Yuandong Zheng

“…In addition, with the ageing and storage time increasing, CML content in raw white feather broiler brisket meat had no significant (P > 0.05) change, while that in boiled brisket meat significantly (P < 0.05) increased during 0–6 h, then decreased during 6–24 h, finally increased again. CML content in leg meat increased significantly (P < 0.05) with the ageing and storage time prolonging. …”
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Biochemical and histopathological profiling of Wistar rat treated with Brassica napus as a supplementary feed by Kazi Md. Mahmudul Hasan, Nasrin Tamanna, Md. Anwarul Haque

“…The levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT),alkaline phosphatase(ALP), creatine kinase-MB (CK-MB) and creatinine of two experimental groups were significantly elevated while compared to the control groups (p < 0.05–0.001). …”
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Evaluation of Tissue Homogenization to Support the Generation of GMP-Compliant Mesenchymal Stromal Cells from the Umbilical Cord by Ryan J. Emnett, Aparna Kaul, Aleksandar Babic, Vicki Geiler, Donna Regan, Gilad Gross, Salem Akel

“…Interestingly, there was no difference in the expression of mesenchymal markers and trilineage differentiation potential of cells generated using either method. Finally, t-H-derived cells had greater clonogenic potential compared to Col-D/FBS but not Col-D/PL and were able to maintain CFU-F capacity through P7. …”
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Enhancing immunotherapy efficacy in colorectal cancer: targeting the FGR-AKT-SP1-DKK1 axis with DCC-2036 (Rebastinib) by Xiguang Chen, Qiting Zeng, Liyang Yin, Bingru Yan, Chen Wu, Jianbo Feng, Ying Wu, Jun He, Wenjun Ding, Jing Zhong, Yingying Shen, Xuyu Zu

“…Abstract This research demonstrates that DCC-2036 (Rebastinib), a potent third-generation tyrosine kinase inhibitor (TKI), effectively suppresses tumor growth in colorectal cancer (CRC) models with functional immune systems. …”
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Feasibility Study of an Alcohol-Based Liquid Scintillation Detector and Its Application by Byoung Chan Kim, Ji Young Choi, Kyung Kwang Joo, Seon Yeong Park, Ye Sung Song, Hee Jin Woo

“…The several feasible physical and optical properties of an alcohol-based liquid scintillator were investigated and presented. Finally, as one of its applications, a range (beam-path length) measurement using an electron beam in medical physics is introduced after irradiating an alcohol-based liquid scintillator with electron beam energies of 6~12 MeV. …”
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Fully 3D Printed Miniaturized Electrochemical Platform With Plug-and-Play Graphitized Electrodes: Exhaustively Validated for Dopamine Sensing by K S Jaya Lakshmi, Ramya K, Khairunnisa Amreen, Sanket Goel

“…The developed device is finally tested for real-time analysis on human blood and serum samples.…”
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Strategies for improving the competitiveness of agricultural products and China's trade policy in the world market by Mahammad Aliyev, Mushfig Guliyev, Ulmas Abdullaev, Lamiya Huseynova, Gulnara Azizova

“…In addition, the analysis shows that the supply chain ecosystem requires Optimisation to allocate resources more efficiently and reduce transportation costs. Finally, the study emphasised the importance of sustainable development and the environment in the context of global challenges, including climate change and food security. …”
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Multi-Strategy Improved Red-Tailed Hawk Algorithm for Real-Environment Unmanned Aerial Vehicle Path Planning by Mingen Wang, Panliang Yuan, Pengfei Hu, Zhengrong Yang, Shuai Ke, Longliang Huang, Pai Zhang

“…The experimental results demonstrate that the IRTH algorithm yields competitive performance. Finally, to validate its applicability in real-world scenarios, we apply the IRTH algorithm to the UAV path-planning problem in practical environments, achieving improved results and successfully performing path planning for UAVs.…”
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Antioxidant Action and In Vivo Anti-Inflammatory and Antinociceptive Activities of Myrciaria floribunda Fruit Peels: Possible Involvement of Opioidergic System by Izabelly Bianca da Silva Santos, Bruno Santos dos Santos, João Ricardhis Saturnino de Oliveira, Wêndeo Kennedy Costa, Adrielle Zagmignan, Luís Cláudio Nascimento da Silva, Magda Rhayanny Assunção Ferreira, Vilmar Luiz Lermen, Maria Silvanete Benedito de Sousa Lermen, Alexandre Gomes da Silva, Rafael Matos Ximenes, Luiz Alberto Lira Soares, Patrícia Maria Guedes Paiva, Vera Lúcia de Menezes Lima, Maria Tereza dos Santos Correia, Márcia Vanusa da Silva

“…The extract with higher potential was selected for in vivo evaluation of its antinociceptive and anti-inflammatory action. Finally, the chemical characterization of this extract was performed by high-performance liquid chromatography (HPLC). …”
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