Trimethyltin-Induced Microglial Activation via NADPH Oxidase and MAPKs Pathway in BV-2 Microglial Cells by Da Jung Kim, Yong Sik Kim

“…These findings indicate that NADPH oxidase-dependent ROS generation activated p38 and JNK mitogen-activated protein kinases (MAPKs), which then stimulated NF-κB to release proinflammatory mediators in the TMT-treated BV-2 cells.…”
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A Reference Architecture for Data-Driven Intelligent Public Transportation Systems by Franca Rocco Di Torrepadula, Sergio Di Martino, Nicola Mazzocca, Paolo Sannino

“…Still, being independent from the specific considered urban scenario, the architecture can be easily instantiated in different cities with similar needs. Finally, we discuss some research challenges which should be further investigated in this domain.…”
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Fracture Mechanical Behavior of Cracked Cantilever Roof with Large Cutting Height Mining by Zenghui Zhao, Wei Sun, Mingzhong Zhang, Xiaojie Gao, Shaojie Chen

“…Based on the boundary equation, the influences of crack size, crack inclination, roof lithology, and roof thickness on the roof crack-affected area were analyzed in detail. Finally, the accuracy of the theoretical model was verified by numerical experiments using the extended finite element method. …”
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Performance of the Cold-Bending Channel-Angle Buckling-Restrained Brace under Cyclic Loading by Kun Wang, Junwu Xia, Xiaomiao Chen, Bo Xu, Xiangzhou Liang, Jian Wang

“…The initial elastic stiffness of the brace used in practice should contain overall portions of the brace instead of the yielding portion of the brace. Finally, all the tested CCA-BRBs exhibited a stable energy absorption performance and verified the specimens’ construction was rational.…”
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CR-DEQ-SAR: A Deep Equilibrium Sparse SAR Imaging Method for Compound Regularization by Guoru Zhou, Yixin Zuo, Zhe Zhang, Bingchen Zhang, Yirong Wu

“…This is particularly advantageous in memory-intensive SAR imaging applications. Finally, we validate the effectiveness and superiority of the proposed method through experiments on real SAR scenes. …”
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Actin-Binding Proteins as Potential Biomarkers for Chronic Inflammation-Induced Cancer Diagnosis and Therapy by Yu-Gui Zhang, Jiang-Tao Niu, Hong-Wei Wu, Xin-Lei Si, Shu-Juan Zhang, Dong-Hui Li, Tian-Tian Bian, Yue-Feng Li, Xing-Ke Yan

“…In simple terms, abnormal expression of ABPs contributes to the chronic inflammation developing into cancer. Finally, we provide our viewpoint regarding these unusual ABPs serving as potential biomarkers for chronic inflammation-induced cancer diagnosis and therapy, and interventions to reverse the abnormal expression of ABPs represent a potential approach to preventing or treating the corresponding cancers.…”
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EGFR-Mutant Non-small Cell Lung Cancer: State-of-the-Art and Future Perspectives by Antonio Rossi, Ettore Mari

“… EGFR mutations are the first identified targetable driver alterations in advanced non-small cell lung cancer (NSCLC), for which specific epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKI) have been developed. These small molecules, administered orally, changed the natural history of patients with EGFR-mutated NSCLC, reporting impressive response and survival data. …”
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Fault Diagnosis of Variable Load Bearing Based on Quantum Chaotic Fruit Fly VMD and Variational RVM by Bo Xu, Huipeng Li, Fengxing Zhou, Baokang Yan, Yi Liu, Yajie Ma

“…The two-dimensional MSE of each intrinsic modal component is used as a learning sample for VRVM. Finally, the bearing fault data under 1 hp load are taken as training samples, and the bearing fault data under two loads of 0 hp and 3 hp are used as test samples to verify the effectiveness of the intelligent diagnosis model. …”
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The Effect of Electroacupuncture on PKMzeta in the ACC in Regulating Anxiety-Like Behaviors in Rats Experiencing Chronic Inflammatory Pain by Junying Du, Junfan Fang, Cun Wen, Xiaomei Shao, Yi Liang, Jianqiao Fang

“…Electroacupuncture (EA) has effects on chronic pain and pain-related anxiety. Protein kinase Mzeta (PKMzeta) has been proposed to be essential for the maintenance of pain and may interact with GluR1 to maintain CNS plasticity in the anterior cingulate cortex (ACC). …”
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Ethanolic Extract of Red Okra Pods Induces Aberrant Spindle Segregation and Apoptotic Cell Death by Disrupting the Wnt Signaling Pathway in Colon Cancer Cells by Firli Rahmah Primula Dewi, Sri Puji Astuti Wahyuningsih, Vuanghao Lim, Lionel Lian Aun In, Alfiah Hayati

“…Moreover, it notably decreased β-catenin protein levels, resulting in an augmented occurrence of cells displaying abnormal spindle segregation during mitosis (P=0.04).Conclusion: EEROP treatment reduces β-catenin protein levels, promotes abnormal spindle apparatus segregation, and finally leads to apoptotic cell death in CRC cells.…”
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Smoothing Photovoltaic Power Fluctuations for Cascade Hydro-PV-Pumped Storage Generation System Based on a Fuzzy CEEMDAN by Lei Chen, Jun Wang, Zhang Sun, Tao Huang, Fan Wu

“…Furthermore, in order to overcome the drawback that too frequent conversion of unit operating mode would reduce the service life and smoothing effect of the VSPSS unit, the optimization model of the base power of the VSPSS is established and solved by the grid adaptive direct search method (MADS) to obtain the control signal of the VSPSS for suppressing the short-term fluctuations of the PV output. Finally, the performance of the method is evaluated through using the PV station data in Xiaojin County, Sichuan province, China. …”
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RNA modifications: emerging players in the regulation of reproduction and development by Wen Junfei, Zhu Qifan, Liu Yong, Gou Lan-Tao

“…Elucidating the molecular mechanisms by which RNA modifications influence diverse developmental processes holds promise for developing innovative strategies to manage developmental disorders. Finally, we outline several unexplored areas in the field of RNA modification that warrant further investigation.…”
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Symmetry-invariant quantum machine learning force fields by Isabel Nha Minh Le, Oriel Kiss, Julian Schuhmacher, Ivano Tavernelli, Francesco Tacchino

“…Furthermore, we study a water dimer as a minimal example of a system with multiple components, showcasing the versatility of our proposed approach and opening the way towards larger simulations. Finally, we perform a barren plateau analysis and numerically observe that our model does not exhibit a barren plateau in the shallow depth regime. …”
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Graphene nanomaterial-based electrochemical biosensors for salivary biomarker detection: A translational approach to oral cancer diagnostics by D. Mahalakshmi, J. Nandhini, G. Meenaloshini, E. Karthikeyan, KK Karthik, J. Sujaritha, Vandhana, V, C. Ragavendran

“…The challenges associated with the development and clinical translation of these biosensors are also addressed, emphasizing the need for improved functionalization strategies, enhanced stability, and standardized validation protocols. Finally, we present a futuristic outlook on the integration of graphene-based biosensors with artificial intelligence, microfluidics, and telemedicine platforms to enable personalized diagnostics and treatment monitoring. …”
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The deleterious effects of CDK4/6 inhibition on renal recovery post-acute kidney injury by Shanshan Zhou, Rouzhang Peng, Yanting Shen, Liuwei Huang, Suying Han, Jun Wang, Jie Guo

“…The acute protective effects of Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors in AKI have been examined, there is still relatively little known regarding the impact of acute CDK4/6 inhibition on the chronic sequence of AKI. …”
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Evaluation of Water Retention Capacity of Bulkheads in Underground Coal Mines by Yuan Hang, Lichuang Jin, Binbin Yang, Ning Li, Shichong Yuan, Zhilin Gao, Linxuan Sun, Sen Zheng, Mingming Hu

“…When the safety factor is less than 1.68, water leakage has occurred in a number of cases. Finally, changes in the water pressure in the bulkheads with time and changes in the seepage flow with time in the surrounding rock are analyzed. …”
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A sedimentary ancient DNA perspective on human and carnivore persistence through the Late Pleistocene in El Mirón Cave, Spain by Pere Gelabert, Victoria Oberreiter, Lawrence Guy Straus, Manuel Ramón González Morales, Susanna Sawyer, Ana B. Marín-Arroyo, Jeanne Marie Geiling, Florian Exler, Florian Brueck, Stefan Franz, Fernanda Tenorio Cano, Sophie Szedlacsek, Evelyn Zelger, Michelle Hämmerle, Brina Zagorc, Alejandro Llanos-Lizcano, Olivia Cheronet, José-Miguel Tejero, Thomas Rattei, Stephan M. Kraemer, Ron Pinhasi

“…Additionally, we provide phylogenetic analyses on 70 sedaDNA mtDNA genomes of fauna including the densest Iberian Pleistocene sampling of C. lupus. Finally, we recover three human mtDNA sequences from the Solutrean levels. …”
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Pre-therapeutic efficacy of the CDK inhibitor dinaciclib in medulloblastoma cells by Marta Buzzetti, Sonia Morlando, Dimitrios Solomos, Ammara Mehmood, Alexander W. I. Cox, Mattia Chiesa, Yuri D’Alessandra, Michela Garofalo, Caroline H. Topham, Gianpiero Di Leva

“…Abstract Medulloblastoma (MB) is the most common aggressive paediatric brain tumour and, despite the recent progress in the treatments of MB patients, there is still an urgent need of complementary or alternative therapeutic options for MB infants. Cyclin Dependent Kinase inhibitors (CDKi) are at the front-line of novel targeted treatments for multiple cancers and the CDK4/6 specific inhibitor palbociclib has been pre-clinically identified as an effective option for MB cells. …”
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Interfacial cfDNA Enrichment and Amplification with On‐Chip Thermoplasmonics for Highly Sensitive Cancerous Liquid Biopsy by Danhua Wang, Linlin Liu, Wenjing Chi, Zhenping Liu, Jiayun Wu, Yirou Liang, Fei He, Ruixiang Zhang, Pengxin Huang, Yunbo Li, Guangyu Qiu

“…Typical cfDNA biomarkers, including epidermal growth factor receptor (EGFR), tumor protein 53 (TP53), phosphatase and tensin homologue deleted on chromosome 10 (PTEN), and cyclin‐dependent kinase inhibitor (CDKN2A), are quantified with detection limits down to femtomolar‐level. …”
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Renewable syngas production from electrified catalytic steam reforming of biomass pyrolysis volatiles by José Juan Bolívar Caballero, Fereshteh Talkhab, Hanmin Yang, Samina Gulshan, Pengcheng Cao, Thomas Lewin, Pär G. Jönsson, Weihong Yang

“…The effect of the catalyst’s structure on the bio-oil reforming and heat efficiency was complemented using CFD simulations and compared to a simple geometry based on commercial extruded monoliths. Finally, the biomass-derived syngas upgrading to H2 production was assessed using different process simulations and compared to existing H2-producing technologies in terms of energy efficiency and emissions.…”
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