Function of Dicer with regard to Energy Homeostasis Regulation, Structural Modification, and Cellular Distribution by Xiaohui Tong, Nianjun Yu, Rongchun Han, Tongsheng Wang

“…Moreover, by influencing canonical energy sensors like adenosine monophosphate-activated protein kinase (AMPK) or mammalian target of rapamycin (mTOR), Dicer favors catabolism in the periphery. …”
Get full text

Caffeic Acid Phenethyl Ester Regulates PPAR’s Levels in Stem Cells-Derived Adipocytes by Luca Vanella, Daniele Tibullo, Justyna Godos, Francesca Romana Pluchinotta, Claudia Di Giacomo, Valeria Sorrenti, Rosaria Acquaviva, Alessandra Russo, Giovanni Li Volti, Ignazio Barbagallo

“…We examined the effects of Caffeic Acid Phenethyl Ester (Cape), isolated from propolis, a honeybee hive product, on Adipose Stem Cells (ASCs) differentiation to the adipocyte lineage. Finally we tested the effects of Cape on insulin-resistant adipocytes. …”
Get full text

Electrochemical corrosion of Al-Pd alloys in HCl and NaOH solutions by Palcut M., Ďuriška L., Špoták M., Vrbovský M., Gerhátová Ž., Černičková I., Janovec J.

“…The local nobility of individual intermetallic compounds is discussed. Finally, the conclusions for the alloys corrosion performance in acidic and basic solutions are provided.…”
Get full text

Protective Effects of Tormentic Acid on Unilateral Ureteral Obstruction-Induced Renal Injury, Inflammation, and Fibrosis: A Comprehensive Approach to Reducing Oxidative Stress, Apo... by Ah Young Yang, Jung-Yeon Kim, Mi-Gyeong Gwon, Hyun Hee Kwon, Jaechan Leem, Eon-Ju Jeon

“…It suppressed cytokine expression and reduced immune cell infiltration, inhibited the activation of the mitogen-activated protein kinase cascade, and alleviated endoplasmic reticulum stress. …”
Get full text

Activating PKC-ε induces HIV expression with improved tolerability. by Alivelu M Irrinki, Jasmine Kaur, Bally Randhawa, Ryan McFadden, Chelsea Snyder, Hoa Truong, Daniel Soohoo, Eric Hu, Helen Yu, Bernard P Murray, Bing Lu, Dmytro Kornyeyev, Ishak Darryl Irwan, Lan Nguyen, Yu-San Yang, Jean-Philippe Belzile, Uli Schmitz, Todd C Appleby, Brian Schultz, Jay Lalezari, Steven Deeks, Tomas Cihlar, Jeffrey P Murry

“…Activation of latent HIV during ART could improve recognition and elimination of infected cells by the immune system. Protein kinase C (PKC) isozymes increase HIV transcription and hence are potential latency reversal agents. …”
Get full text

Flow Cytometric Detection of p38 MAPK Phosphorylation and Intracellular Cytokine Expression in Peripheral Blood Subpopulations from Patients with Autoimmune Rheumatic Diseases by Athanasios Mavropoulos, Dimitrios P. Bogdanos, Christos Liaskos, Timoklia Orfanidou, Theodora Simopoulou, Efterpi Zafiriou, Lazaros I. Sakkas, Eirini I. Rigopoulou

“…Flow cytometric analysis of p38 mitogen-activated protein kinase (p38 MAPK) signaling cascade is optimally achieved by methanol permeabilization protocols. …”
Get full text

Exploring TNFR1: from discovery to targeted therapy development by Yingying Li, Ruiwei Ye, Haorui Dai, Jiayi Lin, Yue Cheng, Yonghong Zhou, Yiming Lu

“…As a critical cell-surface receptor, TNFR1 regulates key signaling pathways, such as nuclear factor kappa-B (NF-κB) and mitogen-activated protein kinase (MAPK), which are associated with pro-inflammatory responses and cell death. …”
Get full text

A High-Precision Dynamic Six Degree-of-Freedom Pose Measurement of the Subreflectors of Large Antennas Based on a Position Sensitive Detector and Laser Array by Shangmin Lin, Wei Wang, Hu Wang, Yang Song, Yue Pan, Jiang Qiao, Yaoke Xue, Qinfang Chen, Meiying Liu, Yang Shen, Jie Liu, Yang Liu, Yongjie Xie, Canglong Zhou

“…The two-dimensional coordinates of the centroids of three laser spots are extracted using the PSD, and then the bursa model is established to complete the coordinate transformation. Finally, the 6-DOF attitude information of the antenna subreflector is obtained. …”
Get full text

Increased RTN3 phenocopies nonalcoholic fatty liver disease by inhibiting the AMPK–IDH2 pathway by Hao Huang, Shuai Guo, Ya‐Qin Chen, Yu‐Xing Liu, Jie‐Yuan Jin, Yun Liang, Liang‐Liang Fan, Rong Xiang

“…Mechanistically, RTN3 regulated these events through its interactions with glucose‐regulated protein 78 (GRP78), which further inhibited the adenosine 5 monophosphate‐activated protein kinase (AMPK)–isocitrate dehydrogenase 2 (IDH2) pathway. …”
Get full text

AIS-Based Vessel Trajectory Compression: A Systematic Review and Software Development by Ryan Wen Liu, Shiqi Zhou, Shangkun Yin, Yaqing Shu, Maohan Liang

“…In addition, compressive experiments on several publicly available data sets have been implemented to evaluate the batch and online compression methods in terms of computation time, compression ratio, trajectory similarity, and trajectory length loss rate. Finally, we develop a flexible and open software, called <italic>AISCompress</italic>, for AIS-based batch and online vessel trajectory compression. …”
Get full text

Tumor-associated neutrophils and macrophages interaction contributes to intrahepatic cholangiocarcinoma progression by activating STAT3 by Jian Zhou, Jia Fan, Zhiqiang Hu, Jia Li, Zhengjun Zhou, Pengcheng Wang, Rongqi Sun, Haoyang Xin, Chubin Luo, Shaolai Zhou

“…We then investigated the mechanistic basis of the effects using PCR array, western blot analysis and ELISA experiments. Finally, we validated our results in a tissue microarray composed of primary tumor tissues from 359 patients with ICC.Results The spatial distributions of TANs and TAMs were correlated with each other in patient-derived ICC samples. …”
Get full text

PPARγ and the Innate Immune System Mediate the Resolution of Inflammation by Amanda Croasdell, Parker F. Duffney, Nina Kim, Shannon H. Lacy, Patricia J. Sime, Richard P. Phipps

“…These effects contribute towards the attenuation of multiple disease states, including COPD, colitis, Alzheimer’s disease, and obesity in animal models. Finally, novel specialized proresolving mediators—eicosanoids with critical roles in resolution—may act through PPARγ modulation to promote resolution, providing another exciting area of therapeutic potential for this receptor.…”
Get full text

Sphingosine-1-Phosphate Signaling in Immune Cells and Inflammation: Roles and Therapeutic Potential by Masayo Aoki, Hiroaki Aoki, Rajesh Ramanathan, Nitai C. Hait, Kazuaki Takabe

“…It is produced by the phosphorylation of sphingosine by sphingosine kinases (SphKs) and exported out of cells via transporters such as spinster homolog 2 (Spns2). …”
Get full text

Effects of Activating Mutations on EGFR Cellular Protein Turnover and Amino Acid Recycling Determined Using SILAC Mass Spectrometry by Michael J. Greig, Sherry Niessen, Scott L. Weinrich, Jun Li Feng, Manli Shi, Ted O. Johnson

“…The measurement of EGFR turnover rate in PC-9 cells dosed with irreversible inhibitors has additional complexity due to inhibitor effects on cell viability and results were reported as a range. Finally, essential amino acid recycling (K and R) was measured in different cell lines. …”
Get full text

Role of p16INK4A in Replicative Senescence and DNA Damage-Induced Premature Senescence in p53-Deficient Human Cells by Razmik Mirzayans, Bonnie Andrais, Gavin Hansen, David Murray

“…By inhibiting cyclin-dependent kinases, p16 activates the G1-S checkpoint, and this response is often considered to be critical for establishing a senescence-like growth arrest. …”
Get full text

Process-based VOCs Source Profiles and Contributions to Ozone Formation in Typical Organic Solvent-used Industries in Hangzhou by Zhinian Li, Wenjuan Li, Rong Zhou, Xiaoping Miao, Jianhai Lu, Zhongren Wang, Zhongping Yang, Jian Wu

“…For printing industry, the contributions of top five species to the OFPs were relatively balanced, which indicated these species should all be given more attention. Finally, the low-temperature plasma technology and the combined technology of activated carbon adsorption with condensation were found to reduce the OFPs for their ability to preferably removing aromatics or olefins. …”
Get full text

Optimal Molecular Methods in Detecting p190BCR-ABL Fusion Variants in Hematologic Malignancies: A Case Report and Review of the Literature by Rebecca J. Sonu, Brian A. Jonas, Denis M. Dwyre, Jeffrey P. Gregg, Hooman H. Rashidi

“…Patients with BCR-ABL1 positive hematologic malignancies and Philadelphia-like B-lymphoblastic leukemia (B-ALL) are potential candidates for targeted therapy with tyrosine kinase inhibitors (TKI). Before TKIs, patients with B-ALL had a much worse prognosis and current treatments with targeted TKI therapy have improved outcomes. …”
Get full text

Disease-Specific Target Gene Expression Profiling of Molecular Imaging Probes: Database Development and Clinical Validation by Lawrence Wing-Chi Chan, Connie Hiu-Ching Ngo, Fengfeng Wang, Moss Y. Zhao, Mengying Zhao, Helen Ka-Wai Law, Sze Chuen Cesar Wong, Benjamin Yat-Ming Yung

“…The retrieved records show that choline kinase beta and glucose transporters were positively and significantly associated with lung cancer among the targets of 11 C-choline and [ 18 F]fluoro-2- deoxy-2-D-glucose (FDG), respectively. …”
Get full text

A Study of Inflammatory/Necrosis Biomarkers in the Fracture of the Femur Treated with Proximal Femoral Nail Antirotation by Mariapaola Marino, Giuseppe Palmieri, Marco Peruzzi, Flavia Scuderi, Emanuela Bartoccioni

“…Serum tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), and plasma creatin kinase (CK) were evaluated 1 hour preoperatively and 24 hours postoperatively. …”
Get full text

Particle motion and QPOs around Euler-Heisenberg black hole immersed in cold dark matter halo by G. Mustafa, S.K. Maurya, Tayyab Naseer, Arzu Cilli, Ertan Güdekli, Assmaa Abd-Elmonem, Neissrien Alhubieshi

“…The model parameters significantly affect the motion of the particles. Finally, we compare the particle dynamics surrounding a Euler-Heisenberg black hole within a cold dark-matter halo to those around a Schwarzschild black hole within a cold dark-matter halo and a Schwarzschild black hole devoid of a cold dark matter halo.…”
Get full text