Exploring the microbiota-gut-brain axis: impact on brain structure and function by Lidya K. Yassin, Mohammed M. Nakhal, Alreem Alderei, Afra Almehairbi, Ayishal B. Mydeen, Amal Akour, Mohammad I. K. Hamad

“…Subsequently, we will examine the technical strategies employed to study MGBA interactions, including using germ-free (GF) animals, probiotics, fecal microbiota transplantation (FMT), and antibiotics-induced dysbiosis. Finally, we will examine how particular bacterial strains can affect brain structure and function. …”
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How NaCl addition destabilizes ionic liquid micellar suspension until phase separation by Dufrêche, Jean-François, Plazanet, Marie, Meyer, Gautier, Billard, Isabelle

“…The lowering of the repulsive interactions between micelles finally allows coalescence and thus phase separation. …”
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Molecular cloning of EZH2 oncogene in chronic myeloid leukemia and therapeutic prospects by Juliana Costa Gaspar, Lucas Santos de Santana, Camila Menezes Freire de Souza, Marcos Montani Caseiro, Rosane Rezende de Souza Giuliani, Cleide Barbieri de Souza

“…Chronic myeloid leukemia (CML) is a myeloproliferative neoplasia, caused in 95 % of the cases by a cytogenetic abnormality characterized by the reciprocal translocation between chromosomes 9 and 22 t(9; 22) (q34; q11), resulting in Philadelphia chromosome (Ph).Considering that CML cure is only possible with a successful bone marrow transplantation and that there are resistance cases to the tyrosine kinase inhibitor Imatinib Mesylate, prescribed in first line drug treatment; it is important to know in detail the genes and proteins that are possibly altered in CML, favoring effective therapeutic strategies, optimized diagnosis and minimal residual disease detection. …”
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Sarcoidosis: molecular mechanisms and therapeutic strategies by Danfeng Xu, Xiaohua Tao, Yibin Fan, Yan Teng

“…Promising therapeutic agents encompass inhibitors of cytokines, like those targeting tumor necrosis factor (TNF)-α, as well as inhibitors of signaling pathways, such as Janus kinase (JAK) inhibitors, which exhibit favorable prospects for application. …”
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Evaluation of Hypoglycemic Efficacy of Tangningtongluo Formula, a Traditional Chinese Miao Medicine, in Two Rodent Animal Models by Long Cheng, Xiang-bao Meng, Shan Lu, Ting-ting Wang, Yue Liu, Gui-bo Sun, Xiao-bo Sun

“…Additionally, oral glucose tolerance in TNTL-treated mice improved significantly, compared with diabetic mice receiving metformin. Finally, tissue histopathology and biochemical index evaluations revealed significant improvement in TNTL-treated mice. …”
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Instability Process of Crack Propagation and Tunnel Failure Affected by Cross-Sectional Geometry of an Underground Tunnel by Xianjie Hao, Shaohua Wang, Duoxiang Jin, Bo Ren, Xiangyang Zhang, Kailong Qiu, Yingjie Fan

“…After the deep chamber was excavated, continuous spalling was found to occur at the foot of the horseshoe tunnel and microcracks in the surrounding rock were initially generated from the foot of the side wall and then developed upwards to form a conjugate sliding shape to the foot of the arch roof, where the cracks finally coalesced. Discontinuous spalling occurred at the midheight of the side wall of the circular tunnel after excavation, and microcracks in the surrounding rock were initially generated from the midheight of the side wall and then extended concentrically to greater depth in the rock mass surrounding the tunnel. …”
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Regulatory Role of GSK-3β on NF-κB, Nitric Oxide, and TNF-α in Group A Streptococcal Infection by Yu-Tzu Chang, Chia-Ling Chen, Chiou-Feng Lin, Shiou-Ling Lu, Miao-Huei Cheng, Chih-Feng Kuo, Yee-Shin Lin

“…Efforts to minimize the associated morbidity and mortality represent a critical issue. Glycogen synthase kinase-3β (GSK-3β) is known to regulate inflammatory response in infectious diseases. …”
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The impact of individual and organizational factors on employee innovative work behavior: Empirical evidence from private companies in Vietnam by Tran Hai Yen, Chu Tien Minh, Nguyen Ngoc Diep, Khuc Dai Long

“…Simultaneously, the innovation climate exerts a minor influence on innovative work behavior, with a score of 0.142. Finally, innovative work behavior directly and positively affects employee job performance, scoring 0.641.…”
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Regulatory mechanism of carbohydrate metabolism pathways on oil biosynthesis of oil plant Symplocos paniculata by Wenbin Zeng, Beilei Xie, Yunzhu Chen, Jingzhen Chen, Peiwang Li, Lijuan Jiang, Changzhu Li, Qiang Liu, Yan Yang

“…Whereas, during the fruit maturation stage (from 90 DAF to 170 DAF), the expression of phosphofructokinase 1 (PFK-1), pyruvate kinase (PK) and pyruvate dehydrogenase (PDH) enzyme genes involved in the glycolysis pathway was significantly upregulated, thereby facilitating a rapid and substantial accumulation of oil. …”
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Risk assessment of rail transit systems with variable renewable energy based on uncertain random theory by Yanbo Chen, Xiaoxue Li, Zhi Zhang

“…Firstly, the uncertainty random theory is applied to take the first failure time of the new energy generation equipment and the traditional equipment as an uncertain variable and a random variable, respectively, the value-at-risk function is defined in combination with the consequences of the system failure; next, the competing failure model for the random system is established by thoroughly considering degradation and shock failures; for the uncertain system, the evidence theory’s framework is used to establish the multiple sources imprecise information conflict and fusion model; finally, the consequences of failure of the system are quantified and the value-at-risk calculation method for the rail transit systems with variable renewable energy is propose. …”
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AURKB affects the proliferation of clear cell renal cell carcinoma by regulating fatty acid metabolism by Yang Yang, Dan Li, Zhigang Liu, Kai Zhou, Wenxing Li, Yanqi Yang, Ruifang Sun, Yulong Li

“…The molecular mechanism of ccRCC development, however, needs further study. Aurora kinase B (AURKB) functions as an important oncogene in various tumors; therefore, in the present study, we aimed to explore the mechanism by which AURKB affects ccRCC development. …”
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GFRα1 Promotes Axon Regeneration after Peripheral Nerve Injury by Functioning as a Ligand by Tomoaki Suzuki, Ken Kadoya, Takeshi Endo, Miwako Yamasaki, Masahiko Watanabe, Norimasa Iwasaki

“…This is further confirmed by the Ret Y1062F knock‐in mice, which cannot transmit most of GDNF‐RET signaling. Finally, local administration of GFRα1 into injured sciatic nerve promoted functional recovery. …”
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LncRNA FEZF1-AS1 Promotes TGF-β2-Mediated Proliferation and Migration in Human Lens Epithelial Cells SRA01/04 by Yong Wang, Lili Chen, Yonghui Gu, Ying Wang, You Yuan, Qiujian Zhu, Mingchao Bi, Shuyan Gu

“…Accordingly, FEZF1-AS1 overexpression promoted the TGF-β2-induced proliferation and migration of SRA01/04 cells. Finally, FEZF1-AS1 upregulated TGF-β2-induced SRA01/04 cell proliferation and migration via boosting FEZF1 protein levels. …”
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Dual-Polarimetric SAR Measurements to Observe Liquefaction Surface Manifestations by Ferdinando Nunziata, Anna Verlanti, Nicola Angelo Famiglietti, Maurizio Migliaccio, Annamaria Vicari

“…The latter is evaluated using the coseismic scenes and contrasted with the preseismic one to have rough information on the time-variability of the scattering mechanisms occurred in the area affected by soil liquefaction. Finally, the obtained maps are qualitatively contrasted against state-of-the-art optical and interferometric SAR methodologies. …”
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Oilpalm-RTMDet: An lightweight oil palm detector base on RTMDet by Jirong Ding, Runlian Huang, Yehua Liang, Xin Weng, Jianjun Chen, Haotian You

“…First, the SimSPPF structure is used to replace the SPPF structure of backbone, then the CSP-ELAN structure is used to replace the CSPLayer structure in the original neck, and the UpsamplingBiliearn is used as the upsampling method. Finally, the SGEAttention mechanism is introduced to enhance the extraction ability of oil palm tree features. …”
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Mining versatile feruloyl esterases: phylogenetic classification, structural features, and deep learning model by Liang Guo, Yuxin Dong, Deyong Zhang, Xinrong Pan, Xinjie Jin, Xinyu Yan, Yin Lu

“…Further, molecular dynamics simulations and dynamical cross-correlation matrix analysis were employed to explore structural dynamics differences between promiscuous and substrate-specific FEs. Finally, to expand the repertoire of versatile FEs, we employed deep learning models to predict potentially promiscuous enzymes and identified 38 and 75 potential versatile FEs from cluster 1 and cluster 3 with a probability score exceeding 90%. …”
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Loss of Lkb1 cooperates with BrafV600E and ultraviolet radiation, increasing melanoma multiplicity and neural‐like dedifferentiation by Kimberley McGrail, Elena González‐Sánchez, Paula Granado‐Martínez, Roberto Orsenigo, Yuxin Ding, Berta Ferrer, Javier Hernández‐Losa, Iván Ortega, Juan Martín‐Caballero, Eva Muñoz‐Couselo, Vicente García‐Patos, Juan A. Recio

“…Analysis of human melanoma tumors [data from The Cancer Genome Atlas (TCGA)] revealed that 50% or more of the samples expressed no or low amounts of serine/threonine protein kinase STK11 (also known as LKB1) protein. Here, we report that, in a mouse model, concomitant neonatal BrafV600E activation and Lkb1 tumor suppressor ablation in melanocytes led to full melanoma development. …”
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Tumor Reduction with Pazopanib in a Patient with Recurrent Lumbar Chordoma by Maurício Fernando Silva Almeida Ribeiro, Micelange Carvalho de Sousa, Samir Abdallah Hanna, Marcos Vinicius Calfat Maldaun, Ceci Obara Kurimori, Luiz Guilherme Cernaglia Aureliano de Lima, Romulo Loss Mattedi, Rodrigo Ramella Munhoz

“…A large proportion of these tumors express stem-cell factor receptor (c-KIT) and platelet-derived growth factor receptors (PDGFRs), providing a rationale for the use of tyrosine-kinase inhibitors (TKIs). Case report. A 27-year-old male presented with recurrent chordoma of the lumbar spine 4 years after initial diagnosis. …”
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Phenotypic Characterization of Fine-Aroma Cocoa from Northeastern Peru by Manuel Oliva-Cruz, Malluri Goñas, Ligia M. García, Raúl Rabanal-Oyarse, Cástula Alvarado-Chuqui, Patricia Escobedo-Ocampo, Jorge L. Maicelo-Quintana

“…More importantly, cocoa beans needed to produce between 14 and 16 pods to obtain one kilogram of dry cocoa, which reflects a good level of productivity. Finally, there was a positive relationship between elevation levels and the presence of fine-flavoured native cocoa, i.e., the greatest diversity of native cocoa with floral and fruity notes was found above 501 metres above sea level.…”
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Pre-screening of endomysial microvessel density by fast random forest image processing machine learning algorithm accelerates recognition of a modified vascular network in idiopath... by Alessandro Massaro, Gerardo Cazzato, Giuseppe Ingravallo, Nadia Casatta, Carmelo Lupo, Angelo Vacca, Florenzo Iannone, Francesco Girolamo

“…The good performance of the FRF demonstrates that the CD31 pixel percentage of endomysial capillaries is sufficient for a correct estimation. Finally, the paper proposes a procedure to integrate AI in the pre-screening process.…”
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