The PRC2.1 subcomplex opposes G1 progression through regulation of CCND1 and CCND2 by Adam D Longhurst, Kyle Wang, Harsha Garadi Suresh, Mythili Ketavarapu, Henry N Ward, Ian R Jones, Vivek Narayan, Frances V Hundley, Arshia Zernab Hassan, Charles Boone, Chad L Myers, Yin Shen, Vijay Ramani, Brenda J Andrews, David P Toczyski

“…Our results demonstrate a role for PRC2.1, but not PRC2.2, in antagonizing G1 progression in a diversity of cell linages, including chronic myeloid leukemia (CML), breast cancer, and immortalized cell lines.…”
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Orthogonal Design Study on Factors Affecting the Determination of Common Odors in Water Samples by Headspace Solid-Phase Microextraction Coupled to GC/MS by Shifu Peng, Zhen Ding, Weiwen Xia, Hao Zheng, Yuting Xia, Xiaodong Chen

“…Calculated calibration curves gave high levels of linearity with a correlation coefficient value of 0.9999 for them. Finally, the proposed method was applied to water samples, which were previously analyzed and confirmed to be free of target analytes. …”
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The Stability-Indicating Ultra High-Performance Liquid Chromatography with Diode Array Detector and Tandem Mass Spectrometry Method Applied for the Forced Degradation Study of Ritl... by Jelena Kovačić, Daniela Amidžić Klarić, Nikša Turk, Željko Krznarić, Emma Riordan, Ana Mornar

“…Background/Objectives: Janus kinase inhibitors open new horizons for small-molecule drugs in treating inflammatory bowel disease, with ritlecitinib demonstrating significant efficacy in clinical trials for ulcerative colitis and Crohn’s disease. …”
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Involvement of Mechanistic Target of Rapamycin (mTOR) in Valine Orexigenic Effects in Rainbow Trout by Sara Comesaña, Mauro Chivite, Ayelén M. Blanco, María Alborja-Valado, Jessica Calo, Marta Conde-Sieira, José L. Soengas

“…In the second experiment, we evaluated in the hypothalamus and telencephalon the following: (1) the phosphorylation status of mTOR and its downstream effectors ribosomal protein S6 and p70 S6 kinase 1 (S6K1), (2) the abundance and phosphorylation status of transcription factors involved in appetite regulation, and (3) the mRNA levels of key neuropeptides associated with homeostatic regulation of feed intake in fish. …”
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Exertional Myopathy in a Juvenile Green Sea Turtle (Chelonia mydas) Entangled in a Large Mesh Gillnet by Brianne E. Phillips, Sarah A. Cannizzo, Matthew H. Godfrey, Brian A. Stacy, Craig A. Harms

“…Plasma biochemistry analysis showed elevated aspartate aminotransferase and creatine kinase, marked hypercalcemia, hyperphosphatemia, and hyperkalemia. …”
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Evolution of copro-tests in active detection of colorectal cancer by V. I. Chissov, N. S. Sergeyeva, Ye. V. Zenkina, N. V. Marshrutina

“…Besides that, detection of the tumor-specific pyruvate kinase type М2 in feces (fTu M2-PK) also can be used in the screening programs for active detection of CRC, as it was shown in series of studies.Conclusion. …”
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Cathepsin G, a Neutrophil Protease, Induces Compact Cell-Cell Adhesion in MCF-7 Human Breast Cancer Cells by Tomoya Kudo, Hideaki Kigoshi, Takashi Hagiwara, Takahisa Takino, Masatoshi Yamazaki, Satoru Yui

“…Cathepsin G also promotes E-cadherin/protein kinase D1 (PKD1) complex formation, and Go6976, the selective PKD1 inhibitor, suppressed the cathepsin G-induced cell condensation. …”
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Distribution network fault comprehensive identification method based on voltage–ampere curves and deep ensemble learning by Jian Wang, Bo Zhang, Dong Yin, Jinxin Ouyang

“…Moreover, a vertical segmentation technique is employed to enhance the feature extraction for fault location by using fault-phase voltage-ampere curves at the identified section to improve the overall fault comprehensive identification performance. Finally, the advantages of the proposed fault identification model and fault location model are validated through comparison experiments. …”
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Rolling Bearing Fault Diagnosis Based on Domain Adaptation and Preferred Feature Selection under Variable Working Conditions by Xiao Yu, Wei Chen, Chuanlong Wu, Enjie Ding, Yuanyuan Tian, Haiwei Zuo, Fei Dong

“…Furthermore, preferred feature selection by fault sensitivity and feature correlation (PSFFC) is embedded into this framework for selecting features which are more beneficial to fault pattern recognition and reduce the redundancy of feature set. Finally, vibration datasets collected from two test platforms are used for experimental analysis. …”
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Bone Response to Surface-Modified Titanium Implants: Studies on the Early Tissue Response to Implants with Different Surface Characteristics by C. Larsson Wexell, P. Thomsen, B.-O. Aronsson, P. Tengvall, M. Rodahl, J. Lausmaa, B. Kasemo, L. E. Ericson

“…Glow-discharge cleaning and oxidizing resulted in a highly stoichiometric TiO2 surface, while a glow-discharge treatment in nitrogen gas resulted in implants with essentially a surface of titanium nitride, covered with a very thin titanium oxide. Finally, hydrogen peroxide treatment of implants resulted in an almost stoichiometric TiO2, rich in hydroxyl groups on the surface. …”
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CRISPR-Cas9 in basic and translational aspects of cancer therapy by Maryam Samareh Salavatipour, Zahra Poursalehi, Negin Hosseini Rouzbahani, Sohaib Mohammadyar, Mohammad Vasei

“…Results: We have defined the basics of this technology and then mentioned some clinical and preclinical studies using this technology in the treatment of a variety of solid tumors as well as hematologic neoplasms. Finally, we described the progress made by this technology in boosting immune-mediated cell therapy in oncology, such as CAR-T cells, CAR-NK cells, and CAR-M cells. …”
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Resonant analogue configurations in atomic condensates by Muñoz de Nova, Juan Ramón, Fernández Palacios, Pablo, Alcázar Guerrero, Pedro , Zapata, Ivar, Sols, Fernando

“…We also discuss how these results have served as inspiration for the rapidly expanding field of quantum information in high-energy colliders. Finally, we study the physics of black-hole lasers as further examples of resonant analogue structures, distinguishing three stages in its time evolution. …”
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An Unsuspected Finding of t(9;22): A Rare Case of Philadelphia Chromosome-Positive B-Lymphoblastic Lymphoma by Prajwal Boddu, C. Cameron Yin, Rashmi Kanagal-Shamanna, Guillin Tang, Beenu Thakral, Tapan Kadia, Marina Konopleva, Elias Jabbour, Nitin Jain

“…Had it not been for this fortuitous discovery, the patient would not have been treated with tyrosine kinase inhibitors. We emphasize that FISH and PCR testing for BCR-ABL1 rearrangement are integral to arriving at an accurate diagnosis and should be routinely tested on B-LBL biopsy specimens.…”
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Prediction of football injuries using GPS-based data in Iranian professional football players: a machine learning approach by Reza Saberisani, Amir Hossein Barati, Mostafa Zarei, Paulo Santos, Armin Gorouhi, Luca Paolo Ardigò, Hadi Nobari

“…The acute-tochronic workload ratio was calculated separately for each variable using a ratio of 1:3 weeks. Finally, the decision tree algorithm with machine learning was utilised to assess the predictive power of injury occurrence based on the acute-to-chronic workload ratio.ResultsThe results showed that the variable of the number of decelerations had the highest predictive power compared to other variables [area under the curve (AUC) = 0.91, recall = 87.5%, precision = 58.3%, accuracy = 94.7%].ConclusionAlthough none of the selected external load variables in this study had high predictive power (AUC > 0.95), due to the high predictive power of injury of the number of deceleration variables compared with other variables, the necessity of attention and management of this variable as a risk factor for injury occurrence is essential for preventing future injuries.…”
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De la imagen del poder al poder de la imagen. by Javier Herrera Vicente

“…Los escudos que se presentan no son un añadido que simplemente identifica al linaje y ornamenta los muros perimetrales de la parroquia; al contrario, están ontológicamente ligados a una estrategia persuasiva llevada a cabo por su promotor. …”
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Advancing the genetic engineering toolbox by combining AsCas12a knock-in mice with ultra-compact screening by Wei Jin, Yexuan Deng, John E. La Marca, Emily J. Lelliott, Sarah T. Diepstraten, Christina König, Lin Tai, Valentina Snetkova, Kristel M. Dorighi, Luke Hoberecht, Millicent G. Hedditch, Lauren Whelan, Geraldine Healey, Dan Fayle, Kieran Lau, Margaret A. Potts, Moore Z. Chen, Angus P. R. Johnston, Yang Liao, Wei Shi, Andrew J. Kueh, Benjamin Haley, Jean-Philippe Fortin, Marco J. Herold

“…We also present compact, genome-wide Cas12a knockout libraries, with four crRNAs per gene encoded across one (Scherzo) or two (Menuetto) vectors, and demonstrate the utility of these libraries across methodologies: in vitro enrichment and drop-out screening in lymphoma cells and immortalised fibroblasts, respectively, and in vivo screens to identify lymphoma-driving events. Finally, we demonstrate CRISPR multiplexing via simultaneous gene knockout (via Cas12a) and activation (via dCas9-SAM) using primary T cells and fibroblasts. …”
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Metabolic Activity of Micromycetes Affecting Urban Concrete Constructions by Galina Yakovleva, Eugene Sagadeev, Viktor Stroganov, Olga Kozlova, Rodion Okunev, Olga Ilinskaya

“…The alterations in concrete resistances to compression and flexure after fungal attack were recorded at the trend level, mainly due to a short exposure time of concrete to fungal destructors in tests recommended by national Russian standard. Finally, using scanning electron microscopy we have shown that colonization of concrete by the dominant fungi includes their penetration into the thickness of concrete and germination in cracks. …”
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Psychological intervention, from the positive psychology approach, in infertile couples who are in the artificial insemination process by Arelys Pérez Figueroa, Damaisy Miranda Otero, Laziel Canovas Rodriguez

“…<br /><strong>Methods:</strong> prospective study, with a mixed approach, which included eleven couples undergoing artificial insemination treatment, treated at the Abel Santamaría Hospital Reproduction Center, in Pinar de Río, from December 2021 to April 2022. The essential route for localization and accessibility of the sample under study was the psychology consultation within the multidisciplinary commission that studies these couples. …”
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MacSyFinder v2: Improved modelling and search engine to identify molecular systems in genomes by Néron, Bertrand, Denise, Rémi, Coluzzi, Charles, Touchon, Marie, Rocha, Eduardo P.C., Abby, Sophie S.

“…We also introduce the novel macsydata companion tool that enables the easy installation and broad distribution of the models developed for MacSyFinder (macsy-models) from GitHub repositories. Finally, we have updated and improved MacSyFinder popular models: TXSScan to identify protein secretion systems, TFFscan to identify type IV filaments, CONJscan to identify conjugative systems, and CasFinder to identify CRISPR associated proteins. …”
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Inhibition of transcriptional regulation of detoxification genes contributes to insecticide resistance management in Spodoptera exigua by Bo Hu, Yuping Deng, Tao Lu, Miaomiao Ren, Kuitun Liu, Cong Rao, Hailiang Guo, Jianya Su

“…Bioassay results showed that sofalcone significantly enhanced the toxicity (more than 3-fold) of chlorpyrifos and lambda-cyhalothrin against S. exigua larvae. Finally, we demonstrate that sofalcone can greatly improve the susceptibility of S. exigua larvae to insecticides by inhibiting the activity of the ROS/CncC-dependent detoxifying enzymes and downregulating the expression levels of detoxification genes. …”
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