Tofacitinib and budesonide treatment affect stemness and chemokine release in IBD patient-derived colonoids by Arun Sridhar, Ingunn Bakke, Shreya Gopalakrishnan, Nimo Mukhtar Mohamud Osoble, Emilie Prytz Hammarqvist, Henrik P. Sahlin Pettersen, Arne Kristian Sandvik, Ann Elisabet Østvik, Marianne Doré Hansen, Torunn Bruland

“…We investigated cellular effects of pan-Janus Kinase (JAK) inhibitor tofacitinib and the corticosteroid budesonide on uninflamed and TNF + Poly(I:C) stimulated human colon organoids (colonoids) from healthy donors and IBD-patients. …”
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A data-driven intelligent fault diagnosis framework for permanent magnet in PMSM by Huizhen Wang, Lei Wang, QiYa Wu, Haoying Pei, Lijun Diao

“…Second, fault diagnosis is carried out using the Genetic Algorithm-Support Vector Machine (GA-SVM) to accurately classify demagnetization faults. Finally, the Pauta criterion is applied to process the intermediate Support Vector Domain Description (SVDD) variables, generating anomaly scores that classify PMSM health states based on segmented thresholds. …”
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Peroxiredoxin 6 Attenuates Alloxan-Induced Type 1 Diabetes Mellitus in Mice and Cytokine-Induced Cytotoxicity in RIN-m5F Beta Cells by Elena G. Novoselova, Olga V. Glushkova, Sergey M. Lunin, Maxim O. Khrenov, Svetlana B. Parfenyuk, Tatyana V. Novoselova, Mars G. Sharapov, Vladimir I. Novoselov, Evgeny E. Fesenko

“…Signal transduction studies showed that PRDX6 prevented the activation of NF-κB and c-Jun N-terminal kinase signaling cascades in RIN-m5F β cells cultured with cytokines. …”
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Study of Wind Loads and Wind Speed Amplifications on High-Rise Building with Opening by Numerical Simulation and Wind Tunnel Test by Fu-Bin Chen, Xiao-Lu Wang, Yun Zhao, Yuan-Bo Li, Qiu-Sheng Li, Ping Xiang, Yi Li

“…Finally, the wind speed amplifications in the openings were studied and verified by the numerical simulation results.…”
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Method for improving voltage sag tolerance of dual power supply PET based on inter-port power coordination by ZHANG Tengfei, WANG Guanghua, GAO Long, LI Jing, XU Yonghai, WANG Chong

“…Then, from the perspective of power balance, a real-time analysis method of voltage sag immunity of DPSC-PET as well as power coordination method between dual input ports when voltage sag occurs on different power supply are proposed to achieve a perfect recovery of low-voltage DC bus voltage, which means the significant improvement of DPSC-PET to cope with transient disturbances. Finally, the simulation model of DPSC-PET is established and the simulations for voltage sag occurred with different magnitudes on different power supply are cited out. …”
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Development and external validation of a nomogram for the early prediction of acute kidney injury in septic patients: a multicenter retrospective clinical study by Qin-Yue Su, Wen-Jie Chen, Yan-Jun Zheng, Wen Shi, Fang-Chen Gong, Shun-Wei Huang, Zhi-tao Yang, Hong-Ping Qu, En-Qiang Mao, Rui-Lan Wang, Du-Ming Zhu, Gang Zhao, Wei Chen, Sheng Wang, Qian Wang, Chang-Qing Zhu, Gao Yuan, Er-Zhen Chen, Ying Chen

“…The model included five independent indicators: chronic kidney disease stages 1 to 3, blood urea nitrogen, procalcitonin, D-dimer and creatine kinase isoenzyme. The AUC of the model in the development and validation cohorts was 0.914 (95% CI, 0.894–0.934) and 0.923 (95% CI, 0.895–0.952), respectively. …”
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Migratory Dates, Breeding Phenology, and Reproductive Success of European Turtle Doves between Lowlands and Highest Breeding Habitats in North Africa by Ismail Mansouri, Mohamed Mounir, Wafae Squalli, Laila Elhanafi, Mohamed Dakki, Lahsen El Ghadraoui

“…As a response, at Midelt breeding period was shorter and shifted to hot periods to ensure better reproductive success. Finally, our results highlight that the turtle dove breeding season is later and shorter at breeding highlands, which might allow this bird to avoid the vigorous climate conditions at mountains and their effect on reproductive success.…”
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Current Molecular Targeted Therapy in Advanced Gastric Cancer: A Comprehensive Review of Therapeutic Mechanism, Clinical Trials, and Practical Application by Kaichun Li, Jin Li

“…The VEGFR-2 tyrosine kinase inhibitor, apatinib, can improve the survival of advanced gastric cancer patients after second-line chemotherapy failure. …”
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Vitamin C exerts anti-cadmium induced fracture functions/targets: bioinformatic and biostructural findings by Rong Li, Songzuo Yu, Xiao Liang, Yu Li, Keng Po Lai

“…Nine core targets were characterized, including tumor protein p53, epidermal growth factor receptor, proto-oncogene c, mitogen-activated protein kinase-1 (MAPK1), MAPK3, signal transducer and activator of transcription-3, MAPK14, prostaglandin-endoperoxide synthase 2, and estrogen receptor alpha. …”
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Research progress in integrated groundwater-surface water models by Shuyan PENG, Zheng LU, Tingting WU, Xiaofan YANG

“…In addition, the integrated models are facing multiple challenges, such as the increasing demand for basic data, higher requirements for hardware platforms, the difficulty in accurately determining the modeling region, and the evident trend of interdisciplinary integration. Finally, the integrated model development is expected to focus on enriching the approaches to obtaining model parameters, improving the simulation efficiency, and strengthening the integration of model coupling with different disciplines.…”
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Locating Station of One-Way Carsharing Based on Spatial Demand Characteristics by Xiaohong Chen, Jiaqi Cheng, Jianhong Ye, Yong Jin, Xi Li, Fei Zhang

“…The adaptive elastic net regression is developed to identify factors that influence carsharing usage intensity and degree of usage imbalance after factor selection using extra-randomized-tree algorithm. Finally, a station layout is proposed according to both usage intensity and degree of imbalance. …”
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Atractylenolide I prevents acute liver failure in mouse by regulating M1 macrophage polarization by Hui Zhang, Min Gao, Haiyan Wang, Junfeng Zhang, Lin Wang, Guanjun Dong, Qun Ma, Chunxia Li, Jun Dai, Zhihua Li, Fenglian Yan, Huabao Xiong

“…In vitro experiments with bone marrow-derived macrophages indicate that ATR-I regulates macrophage polarization through the mitogen-activated protein kinase (MAPK) and interferon regulatory factor (IRF) signaling pathways. …”
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Association between Waste Management and HBV among Solid Municipal Waste Workers: A Systematic Review and Meta-Analysis of Observational Studies by Carmela Romana Natalina Corrao, Angela Del Cimmuto, Carolina Marzuillo, Emanuele Paparo, Giuseppe La Torre

“…Results. 160 studies were found and checked. Finally, 5 observational studies were considered suitable, all cross-sectional. …”
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Denitrification research based on green electron supply and cell metabolism regulation by LIU Chao, FAN Xinyun, ZHANG Xuemeng, CHEN Chuang, ZHU Mengru, CHEN Yinguang*

“…Then, the microbial metabolic pathway of denitrification using methane, propane, and other short-chain alkanes as carbon sources is described, the performance of kitchen waste and other organic wastes as carbon source is introduced, and the formation mechanism and utilization characteristics of microbial carbon sources are also analyzed. Finally, the mechanisms of promoting denitrification by improving electron utilization efficiency of microorganisms are discussed, in order to expand the understanding of efficient biological nitrogen removal mechanisms. …”
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Advancements in MEMS Micromirror and Microshutter Arrays for Light Transmission Through a Substrate by Shilby Baby, Mustaqim Siddi Que Iskhandar, Md Kamrul Hasan, Steffen Liebermann, Jiahao Chen, Hasnain Qasim, Shujie Liu, Eslam Farrag, Dennis Löber, Naureen Ahmed, Guilin Xu, Hartmut Hillmer

“…The recent advancements in MEMS smart glass technology for daylight steering are discussed, focusing on aspects like the switching speed, scalability, transmission, lifetime study, and reliability of micromirror arrays. Finally, simulations demonstrating the potential yearly energy savings for investments in MEMS smart glazing are presented, including a comparison to traditional automated external blind systems in a model office room with definite user interactions throughout the year. …”
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IL-10 and ARG-1 Concentrations in Bone Marrow and Peripheral Blood of Metastatic Neuroblastoma Patients Do Not Associate with Clinical Outcome by Fabio Morandi, Michela Croce, Giuliana Cangemi, Sebastiano Barco, Valentina Rigo, Barbara Carlini, Loredana Amoroso, Vito Pistoia, Silvano Ferrini, Maria Valeria Corrias

“…Moreover, ARG-1 plasma concentration was lower than in controls, and no association with patient outcome was found. Finally, in metastatic NB patients, the percentage of circulating Treg was higher than in controls, whereas that of Tr1 cells was lower. …”
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Up-Regulation of Endothelin Receptors Induced by Cigarette Smoke — Involvement of MAPK in Vascular and Airway Hyper-Reactivity by Yaping Zhang, Lars Edvinsson, Cang-Bao Xu

“…This review focuses on cigarette smoke exposure that induces activation of intracellular mitogen-activated protein kinase (MAPK) and subsequently results in the up-regulation of endothelin receptors in the vasculature and airways, which mediates vascular and airway hyper-reactivity, one of the important pathogenic characteristics of cardiovascular and airway diseases. …”
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Toward super-clean bearing steel by a novel physical-data integrated design strategy by Jian Guan, Guolei Liu, Wenguang Hu, Hongwei Liu, Paixian Fu, Yanfei Cao, Dong-Rong Liu, Dianzhong Li

“…Furthermore, five ML algorithms were utilized to predict the cleanliness assessment score (CAS) based on inclusion size and distribution data from various VAR processing parameters, with gradient boosting regression (GBR) showing the best performance. Finally, a systematic framework based on a genetic algorithm was proposed to select the optimal combination of CAS. …”
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Muramyl Dipeptide Enhances Lipopolysaccharide-Induced Osteoclast Formation and Bone Resorption through Increased RANKL Expression in Stromal Cells by Masahiko Ishida, Hideki Kitaura, Keisuke Kimura, Haruki Sugisawa, Tomo Aonuma, Haruhiko Takada, Teruko Takano-Yamamoto

“…MDP also enhanced LPS-induced mitogen-activated protein kinase (MAPK) signaling, including ERK, p38, and JNK, in stromal cells. …”
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Proteomic and N-glycosylation analysis of fertile egg white during storage and incubation in chickens by Daqing Dai, Xiqiong Wang, Kexin Wu, Fangren Lan, Jiaming Jin, Wenxin Zhang, Chaoliang Wen, Junying Li, Ning Yang, Congjiao Sun

“…We found that the differential N-glycoproteins in the early stage of storage were mainly related to protein structure changes, antibacterial activity, and cell proliferation, and that there were more protease inhibitors in egg whites, which decreased in the later stage of storage. Finally, eleven possible protein markers and N-glycosylation sites were identified to significantly change during storage and may exert an effect on hatchability, including the proteins involved in antibacterial activity (OVOA-N855, CLU-N154, ogchi-N82, PIGR-N290, WFDC2-N120), protein structure (LOC776816), and cell proliferation (ASAH1-N173). …”
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