hERG activators exhibit antitumor effects in breast cancer through calcineurin and β-catenin-mediated signaling pathways by Yan Yu, Chengchun Zhu, Xiao Wang, Ying Shi, Yiping Gao, Zhiyi Yu

“…Furthermore, both SDUY429 and SDUY436 remarkably suppressed the migration and invasion of MDA-MB-231 cells by downregulating the protein kinase B (AKT)/glycogen synthase kinase-3 beta (GSK3β)/β-catenin signaling pathway. …”
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Beta-hydroxy-beta-methylbutyrate (HMB) improves daily activity and whole-body protein metabolism in Duchenne muscular dystrophy dogs: a pilot study by Peter P. Nghiem, Alexis M. Rutledge, Kyle Tehas, Corine Kaderli, Meredith Poling, Sidney Arnim, Vitaliy Dernov, Celine van Sas, Macie L. Mackey, Gabriella A. M. ten Have, Mariëlle P. K. J. Engelen, Nicolaas E. P. Deutz

“…We tracked daily activity with an activity monitoring device and measured plasma creatine kinase and standard clinical biochemistry panels to monitor muscle and organ function. …”
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Daidzein improves muscle atrophy caused by lovastatin by regulating the AMPK/FOXO3a axis by Keke Wang, Hao Zeng, Hua Yang

“…Results In this study, we demonstrated that daidzein could dose-dependently alleviate lovastatin-induced mice skeletal muscle atrophy, reduce serum creatine kinase, and improve muscle grip strength in mice. …”
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POTENTIAL OF THE KANTIAN NOTION OF SOCIAL JUSTICE by Z. Kieliszek

“…Then, I will reference his understanding of social justice against three fundamental models of social justice thus far established in the philosophical tradition: the legal, distributive, and contractual justice. Finally, I will explain how the Kantian understanding of social justice is reflected in select modern interpretations of a just state system and justice in international relationships, and how we can grasp the current practice and the expected development of sociopolitical life in the framework of social justice as understood by Kant. …”
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Prediction of Groundwater Level Based on the Integration of Electromagnetic Induction, Satellite Data, and Artificial Intelligent by Fei Wang, Lili Han, Lulu Liu, Yang Wei, Xian Guo

“…Careful analysis of the scatter plots between predicted ECa and GWL revealed that when ECa varies between 0–600 mS/m, 600–800 mS/m, 800–1100 mS/m, and >1100 mS/m, the fluctuation ranges of the corresponding GWL correspond to 0–31 m, 0–15 m, 0–10 m, and 0–5 m. Finally, combining the spatial variability of ECa and RS_GWL spatial distribution map, the following optimization strategies were finally established: GWL < 5 m (in natural land with ECa > 1100 mS/m), GWL < 5 m (occupied by farmland from RS_GWL) and GWL > 10 m (from RS_GWL), and 3 < GWL < 10 m (speculated). …”
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The RNA-binding protein Puf5 and the HMGB protein Ixr1 regulate cell cycle-specific expression of CLB1 and CLB2 in Saccharomyces cerevisiae. by Megumi Sato, Varsha Rana, Yasuyuki Suda, Tomoaki Mizuno, Kenji Irie

“…Moreover, the ixr1Δ mutation is known to be synthetically lethal with deletion of the DUN1 gene encoding the checkpoint kinase. We found that the clb2Δ mutation restored the lethality of ixr1Δ dun1Δ double mutant. …”
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TÉCNICAS DE LIQUENOMETRÍA BASADAS EN RHIZOCARPON SUBGÉNERO RHIZOCARPON PARA DATAR DEPÓSITOS GLACIARES EN LOS ANDES PATAGÓNICOS by Irene Garibotti, Ricardo Villalba

“…El primer período se extiende desde la mitad del siglo XVII hasta finales del siglo XIX, y está caracterizado por morenas muy prominentes. …”
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Técnicas de liquenometría basadas en rhizocarpon subgénero rhizocarpon para datar depósitos glaciares en los Andes Patagónicos by Irene Garibotti, Ricardo Villalba

“…El primer período se extiende desde la mitad del siglo XVII hasta finales del siglo XIX, y está caracterizado por morenas muy prominentes. …”
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Study on the Genetic Differences in Reservoir Characteristics Based on the Bidirectional Provenance of the Yanchang Formation in the Jiyuan Area, Ordos Basin, China by Qiang Tong, Zhaohui Xia, Jixin Huang, Junchang Wu, Yusheng Wang, Zheng Meng, Chaoqian Zhang

“…Furthermore, the diagenetic facies are characterized by a cluster analysis of logging data, and finally, the reasons for the differences in reservoir distribution and the genetic mechanism between the Yinshan provenance area (YPA) and Alxa provenance area (APA) are obtained. …”
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Genome Characteristic of NDM-5-Producing Klebsiella Quasipneumoniae and Klebsiella Pneumoniae in China by Chen L, Liu R, Ye H, Qian J, Lou D

“…Lifeng Chen,1,&ast; Ruishan Liu,2,3,&ast; Haowei Ye,2 Jiajie Qian,4 Danfeng Lou5 1Department of Clinical Engineering and Materials Supplies, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China; 2State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China; 3Jinan Microecological Biomedicine, Shandong Laboratory, Jinan, People’s Republic of China; 4Department of Gastrointestinal Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China; 5Department of Infectious Diseases, Shulan (Hangzhou) Hospital, Hangzhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Danfeng Lou, Department of Infectious Diseases, Shulan (Hangzhou) Hospital, No. 848 Dongxin Road, Hangzhou, People’s Republic of China, Email loudanfeng@126.com Jiajie Qian, Department of Gastrointestinal Surgery, The First Affiliated Hospital, College of Medicine Zhejiang University, No. 79 Qingchun Road, Hangzhou, People’s Republic of China, Email 1202058@zju.edu.cnAbstract: The global dissemination of carbapenem-resistant Enterobacteriaceae poses a significant threat to public health. …”
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IMITATION OF STANDARD VOLUMETRIC ACTIVITY METAL SAMPLES by A. I. Zhukouski, A. O. Nichyparchuk, A. A. Khrutchinsky, S. A. Kutsen

“…Instrumental experimental and theoretical spectra obtained by using standard samples and their imitators show a high compliance between experimental spectra of real samples and the theoretical ones of their Monte-Carlo models, between spectra of real samples and the ones of their imitators and finally, between experimental spectra of real sample imitators and the theoretical ones of their Monte-Carlo models. …”
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Effect of Astragalus injection treatment for viral myocarditis: a systematic review and meta-analysis by Dinala jialiken, Lichao Qian, Shiwu Wen, Shuai Ren, Yadong Fan, Yi xuan Dong, Chong Zou

“…The outcome measures of this study included the effectiveness rate, creatine kinase (CK), aspartate aminotransferase (AST), creatine kinase Isoenzyme (CK-MB), lactate dehydrogenase (LDH), cardiac troponin I (cTnI), and electrocardiogram (ECG). …”
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National Patient Satisfaction Survey as a Predictor for Quality of Care and Quality Improvement &ndash; Experience and Practice by Cui J, Du J, Zhang N, Liang Z

“…Juan Cui,1,2 Jing Du,2 Ning Zhang,1 Zhanming Liang3 1Affairs Management Office, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong Province, People’s Republic of China; 2Department of Medical Management, Health Commission of Shandong Province, Jinan, Shandong Province, People’s Republic of China; 3College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Queensland, AustraliaCorrespondence: Ning Zhang, Email zn394114326@126.comBackground: Patient satisfaction is an important predictor of quality of care and hospital services. …”
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Mining Potential Drug Targets and Constructing Diagnostic Models for Heart Failure Based on miRNA-mRNA Networks by Xiangming Fang, Rensheng Song, Jiaxing Wei, Qin Liao, Zhenhong Zeng

“…In addition, further drug identification was performed by molecular docking. Finally, diagnostic models were constructed based on differential miRNAs. …”
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Association between sex steroid hormones and α-klotho: Results from the NHANES 2013-2016 and Mendelian randomization study by Andong Guo, Pengcheng Chen, Jishuang Cao, Chenrui Wu, Sentai Ding

“…Then, utilizing summary data from genome-wide association studies (GWAS), a bidirectional two-sample Mendelian randomization (MR) was conducted to assess the causal relationship between sex steroid hormones and α-Klotho. Finally, mediation analysis was conducted to delineate the influence of five identified potential mediators on the sex steroid hormones-α-Klotho association. …”
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Single-cell profiling of SLC family transporters: uncovering the role of SLC7A1 in osteosarcoma by Yan Liao, Junkai Chen, Hao Yao, Ting Zheng, Jian Tu, Weidong Chen, ZeHao Guo, Yutong Zou, Lili Wen, Xianbiao Xie

“…Co-culture models confirmed the involvement of SLC7A1 in macrophage polarization. Finally, virtual screening and CETSA identified Cepharanthine as potential inhibitors of SLC7A1. …”
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A Bio-Inspired Visual Neural Model for Robustly and Steadily Detecting Motion Directions of Translating Objects Against Variable Contrast in the Figure-Ground and Noise Interferenc... by Sheng Zhang, Ke Li, Zhonghua Luo, Mengxi Xu, Shengnan Zheng

“…Thirdly, the non-linear instantaneous feedback mechanism in divisive contrast normalization is adopted to reduce local contrast sensitivity; further, the parallel ON and OFF contrast pathways are activated. Finally, the parallel motion and contrast pathways converge on the LPTC in the lobula complex. (3) Results: By comparing numerous experimental simulations with state-of-the-art (SotA) bio-inspired models, we can draw four conclusions. …”
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CaMKII-dependent non-canonical RIG-I pathway promotes influenza virus propagation in the acute-phase of infection by Shinichiro Hama, Miho Watanabe-Takahashi, Hiroki Nishimura, Jumpei Omi, Masakazu Tamada, Takashi Saitoh, Katsumi Maenaka, Yuta Okuda, Aoi Ikegami, Asami Kitagawa, Koudai Furuta, Kana Izumi, Eiko Shimizu, Takashi Nishizono, Makoto Fujiwara, Tomohiro Miyasaka, Shigeo Takamori, Hiroshi Takayanagi, Keizo Nishikawa, Toshihiko Kobayashi, Noriko Toyama-Sorimachi, Makoto Yamashita, Toshiya Senda, Takatsugu Hirokawa, Haruhiko Bito, Kiyotaka Nishikawa

“…ABSTRACT Ca2+/calmodulin-dependent protein kinase II (CaMKII) is one of hundreds of host-cell factors involved in the propagation of type A influenza virus (IAV), although its mechanism of action is unknown. …”
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Influence of Coal Caving Time and Tail Beam Swing Angle on the Evolution of the Coal Gangue Boundary Line during Top Coal Caving by Qingliang Zeng, Yanpeng Zhu, Yang Yang, Zhe Li, Lirong Wan

“…After the end of coal caving, the coal gangue boundary finally presents a double arch structure. The research in this paper has important reference significance for the selection of caving time and tail beam swing angle and further research.…”
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The necroptosis-related lncRNA ENSG00000253385.1 promotes the progression of esophageal squamous cell carcinoma by targeting the miR-16-2-3p/VDAC1 axis by Xiaoyang Duan, Jian Shi, Ran Hou, Yajie Huang, Chunyan Wang, Huazhen Du

“…Knockdown of the lncRNA ENSG00000253385.1 could inhibit the proliferation, migration and invasion, promote the apoptosis, and result in increases in the necroptosis-related proteins p-receptor-interacting protein kinase 3 (RIPK3)/RIPK3 and p-mixed lineaae kinase domain-like protein (MLKL)/MLKL and a decrease in the VDAC1 protein levels in ESCC cells, whereas miR-16-2-3p inhibition rescued these effects. …”
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