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    Regulation of enzymatic lipid peroxidation in osteoblasts protects against postmenopausal osteoporosis by Qiong-Yi Zhang, Hai-Biao Gong, Man-Ya Jiang, Fujun Jin, Guan Wang, Chang-Yu Yan, Xiang Luo, Wan-Yang Sun, Shu-Hua Ouyang, Yan-Ping Wu, Wen-Jun Duan, Lei Liang, Yun-Feng Cao, Xin-Xin Sun, Meijing Liu, Gen-Long Jiao, Hua-Jun Wang, Kurihara Hiroshi, Xiaogang Wang, Rong-Rong He, Yi-Fang Li

    Published 2025-01-01
    “…Mechanistically, 4-hydroxynonenal, an end-product of phospholipid peroxidation, binds to integrin-linked kinase and triggers its protein degradation, disrupting RUNX2 signaling and inhibiting osteoblastogenesis. …”
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    Identification of therapeutic target genes for age-related hearing loss through systematic genome-wide mendelian randomization of druggable genes by Kun Zhang, Bo Hou, Tao Yan, Ruru Qiao, Peng Qu, Xinbo Xu, Hanbing Zhang

    Published 2025-02-01
    “…After filtering using methods such as phenome-wide research, enrichment analysis, protein network construction, drug prediction, and molecular docking, six potentially druggable genes (BAK1, AMFR, LAMP3, STK17B, ACP5, and CD9) and six drugs (beclomethasone, propyl pyrazole triol, momelotinib, monoisoamyl-2,3-dimercaptosuccinate, pterostilbene, and naftidrofuryl) that may affect ARHL outcomes were finally identified. Conclusions: Our findings identified 14 potential drug targets for ARHL. …”
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